Osteosarcoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2024-09-04Clinical Trial Update: Samotolisib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With TSC or PI3K/MTOR Mutations (A Pediatric MATCH Treatment Trial) [Phase 2]
Phase 2 Pediatric MATCH trial evaluating samotolisib in pediatric patients with relapsed or refractory tumors harboring TSC or PI3K/mTOR mut…
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CLINICAL_TRIALS trial_result · 2024-08-26Clinical Trial Update: Biospecimen Analysis in Determining Effects of Chemotherapy on Fertility in Osteosarcoma Survivors
This completed clinical trial conducted biospecimen analyses to assess how chemotherapy impacts fertility in osteosarcoma survivors.
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CLINICAL_TRIALS research · 2024-08-23Clinical Trial Update: ARTEMIS-002: HS-20093 in Patients With Relapsed or Refractory Osteosarcoma and Other Sarcomas [Phase 2]
Phase 2 study ARTEMIS-002 (HS-20093) is evaluating HS-20093 in patients with relapsed or refractory osteosarcoma and other sarcomas; the tri…
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CLINICAL_TRIALS research · 2024-08-22Clinical Trial Update: Safety and Feasibility of Intraoperative Visualization With Cytalux in Children [Phase 1]
Phase 1 safety and feasibility trial evaluating intraoperative visualization with Cytalux (pafolacianine) in children with osteosarcoma and …
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CLINICAL_TRIALS trial_result · 2024-08-13Clinical Trial Update: Trial of Sunitinib and/or Nivolumab Plus Chemotherapy in Advanced Soft Tissue and Bone Sarcomas [Phase 1, Phase 2]
A completed Phase 1/2 trial evaluating sunitinib and/or nivolumab with chemotherapy in advanced soft tissue and bone sarcomas.
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CLINICAL_TRIALS research · 2024-08-07Clinical Trial Update: Single High-dose Brachytherapy for Giant Osteosarcoma Masses [Phase 2]
Phase 2 clinical trial update on single high-dose brachytherapy for giant osteosarcoma masses; the study status is not yet recruiting.
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CLINICAL_TRIALS research · 2024-08-02Clinical Trial Update: ICONIC: Improving Outcomes Through Collaboration in OsteosarComa
University College London is leading an ongoing clinical trial called ICONIC (Improving Outcomes Through Collaboration in Osteosarcoma), cur…
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CLINICAL_TRIALS trial_result · 2024-07-31Clinical Trial Update: Apatinib With Ifosfamide Plus Etoposide for Relapsed or Refractory Osteosarcoma (OAIE) [Phase 2]
A Phase 2 clinical trial evaluating Apatinib in combination with ifosfamide and etoposide (OAIE) for relapsed or refractory osteosarcoma has…
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CLINICAL_TRIALS trial_result · 2024-07-03Clinical Trial Update: Dendritic Cell Vaccine for Children and Adults With Sarcoma [Phase 1]
This Phase 1 trial update reports the completion of a dendritic cell vaccine study in children and adults with soft tissue and bone sarcoma.
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FDA approval · 2024-06-03FDA Approved: METHOTREXATE — Original Application (Alembic Pharmaceuticals Inc.)
FDA approved Alembic Pharmaceuticals' original application for methotrexate, authorizing the generic version of the drug.
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CLINICAL_TRIALS trial_result · 2024-05-20Clinical Trial Update: ABCB1/P-glycoprotein Expression as Biologic Stratification Factor for Patients With Non Metastatic Osteosarcoma [Phase 2]
Phase 2 clinical trial evaluating ABCB1/P-glycoprotein expression as a biomarker to stratify patients with non-metastatic osteosarcoma; the …
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CLINICAL_TRIALS trial_result · 2024-05-16Clinical Trial Update: A Phase I Trial of T Cells Expressing an Anti-GD2 Chimeric Antigen Receptor in Children and Young Adults With GD2+ Solid Tumors [Phase 1]
Phase I trial update of T cells engineered to express an anti-GD2 chimeric antigen receptor in children and young adults with GD2-positive s…
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CLINICAL_TRIALS trial_result · 2024-05-16Clinical Trial Update: A Study of Surufatinib in Combination With Gemcitabine in Pediatric, Adolescent, and Young Adult Patients With Recurrent or Refractory Solid Tumors [Phase 1, Phase 2]
This completed Phase 1/2 study evaluated the safety and preliminary efficacy of combining surufatinib with gemcitabine in pediatric, adolesc…
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CLINICAL_TRIALS research · 2024-05-14Clinical Trial Update: Soluble B7-H3 as a Biomarker for Osteosarcoma
This study investigates soluble B7-H3 as a biomarker for osteosarcoma progression. It is currently recruiting and sponsored by Peking Univer…
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CLINICAL_TRIALS trial_result · 2024-05-14Clinical Trial Update: IM83 Clinical Study of CAR-T Cell Therapy in Patients With Relapsed or Refractory Osteosarcoma [Phase 1]
Phase 1 trial update for IM83 CAR-T cell therapy in relapsed or refractory osteosarcoma; the study status is not yet recruiting.
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CLINICAL_TRIALS other · 2024-05-14Clinical Trial Update: Apatinib Plus IE Chemotherapy (Ifosfamide and Etoposide) for Relapsed or Refractory Osteosarcoma [Phase 2]
Phase 2 clinical trial update evaluating apatinib in combination with ifosfamide and etoposide for relapsed or refractory osteosarcoma; the …
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CLINICAL_TRIALS trial_result · 2024-04-25Clinical Trial Update: Olaparib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Defects in DNA Damage Repair Genes (A Pediatric MATCH Treatment Trial) [Phase 2]
A pediatric MATCH phase 2 trial assessed olaparib in children with relapsed or refractory advanced solid tumors or non-Hodgkin lymphoma carr…
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CLINICAL_TRIALS trial_result · 2024-04-24Clinical Trial Update: Palbociclib in Treating Patients With Relapsed or Refractory Rb Positive Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Activating Alterations in Cell Cycle Genes (A Pediatric MATCH Treatment Trial) [Phase 2]
Phase 2 pediatric MATCH trial evaluating palbociclib in relapsed or refractory pediatric tumors with activating alterations in cell cycle ge…
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CLINICAL_TRIALS trial_result · 2024-04-01Clinical Trial Update: Neoadjuvant Combination of Doxorubicin, Cisplatin and Methotrexate in Patients Aged 24-40 Years With Primary Bone Tumors [Phase 2, Phase 3]
A Neoadjuvant combination therapy trial using doxorubicin, cisplatin, and methotrexate in young adults with primary bone tumors has reported…
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CLINICAL_TRIALS trial_result · 2024-02-07Clinical Trial Update: Perioperative Use of Tranexamic (TXA) in Bone Tumor Surgery Will Change in Blood Loss and Transfusion Requirements. [Phase 3]
A Phase 3 trial evaluating perioperative tranexamic acid use in bone tumor surgery for Ewing sarcoma of bone and osteosarcoma completed.
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CLINICAL_TRIALS trial_result · 2024-01-23Clinical Trial Update: Trial of Palbociclib in Second Line of Advanced Sarcomas With CDK4 Overexpression. [Phase 2]
A Phase 2 trial evaluating palbociclib in second-line treatment of advanced sarcomas with CDK4 overexpression; current status unknown.
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CLINICAL_TRIALS trial_result · 2024-01-22Clinical Trial Update: Trilaciclib Combined With Chemotherapy for Perioperative Treatment of Osteosarcoma [Phase 2]
Phase 2 clinical trial update evaluating trilaciclib in combination with chemotherapy as perioperative treatment for osteosarcoma.
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CLINICAL_TRIALS trial_result · 2024-01-16Clinical Trial Update: Study of CB-103 in Adult Patients With Advanced or Metastatic Solid Tumours and Haematological Malignancies [Phase 1, Phase 2]
Early-phase study of CB-103 in adults with various advanced solid tumors and hematologic malignancies has been terminated; results were post…
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CLINICAL_TRIALS trial_result · 2023-12-04Clinical Trial Update: Safety, Tolerability, Efficacy and Pharmacokinetics of Copanlisib in Pediatric Patients [Phase 1, Phase 2]
Clinical trial update on Copanlisib in pediatric patients with relapsed or refractory solid tumors or lymphoma, including neuroblastoma, wit…
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CLINICAL_TRIALS trial_result · 2023-11-14Clinical Trial Update: 18F-FTC-146 PET/CT in Newly-Diagnosed Osteosarcoma [Phase 2]
Phase 2 clinical trial update for 18F-FTC-146 PET/CT in newly diagnosed osteosarcoma; study terminated with results posted in 2023.