Pineoblastoma

• CLINICAL_TRIALS trial_result · 2026-04-13
  Clinical Trial Update: Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors [Phase 1]

  Phase 1 clinical trial evaluating B7-H3–specific CAR T cell therapy delivered locoregionally for diffuse intrinsic pontine glioma/diffuse mi…

• CLINICAL_TRIALS research · 2026-03-10
  Clinical Trial Update: Immunotherapy for Malignant Pediatric Brain Tumors Employing Adoptive Cellular Therapy (IMPACT) [Phase 1]

  This clinical trial update describes an ongoing Phase 1 study evaluating adoptive cellular therapy immunotherapy for several pediatric malig…

• CLINICAL_TRIALS research · 2026-02-27
  Clinical Trial Update: Pilot Study of IT Topotecan and Maintenance Chemotherapy for HR-EBTs in Children < 6 Years, Post Consolidation [EARLY_Phase 1]

  This is a pediatric early-phase 1 trial update evaluating intrathecal topotecan with maintenance chemotherapy for high-risk embryonal centra…

• CLINICAL_TRIALS trial_result · 2026-02-05
  Clinical Trial Update: B7-H3.CD28Z.CART in CNS Neoplasms [Phase 1]

  A Phase 1 clinical trial evaluating B7-H3.CD28Z.CART for central nervous system neoplasms is currently not yet recruiting.

• CLINICAL_TRIALS research · 2026-01-27
  Clinical Trial Update: GPC2-CAR T Cell Therapy for Relapsed or Refractory Medulloblastoma in Children and Young Adults [Phase 1]

  Stanford is conducting a Phase 1 study of GPC2-CAR T cell therapy for relapsed or refractory medulloblastoma and related CNS embryonal tumor…

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• CLINICAL_TRIALS trial_result · 2025-12-17
  Clinical Trial Update: EGFR806-specific CAR T Cell Locoregional Immunotherapy for EGFR-positive Recurrent or Refractory Pediatric CNS Tumors [Phase 1]

  Phase 1 trial evaluating locoregional EGFR806-specific CAR T cells for EGFR-positive pediatric CNS tumors. The study status is completed.

• CLINICAL_TRIALS trial_result · 2025-08-13
  Clinical Trial Update: Proton Beam Radiotherapy for Medulloblastoma and Pineoblastoma [NA]

  A clinical trial evaluating proton beam radiotherapy for medulloblastoma and pineoblastoma has completed and posted results.

• CLINICAL_TRIALS research · 2025-06-17
  Clinical Trial Update: A Phase 0/1 Study of cDNA for TP53, Checkpoint Inhibition and Radiation in Children With Recurrent, Progressive or Refractory CNS Malignancies. [EARLY_Phase 1]

  An early-phase trial evaluating TP53 cDNA gene therapy combined with checkpoint inhibition and radiation in children with recurrent or refra…

• CLINICAL_TRIALS research · 2025-01-30
  Clinical Trial Update: International PPB/DICER1 Registry

  An international registry to collect data on tumors associated with DICER1 syndrome, including Pleuropulmonary Blastoma and related tumors, …

• CLINICAL_TRIALS withdrawal · 2024-10-09
  Clinical Trial Update: StrataXRT in Preventing Radiation Dermatitis in Pediatric Patients Undergoing Radiation Therapy to the Brain or Spinal Cord [Phase 1]

  Phase 1 trial evaluating StrataXRT to prevent radiation dermatitis in pediatric patients undergoing brain or spinal irradiation has been wit…

• CLINICAL_TRIALS trial_result · 2024-05-31
  Clinical Trial Update: SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors [Phase 1]

  The SJDAWN Phase 1 trial at St. Jude evaluated molecularly-driven doublet therapies for children and young adults with recurrent brain tumor…

• CLINICAL_TRIALS trial_result · 2022-10-05
  Clinical Trial Update: Adavosertib and Irinotecan Hydrochloride in Treating Younger Patients With Relapsed or Refractory Solid Tumors [Phase 1, Phase 2]

  Phase 1/2 trial evaluating adavosertib in combination with irinotecan hydrochloride for relapsed or refractory solid tumors in younger patie…

• CLINICAL_TRIALS trial_result · 2021-08-05
  Clinical Trial Update: Prospective Pilot Trial to Assess a Multimodal Molecular Targeted Therapy in Children, Adolescent and Young Adults With Relapsed or Refractory High-grade Pineoblastoma [Phase 2]

  Phase 2 pilot trial evaluating multimodal molecular targeted therapy for relapsed or refractory pineoblastoma in children, adolescents, and …

• CLINICAL_TRIALS trial_result · 2020-08-05
  Clinical Trial Update: Stem Cell Transplant for High Risk Central Nervous System (CNS) Tumors [Phase 2]

  Phase 2 clinical trial update on stem cell transplant for high-risk CNS tumors including glioblastoma and astrocytoma; trial completed.

• CLINICAL_TRIALS trial_result · 2019-09-13
  Clinical Trial Update: Temozolomide and Irinotecan Hydrochloride With or Without Bevacizumab in Treating Young Patients With Recurrent or Refractory Medulloblastoma or CNS Primitive Neuroectodermal Tumors [Phase 2]

  Phase 2 trial evaluating temozolomide and irinotecan with or without bevacizumab in young patients with recurrent or refractory medulloblast…

• CLINICAL_TRIALS trial_result · 2017-08-21
  Clinical Trial Update: Proton Beam Radiation Therapy in Treating Young Patients Who Have Undergone Biopsy or Surgery for Medulloblastoma or Pineoblastoma [NA]

  A completed clinical trial evaluating proton beam radiation therapy in young patients after biopsy or surgery for medulloblastoma or pineobl…

• CLINICAL_TRIALS trial_result · 2015-12-29
  Clinical Trial Update: Morphological Analysis of the Pineal Gland in Pediatric Retinoblastoma Patients Using Magnetic Resonance Imaging

  A completed clinical trial evaluating MRI-based morphology of the pineal gland in pediatric retinoblastoma patients, including pineoblastoma…

• CLINICAL_TRIALS trial_result · 2014-11-05
  Clinical Trial Update: Gamma-Secretase Inhibitor RO4929097 in Treating Young Patients With Relapsed or Refractory Solid Tumors, CNS Tumors, Lymphoma, or T-Cell Leukemia [Phase 1]

  Phase 1 study of RO4929097, a gamma-secretase inhibitor, in pediatric patients with relapsed or refractory solid tumors, CNS tumors, lymphom…

• CLINICAL_TRIALS trial_result · 2013-01-16
  Clinical Trial Update: Positron Emission Tomography Using Fluorine F 18 EF5 to Find Oxygen in Tumor Cells of Patients Who Are Undergoing Surgery or Biopsy for Newly Diagnosed Brain Tumors [Phase 1]

  This document is a terminated Phase 1 trial update evaluating PET imaging with 18F-EF5 to measure oxygenation in brain tumor cells of adults…