Patent Ductus Arteriosus
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-04-16Clinical Trial Update: Ibuprofen vs Expectant Management for hsPDA in Preterm Infants: Retrospective Cohort
A retrospective cohort study comparing ibuprofen treatment to expectant management for hemodynamically significant patent ductus arteriosus …
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CLINICAL_TRIALS trial_result · 2026-04-07Clinical Trial Update: Prophylactic IV Paracetamol in Extremely Premature Infants [Phase 2, Phase 3]
A completed Phase 2/Phase 3 trial evaluated prophylactic intravenous paracetamol for prevention of patent ductus arteriosus in extremely pre…
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CLINICAL_TRIALS trial_result · 2026-03-24Clinical Trial Update: The Role of Thiamine After Transcatheter Closure in Children With Left-to-Right Shunt Congenital Heart Disease [EARLY_Phase 1]
An early-phase 1 clinical trial evaluated the potential role of thiamine after transcatheter closure in children with left-to-right shunt co…
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CLINICAL_TRIALS trial_result · 2026-03-16Clinical Trial Update: Prophylactic Treatment of the Ductus Arteriosus in Preterm Infants by Acetaminophen [Phase 2, Phase 3]
Phase 2 and Phase 3 clinical trials evaluating prophylactic acetaminophen to prevent patent ductus arteriosus in preterm infants have comple…
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CLINICAL_TRIALS trial_result · 2026-01-27Clinical Trial Update: Post Marketing Clinical Follow Up Study to Evaluate Efficacy and Safety of the Occlutech PDA Occluder in Patients With Patent Ductus Arteriosus Defects
A post-marketing clinical follow-up study is ongoing to assess the efficacy and safety of the Occlutech PDA Occluder in patients with patent…
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CLINICAL_TRIALS trial_result · 2025-09-24Clinical Trial Update: Description of Changes in NIRS as a Function of Ductus Arteriosus Status in Very Premature Babies Born Before 32 WG at the DIJON University Hospital
Completed clinical trial update describing how near-infrared spectroscopy (NIRS) measurements vary with ductus arteriosus status in extremel…
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CLINICAL_TRIALS trial_result · 2025-05-30Clinical Trial Update: Liver Regional Oxygen Saturation in Preterm Patent Ductus Arteriosus
Clinical trial update indicating completion of a study evaluating liver regional oxygen saturation in preterm infants with patent ductus art…
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CLINICAL_TRIALS trial_result · 2025-03-04Clinical Trial Update: Improving Care for Children With Congenital Heart Disease. [NA]
An update from Lund University Hospital notes an ongoing clinical trial to improve care for children with congenital heart disease. The stud…
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CLINICAL_TRIALS trial_result · 2025-01-08Clinical Trial Update: Comparative Analysis of Isolated Venous, Isolated Arterial, and Standard Access for Transcatheter Closure of Patent Ductus Arteriosus (PDA) [NA]
A completed clinical trial comparing isolated venous, isolated arterial, and standard access for transcatheter closure of patent ductus arte…
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CLINICAL_TRIALS trial_result · 2024-10-18Clinical Trial Update: Paracetamol And Ibuprofen/Indomethacin in Closing Patent Ductus Arteriosus [Phase 1]
This clinical trial update notes the termination of a Phase 1 study evaluating paracetamol in combination with ibuprofen or indomethacin for…
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CLINICAL_TRIALS trial_result · 2024-06-21Clinical Trial Update: Canadian National PDA Treatment Study
A clinical trial in Canada addressing PDA treatment has completed.
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CLINICAL_TRIALS trial_result · 2024-06-21Clinical Trial Update: Selective Early Medical Treatment of Patent Ductus Arteriosus in Extremely Low Gestational Age Infants: A Pilot RCT [Phase 3]
Phase 3 randomized trial evaluating selective early medical treatment of patent ductus arteriosus in extremely preterm infants; recruitment …
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CLINICAL_TRIALS trial_result · 2024-02-13Clinical Trial Update: Assessment of Therapeutic Effect of Rectal Vs. Intravenous Paracetamol in The Treatment of Patent Ductus Arteriosus (PDA) in Neonates [Phase 1, Phase 2]
A clinical trial update comparing rectal versus intravenous paracetamol for treating Patent Ductus Arteriosus in neonates, currently in Phas…
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CLINICAL_TRIALS trial_result · 2024-02-07Clinical Trial Update: Preliminary Percutaneous Intervention Versus Observational Trial of Arterial Ductus in Low-weight Infants [NA]
A terminated clinical trial evaluating percutaneous intervention versus observational management for patent ductus arteriosus in low-weight …
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CLINICAL_TRIALS trial_result · 2023-12-01Clinical Trial Update: Comparision Between Paracetamol and Ibuprofen in Closure of Patent Ductus Arteriosus [Phase 2]
Phase 2 clinical trial comparing paracetamol and ibuprofen for closure of patent ductus arteriosus.
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CLINICAL_TRIALS trial_result · 2023-10-30Clinical Trial Update: PAIR (Paracetamol and Ibuprofen Research) Pilot Trial [Phase 2, Phase 3]
A pilot trial (Phase 2/Phase 3) investigating paracetamol and ibuprofen for patent ductus arteriosus is in early/unknown status.
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CLINICAL_TRIALS trial_result · 2023-02-28Clinical Trial Update: Oral Ibuprofen Versus Placebo in Treatment of Patent Ductus Arteriosus (PDA)in Preterm Infants [Phase 2]
Phase 2 trial comparing oral ibuprofen to placebo for treatment of patent ductus arteriosus in preterm infants has completed.
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CLINICAL_TRIALS trial_result · 2022-09-16Clinical Trial Update: Fenoldopam to Prevent Renal Dysfunction in Indomethacin Treated Preterm Infants [Phase 2, Phase 3]
Phase 2/3 trial investigating fenoldopam to prevent renal dysfunction in indomethacin-treated preterm infants was terminated; results posted…
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CLINICAL_TRIALS trial_result · 2021-05-11Clinical Trial Update: Randomized Controlled Trial to Evaluate the Safety and Efficacy of Acetaminophen in Preterm Infants Used in Combination With Ibuprofen for Closure of the Ductus Arteriosus [Phase 2]
Phase 2 randomized trial evaluating safety and efficacy of acetaminophen with ibuprofen for closing the ductus arteriosus in preterm infants…
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CLINICAL_TRIALS trial_result · 2020-10-05Clinical Trial Update: AMPLATZER Duct Occluder II Additional Sizes [NA]
Clinical trial update reporting results for AMPLATZER Duct Occluder II with additional sizes for closing patent ductus arteriosus. The study…
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CLINICAL_TRIALS trial_result · 2019-12-03Clinical Trial Update: Acetaminophen vs Indomethacin in Treating hsPDA [Phase 3]
A Phase 3 trial comparing acetaminophen versus indomethacin for treating patent ductus arteriosus was terminated.
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CLINICAL_TRIALS trial_result · 2019-07-12Clinical Trial Update: Paracetamol in Patent Ductus Arteriosus [Phase 2]
Phase 2 clinical trial update for paracetamol in treating patent ductus arteriosus has completed.
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CLINICAL_TRIALS trial_result · 2019-07-08Clinical Trial Update: Early Ibuprofen Treatment of Patent Ductus Arteriosus (PDA) in Premature Infants (TRIOCAPI) [Phase 3]
Phase 3 trial update on early ibuprofen treatment for patent ductus arteriosus in premature infants (TRIOCAPI) completed.
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CLINICAL_TRIALS trial_result · 2018-11-30Clinical Trial Update: Early Treatment Versus Delayed Conservative Treatment of the Patent Ductus Arteriosus [Phase 2]
Phase 2 trial comparing early treatment versus delayed conservative management for patent ductus arteriosus; results posted after completion…
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CLINICAL_TRIALS trial_result · 2018-05-07Clinical Trial Update: The Use of B-type Natriuretic Peptide (BNP) to Predict Closure of a Patent Ductus Arteriosus (PDA) in Premature Infants [NA]
This update reports a completed trial investigating whether B-type natriuretic peptide can predict the closure of patent ductus arteriosus i…