Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia
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CLINICAL_TRIALS trial_result · 2026-06-09Clinical Trial Results: Ibrutinib and Blinatumomab in Treating Patients With Relapsed or Refractory B Acute Lymphoblastic Leukemia [Phase 2]
Phase 2 trial evaluating the combination of ibrutinib and blinatumomab in relapsed or refractory adult B-ALL, including Philadelphia chromos…
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CLINICAL_TRIALS trial_result · 2026-03-30Clinical Trial Update: Study of Chemotherapy-Free Induction Regimen for Ph+ Acute Lymphoblastic Leukemia With Inotuzumab Ozogamicin (InO) [Phase 2]
A Phase 2 study evaluating a chemotherapy-free induction regimen for Philadelphia chromosome-positive acute lymphoblastic leukemia using ino…
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CLINICAL_TRIALS trial_result · 2026-03-25Clinical Trial Update: Asciminib & Standard-of-Care Integration in Maintenance Therapy for POST Allogeneic Stem Cell Transplant (Allo-HSCT) of Patient With Ph+ B-ALL or Blastic Transformed CML [Phase 2]
Phase 2 clinical trial evaluating asciminib in combination with standard-of-care as maintenance therapy after allogeneic stem cell transplan…
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CLINICAL_TRIALS trial_result · 2026-02-11Clinical Trial Update: Dasatinib Combined With Chemotherapy in Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia [Phase 2]
A Phase 2 clinical trial evaluating dasatinib in combination with chemotherapy for Philadelphia chromosome-positive acute lymphoblastic leuk…
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CLINICAL_TRIALS trial_result · 2025-12-12Clinical Trial Update: ADCT-602 in Treating Patients With Recurrent or Refractory B-cell Acute Lymphoblastic Leukemia [Phase 1, Phase 2]
A Phase 1/2 trial of ADCT-602 for recurrent or refractory B-cell acute lymphoblastic leukemia has been terminated.
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CLINICAL_TRIALS trial_result · 2025-11-05Clinical Trial Update: Study of HQP1351 in Subjects With Refractory CML and Ph+ ALL [Phase 1]
HQP1351 is being investigated in a Phase 1 trial for patients with refractory chronic myeloid leukemia and Philadelphia chromosome-positive …
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CLINICAL_TRIALS trial_result · 2025-09-23Clinical Trial Update: Blinatumomab in Treating Patients With B-cell Acute Lymphoblastic Leukemia With Minimal Residual Disease [Phase 2]
Phase 2 trial assessing blinatumomab in adults with B-cell acute lymphoblastic leukemia in complete remission who have minimal residual dise…
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CLINICAL_TRIALS trial_result · 2025-07-20Clinical Trial Update: Efficacy, Safety, and Pharmacokinetics of ThisCART19A Combined With Olverembatinib in Patients With Newly Diagnosed Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia. [EARLY_Phase 1]
An early Phase 1 trial assessing the safety, efficacy signals, and pharmacokinetics of ThisCART19A combined with olverembatinib in patients …
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CLINICAL_TRIALS trial_result · 2025-06-03Clinical Trial Update: Olverembatinib Combined With Reduced-Intensity Chemotherapy and Venetoclax for de Novo Ph+ ALL [Phase 2]
A Phase 2 study evaluating olverembatinib with reduced-intensity chemotherapy and venetoclax for newly diagnosed Philadelphia chromosome–pos…
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CLINICAL_TRIALS trial_result · 2025-02-17Clinical Trial Update: Combination Chemotherapy and Dasatinib in Treating Participants With Philadelphia Positive or BCR-ABL Positive Acute Lymphoblastic Leukemia. [Phase 2]
Phase 2 trial evaluating the combination of chemotherapy with dasatinib in Philadelphia chromosome–positive or BCR-ABL–positive acute lympho…
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CLINICAL_TRIALS trial_result · 2025-01-15Clinical Trial Update: A Study of Ponatinib With Chemotherapy in Children, Teenagers, and Adults With Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia [Phase 1, Phase 2]
A Phase 1/Phase 2 study evaluating ponatinib with chemotherapy in children, teenagers, and adults with Philadelphia chromosome–positive ALL,…
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CLINICAL_TRIALS trial_result · 2023-10-27Clinical Trial Update: A Study of Ponatinib Versus Imatinib in Adults With Acute Lymphoblastic Leukemia [Phase 3]
A Phase 3 clinical trial comparing ponatinib to imatinib in adults with Philadelphia chromosome–positive acute lymphoblastic leukemia; resul…
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CLINICAL_TRIALS trial_result · 2022-10-12Clinical Trial Update: Ph+/Bcr-Abl+ ALL Imatinib and Nilotinib Rotational Study [Phase 2]
A phase 2 clinical trial evaluating rotational therapy with Imatinib and Nilotinib in Ph+ BCR-ABL+ acute lymphoblastic leukemia (ALL), compl…
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CLINICAL_TRIALS trial_result · 2022-06-13Clinical Trial Update: A Study of Ponatinib in Japanese Participants With Chronic Myeloid Leukemia (CML) and Ph+ Acute Lymphoblastic Leukemia (ALL) [Phase 1, Phase 2]
Phase 1/2 trial update of ponatinib in Japanese patients with Chronic Myeloid Leukemia and Philadelphia chromosome-positive Acute Lymphoblas…
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CLINICAL_TRIALS trial_result · 2022-05-24Clinical Trial Update: Sapanisertib in Treating Patients With Relapsed and/or Refractory Acute Lymphoblastic Leukemia [Phase 2]
Phase 2 clinical trial evaluating sapanisertib in adults with relapsed or refractory acute lymphoblastic leukemia; results were posted in Ma…
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CLINICAL_TRIALS trial_result · 2021-11-30Clinical Trial Update: Phase II Front-line Ponatinib in Adult Philadelphia+/BCR-ABL+ Acute Lymphoblastic Leukemia. [Phase 2]
Phase II study of front-line ponatinib in adults with Philadelphia-positive/BCR-ABL-positive acute lymphoblastic leukemia has completed.
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CLINICAL_TRIALS trial_result · 2020-07-30Clinical Trial Update: Evaluation of Efficacy and Safety of Nilotinib in Combination With Chemotherapy in Elderly Patients With Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia [Phase 2]
Phase 2 trial evaluating the efficacy and safety of nilotinib in combination with chemotherapy for elderly patients with Philadelphia chromo…
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CLINICAL_TRIALS trial_result · 2020-01-29Clinical Trial Update: Ponatinib for Chronic Myeloid Leukemia (CML) Evaluation and Ph+ Acute Lymphoblastic Leukemia (ALL) [Phase 2]
Phase 2 trial update for ponatinib in chronic myeloid leukemia and Philadelphia chromosome–positive acute lymphoblastic leukemia has complet…
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CLINICAL_TRIALS trial_result · 2019-01-30Clinical Trial Update: SCT in Ph Positive Acute Lymphoblastic Leukemia
This clinical trial update reports that the study investigating stem cell transplantation for Philadelphia chromosome-positive acute lymphob…
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CLINICAL_TRIALS trial_result · 2017-11-08Clinical Trial Update: TKI Therapy Based on Molecular Monitoring in Allogeneic-HSCT Recipients With Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia [Phase 2]
Phase 2 clinical trial update evaluating tyrosine kinase inhibitor therapy guided by molecular monitoring in allogeneic stem cell transplant…
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CLINICAL_TRIALS trial_result · 2017-08-08Clinical Trial Update: Entinostat And Imatinib Mesylate In Treating Patients With Relapsed or Refractory Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia [Phase 1, Phase 2]
Phase 1/2 trial of entinostat plus imatinib mesylate in relapsed/refractory Philadelphia chromosome-positive acute lymphoblastic leukemia; t…
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CLINICAL_TRIALS trial_result · 2017-05-15Clinical Trial Update: Nilotinib and Imatinib Mesylate After Donor Stem Cell Transplant in Treating Patients With ALL or CML [Phase 1, Phase 2]
A completed Phase 1/2 clinical trial evaluating the use of nilotinib and imatinib after donor stem cell transplant in patients with acute ly…
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CLINICAL_TRIALS trial_result · 2017-02-23Clinical Trial Update: Efficacy Study of Imatinib Mesylate to Treat Philadelphia-Positive Acute Lymphocytic Leukemia [Phase 2]
Phase 2 efficacy study of imatinib mesylate for Philadelphia chromosome-positive acute lymphoblastic leukemia has been completed.
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CLINICAL_TRIALS trial_result · 2016-09-05Clinical Trial Update: Dasatinib and Low Intensity Chemotherapy for Ph+ Acute Lymphoblastic Leukemia [Phase 2]
A phase 2 trial evaluating dasatinib with low-intensity chemotherapy for Philadelphia chromosome–positive acute lymphoblastic leukemia has c…
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CLINICAL_TRIALS trial_result · 2016-02-24Clinical Trial Update: Low-dose Chemotherapy Combine With Tyrosine Kinase Inhibitor to Treat ph+ Acute Lymphoblastic Leukemia Patients [Phase 4]
This entry describes a Phase 4 clinical trial evaluating a low-dose chemotherapy regimen combined with a tyrosine kinase inhibitor to treat …