Septic Shock
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Role of Echocardiography and Ultrasound Indices in Resuscitation of Septic Shock Patients
A clinical trial update describing a study evaluating the role of echocardiography and ultrasound indices in guiding fluid resuscitation for…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: Early Norepinephrine Administration and Rapid Dose Adjustment [NA]
Ongoing clinical trial at Siriraj Hospital evaluating early norepinephrine administration and rapid dose adjustment in sepsis and septic sho…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: Effect of oXiris Hemofilter Use in Septic Shock: A Multicenter Retrospective Cohort Study
An ongoing multicenter retrospective cohort study evaluating the use of the oXiris hemofilter in septic shock and multiorgan dysfunction, cu…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: Comparative Efficacy and Safety of Propofol-Ketamine Combination Versus Propofol Monotherapy in Geriatric Patients Under Invasive Ventilation [Phase 3]
Phase 3 clinical trial comparing propofol-ketamine combination versus propofol alone in geriatric patients on invasive ventilation; currentl…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: In Vivo Antibiotics Removal During Hemoadsorption Cartridges and Continuous Renal Replacement Therapy in the Intensive Care Unit
Clinical trial update describing a recruiting study that investigates removal of antibiotics during hemoadsorption and continuous renal repl…
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: Veno-arterial Carbon Dioxide Partial Pressure Difference (CO2gap) for Early Resuscitation of Septic Shock [NA]
This clinical trial evaluates the venous-arterial CO2 gap (CO2gap) as a potential guide for early resuscitation in septic shock and is curre…
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: Blood Purification for the Treatment of Pathogen Associated Shock [NA]
A clinical trial evaluating blood purification for septic shock sponsored by ExThera Medical Corporation is currently active but not recruit…
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CLINICAL_TRIALS research · 2026-04-09Clinical Trial Update: Peripheral Perfusion Index-guided Fluid Resuscitation for Preventing Acute Skin Failure in Elderly Critically Ill Patients [NA]
This clinical trial is recruiting to evaluate whether guiding fluid resuscitation by peripheral perfusion index can prevent acute skin failu…
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CLINICAL_TRIALS research · 2026-04-07Clinical Trial Update: Dynamic SvO2 in Predicting Fluid Responsiveness in Septic Shock
This clinical trial investigating Dynamic SvO2 to predict fluid responsiveness in septic shock is currently not recruiting, sponsored by Men…
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CLINICAL_TRIALS research · 2026-04-01Clinical Trial Update: Neuromodulation to Regulate Inflammation and Autonomic Imbalance in Sepsis [NA]
The University of Oklahoma is conducting a clinical trial to study neuromodulation to regulate inflammation and autonomic imbalance in septi…
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CLINICAL_TRIALS research · 2026-04-01Clinical Trial Update: Protocolized Reduction of Non-resuscitation Fluids Versus Usual Care in Septic Shock Patients [NA]
This clinical trial update describes a protocol evaluating protocolized reduction of non-resuscitation fluids versus usual care in septic sh…
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CLINICAL_TRIALS research · 2026-03-31Clinical Trial Update: Mechanistic Assessment of Norepinephrine Therapy vs. Angiotensin-II in Septic Shock [Phase 4]
Phase 4 mechanistic trial comparing norepinephrine versus angiotensin II in septic shock; the study is currently not yet recruiting.
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CLINICAL_TRIALS research · 2026-03-31Clinical Trial Update: The PvCO2-PaCO2/CaO2-CvO2 Ratio in Septic Shock
This clinical trial investigates the PvCO2-PaCO2/CaO2-CvO2 ratio in septic shock and is currently recruiting participants.
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: Assessing the Efficacy of Dapagliflozin as a Vasculoprotective Treatment in Septic Shock Patients With Microcirculatory Dysfunction [Phase 3]
Phase 3 clinical trial evaluating dapagliflozin as a vasculoprotective treatment for septic shock with microcirculatory dysfunction; sponsor…
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: Early Methylene Blue in the Microhemodynamics of Septic Patients [Phase 2, Phase 3]
Phase 2/3 clinical trial evaluating methylene blue for septic shock and hypoperfusion is currently recruiting.
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CLINICAL_TRIALS research · 2026-03-25Clinical Trial Update: Validation of the Use of the Arteriovenous Tension Difference in CO2 Under Hyperbaric Conditions
An update on a clinical trial validating arteriovenous tension difference in CO2 under hyperbaric conditions. The study is not yet recruitin…
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CLINICAL_TRIALS research · 2026-03-19Clinical Trial Update: Association Between Muscle L3 CT Scan Muscle Derived Parameters of Muscle Function Upon Intensive Care Unit Admission and 3 Months Mortality After ICU Discharge for Patients Admitted for Septic Shock. The SIMS Study [NA]
This clinical study, The SIMS Study, will investigate whether muscle function parameters from L3 CT scans at ICU admission predict 3-month m…
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CLINICAL_TRIALS research · 2026-03-19Clinical Trial Update: Sepsis: From Syndrome to Personalized Care
This clinical trial update describes an Oslo University Hospital study aiming to personalize sepsis care. The trial is currently recruiting …
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CLINICAL_TRIALS research · 2026-03-17Clinical Trial Update: Australasian Resuscitation In Sepsis Evaluation: FLUid or Vasopressors In Emergency Department Sepsis [Phase 3]
Phase 3 trial evaluating fluid resuscitation versus vasopressor-based hemodynamic management in emergency department sepsis; status currentl…
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CLINICAL_TRIALS research · 2026-03-17Clinical Trial Update: Sepsis in the ICU-II
An update on the ICU Sepsis II trial shows it is currently active but not recruiting. The conditions listed include septic shock, sepsis, ca…
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CLINICAL_TRIALS research · 2026-03-16Clinical Trial Update: Study on the Efficacy and Timing of ECMO Therapy in Children With Refractory Septic Shock
This trial investigates the efficacy and optimal timing of extracorporeal membrane oxygenation (ECMO) in children with refractory septic sho…
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CLINICAL_TRIALS research · 2026-03-13Clinical Trial Update: Early Dexmedetomidine and Sympathetic Regulation in Sepsis [Phase 4]
A Phase 4 clinical trial update evaluating early dexmedetomidine for sympathetic regulation in sepsis and septic shock, currently not yet re…
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CLINICAL_TRIALS research · 2026-03-12Clinical Trial Update: Early Versus Late Adjunctive Vasopressin in Septic Shock [Phase 4]
A Phase 4 clinical trial update evaluating early versus late adjunctive vasopressin therapy in septic shock, currently recruiting.
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CLINICAL_TRIALS research · 2026-03-11Clinical Trial Update: Early Angiotensin II in the Emergency Department [Phase 4]
Phase 4 clinical trial update investigating early use of angiotensin II in the emergency department for septic shock. Recruitment is ongoing…
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CLINICAL_TRIALS research · 2026-03-10Clinical Trial Update: Implementation of Timely Management of Sepsis and Septic Shock Protocol in the Emergency Department and Intensive Care Unit: A Quality Improvement Project at AFHJ [NA]
A quality improvement clinical trial at AFHJ aims to implement a timely sepsis and septic shock management protocol in the emergency departm…