Progressive Multiple Sclerosis
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-08-11Clinical Trial Results: A Phase III, Non-Inferiority, Randomized, Open-Label, Parallel Group, Multicenter Study To Investigate The Pharmacokinetics, Pharmacodynamics, Safety And Radiological And Clinical Effects Of Subcutaneous Ocrelizumab Versus Intravenous Ocrelizumab In Patients With Multiple Sclerosis [Phase 3]
Phase III non-inferiority trial comparing subcutaneous versus intravenous ocrelizumab in relapsing and primary progressive multiple sclerosi…
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CLINICAL_TRIALS trial_result · 2026-07-23Clinical Trial Update: A Study to Evaluate Ocrelizumab Treatment in Participants With Progressive Multiple Sclerosis [Phase 3]
A Phase 3 clinical trial evaluating ocrelizumab in participants with Progressive Multiple Sclerosis is active but not recruiting.
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CLINICAL_TRIALS trial_result · 2026-04-23Clinical Trial Update: Safety and Efficacy of Monthly Long-acting IM Injection of 25mg or 40 mg GA Depot in Subjects With PPMS [Phase 2]
Phase 2 trial evaluating monthly long-acting GA Depot injections (25 mg or 40 mg) for primary progressive multiple sclerosis has been termin…
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CLINICAL_TRIALS trial_result · 2026-04-23Clinical Trial Update: The Effects of a 12-week In-phase Bilateral Exercise Programme on the Corticospinal Plasticity in People With Progressive Multiple Sclerosis [NA]
This clinical trial update notes the completion of a 12-week in-phase bilateral exercise program evaluating its effect on corticospinal plas…
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CLINICAL_TRIALS trial_result · 2026-03-19Clinical Trial Update: Motor Asymmetry in Progressive Multiple Sclerosis Patients
A completed clinical trial update investigating motor asymmetry in patients with progressive multiple sclerosis.
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CLINICAL_TRIALS trial_result · 2026-03-09Clinical Trial Update: Effect of Ocrelizumab on Choroid Plexus Changes in Patients With PPMS
This clinical trial update reports completion of a study evaluating the effect of ocrelizumab on choroid plexus changes in patients with pri…
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CLINICAL_TRIALS trial_result · 2026-02-27Clinical Trial Update: A Study of Anti-CD19 Chimeric Antigen Receptor T-Cell ( CAR-T) Therapy in Subjects With Non-relapsing and Progressive Forms of Multiple Sclerosis [Phase 1]
A Phase 1 clinical trial sponsored by Stanford University is evaluating anti-CD19 CAR-T cell therapy for non-relapsing and progressive forms…
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CLINICAL_TRIALS trial_result · 2026-02-23Clinical Trial Update: A Study to Evaluate the Efficacy and Safety of Ocrelizumab in Adults With Primary Progressive Multiple Sclerosis [Phase 3]
Phase 3 trial evaluating ocrelizumab in adults with primary progressive multiple sclerosis has posted results assessing efficacy and safety;…
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CLINICAL_TRIALS trial_result · 2026-02-20Clinical Trial Update: Safety and Efficacy of Melatonin in Patients With Multiple Progressive Primary Sclerosis [Phase 1, Phase 2]
Clinical trial update assessing safety and efficacy of melatonin in patients with multiple sclerosis, including primary progressive multiple…
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CLINICAL_TRIALS trial_result · 2026-02-17Clinical Trial Update: Non-interventional Study of Ocrelizumab in Participants With Relapsing or Primary Progressive Multiple Sclerosis
A completed non-interventional study evaluating ocrelizumab in participants with relapsing-remitting or primary progressive multiple scleros…
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CLINICAL_TRIALS trial_result · 2026-02-13Clinical Trial Update: A Study to Investigate Long-term Safety and Tolerability of Tolebrutinib in Participants With Multiple Sclerosis. [Phase 3]
A Phase 3 clinical trial update evaluating the long-term safety and tolerability of tolebrutinib in participants with multiple sclerosis, in…
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CLINICAL_TRIALS trial_result · 2026-01-08Clinical Trial Update: Intrathecal Administration of DUOC-01 in Adults With Primary Progressive Multiple Sclerosis [Phase 1]
A Phase 1 trial evaluating intrathecal administration of DUOC-01 in adults with Primary Progressive Multiple Sclerosis has completed.
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CLINICAL_TRIALS trial_result · 2026-01-07Clinical Trial Update: Primary Progressive Multiple Sclerosis (PPMS) Study of Bruton's Tyrosine Kinase (BTK) Inhibitor Tolebrutinib (SAR442168) (PERSEUS) [Phase 3]
The Phase 3 PERSEUS trial of the BTK inhibitor tolebrutinib (SAR442168) for primary progressive multiple sclerosis has completed.
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CLINICAL_TRIALS trial_result · 2025-12-04Clinical Trial Update: A Study of Orelabrutinib in Patients With Primary Progressive Multiple Sclerosis [Phase 3]
A Phase 3 clinical trial evaluating orelabrutinib for primary progressive multiple sclerosis is currently recruiting.
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CLINICAL_TRIALS trial_result · 2025-11-28Clinical Trial Update: Special Drug-use Surveillance for Kesimpta for s.c. Injection 20 mg Pen
Clinical trial update reporting the completion of a Special Drug-use Surveillance study for Kesimpta (ofatumumab) 20 mg subcutaneous injecti…
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CLINICAL_TRIALS trial_result · 2025-09-11Clinical Trial Update: A Real-world Study About the Impact of Siponimod Treatment on Secondary Progressive Multiple Sclerosis Patients in Russia
A real-world study conducted in Russia assessed the impact of siponimod treatment on patients with secondary progressive multiple sclerosis;…
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CLINICAL_TRIALS trial_result · 2025-08-06Clinical Trial Update: A Phase III, Non-Inferiority, Randomized, Open-Label, Parallel Group, Multicenter Study To Investigate The Pharmacokinetics, Pharmacodynamics, Safety And Radiological And Clinical Effects Of Subcutaneous Ocrelizumab Versus Intravenous Ocrelizumab In Patients With Multiple Sclerosis [Phase 3]
A Phase 3, non-inferiority trial comparing subcutaneous versus intravenous ocrelizumab in relapsing and primary progressive multiple scleros…
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CLINICAL_TRIALS trial_result · 2025-07-25Clinical Trial Update: Neuropsychological Management of Multiple Sclerosis: Benefits of a Computerised Semi-autonomous At-home Cognitive Rehabilitation Programme [NA]
Completed clinical trial evaluating a computerised semi-autonomous at-home cognitive rehabilitation programme for people with relapsing-remi…
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CLINICAL_TRIALS trial_result · 2025-07-22Clinical Trial Update: Metformin Treatment in Progressive Multiple Sclerosis [EARLY_Phase 1]
This early-phase 1 trial evaluated metformin as a treatment for progressive multiple sclerosis, and the study has completed.
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CLINICAL_TRIALS trial_result · 2025-07-01Clinical Trial Update: Simvastatin in Secondary Progressive Multiple Sclerosis [Phase 2]
Phase 2 trial evaluating simvastatin in people with secondary progressive multiple sclerosis has completed and results have been posted.
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CLINICAL_TRIALS trial_result · 2025-06-18Clinical Trial Update: Nonrelapsing Secondary Progressive Multiple Sclerosis (NRSPMS) Study of Bruton's Tyrosine Kinase (BTK) Inhibitor Tolebrutinib (SAR442168) (HERCULES) [Phase 3]
Phase 3 HERCULES study of the BTK inhibitor Tolebrutinib (SAR442168) in non-relapsing secondary progressive multiple sclerosis has completed…
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CLINICAL_TRIALS trial_result · 2025-06-11Clinical Trial Update: Intrathecal Administration of Autologous Mesenchymal Stem Cell-derived Neural Progenitors (MSC-NP) in Progressive Multiple Sclerosis [Phase 2]
Phase 2 trial results for intrathecal autologous mesenchymal stem cell-derived neural progenitors in progressive multiple sclerosis have bee…
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CLINICAL_TRIALS trial_result · 2025-06-06Clinical Trial Update: Intermediate-Size Patient Population Expanded Access: Foralumab in Non-Active Secondary Progressive MS Patients
Tiziana Life Sciences reports an expanded-access update for Foralumab in non-active secondary progressive multiple sclerosis, expanding the …
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CLINICAL_TRIALS trial_result · 2025-05-13Clinical Trial Update: Study to Assess the Efficacy of Mayzent on Microglia in Secondary Progressive Multiple Sclerosis [Phase 2, Phase 3]
A phase 2/3 study evaluating siponimod (Mayzent) for its effects on microglia in secondary progressive multiple sclerosis has been terminate…
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CLINICAL_TRIALS trial_result · 2025-04-30Clinical Trial Update: IDP-023 g-NK Cells Plus Ocrelizumab in Patients With Progressive Multiple Sclerosis [Phase 1]
Phase 1 trial of IDP-023 g-NK cells plus ocrelizumab for progressive multiple sclerosis has been suspended.