Non-small Cell Lung Cancer
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: First-In-Human Study of STX-721/PFL-721 in Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Harboring EGFR or HER2 Exon 20 Insertion Mutations [Phase 1, Phase 2]
This document reports an ongoing first-in-human study of STX-721/PFL-721 in locally advanced or metastatic non-small cell lung cancer with E…
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Whole Genomic Landscape of Advanced EGFR-mutant NSCLC [NA]
This entry notes an active-not-recruiting clinical trial investigating the whole genomic landscape of advanced EGFR-mutant non-small cell lu…
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Erlotinib Hydrochloride in Treating Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been Completely Removed by Surgery (An ALCHEMIST Treatment Trial) [Phase 3]
A Phase 3 clinical trial update evaluating erlotinib hydrochloride as adjuvant therapy after complete surgical resection for stage IB-IIIA n…
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: ORIC-114 in Combination With Subcutaneous Amivantamab in Patients With EGFR Exon20 Insertion Mutant NSCLC [Phase 1]
A Phase 1 trial evaluating ORIC-114 in combination with subcutaneous amivantamab for EGFR exon 20 insertion-mutant non-small cell lung cance…
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: AZD9291 in Combination With Ascending Doses of Novel Therapeutics [Phase 1]
Phase 1 study evaluating AZD9291 (osimertinib) in combination with escalating doses of novel therapies for advanced non-small cell lung canc…
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Tissue Procurement and Natural History Study of People With Non-Small Cell Lung Cancer, Small Cell Lung Cancer, Extrapulmonary Small Cell Cancer, Pulmonary Neuroendocrine Tumors, and Thymic Epithelial Tumors
This clinical trial update from the National Cancer Institute describes tissue procurement and a natural history study enrolling people with…
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: A Global Phase III Study of Rilvegostomig or Pembrolizumab Monotherapy for First-Line Treatment of PD-L1-high Metastatic Non-small Cell Lung Cancer [Phase 3]
Global Phase III trial evaluating rilvegostomig or pembrolizumab monotherapy as first-line treatment for PD-L1-high metastatic non-small cel…
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: ONC-392 Versus Docetaxel in Metastatic NSCLC That Progressed on PD-1/PD-L1 Inhibitors [Phase 3]
A Phase 3 clinical trial comparing ONC-392 to docetaxel in metastatic Non-Small Cell Lung Cancer that progressed on PD-1/PD-L1 inhibitors. T…
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Neoantigens in People With Metastatic Cancer [Phase 2]
Phase 2 clinical trial evaluating autologous T cells engineered to express T-cell receptors against neoantigens in metastatic cancer, curren…
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Neoadjuvant Inhaled Azacytidine With Platinum-Based Chemotherapy and Durvalumab (MEDI4736) - a Combined Epigenetic-Immunotherapy (AZA-AEGEAN) Regimen for Operable Early-Stage Non-Small Cell Lung Cancer (NSCLC) [Phase 1, Phase 2]
This clinical trial update describes the AZA-AEGEAN regimen—neoadjuvant inhaled azacitidine with platinum-based chemotherapy and durvalumab—…
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Genetic Testing in Screening Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been or Will Be Removed by Surgery (The ALCHEMIST Screening Trial) [NA]
An update on the ALCHEMIST Screening Trial, a National Cancer Institute study evaluating genetic testing in screening patients with operable…
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Anti-PD-1 mAb Plus Metabolic Modulator in Solid Tumor Malignancies [Phase 2]
Phase 2 clinical trial evaluating a PD-1–blocking monoclonal antibody in combination with a metabolic modulator for several solid tumors is …
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Relatrilfa-α Plus Single-Agent Chemotherapy as Neoadjuvant Therapy for Resectable Stage II-III NSCLC (Phase 2) [Phase 2]
Phase 2 clinical trial evaluating Relatrilfa-α in combination with single-agent chemotherapy as neoadjuvant therapy for resectable stage II-…
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Sacituzumab Tirumotecan (MK-2870) Versus Pemetrexed and Carboplatin Combination Therapy in Participants With Epidermal Growth Factor (EGFR)-Mutated, Advanced Nonsquamous Non-small Cell Lung Cancer (NSCLC) Who Have Progressed on Prior EGFR Tyrosine Kinase Inhibitors (MK-2870-009) [Phase 3]
A Phase 3 trial comparing Sacituzumab Tirumotecan versus pemetrexed plus carboplatin in EGFR-mutated, advanced nonsquamous non-small cell lu…
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Sleeve Lobectomy for Lung Cancer in Minimally Invasive Surgical Techniques
A clinical trial is evaluating sleeve lobectomy for lung cancer using minimally invasive surgical techniques and is currently recruiting.
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Nivolumab After Surgery and Chemotherapy in Treating Patients With Stage IB-IIIA Non-small Cell Lung Cancer (An ALCHEMIST Treatment Trial) [Phase 3]
Nivolumab is being studied after surgery and chemotherapy in stage IB to IIIA non-small cell lung cancer as part of the ALCHEMIST Treatment …
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: KEYMAKER-U01 Substudy 01J: A Study of Pembrolizumab Plus MK-1084 in Participants With Non-Small Cell Lung Cancer (NSCLC) With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) G12C Mutations (MK-3475-01J/KEYMAKER-U01J) [Phase 2]
A Phase 2 clinical trial is evaluating pembrolizumab in combination with MK-1084 in KRAS G12C-mutant non-small cell lung cancer. The study i…
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202) [Phase 3]
A Phase 3 randomized trial (CodeBreaK 202) comparing a sotorasib-platinum doublet to a pembrolizumab-platinum doublet as first-line therapy …
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Zorifertinib Plus Intra-Ommaya CSF Chemotherapy for Leptomeningeal Progression in NSCLC After Third-Generation EGFR-TKI [Phase 2]
Phase 2 trial investigating Zorifertinib with intra-Ommaya CSF chemotherapy for leptomeningeal progression in non-small cell lung cancer aft…
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: A Study to Evaluate the Efficacy and Safety of Sutetinib Maleate Capsule in Locally Advanced or Metastatic NSCLC [Phase 2]
Phase 2 clinical trial evaluating the efficacy and safety of Sutetinib Maleate Capsule in locally advanced or metastatic non-small cell lung…
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: A Study of BH-30643 in Subjects With Locally Advanced or Metastatic NSCLC Harboring EGFR and/or HER2 Mutations [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating BH-30643 in subjects with locally advanced or metastatic non-small cell lung cancer harboring EGFR and…
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Chemotherapy Combined With Immunotherapy Versus Immunotherapy Alone for Older Adults With Stage IIIB-IV Lung Cancer, The ACHIEVE Trial [Phase 3]
A Phase 3 clinical trial (ACHIEVE) is evaluating chemotherapy plus immunotherapy versus immunotherapy alone in older adults with stage IIIB-…
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: A Global Study to Assess the Effects of Durvalumab + Domvanalimab Following Concurrent Chemoradiation in Participants With Stage III Unresectable NSCLC [Phase 3]
Phase 3 global trial assessing durvalumab plus domvanalimab after concurrent chemoradiation in stage III unresectable non-small cell lung ca…
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: A Phase II Study of Sacituzumab Tirumotecan in Combination With Furmonertinib in Patients With Non-squamous Non-Small Cell Lung Cancer Who Have Progressed After EGFR-TKI and Platinum-Based Chemotherapy [Phase 2]
Phase II trial evaluating sacituzumab tirumotecan in combination with furmonertinib for non-squamous non-small cell lung cancer that progres…
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: A First-in-Human Study of CKD-703 in Advanced Solid Tumors and Non-Small Cell Lung Cancer [Phase 1, Phase 2]
A first-in-human study of CKD-703 in advanced solid tumors and non-small cell lung cancer is currently recruiting in Phase 1/Phase 2.