Progressive Multiple Sclerosis
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Sign up freeTop drugs studied for this disease
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FDA approval · 2025-08-21FDA Approved: MAYZENT — Supplemental Application (Novartis Pharmaceuticals Corporation)
FDA approved a supplemental application for MAYZENT (siponimod) to expand its indication to include treatment of secondary progressive multi…
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FDA approval · 2025-08-18FDA Approved: OCREVUS ZUNOVO — Supplemental Application (Genentech, Inc.)
FDA approved a supplemental application for OCREVUS ZUNOVO (ocrelizumab and hyaluronidase) from Genentech, expanding administration options …
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CLINICAL_TRIALS trial_result · 2025-08-06Clinical Trial Update: A Phase III, Non-Inferiority, Randomized, Open-Label, Parallel Group, Multicenter Study To Investigate The Pharmacokinetics, Pharmacodynamics, Safety And Radiological And Clinical Effects Of Subcutaneous Ocrelizumab Versus Intravenous Ocrelizumab In Patients With Multiple Sclerosis [Phase 3]
A Phase 3, non-inferiority trial comparing subcutaneous versus intravenous ocrelizumab in relapsing and primary progressive multiple scleros…
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CLINICAL_TRIALS research · 2025-07-28Clinical Trial Update: Non-inferiority Study of Ocrelizumab and Rituximab in Active Multiple Sclerosis [Phase 3]
A Phase 3 non-inferiority trial comparing ocrelizumab with rituximab in active multiple sclerosis is described; the study is currently activ…
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CLINICAL_TRIALS trial_result · 2025-07-25Clinical Trial Update: Neuropsychological Management of Multiple Sclerosis: Benefits of a Computerised Semi-autonomous At-home Cognitive Rehabilitation Programme [NA]
Completed clinical trial evaluating a computerised semi-autonomous at-home cognitive rehabilitation programme for people with relapsing-remi…
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CLINICAL_TRIALS trial_result · 2025-07-22Clinical Trial Update: Metformin Treatment in Progressive Multiple Sclerosis [EARLY_Phase 1]
This early-phase 1 trial evaluated metformin as a treatment for progressive multiple sclerosis, and the study has completed.
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CLINICAL_TRIALS research · 2025-07-03Clinical Trial Update: ABA-101 in Participants With Progressive Multiple Sclerosis [Phase 1]
Abata Therapeutics is conducting a Phase 1 clinical trial of ABA-101 in participants with progressive multiple sclerosis. The study status i…
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CLINICAL_TRIALS trial_result · 2025-07-01Clinical Trial Update: Simvastatin in Secondary Progressive Multiple Sclerosis [Phase 2]
Phase 2 trial evaluating simvastatin in people with secondary progressive multiple sclerosis has completed and results have been posted.
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CLINICAL_TRIALS research · 2025-06-24Clinical Trial Update: Metformin Add-on Clinical Study in Multiple Sclerosis to Evaluate Brain Remyelination And Neurodegeneration [Phase 2]
This is a Phase 2 add-on trial evaluating metformin for brain remyelination and neurodegeneration in multiple sclerosis, including primary p…
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CLINICAL_TRIALS trial_result · 2025-06-18Clinical Trial Update: Nonrelapsing Secondary Progressive Multiple Sclerosis (NRSPMS) Study of Bruton's Tyrosine Kinase (BTK) Inhibitor Tolebrutinib (SAR442168) (HERCULES) [Phase 3]
Phase 3 HERCULES study of the BTK inhibitor Tolebrutinib (SAR442168) in non-relapsing secondary progressive multiple sclerosis has completed…
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CLINICAL_TRIALS trial_result · 2025-06-11Clinical Trial Update: Intrathecal Administration of Autologous Mesenchymal Stem Cell-derived Neural Progenitors (MSC-NP) in Progressive Multiple Sclerosis [Phase 2]
Phase 2 trial results for intrathecal autologous mesenchymal stem cell-derived neural progenitors in progressive multiple sclerosis have bee…
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CLINICAL_TRIALS trial_result · 2025-06-06Clinical Trial Update: Intermediate-Size Patient Population Expanded Access: Foralumab in Non-Active Secondary Progressive MS Patients
Tiziana Life Sciences reports an expanded-access update for Foralumab in non-active secondary progressive multiple sclerosis, expanding the …
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CLINICAL_TRIALS research · 2025-06-02Clinical Trial Update: Cladribine Tablets as an Exit Therapy Strategy
A clinical trial is evaluating cladribine tablets as an exit therapy strategy for multiple sclerosis, including relapsing-remitting and seco…
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CLINICAL_TRIALS research · 2025-05-16Clinical Trial Update: Visual Processing Speed and Objective Analysis of Ocular Movements in Multiple Sclerosis
An ongoing IOBA-sponsored study is evaluating visual processing speed and objective ocular movement analysis in individuals with Multiple Sc…
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CLINICAL_TRIALS trial_result · 2025-05-13Clinical Trial Update: Study to Assess the Efficacy of Mayzent on Microglia in Secondary Progressive Multiple Sclerosis [Phase 2, Phase 3]
A phase 2/3 study evaluating siponimod (Mayzent) for its effects on microglia in secondary progressive multiple sclerosis has been terminate…
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CLINICAL_TRIALS research · 2025-05-07Clinical Trial Update: Study of NG01 Cell Therapy in Secondary Progressive Multiple Sclerosis [Phase 2]
A Phase 2 clinical trial evaluating NG01 cell therapy for Secondary Progressive Multiple Sclerosis by NeuroGenesis Ltd is not yet recruiting…
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CLINICAL_TRIALS trial_result · 2025-04-30Clinical Trial Update: IDP-023 g-NK Cells Plus Ocrelizumab in Patients With Progressive Multiple Sclerosis [Phase 1]
Phase 1 trial of IDP-023 g-NK cells plus ocrelizumab for progressive multiple sclerosis has been suspended.
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CLINICAL_TRIALS research · 2025-04-04Clinical Trial Update: Identification of Retinal Perivascular Inflammation in Patients With Multiple Sclerosis Using Adaptive Optics (RETIMUS) [NA]
A completed clinical trial (RETIMUS) investigating the detection of retinal perivascular inflammation in multiple sclerosis patients using a…
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CLINICAL_TRIALS research · 2025-03-28Clinical Trial Update: A Study of Allogeneic Hematopoietic Cell Transplantation for Primary Progressive Multiple Sclerosis [Phase 1]
This update describes a Phase 1 study evaluating allogeneic hematopoietic cell transplantation for primary progressive multiple sclerosis, w…
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CLINICAL_TRIALS trial_result · 2025-02-27Clinical Trial Update: Effect of Variance on Error Correction During Coupling [NA]
A completed Hasselt University clinical trial investigating how variance affects error correction during coupling in the context of Multiple…
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CLINICAL_TRIALS research · 2025-01-13Clinical Trial Update: KYSA-7: A Study of Anti-CD19 CAR T-Cell Therapy, in Subjects With Refractory Primary and Secondary Progressive Multiple Sclerosis [Phase 2]
This is a Phase 2 clinical trial update for KYSA-7, an anti-CD19 CAR T-cell therapy from Kyverna Therapeutics, studied in adults with refrac…
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CLINICAL_TRIALS trial_result · 2024-10-28Clinical Trial Update: Upper Extremity Function in Multiple Sclerosis Patients With Advanced Disability Treated With Ocrevus
A completed clinical trial evaluating upper-extremity function in advanced multiple sclerosis patients treated with ocrelizumab (Ocrevus) an…
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CLINICAL_TRIALS research · 2024-10-16Clinical Trial Update: Effects of Transcranial Static Magnetic Field Stimulation (tSMS) in Progressive Multiple Sclerosis [NA]
A clinical trial is ongoing to evaluate the effects of transcranial static magnetic field stimulation in progressive multiple sclerosis. The…
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CLINICAL_TRIALS trial_result · 2024-09-26Clinical Trial Update: Effect of Ocrelizumab on Cortical Lesion Accumulation in Patients With PPMS (ORATORIO-Cortical)
The ORATORIO-Cortical clinical trial update reports on the effect of ocrelizumab on cortical lesion accumulation in patients with primary pr…
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: The Effects of In-phase Bilateral Exercise in People with Progressive Multiple Sclerosis [NA]
This clinical trial update summarizes a completed study evaluating the effects of in-phase bilateral exercise in people with progressive mul…