Septic Shock
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CLINICAL_TRIALS trial_result · 2018-03-08Clinical Trial Update: Changes in Microvascular Perfusion During Blood Purification With Cytosorb® in Septic Shock
This clinical trial update reports changes in microvascular perfusion during blood purification with Cytosorb in septic shock, and the study…
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CLINICAL_TRIALS trial_result · 2018-03-07Clinical Trial Update: ASSET - a Double-Blind, Randomized Placebo-Controlled Clinical Investigation With Alteco® LPS Adsorber [NA]
The ASSET trial evaluating the Alteco LPS adsorber for septic shock has been terminated.
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CLINICAL_TRIALS trial_result · 2018-02-14Clinical Trial Update: Early Warning System for Clinical Deterioration on General Hospital Wards [NA]
Clinical trial completed evaluating an early warning system for deterioration on general hospital wards; results posted in 2018.
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CLINICAL_TRIALS trial_result · 2018-01-31Clinical Trial Update: Effect of Different Strategies for Titrating a High MAP on Microcirculation [Phase 4]
Phase 4 clinical trial evaluating different strategies for titrating a high mean arterial pressure on microcirculation in septic shock and h…
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CLINICAL_TRIALS trial_result · 2018-01-30Clinical Trial Update: Evaluating in Cirrhotics With Refractory Vasoplegia the Effect of Methylene Blue [Phase 4]
Phase 4 trial evaluating methylene blue for refractory vasoplegia in cirrhotics with septic shock has completed.
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CLINICAL_TRIALS trial_result · 2018-01-24Clinical Trial Update: Effect of Dexmedetomidine on Perfusion Index and Microcirculation in Severe Sepsis and Septic Shock Patients [Phase 3]
Phase 3 clinical trial update examining dexmedetomidine effects on perfusion index and microcirculation in patients with septic shock.
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CLINICAL_TRIALS trial_result · 2018-01-09Clinical Trial Update: Vasculopathic Injury and Plasma as Endothelial Rescue in Septic Shock Trial. VIPER-Sepsis (EudraCT no. 2016-000707-81) [Phase 4]
Phase 4 trial investigating vasculopathic injury and plasma as endothelial rescue in septic shock (VIPER-Sepsis) was terminated.
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CLINICAL_TRIALS trial_result · 2017-12-12Clinical Trial Update: ADjunctive coRticosteroid trEatment iN criticAlly ilL Patients With Septic Shock [Phase 4]
Phase 4 clinical trial evaluating adjunctive corticosteroid therapy in critically ill patients with septic shock has completed.
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CLINICAL_TRIALS trial_result · 2017-11-29Clinical Trial Update: Immune Reconstitution of Immunosuppressed Sepsis Patients [Phase 2]
Phase 2 trial investigating immune reconstitution in immunosuppressed sepsis patients was terminated.
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CLINICAL_TRIALS trial_result · 2017-11-20Clinical Trial Update: Treatment of Septic Shock by Inhibiting Autodigestion and Preserving Gut Integrity With Enteric LB1148 [Phase 2]
Phase 2 trial update for LB1148 in septic shock; study terminated with posted results in 2017.
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CLINICAL_TRIALS trial_result · 2017-10-26Clinical Trial Update: Phenylephrine in Septic Shock [Phase 2]
Phase 2 clinical trial of phenylephrine for septic shock has completed.
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CLINICAL_TRIALS trial_result · 2017-10-17Clinical Trial Update: SIRS and Bacterial Sepsis Discrimination by Biomarkers in ICU
A completed clinical trial evaluates biomarkers to discriminate systemic inflammatory response syndrome from bacterial sepsis in ICU patient…
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CLINICAL_TRIALS trial_result · 2017-10-12Clinical Trial Update: Plasma and Lung Tissue Concentrations of Linezolid in Septic Shock Patients
This clinical trial update reports measurements of linezolid concentrations in plasma and lung tissue from septic shock patients participati…
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CLINICAL_TRIALS trial_result · 2017-10-06Clinical Trial Update: Hyperglycemia and Effects of Daily 100 mg Versus 200 mg of Hydrocortisone Therapy in Patients With Septic Shock [Phase 4]
A Phase 4 trial comparing daily hydrocortisone doses (100 mg vs 200 mg) in septic shock and its association with hyperglycemia.
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CLINICAL_TRIALS trial_result · 2017-09-29Clinical Trial Update: The Effects of Interferon-gamma on Sepsis-induced Immunoparalysis [Phase 3]
Phase 3 trial evaluating interferon-gamma for sepsis-induced immunoparalysis has completed.
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CLINICAL_TRIALS trial_result · 2017-09-20Clinical Trial Update: Piperacillin/Tazobactam in Critically Ill Patients With Severe Sepsis and Septic Shock [Phase 4]
Phase 4 trial update on piperacillin/tazobactam in critically ill patients with severe sepsis and septic shock; study completed.
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CLINICAL_TRIALS trial_result · 2017-09-01Clinical Trial Update: Central Venous Catheter Colonisation Among Critically Ill Patients in Intensive Care Units
A completed clinical trial evaluating central venous catheter colonisation in critically ill ICU patients, including individuals with sepsis…
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CLINICAL_TRIALS trial_result · 2017-08-29Clinical Trial Update: Evaluation of Intestinal Brush Border Enzyme Function in Critically Ill Patients [NA]
A completed clinical trial evaluating intestinal brush border enzyme function in critically ill patients, including those with septic shock …
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CLINICAL_TRIALS trial_result · 2017-08-15Clinical Trial Update: Epidemiology of Sepsis in Turkish ICUs.
A completed clinical trial update examining the epidemiology of sepsis in Turkish intensive care units.
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CLINICAL_TRIALS trial_result · 2017-08-07Clinical Trial Update: Initiation of Hydrocortisone for the Treatment of Septic Shock [NA]
Completed clinical trial evaluating hydrocortisone for septic shock, with results posted in 2017.
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CLINICAL_TRIALS trial_result · 2017-08-03Clinical Trial Update: Examination of ADMA Serum Level and DDAH II
A completed clinical trial examining ADMA serum levels and DDAH II in septic shock and sepsis.
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CLINICAL_TRIALS trial_result · 2017-07-28Clinical Trial Update: Upregulation of Alpha-1 Receptors Upon Septic Shock? [Phase 2, Phase 3]
A Phase 2/3 trial investigating upregulation of alpha-1 receptors in septic shock has been terminated.
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CLINICAL_TRIALS trial_result · 2017-06-15Clinical Trial Update: Prehospital Antibiotics Against Sepsis Trial [NA]
The trial evaluating prehospital antibiotics for sepsis has completed, sponsored by Amsterdam UMC and conducted at VUmc.
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CLINICAL_TRIALS trial_result · 2017-06-14Clinical Trial Update: Statin Therapy in the Treatment of Sepsis [Phase 2, Phase 3]
A completed Phase 2/Phase 3 trial evaluated statin therapy for septic shock; results have been posted.
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CLINICAL_TRIALS trial_result · 2017-06-14Clinical Trial Update: Activated Protein C and Corticosteroids for Human Septic Shock [Phase 3]
Phase 3 trial evaluating activated protein C in combination with corticosteroids for septic shock has completed.