Septic Shock
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CLINICAL_TRIALS research · 2025-10-30Clinical Trial Update: Stress Hydrocortisone In Pediatric Septic Shock [Phase 3]
An ongoing Phase 3 clinical trial is evaluating stress-dose hydrocortisone in pediatric septic shock; the study is currently recruiting.
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CLINICAL_TRIALS research · 2025-10-21Clinical Trial Update: Vasopressin for Septic Shock Pragmatic Trial [Phase 4]
A Phase 4 pragmatic trial evaluating vasopressin for septic shock is currently active but not recruiting. The sponsor is Intermountain Healt…
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CLINICAL_TRIALS research · 2025-10-09Clinical Trial Update: Phase IIb Multicenter Randomized Controlled Trial Evaluating the Efficacy of Sivelestat in Patients With Septic Coagulopathy [Phase 2]
This Phase IIb multicenter randomized controlled trial is evaluating the efficacy of Sivelestat in patients with septic coagulopathy and is …
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CLINICAL_TRIALS research · 2025-10-02Clinical Trial Update: Towards Novel BIOmarkers to Diagnose SEPsis on the Emergency Room
Clinical trial sponsored by Amsterdam University Medical Centers aims to identify BIOmarkers to diagnose sepsis in the emergency department;…
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CLINICAL_TRIALS research · 2025-09-26Clinical Trial Update: A Combination Therapy With Ceftazidime and Fosfomycin Will be Compared to Ceftazidime Alone in Hospitalized Adult Patients With Suspected Severe Gram-negative Bacterial Infections [Phase 3]
Phase 3 trial update evaluating the combination of ceftazidime and fosfomycin versus ceftazidime alone in hospitalized adults with suspected…
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CLINICAL_TRIALS research · 2025-09-22Clinical Trial Update: Nucleosome Monitoring Relevance for Outcome Prediction in Critically Ill Patients
A clinical trial update investigates nucleosome monitoring as a predictor of outcomes in critically ill patients, including sepsis, septic s…
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CLINICAL_TRIALS research · 2025-09-19Clinical Trial Update: Reducing Empiric VAncomycin Use in Pediatric Suspected Sepsis [NA]
A pediatric clinical trial is actively recruiting to reduce empiric vancomycin use in suspected sepsis, including scenarios involving MRSA, …
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CLINICAL_TRIALS research · 2025-09-18Clinical Trial Update: Adaptive Blood Purification for the Treatment of Patients With Septic Shock [NA]
The document reports an ongoing clinical trial evaluating adaptive blood purification for septic shock, with enrollment by invitation curren…
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CLINICAL_TRIALS research · 2025-09-16Clinical Trial Update: Population-Based Analysis of Incidence and Mortality of Septic Shock
This clinical trial update reports a population-based analysis of incidence and mortality for septic shock.
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CLINICAL_TRIALS research · 2025-09-15Clinical Trial Update: Prospective, Randomized Trial of Personalized Medicine With Pentaglobin® After Surgical Infectious Source Control in Patients With Peritonitis [Phase 2]
Phase 2 randomized trial evaluating the use of Pentaglobin as personalized adjunct therapy after surgical source control in patients with pe…
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CLINICAL_TRIALS research · 2025-09-11Clinical Trial Update: CytOSorb TreatMent Of Critically Ill PatientS Registry
A Clinical Trials registry update shows that CytoSorbents is recruiting for a registry trial evaluating Cytosorb hemoadsorption in criticall…
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CLINICAL_TRIALS research · 2025-09-11Clinical Trial Update: Predictive Model for Multidrug Resistance in Patients Admitted to the Emergency Department With Sepsis
Clinical trial update describes a predictive model for multidrug resistance in patients with sepsis admitted from the emergency department. …
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CLINICAL_TRIALS research · 2025-08-24Clinical Trial Update: Comparison of Landiolol Versus Standard of Care for Prevention of Mortality in Patients Hospitalized for a Septic Shock With Hypercontractility [Phase 3]
This document describes a Phase 3 clinical trial comparing landiolol to standard of care for preventing mortality in patients with septic sh…
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CLINICAL_TRIALS research · 2025-08-24Clinical Trial Update: Does High-dose Vitamin B3 Supplementation Prevent Major Adverse Kidney Events During Septic Shock? [Phase 3]
This update describes a Phase 3 trial assessing whether high-dose nicotinamide (Vitamin B3) can prevent major adverse kidney events in septi…
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CLINICAL_TRIALS research · 2025-08-24Clinical Trial Update: Microvascular Monitoring in Circulatory Shock and Sepsis (MiMICSS)
A University of Manitoba-led clinical trial evaluating microvascular monitoring in circulatory shock and sepsis is currently recruiting. It …
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CLINICAL_TRIALS research · 2025-08-22Clinical Trial Update: Prediction of Fluid Responsiveness in Paediatric Patients With Septic Shock Using Carotid Doppler Ultrasonography and Echocardiography
Clinical trial investigating prediction of fluid responsiveness in pediatric septic shock using carotid Doppler ultrasonography and echocard…
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CLINICAL_TRIALS research · 2025-08-17Clinical Trial Update: Therapeutic Plasma Exchange in Septic Shock: A Pilot Study [Phase 2]
A Phase 2 clinical trial evaluating therapeutic plasma exchange for septic shock is currently recruiting.
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CLINICAL_TRIALS research · 2025-08-15Clinical Trial Update: Prognostic Power of the VEXUS Score in Septic Shock: Effectiveness in Mortality Prediction
The trial examines whether the VEXUS ultrasound score can predict mortality in septic shock, and is currently listed as not yet recruiting.
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CLINICAL_TRIALS research · 2025-08-08Clinical Trial Update: Systematic Adjunction of Vasopressine in Septic Shock [Phase 3]
A Phase 3 clinical trial evaluating the adjunctive use of vasopressin in septic shock; the study is not yet recruiting.
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CLINICAL_TRIALS research · 2025-08-01Clinical Trial Update: LANdiolol MIcrocirculatory Effects During Septic chOc (MILANOS) [Phase 3]
A Phase 3 clinical trial evaluating the microcirculatory effects of landiolol in patients with septic shock, currently recruiting.
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CLINICAL_TRIALS research · 2025-07-28Clinical Trial Update: Can Gdf-15 Level Predict Progression to Multiple Organ Failure in Patients With Septic Shock
This clinical trial update notes a study investigating whether GDF-15 levels can predict progression to multiple organ dysfunction syndrome …
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CLINICAL_TRIALS research · 2025-07-24Clinical Trial Update: Clinical Performance Study of Microbio InfectID-BSI for Detection of Bacteria and Yeast With Patient Blood Samples
A clinical performance study of Microbio InfectID-BSI for detecting bacteria and yeast in patient blood samples is described, with the study…
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CLINICAL_TRIALS research · 2025-07-16Clinical Trial Update: Molecular Subtype-Specific Mechanisms and Therapeutic Strategies in Sepsis
An ongoing clinical trial from Mater Dei Hospital Malta examines molecular subtype–specific mechanisms and therapies for sepsis and septic s…
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CLINICAL_TRIALS research · 2025-07-04Clinical Trial Update: Focused Ultrasound Spleen Stimulation and Inflammation in Septic Shock [NA]
Clinical trial update for a study evaluating focused ultrasound–mediated spleen stimulation to modulate inflammation in septic shock. The st…
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CLINICAL_TRIALS research · 2025-07-04Clinical Trial Update: Xanthohumol as an Adjuvant in the Treatment of Septic Shock [Phase 2]
Phase 2 clinical trial update on Xanthohumol as an adjuvant therapy for septic shock, with recruitment ongoing; the study lists septic shock…