Oral Cavity Squamous Cell Carcinoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: Neoadjuvant Chemotherapy and Programmed Cell Death Protein 1(PD-1) Inhibition for Head and Neck Cancer Treatment De-escalation (NeoScorch HN) [Phase 2]
A Phase 2 trial assesses neoadjuvant chemotherapy combined with a PD-1 inhibitor for head and neck squamous cell carcinoma with the goal of …
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: Remote Audiometry to Monitor for Treatment-Related Hearing Loss in Patients With H&N SCC Receiving Cisplatin and/or Radiation [NA]
A clinical trial update describes remote audiometry being studied to monitor treatment-related hearing loss in patients with head and neck s…
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma [Phase 2]
Phase 2 clinical trial evaluating pembrolizumab given alone versus the standard chemotherapy with radiation after surgery for recurrent head…
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CLINICAL_TRIALS trial_result · 2026-04-17Clinical Trial Update: Testing Docetaxel-Cetuximab or the Addition of an Immunotherapy Drug, Atezolizumab, to the Usual Chemotherapy and Radiation Therapy in High-Risk Head and Neck Cancer [Phase 2, Phase 3]
A Phase 2/3 clinical trial update evaluating either docetaxel plus cetuximab or adding atezolizumab to standard chemotherapy and radiation f…
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: Testing the Addition of Ipatasertib to Usual Chemotherapy and Radiation for Head and Neck Cancer [Phase 1]
A Phase 1 clinical trial is evaluating the addition of the AKT inhibitor ipatasertib to standard chemotherapy and radiation for locally adva…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Testing Whether Cemiplimab (REGN2810) Plus CDX-1140 Given Prior to Surgery Are Better Than Cemiplimab (REGN2810) Alone in Patients With Stage III-IV Head and Neck Cancer [Phase 2]
Phase 2 trial evaluating cemiplimab plus CDX-1140 given before surgery to determine if the combination improves outcomes versus cemiplimab a…
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: Artificial Intelligence for the Diagnosis of Oral Lesions
This clinical trial investigates using artificial intelligence to diagnose oral lesions and is currently not recruiting.
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Testing the Addition of an Anti-cancer Drug, Ipatasertib, to the Usual Immunotherapy Treatment (Pembrolizumab) in Patients With Recurrent or Metastatic Squamous Cell Cancer of the Head and Neck [Phase 2]
A Phase 2 clinical trial is exploring adding ipatasertib to pembrolizumab in patients with recurrent or metastatic head and neck squamous ce…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Nisin in Oral Cavity Squamous Cell Carcinoma (OCSCC) [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating nisIN (nisin) for oral cavity squamous cell carcinoma is currently recruiting.
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CLINICAL_TRIALS research · 2026-04-03Clinical Trial Update: Comparing Sentinel Lymph Node (SLN) Biopsy With Standard Neck Dissection for Patients With Early-Stage Oral Cavity Cancer [Phase 2, Phase 3]
NRG Oncology reports an ongoing Phase 2/3 trial comparing sentinel lymph node biopsy with standard neck dissection for early-stage oral cavi…
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CLINICAL_TRIALS research · 2026-03-24Clinical Trial Update: First Line Weekly Chemo/Immunotherapy for Metastatic Head/Neck Squamous Cell Carcinoma Patients [Phase 2]
Phase 2 trial evaluating first-line weekly chemotherapy combined with immunotherapy for metastatic head and neck squamous cell carcinoma; th…
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CLINICAL_TRIALS research · 2026-03-20Clinical Trial Update: H&N NEO-COMBAT XL: Neoadjuvant XL-092 (Zanzalintinib) and Pembrolizumab (Keytruda) in Surgically Resectable, HPV Negative Oral Cavity Squamous Cell Carcinoma (OCSCC) [Phase 2]
Phase 2 trial exploring neoadjuvant XL-092 (zanzalintinib) with pembrolizumab (Keytruda) for surgically resectable, HPV-negative oral cavity…
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CLINICAL_TRIALS research · 2026-03-12Clinical Trial Update: Immune Biomarker Study for Cisplatin-ineligible Patients Receiving Chemoradiotherapy With Docetaxel
Clinical trial update notes ongoing recruitment for an immune biomarker study in cisplatin-ineligible patients receiving chemoradiotherapy w…
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CLINICAL_TRIALS research · 2026-03-05Clinical Trial Update: Combining Radiation Therapy With Immunotherapy for the Treatment of Metastatic Squamous Cell Carcinoma of the Head and Neck [Phase 3]
Phase 3 trial evaluating combining radiation therapy with immunotherapy for metastatic and stage IV squamous cell carcinomas of the head and…
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CLINICAL_TRIALS research · 2026-03-02Clinical Trial Update: Phase 2 Trial of Neoadjuvant and Adjuvant Tiragolumab Plus Atezolizumab in Patients With Newly Diagnosed PD-L1 CPS Positive Resectable Stage 3-4 Oral Cavity Squamous Cell Carcinoma (OCSCC). [Phase 2]
Phase 2 trial investigating neoadjuvant and adjuvant tiragolumab plus atezolizumab in newly diagnosed PD-L1 CPS-positive resectable stage 3-…
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CLINICAL_TRIALS trial_result · 2026-02-25Clinical Trial Update: A Fluorescent Tumor Marking Agent, Tozuleristide, for Imaging Oral Cavity Squamous Cell Cancer and High-Grade Oral Cavity Dysplasia During Surgery [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating Tozuleristide as a fluorescent tumor marking agent for imaging oral cavity squamous cell carcinoma and…
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CLINICAL_TRIALS research · 2026-02-10Clinical Trial Update: Cemiplimab, Low-Dose Paclitaxel and Carboplatin for the Treatment of Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck [Phase 2]
This document provides an update on a Phase 2 clinical trial evaluating cemiplimab in combination with low-dose paclitaxel and carboplatin f…
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CLINICAL_TRIALS research · 2026-01-29Clinical Trial Update: Lattice-Based Radiotherapy and Chemo-Immunotherapy for Oral Cavity Squamous Cell Carcinoma [Phase 1]
A Phase 1 trial evaluating lattice-based radiotherapy combined with chemo-immunotherapy for oral cavity squamous cell carcinoma; the study i…
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CLINICAL_TRIALS trial_result · 2026-01-28Clinical Trial Update: Pembrolizumab Combined With Cetuximab for Treatment of Recurrent/Metastatic Head & Neck Squamous Cell Carcinoma [Phase 2]
Phase 2 trial evaluating pembrolizumab in combination with cetuximab for recurrent/metastatic head and neck squamous cell carcinoma; the stu…
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CLINICAL_TRIALS trial_result · 2026-01-05Clinical Trial Update: Optimisation of Potential Dental Implant Sites Protection for Rehabilitation in Patients With Head and Neck Cancer: Impact of Virtual Implants Visualisation on Dosimetry (OPPIDOM) [NA]
A clinical trial evaluating the impact of virtual implant visualization on dosimetry for protecting potential dental implant sites in head a…
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CLINICAL_TRIALS trial_result · 2025-12-16Clinical Trial Update: Activity and Safety of Peptide-based Immunotherapy in Patients With Squamous Cell Carcinoma of the Head and Neck. [Phase 2]
A Phase 2 clinical trial evaluating a peptide-based immunotherapy for head and neck squamous cell carcinoma was terminated; the update repor…
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CLINICAL_TRIALS trial_result · 2025-12-05Clinical Trial Update: IRX-2 Regimen and Durvalumab, for Incurable H&N Squamous Cell Carcinoma [Phase 1]
Phase 1 study evaluating IRX-2 regimen with durvalumab for incurable head and neck squamous cell carcinoma has completed, including multiple…
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CLINICAL_TRIALS research · 2025-12-05Clinical Trial Update: Cemiplimab and Cetuximab Prior Salvage Surgery in Patients With Recurrent Oral Cavity Squamous Cell Carcinoma (OCSCC). [Phase 2]
Phase 2 clinical trial evaluating cemiplimab and cetuximab as prior salvage therapy before surgery for locally recurrent oral cavity squamou…
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CLINICAL_TRIALS trial_result · 2025-11-20Clinical Trial Update: Study Comparing Fibula Free-flap MR With or Without PVP in Patients With OOPC [NA]
A completed clinical trial comparing fibula free-flap microreconstruction with or without PVP in patients with oropharyngeal or oral cavity …
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CLINICAL_TRIALS research · 2025-10-02Clinical Trial Update: Compartmentalized Postoperative Radiotherapy in Head and Neck Cancer [Phase 2]
A Phase 2 clinical trial evaluating compartmentalized postoperative radiotherapy in head and neck cancer, currently not yet recruiting.