Patent Ductus Arteriosus
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: NeoDoppler: New Ultrasound Technology for Continuous Monitoring of Cerebral Circulation Pilot
A pilot study update on NeoDoppler, a new ultrasound technology for continuous monitoring of cerebral circulation in neonates, currently rec…
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CLINICAL_TRIALS trial_result · 2026-04-16Clinical Trial Update: Ibuprofen vs Expectant Management for hsPDA in Preterm Infants: Retrospective Cohort
A retrospective cohort study comparing ibuprofen treatment to expectant management for hemodynamically significant patent ductus arteriosus …
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: PREEMIE: Study for Treatment of PDA in Premature Infants [NA]
Clinical trial status update for the PREEMIE study evaluating treatment of patent ductus arteriosus in premature infants; the trial is activ…
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CLINICAL_TRIALS trial_result · 2026-04-07Clinical Trial Update: Prophylactic IV Paracetamol in Extremely Premature Infants [Phase 2, Phase 3]
A completed Phase 2/Phase 3 trial evaluated prophylactic intravenous paracetamol for prevention of patent ductus arteriosus in extremely pre…
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CLINICAL_TRIALS research · 2026-04-06Clinical Trial Update: Co-administration of Acetaminophen With Ibuprofen to Improve Duct-Related Outcomes in Extremely Premature Infants [Phase 2]
Phase 2 clinical trial evaluating co-administration of acetaminophen with ibuprofen to improve duct-related outcomes in extremely premature …
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CLINICAL_TRIALS trial_result · 2026-03-24Clinical Trial Update: The Role of Thiamine After Transcatheter Closure in Children With Left-to-Right Shunt Congenital Heart Disease [EARLY_Phase 1]
An early-phase 1 clinical trial evaluated the potential role of thiamine after transcatheter closure in children with left-to-right shunt co…
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CLINICAL_TRIALS trial_result · 2026-03-16Clinical Trial Update: Prophylactic Treatment of the Ductus Arteriosus in Preterm Infants by Acetaminophen [Phase 2, Phase 3]
Phase 2 and Phase 3 clinical trials evaluating prophylactic acetaminophen to prevent patent ductus arteriosus in preterm infants have comple…
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CLINICAL_TRIALS research · 2026-03-10Clinical Trial Update: Early Prediction of Spontaneous Patent Ductus Arteriosus (PDA) Closure and PDA-Associated Outcomes
Clinical trial update on early prediction of spontaneous patent ductus arteriosus closure and related outcomes in preterm infants.
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EMA approval · 2026-02-16EMA Authorised: Ibuprofen Gen.Orph (Ibuprofen) — Gen.Orph
The European Medicines Agency authorised Ibuprofen Gen.Orph for the treatment of patent ductus arteriosus, with Gen.Orph as the marketing au…
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CLINICAL_TRIALS research · 2026-02-03Clinical Trial Update: PDA for Kidneys Study
Clinical trial update indicates the PDA for Kidneys study is actively recruiting to investigate treatment for patent ductus arteriosus and c…
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CLINICAL_TRIALS research · 2026-01-28Clinical Trial Update: Research on the Individualized Treatment Strategy for Extremely Preterm Infants With hsPDA Based on Biomarkers and Targeted Delivery Systems
This clinical trial update describes a research study at Peking University Third Hospital investigating an individualized treatment strategy…
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CLINICAL_TRIALS trial_result · 2026-01-27Clinical Trial Update: Post Marketing Clinical Follow Up Study to Evaluate Efficacy and Safety of the Occlutech PDA Occluder in Patients With Patent Ductus Arteriosus Defects
A post-marketing clinical follow-up study is ongoing to assess the efficacy and safety of the Occlutech PDA Occluder in patients with patent…
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CLINICAL_TRIALS research · 2026-01-13Clinical Trial Update: Relation Between Prostaglandin E2 Metabolite Levels and the Development of Hemodynamically Significant Patent Ductus Arteriosus in Preterm Neonates
An ongoing Ain Shams University clinical trial examines whether prostaglandin E2 metabolite levels predict the development of hemodynamicall…
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FDA approval · 2025-12-22FDA Approved: PROSTIN VR PEDIATRIC — Supplemental Application (Pharmacia & Upjohn Company LLC)
FDA approved a supplemental application for PROSTIN VR PEDIATRIC (alprostadil) from Pharmacia & Upjohn Company LLC, updating its pediatric u…
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EMA approval · 2025-11-25EMA Authorised: Pedea (Ibuprofen) — Recordati Rare Diseases
The EMA authorised Pedea (ibuprofen) from Recordati Rare Diseases for use in patent ductus arteriosus.
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CLINICAL_TRIALS research · 2025-11-25Clinical Trial Update: Early Hydrocortisone Versus Regular Treatment in Shock in Extremely Preterm Neonates - an Open Randomized Controlled Trial [Phase 4]
An open randomized Phase 4 trial compares early hydrocortisone treatment to standard care for shock in extremely preterm neonates.
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CLINICAL_TRIALS research · 2025-10-03Clinical Trial Update: Amplatzer Piccolo Occluder Japan Post-marketing Database Surveillance
This clinical trial update describes ongoing post-marketing database surveillance in Japan for the Amplatzer Piccolo Occluder used to treat …
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CLINICAL_TRIALS trial_result · 2025-09-24Clinical Trial Update: Description of Changes in NIRS as a Function of Ductus Arteriosus Status in Very Premature Babies Born Before 32 WG at the DIJON University Hospital
Completed clinical trial update describing how near-infrared spectroscopy (NIRS) measurements vary with ductus arteriosus status in extremel…
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CLINICAL_TRIALS research · 2025-09-15Clinical Trial Update: Management of the PDA Trial [Phase 3]
This is a Phase 3 clinical trial update for the management of patent ductus arteriosus in premature and newborn infants, with the study curr…
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CLINICAL_TRIALS research · 2025-08-27Clinical Trial Update: Precision Dosing of Oral Ibuprofen for PDA, A Pilot RCT [Phase 2]
Phase 2 pilot randomized trial evaluating precision dosing of oral ibuprofen for treating patent ductus arteriosus in preterm infants is cur…
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CLINICAL_TRIALS trial_result · 2025-05-30Clinical Trial Update: Liver Regional Oxygen Saturation in Preterm Patent Ductus Arteriosus
Clinical trial update indicating completion of a study evaluating liver regional oxygen saturation in preterm infants with patent ductus art…
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CLINICAL_TRIALS research · 2025-04-30Clinical Trial Update: Dynamic Changes of Ductus Arteriosus in < 31 Weeks Preterm Infants: an Observational Study
This clinical trial update describes an observational study tracking dynamic changes of the ductus arteriosus in extremely preterm infants (…
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CLINICAL_TRIALS other · 2025-03-30Clinical Trial Update: Percutaneous Intervention Versus Observational Trial of Arterial Ductus in Low Weight Infants [NA]
This is a recruiting clinical trial comparing percutaneous intervention to observation for patent ductus arteriosus in low-weight infants.
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CLINICAL_TRIALS trial_result · 2025-03-04Clinical Trial Update: Improving Care for Children With Congenital Heart Disease. [NA]
An update from Lund University Hospital notes an ongoing clinical trial to improve care for children with congenital heart disease. The stud…
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FDA approval · 2025-02-24FDA Approved: INDOMETHACIN — Original Application (Amneal Pharmaceuticals NY LLC)
FDA approved Amneal Pharmaceuticals NY LLC's original application for Indomethacin, authorizing a generic version of the NSAID with the same…