Osteosarcoma
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CLINICAL_TRIALS research · 2026-02-05Clinical Trial Update: An Organoid-based Functional Precision Medicine Trial in Osteosarcoma
A clinical trial in osteosarcoma evaluating organoid-based functional precision medicine is currently recruiting, sponsored by the Jonsson C…
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CLINICAL_TRIALS research · 2026-02-04Clinical Trial Update: Gemcitabine, Docetaxel, and Hydroxychloroquine in Treating Participants With Recurrent or Refractory Osteosarcoma [Phase 1, Phase 2]
Phase 1/2 clinical trial evaluating gemcitabine, docetaxel, and hydroxychloroquine for recurrent or refractory osteosarcoma; the study is cu…
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CLINICAL_TRIALS research · 2026-02-04Clinical Trial Update: Diffusion Weighted Magnetic Resonance in Imaging Younger Patients With Newly Diagnosed Bone or Soft Tissue Sarcomas [NA]
A completed clinical trial update examining diffusion-weighted MRI imaging in younger patients with newly diagnosed bone or soft-tissue sarc…
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CLINICAL_TRIALS research · 2026-02-03Clinical Trial Update: Losartan + Sunitinib in Treatment of Osteosarcoma [Phase 1]
Phase 1 trial investigating the combination of Losartan and Sunitinib for osteosarcoma is currently recruiting.
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CLINICAL_TRIALS research · 2026-02-03Clinical Trial Update: Adherence to a Personalized Home Exercise Program in Patients With Bone Tumor Undergoing Lower Extremity Salvage Surgery
This clinical trial update notes a study evaluating adherence to a personalized home exercise program for bone tumor patients undergoing low…
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CLINICAL_TRIALS research · 2026-01-26Clinical Trial Update: Biomarkers of Resiliency In Childhood Cancer Surgery
Clinical trial update from Mayo Clinic on biomarkers of resiliency in pediatric cancer surgery, currently recruiting.
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CLINICAL_TRIALS research · 2026-01-22Clinical Trial Update: HER2 Chimeric Antigen Receptor (CAR) T Cells in Combination With Checkpoint Blockade in Patients With Advanced Sarcoma [Phase 1]
Phase 1 clinical trial evaluating HER2-targeted CAR T cells in combination with checkpoint blockade for advanced sarcoma; recruitment is ong…
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CLINICAL_TRIALS trial_result · 2026-01-21Clinical Trial Update: Testing the Combination of Two Immunotherapy Drugs (Magrolimab and Dinutuximab) in Patients With Relapsed or Refractory Neuroblastoma or Relapsed Osteosarcoma [Phase 1]
Phase 1 trial sponsored by the National Cancer Institute evaluated the combination of magrolimab and dinutuximab in pediatric patients with …
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CLINICAL_TRIALS trial_result · 2026-01-08Clinical Trial Update: Eflornithine (DFMO) for Ewing Sarcoma and Osteosarcoma [Phase 2]
Phase 2 trial update for eflornithine (DFMO) in osteosarcoma and Ewing sarcoma (including metastatic disease) indicates the study is not yet…
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CLINICAL_TRIALS trial_result · 2026-01-07Clinical Trial Update: Glucarpidase After High-Dose Methotrexate in Patients With Osteosarcoma [EARLY_Phase 1]
This document provides an update on a Phase 1 trial evaluating glucarpidase after high-dose methotrexate in osteosarcoma patients.
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CLINICAL_TRIALS trial_result · 2025-12-29Clinical Trial Update: Intra-arterial Cisplatin Plus Rh-endostatin Combined With Systematic Chemotherapy in Osteosarcoma [Phase 1, Phase 2]
A completed Phase 1/2 clinical trial evaluated intra-arterial cisplatin plus rh-endostatin with systemic chemotherapy in osteosarcoma.
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CLINICAL_TRIALS research · 2025-12-29Clinical Trial Update: PET-imaging of Two Vartumabs in Patients With Solid Tumors [EARLY_Phase 1]
This early-phase PET-imaging trial evaluates two vartumabs in patients with solid tumors and is currently recruiting.
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CLINICAL_TRIALS research · 2025-12-26Clinical Trial Update: Mifamurtide Combined With Post-operative Chemotherapy for Newly Diagnosed High Risk Osteosarcoma Patients [Phase 2]
Phase 2 clinical trial evaluating mifamurtide with postoperative chemotherapy for newly diagnosed high-risk osteosarcoma. The study is curre…
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CLINICAL_TRIALS research · 2025-12-26Clinical Trial Update: Allogeneic Expanded Gamma Delta T Cells With GD2 Chemoimmunotherapy in Relapsed /Refractory Neuroblastoma or Refractory/ Relapsed Osteosarcoma [Phase 1]
Phase 1 clinical trial evaluating allogeneic expanded gamma delta T cells combined with GD2-targeted chemoimmunotherapy in relapsed/refracto…
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EMA approval · 2025-12-18EMA Authorised: Mepact (mifamurtide) — Esteve Pharmaceuticals, S.A.
The European Medicines Agency authorised Mepact (mifamurtide) for the treatment of osteosarcoma; the marketing authorization holder is Estev…
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CLINICAL_TRIALS trial_result · 2025-12-12Clinical Trial Update: TQB2928 Injection Combined Anlotinib Hydrochloride Capsule in Recurrent/Metastatic Osteosarcoma and Other Solid Tumors [Phase 1]
Phase 1 trial of TQB2928 injection combined with Anlotinib hydrochloride capsule for recurrent/metastatic osteosarcoma and other solid tumor…
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CLINICAL_TRIALS research · 2025-12-02Clinical Trial Update: Biology of Osteosarcoma (BOOST) Registry and Biobank
The BOOST Registry and Biobank for osteosarcoma has completed data collection and resource assembly, as reported by the University of Minnes…
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CLINICAL_TRIALS trial_result · 2025-12-01Clinical Trial Update: Nab-Paclitaxel and Gemcitabine for Recurrent/Refractory Sarcoma [Phase 2]
A Phase 2 trial of nab-paclitaxel plus gemcitabine for recurrent or refractory sarcoma has completed and posted results.
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CLINICAL_TRIALS research · 2025-11-21Clinical Trial Update: LN-145 or LN-145-S1 in Treating Patients With Relapsed or Refractory Ovarian Cancer, Triple Negative Breast Cancer (TNBC), Anaplastic Thyroid Cancer, Osteosarcoma, or Other Bone and Soft Tissue Sarcomas [Phase 2]
Phase 2 study of LN-145 (LN-145-S1) in relapsed or refractory ovarian cancer, triple-negative breast cancer, anaplastic thyroid cancer, oste…
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CLINICAL_TRIALS research · 2025-11-20Clinical Trial Update: B7H3 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults [Phase 1]
Phase 1 clinical trial update describing B7H3-targeted CAR T-cell therapy for recurrent/refractory pediatric solid tumors, including several…
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CLINICAL_TRIALS research · 2025-11-20Clinical Trial Update: EGFR806 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults [Phase 1]
A Phase 1 trial update for EGFR806 CAR T cell immunotherapy in pediatric and young adult patients with recurrent/refractory solid tumors; th…
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CLINICAL_TRIALS research · 2025-11-20Clinical Trial Update: A Phase I Feasibility And Safety Study of Fluorescein-Specific (FITC-E2) CAR T Cells In Combination With Parenterally Administered Folate-Fluorescein (UB-TT170) For Osteogenic Sarcoma [Phase 1]
Phase I feasibility and safety study of fluorescein-specific (FITC-E2) CAR T cells in combination with Folate-Fluorescein (UB-TT170) for ost…
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CLINICAL_TRIALS research · 2025-11-14Clinical Trial Update: Cabozantinib With Ifosfamide in Relapsed/Refractory Sarcomas [Phase 1]
A Phase 1 trial evaluating the combination of cabozantinib with ifosfamide in relapsed/refractory sarcomas is currently recruiting at Childr…
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CLINICAL_TRIALS trial_result · 2025-11-12Clinical Trial Update: A Study of Cobolimab Plus Dostarlimab in Pediatric and Young Adult Participants With Cancer [Phase 1, Phase 2]
This document details an ongoing Phase 1/2 clinical trial evaluating cobolimab in combination with dostarlimab in pediatric and young adult …
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CLINICAL_TRIALS trial_result · 2025-11-06Clinical Trial Update: Selpercatinib for the Treatment of Advanced Solid Tumors, Lymphomas, or Histiocytic Disorders With Activating RET Gene Alterations, a Pediatric MATCH Treatment Trial [Phase 2]
This update reports on a Phase 2 pediatric MATCH trial evaluating selpercatinib for patients with activating RET gene alterations across adv…