Osteosarcoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2025-11-03Clinical Trial Update: Testing a New Immune Cell Therapy, GD2-Targeted Modified T-cells (GD2CART), in Children, Adolescents, and Young Adults With Relapsed/Refractory Osteosarcoma and Neuroblastoma, The GD2-CAR PERSIST Trial [Phase 1]
Phase 1 GD2-targeted CAR-T cell therapy (GD2CART) for recurrent/refractory neuroblastoma and osteosarcoma has a suspended status as of the u…
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CLINICAL_TRIALS research · 2025-10-31Clinical Trial Update: SARC038: Phase 2 Study of Regorafenib and Nivolumab in Osteosarcoma [Phase 2]
This ClinicalTrials.gov update describes a Phase 2 study testing regorafenib in combination with nivolumab for osteosarcoma, including pedia…
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CLINICAL_TRIALS trial_result · 2025-10-16Clinical Trial Update: Larotrectinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With NTRK Fusions (A Pediatric MATCH Treatment Trial) [Phase 2]
Phase 2 pediatric MATCH trial evaluating larotrectinib in patients with NTRK gene fusions has posted results; the study remains active but n…
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CLINICAL_TRIALS research · 2025-10-16Clinical Trial Update: Alpha/Beta CD19+ Depleted Haploidentical Transplantation + Zometa for Pediatric Hematologic Malignancies and Solid Tumors [Phase 1]
Phase 1 pediatric trial evaluating alpha/beta CD19+ depleted haploidentical transplantation in combination with Zoledronic acid (Zometa) for…
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CLINICAL_TRIALS research · 2025-10-10Clinical Trial Update: Machine Learning Applied to EHRs Data of Patients With Sarcoma
Completed study from the University of Milano Bicocca applying machine learning to electronic health records of patients with sarcoma (inclu…
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CLINICAL_TRIALS other · 2025-10-07Clinical Trial Update: Combination of Pembrolizumab and Cabozantinib in Patients With Advanced Sarcomas [Phase 2]
A Phase 2 trial evaluating the combination of pembrolizumab and cabozantinib in advanced soft tissue sarcomas, including Ewing sarcoma, oste…
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CLINICAL_TRIALS research · 2025-10-07Clinical Trial Update: Humanized Monoclonal Antibody 3F8 (Hu3F8) With Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) in the Treatment of Recurrent Osteosarcoma [Phase 2]
This clinical trial update describes a Phase 2 study of Hu3F8 (humanized anti-GD2 monoclonal antibody) in combination with GM-CSF for recurr…
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CLINICAL_TRIALS research · 2025-09-22Clinical Trial Update: Tumor Microenvironment in Patients With Localized Osteosarcoma Treated With Mifamurtide: a Translational Study
This translational study investigates how mifamurtide affects the tumor microenvironment in patients with localized osteosarcoma.
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CLINICAL_TRIALS research · 2025-09-22Clinical Trial Update: An Observational Study of Local Relapse After High Grade Osteosarcoma
An observational study assessing local relapse after high-grade osteosarcoma, currently recruiting, sponsored by Istituto Ortopedico Rizzoli…
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CLINICAL_TRIALS research · 2025-09-18Clinical Trial Update: AOH1996 for the Treatment of Refractory Solid Tumors [Phase 1]
AOH1996 is being studied in a Phase 1 trial for patients with refractory solid tumors, including osteosarcoma and several other sarcomas and…
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CLINICAL_TRIALS research · 2025-09-16Clinical Trial Update: A Phase II Study Evaluating Efficacy and Safety of Regorafenib in Patients With Metastatic Bone Sarcomas [Phase 2]
Phase II clinical trial evaluating regorafenib for metastatic bone sarcomas is active but not recruiting, including Ewing sarcoma, chondrosa…
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CLINICAL_TRIALS trial_result · 2025-09-05Clinical Trial Update: START: Safety and Anti-Tumor Activity of PeptiCRAd-1 in Treatment of Cancer [Phase 1]
Phase 1 trial update of PeptiCRAd-1 reports safety signals and anti-tumor activity across multiple cancers; trial status is ACTIVE_NOT_RECRU…
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CLINICAL_TRIALS research · 2025-09-05Clinical Trial Update: A Post-treatment Program to Identify and Manage Complications Related to Oncology or Hematology Treatments in Cancer Survivors. [NA]
This clinical trial update describes a post-treatment program to identify and manage complications related to oncology or hematology treatme…
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CLINICAL_TRIALS research · 2025-09-05Clinical Trial Update: Chemotherapy Resistance in Osteogenic Sarcoma and Other Solid Tumors [NA]
Clinical trial update from Memorial Sloan Kettering Cancer Center on chemotherapy resistance in osteosarcoma and other solid tumors, with th…
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CLINICAL_TRIALS research · 2025-08-27Clinical Trial Update: Envafolimab Combined With Neoadjuvant Chemotherapy Treat Stage IIb Resectable Osteosarcoma Patients [Phase 2]
A Phase 2 trial update reports testing Envafolimab in combination with neoadjuvant chemotherapy for stage IIb resectable osteosarcoma, with …
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CLINICAL_TRIALS research · 2025-08-06Clinical Trial Update: Descriptive Cohort of French Patients Treated With Carbonetherapy Since October 2010 Outside PHRC-ETOILE
Describes a descriptive cohort of French patients treated with carbon ion therapy for various cancers, reported outside a PHRC-ETOILE progra…
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CLINICAL_TRIALS research · 2025-08-06Clinical Trial Update: Clinical Orthopaedic Data Bank (Acute and Chronic)
ClinicalTrials.gov update indicates the Clinical Orthopaedic Data Bank study on acute and chronic conditions is currently recruiting. The li…
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CLINICAL_TRIALS research · 2025-07-25Clinical Trial Update: C7R-GD2.CART Cells for Patients With Relapsed or Refractory Neuroblastoma and Other GD2 Positive Cancers (GAIL-N) [Phase 1]
ClinicalTrials.gov entry updates the Phase 1 study of C7R-GD2.CART cells for relapsed or refractory GD2-positive cancers, including neurobla…
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CLINICAL_TRIALS research · 2025-07-20Clinical Trial Update: Abemaciclib for Bone and Soft Tissue Sarcoma With Cyclin-Dependent Kinase (CDK) Pathway Alteration [Phase 2]
A Phase 2 clinical trial evaluating abemaciclib for bone and soft tissue sarcomas with CDK pathway alterations is currently recruiting.
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CLINICAL_TRIALS research · 2025-07-04Clinical Trial Update: Safety and Efficacy of DIT309 in Advanced Bone and Soft Tissue Sarcomas [Phase 1]
This document reports a Phase 1 clinical trial evaluating the safety and efficacy of DIT309 in advanced bone and soft tissue sarcomas, with …
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CLINICAL_TRIALS trial_result · 2025-06-08Clinical Trial Update: Metronomic Chemotherapy in Patients With Advanced Solid Tumor With Bone Metastasis and Advanced Pretreated Osteosarcoma [Phase 1]
Phase 1 trial evaluating metronomic chemotherapy in patients with advanced solid tumors with bone metastases and pretreated osteosarcoma. Re…
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CLINICAL_TRIALS other · 2025-06-08Clinical Trial Update: Combined Chemotherapy With or Without Zoledronic Acid for Patients With Osteosarcoma [Phase 3]
Phase 3 trial evaluating chemotherapy with or without zoledronic acid for osteosarcoma; the study is currently active but not recruiting.
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CLINICAL_TRIALS trial_result · 2025-06-03Clinical Trial Update: Tipifarnib for the Treatment of Advanced Solid Tumors, Lymphoma, or Histiocytic Disorders With HRAS Gene Alterations, a Pediatric MATCH Treatment Trial [Phase 2]
Phase 2 pediatric MATCH trial results for Tipifarnib in HRAS-altered solid tumors and histiocytic disorders; the study has posted results an…
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CLINICAL_TRIALS research · 2025-05-23Clinical Trial Update: Effects of Dexrazoxane Hydrochloride on Biomarkers Associated With Cardiomyopathy and Heart Failure After Cancer Treatment
An ongoing clinical trial is evaluating whether dexrazoxane hydrochloride affects biomarkers linked to cardiomyopathy and heart failure afte…
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CLINICAL_TRIALS research · 2025-05-13Clinical Trial Update: Early Ageing During Therapy in AYA Cancer Patients
A clinical trial investigating early ageing during therapy in adolescents and young adults with cancer is currently recruiting. The study co…