Non-small Cell Lung Cancer
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2025-04-17Clinical Trial Update: A Randomized Pilot Study of Evolocumab Plus Nivolumab/Ipilimumab in Treatment-Naïve Patients With Metastatic NSCLC [Phase 2]
A Phase 2 randomized pilot trial is investigating evolocumab in combination with nivolumab/ipilimumab for treatment-naïve metastatic non-sma…
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CLINICAL_TRIALS trial_result · 2025-04-17Clinical Trial Update: A Study to Evaluate Subcutaneous Durvalumab in Patients With Non-Small Cell Lung Cancer and Small Cell Lung Cancer [Phase 1]
A Phase 1 trial evaluating subcutaneous durvalumab for non-small cell lung cancer and small cell lung cancer was terminated.
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CLINICAL_TRIALS trial_result · 2025-04-16Clinical Trial Update: A Study of Amivantamab and Lazertinib in Combination With Platinum-Based Chemotherapy Compared With Platinum-Based Chemotherapy in Patients With Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non- Small Cell Lung Cancer After Osimertinib Failure [Phase 3]
Phase 3 trial evaluating the combination of amivantamab and lazertinib with platinum-based chemotherapy versus platinum-based chemotherapy a…
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CLINICAL_TRIALS trial_result · 2025-04-16Clinical Trial Update: A Study of Amivantamab and Lazertinib in Combination With Platinum-Based Chemotherapy Compared With Platinum-Based Chemotherapy in Patients With Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non- Small Cell Lung Cancer After Osimertinib Failure [Phase 3]
Phase 3 trial evaluating amivantamab and lazertinib with platinum chemotherapy versus platinum chemotherapy alone in EGFR-mutated locally ad…
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CLINICAL_TRIALS trial_result · 2025-04-16Clinical Trial Update: Safety and Efficacy of Combination Osimertinib and Ipilimumab in Patients w EGFR Mutated NSCLC [Phase 1]
Phase 1 trial evaluating the safety and efficacy of combining osimertinib with ipilimumab in patients with EGFR-mutated non-small cell lung …
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CLINICAL_TRIALS trial_result · 2025-04-16Clinical Trial Update: Endobronchial Ultrasound Guided Interstitial Photodynamic Therapy in Treating Patients With Locally Advanced Lung Cancer [Phase 1, Phase 2]
Phase 1/2 study of endobronchial ultrasound-guided interstitial photodynamic therapy for locally advanced lung cancer was terminated, with r…
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CLINICAL_TRIALS trial_result · 2025-04-16Clinical Trial Update: A Study of BMS-986315 and Nivolumab in Combination With Chemotherapy in Participants With First-line Stage IV or Recurrent Non-small Cell Lung Cancer (NSCLC) [Phase 2]
A Phase 2 trial of BMS-986315 in combination with nivolumab and chemotherapy for first-line Stage IV or recurrent non-small cell lung cancer…
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CLINICAL_TRIALS research · 2025-04-16Clinical Trial Update: Liquid Biopsy-Based Novel Modality for Postoperative Management of Lung Cancer [NA]
A new clinical trial is evaluating a liquid biopsy-based modality for postoperative management of non-small cell lung cancer and is currentl…
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CLINICAL_TRIALS research · 2025-04-16Clinical Trial Update: Phase II Randomized Trial of Carboplatin+Pemetrexed+Bevacizumab+/- Atezolizumab in Stage IV NSCLC [Phase 2]
Phase II randomized trial at Fox Chase Cancer Center evaluating adding atezolizumab to carboplatin, pemetrexed, and bevaciuzmab vs. standard…
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CLINICAL_TRIALS research · 2025-04-16Clinical Trial Update: Safety, Efficacy, and Survival Outcomes of Neoadjuvant/Induction Immunotherapy in Surgical and Radiotherapeutic Management of Non-Small Cell Lung Cancer
A clinical trial updating on safety, efficacy, and survival outcomes for neoadjuvant/induction immunotherapy in surgical and radiotherapeuti…
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CLINICAL_TRIALS withdrawal · 2025-04-16Clinical Trial Update: A Trial of AN0025 With Chemoradiation Therapy in Stage III NSCLC Participants [Phase 1]
This clinical trial update reports the withdrawal of a Phase 1 study evaluating AN0025 in combination with chemoradiation therapy for stage …
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CLINICAL_TRIALS research · 2025-04-15Clinical Trial Update: A Clinical Study of Furmonertinib in the Treatment of EGFR-Mutated NSCLC With Leptomeningeal Metastases
Clinical trial update for furmonertinib in EGFR-mutated non-small cell lung cancer with leptomeningeal metastasis; the study is currently ac…
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CLINICAL_TRIALS research · 2025-04-13Clinical Trial Update: Adjuvant Chemotherapy in Patients With Intermediate or High Risk Stage I or Stage IIA Non-squamous Non-Small Cell Lung Cancer: AIM-HIGH (Adjuvant Intervention in Molecular High Risk Patients) [NA]
This document reports an update on the AIM-HIGH trial evaluating adjuvant chemotherapy in intermediate/high-risk stage I or stage IIA non-sq…
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CLINICAL_TRIALS research · 2025-04-13Clinical Trial Update: A Study Evaluating the Effect of Aumolertinib on the Pharmacokinetics of Midazolam in Patients With NSCLC [Phase 1]
This Phase 1 trial assesses the effect of Aumolertinib on the pharmacokinetics of midazolam in patients with non-small cell lung cancer. It …
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CLINICAL_TRIALS trial_result · 2025-04-13Clinical Trial Update: A Phase Ib Study of LXH254-centric Combinations in NSCLC or Melanoma [Phase 1]
Phase Ib LXH254-centric combination study in non-small cell lung cancer and melanoma has been terminated.
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CLINICAL_TRIALS other · 2025-04-13Clinical Trial Update: Esomeprazole and Radiation Induced Esophagitis [Phase 2]
Phase 2 clinical trial evaluating whether esomeprazole can prevent or reduce radiation-induced esophagitis in locally advanced non-small cel…
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CLINICAL_TRIALS trial_result · 2025-04-13Clinical Trial Update: SHR0302 Combined With PD-1/PD-L1 Inhibition for Treatment naïve or Acquired Resistant to Immunology NSCLC [Phase 2]
A Phase 2 trial evaluating SHR0302 in combination with PD-1/PD-L1 inhibitors for treatment-naive or immunotherapy-resistant non-small cell l…
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CLINICAL_TRIALS trial_result · 2025-04-11Clinical Trial Update: An Open Label Trial of Afatinib (Giotrif) in Treatment-naive (1st Line) or Chemotherapy Pre-treated Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC) Harboring EGFR Mutation(s) [Phase 3]
An open-label Phase 3 trial evaluating afatinib (Giotrif) in EGFR-mutant locally advanced or metastatic non-small cell lung cancer, includin…
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CLINICAL_TRIALS trial_result · 2025-04-11Clinical Trial Update: Alflutinib Mesylate Versus Gefitinib in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer （FLAG） [Phase 3]
Phase 3 trial comparing alflutinib mesylate to gefitinib in locally advanced or metastatic EGFR-sensitizing mutation-positive non-small cell…
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CLINICAL_TRIALS trial_result · 2025-04-11Clinical Trial Update: JAB-3312 Based Combination Therapy in Adult Patients With Advanced Solid Tumors [Phase 1, Phase 2]
Phase 1/2 trial update of a JAB-3312–based combination therapy in adults with advanced solid tumors has completed (status: completed), inclu…
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CLINICAL_TRIALS research · 2025-04-11Clinical Trial Update: Resistance Mechanisms and Sequential Treatment Strategies Following First-Line Lorlatinib in ALK-Positive NSCLC
This clinical trial update outlines planned research on resistance mechanisms and sequential treatment strategies following first-line lorla…
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CLINICAL_TRIALS research · 2025-04-11Clinical Trial Update: Prospective Cohort Study Evaluating 18FDG PET-CT for the Early Prediction of the Efficacy of Immunotherapy Associated or Not With Chemotherapy in Patients With Locally Advanced or Metastatic Non-Small Cell Broncho-Pulmonary Carcinoma
A prospective cohort study sponsored by Centre Antoine Lacassagne is evaluating whether 18F-FDG PET-CT can predict early response to immunot…
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CLINICAL_TRIALS research · 2025-04-10Clinical Trial Update: Study of Treatment With Sacituzumab and Zimberelimab for Patients With Lung Cancer Confined to the Chest and Previously Operated on Who Were Not Disease-free. [Phase 3]
A Phase 3 trial evaluating sacituzumab govitecan plus zimberelimab for patients with non-small cell lung cancer confined to the chest who ha…
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CLINICAL_TRIALS research · 2025-04-10Clinical Trial Update: New Adjuvant Trial of Chemotherapy vs Chemo-immunotherapy [Phase 3]
A Phase 3 trial compares adjuvant chemotherapy alone to chemo-immunotherapy in non-small cell lung cancer. The study is currently active but…
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CLINICAL_TRIALS research · 2025-04-10Clinical Trial Update: DUMAS: Neo-Adjuvant Immunotherapy for Pancoast Tumors [Phase 2]
This clinical trial update describes a Phase 2 study called DUMAS evaluating neo-adjuvant immunotherapy for Pancoast tumors associated with …