Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Chemotherapy With Targeted-Immunotherapy for Newly Diagnosed Ph+ ALL [NA]
Clinical trial update on using chemotherapy with targeted immunotherapy for newly diagnosed Philadelphia chromosome-positive acute lymphobla…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Dose-Adjusted EPOCH With or Without Rituximab Plus Ponatinib for the Treatment of Newly-Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia/Lymphoma [Phase 2]
A Phase 2 clinical trial evaluating whether adding ponatinib to dose-adjusted EPOCH, with or without rituximab, improves outcomes in newly d…
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: Phase I/II Study of the Combination of Blinatumomab and Asciminib in Patients With Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia [Phase 1, Phase 2]
A Phase I/II clinical trial is evaluating the combination of blinatumomab and asciminib in adults with Philadelphia chromosome-positive acut…
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CLINICAL_TRIALS research · 2026-04-07Clinical Trial Update: Blinatumomab and Tyrosine Kinase Inhibitor Therapy in People With Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia [Phase 2]
Phase 2 clinical trial update evaluating the combination of blinatumomab with a tyrosine kinase inhibitor in Philadelphia chromosome-positiv…
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: Asciminib Maintenance Therapy Following alloHCT or CAR T to Prevent Relapse in Adults With Ph+ALL [Phase 1]
Phase 1 trial evaluating asciminib as maintenance therapy after allo-HCT or CAR T to prevent relapse in adults with Philadelphia chromosome-…
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CLINICAL_TRIALS research · 2026-03-09Clinical Trial Update: Phase II Study of the Combination of Subcutaneous Blinatumomab and Olverembatinib in Patients With Philadelphia Chromosome (ph)-Positive and/or BCR::ABL1 Positive Acute Lymphoblastic Leukemia (ALL) [Phase 2]
Phase II clinical trial evaluating the combination of subcutaneous blinatumomab and olverembatinib for Philadelphia chromosome-positive and/…
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CLINICAL_TRIALS research · 2026-03-04Clinical Trial Update: Adding Asciminib to Usual Treatment for Adults With Newly Diagnosed Philadelphia Chromosome Positive (Ph+) Acute Lymphoblastic Leukemia [Phase 2]
A Phase 2 clinical trial is investigating the addition of asciminib to standard treatment for adults with newly diagnosed Philadelphia chrom…
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CLINICAL_TRIALS research · 2026-03-02Clinical Trial Update: Efficacy and Safety of Olverembatinib Plus Inotuzumab Ozogamicin as First-Line Consolidation Therapy Followed by HSCT in Ph+ ALL [Phase 2]
A Phase 2 trial assesses the efficacy and safety of combining olverembatinib with inotuzumab ozogamicin as a first-line consolidation therap…
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CLINICAL_TRIALS research · 2026-03-02Clinical Trial Update: Efficacy and Safety of TKI Combined With Chemotherapy and Sequential CAR-T Cells in ND Adult Patients With Ph+ ALL [NA]
An ongoing clinical trial evaluating a tyrosine kinase inhibitor combined with chemotherapy and sequential CAR-T cell therapy in newly diagn…
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CLINICAL_TRIALS research · 2026-02-25Clinical Trial Update: Long-term Progression of Patients Treated and Monitored for Relapsed or Refractory Ph+ ALL
This clinical trial update discusses long-term progression of patients treated for relapsed or refractory Philadelphia chromosome–positive a…
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CLINICAL_TRIALS research · 2026-02-23Clinical Trial Update: Imatinib Mesylate and Combination Chemotherapy in Treating Patients With Newly Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia [Phase 3]
Phase 3 clinical trial evaluating imatinib mesylate in combination with chemotherapy for newly diagnosed Philadelphia chromosome-positive ac…
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CLINICAL_TRIALS research · 2026-02-10Clinical Trial Update: Venetoclax, Dasatinib, Prednisone, Rituximab and Blinatumomab for the Treatment of Newly Diagnosed or Relapsed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia or Mixed Phenotype Acute Leukemia [Phase 1]
A Phase 1 clinical trial sponsored by OHSU Knight Cancer Institute is evaluating a five-drug combination (venetoclax, dasatinib, prednisone,…
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CLINICAL_TRIALS research · 2026-02-04Clinical Trial Update: Safety and Efficacy of Asciminib in Pediatrics and Young Adults With Relapse/Refractory (r/r) Philadelphia Positive (Ph+) or ABL-class Ph-like Acute Lymphoblastic Leukemia (ALL) [Phase 1, Phase 2]
This article outlines a Phase 1/2 clinical trial evaluating the safety and efficacy of asciminib in pediatric and young adult patients with …
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CLINICAL_TRIALS research · 2026-01-21Clinical Trial Update: Evaluation of the Efficacy of Ponatinib in Ph+ ALL in the Real-world
This clinical trial update aims to assess the real-world efficacy of ponatinib in Philadelphia chromosome-positive acute lymphoblastic leuke…
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CLINICAL_TRIALS research · 2025-12-24Clinical Trial Update: Subcutaneous Blinatumomab Plus Ponatinib for BCR-ABL+ B-ALL [Phase 2]
Phase 2 clinical trial assessing subcutaneous blinatumomab in combination with ponatinib for Philadelphia chromosome-positive BCR-ABL–positi…
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CLINICAL_TRIALS research · 2025-12-04Clinical Trial Update: A Multicenter Study of CAR-T Cells in Primary Ph+All [Phase 2]
A multicenter Phase 2 clinical trial evaluating CAR-T cell therapy for Philadelphia chromosome-positive acute lymphoblastic leukemia is curr…
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CLINICAL_TRIALS research · 2025-11-18Clinical Trial Update: CD19/CD22 Chimeric Antigen Receptor (CAR) T Cells With or Without NKTR-255 in Adults With Recurrent or Refractory B Cell Malignancies [Phase 1]
A Phase 1 study from Stanford is evaluating CD19/CD22 CAR T cells with or without NKTR-255 in adults with recurrent or refractory B-cell mal…
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CLINICAL_TRIALS research · 2025-11-04Clinical Trial Update: ABL001 + Dasatinib + Prednisone + Blinatumomab in BCR-ABL+ B-ALL or CML [Phase 1]
This is a Phase 1 clinical trial assessing a quadruple combination of ABL001 (asciminib), dasatinib, prednisone, and blinatumomab in patient…
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CLINICAL_TRIALS research · 2025-09-03Clinical Trial Update: Newly-diagnosed Pediatric Ph-positive B-ALL Protocol [Phase 3]
Phase 3 clinical trial protocol for newly diagnosed Philadelphia chromosome-positive pediatric acute lymphoblastic leukemia, currently recru…
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CLINICAL_TRIALS research · 2025-07-02Clinical Trial Update: Adding Ruxolitinib to a Combination of Dasatinib Plus Dexamethasone in Remission Induction Therapy in Newly Diagnosed Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia Patients Aged 40 Years or Older [Phase 1]
This clinical trial update describes adding ruxolitinib to a dasatinib plus dexamethasone induction regimen for newly diagnosed Philadelphia…
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CLINICAL_TRIALS research · 2025-06-27Clinical Trial Update: Asciminib as Maintenance Treatment After Cellular Therapies for Adults With Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia [Phase 1]
Phase 1 clinical trial update evaluating asciminib as maintenance therapy after cellular therapies in adults with Philadelphia chromosome-po…
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CLINICAL_TRIALS research · 2025-05-30Clinical Trial Update: Pembrolizumab and Blinatumomab in Treating Participants With Recurrent or Refractory Acute Lymphoblastic Leukemia [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating pembrolizumab plus blinatumomab for recurrent or refractory CD19-positive, Philadelphia chromosome-pos…
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CLINICAL_TRIALS research · 2025-04-29Clinical Trial Update: Randomized Trial in Adult de Novo Ph Positive ALL With Chemotherapy, Imatinib or Ponatinib, Blinatumomab and SCT [Phase 2]
Phase 2 randomized trial in adults with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia evaluating chemotherap…
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CLINICAL_TRIALS research · 2025-01-23Clinical Trial Update: Sequential Treatment With Ponatinib and Blinatumomab vs Chemotherapy and Imatinib in Newly Diagnosed Adult Ph+ ALL [Phase 3]
A Phase 3 trial is comparing sequential ponatinib and blinatumomab against chemotherapy and imatinib in newly diagnosed adult Philadelphia c…
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CLINICAL_TRIALS research · 2024-11-07Clinical Trial Update: A Study of Olverembatinib in Patients With Newly Diagnosed Ph+ALL. [Phase 3]
A Phase 3 clinical trial is evaluating olverembatinib in newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia, with…