Myeloproliferative Neoplasms
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CLINICAL_TRIALS research · 2025-07-30Clinical Trial Update: Impact of Epigenetic Age on Clinic-biological Presentation and Prognosis in Myeloproliferative Neoplasms Epigenetic Age in Myeloproliferative Neoplasms (EpiC)
This update covers the EpiC clinical study examining how epigenetic age relates to clinical presentation and prognosis in myeloproliferative…
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CLINICAL_TRIALS trial_result · 2025-07-30Clinical Trial Update: MASCOT Registry of Patients With Myeloproliferative Neoplasms Associated Splanchnic Vein Thrombosis
This clinical trial registry update reports that the MASCOT study of patients with myeloproliferative neoplasms and splanchnic vein thrombos…
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CLINICAL_TRIALS research · 2025-07-23Clinical Trial Update: A Study of LY2784544 in Participants With Myeloproliferative Neoplasms [Phase 2]
Phase 2 clinical trial update for LY2784544 in participants with myeloproliferative neoplasms; the study is currently active but not recruit…
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CLINICAL_TRIALS research · 2025-07-23Clinical Trial Update: Improving Cognitive Function in Older Adults Undergoing Stem Cell Transplant [NA]
This study update notes that a trial investigating cognitive outcomes in older adults receiving stem cell transplant is currently in RECRUIT…
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CLINICAL_TRIALS trial_result · 2025-07-20Clinical Trial Update: A Study of VAC85135, a Neoantigen Vaccine Regimen, Concurrently Administered With Ipilimumab for the Treatment of Myeloproliferative Neoplasms [Phase 1]
Phase 1 trial evaluating VAC85135, a neoantigen vaccine, given with ipilimumab for myeloproliferative neoplasms has completed.
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CLINICAL_TRIALS research · 2025-07-10Clinical Trial Update: An Efficacy and Safety Study of Luspatercept (ACE-536) Versus Placebo in Subjects With Myeloproliferative Neoplasm-Associated Myelofibrosis on Concomitant JAK2 Inhibitor Therapy and Who Require Red Blood Cell Transfusions [Phase 3]
This Phase 3 trial compares luspatercept against placebo in patients with myeloproliferative neoplasm-associated myelofibrosis who are on JA…
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CLINICAL_TRIALS research · 2025-07-08Clinical Trial Update: 3'-Deoxy-3'-[18F] Fluorothymidine PET Imaging in Patients With Cancer
This clinical trial update describes the use of the PET imaging agent 18F-fluorothymidine (18F-FLT) in cancer patients to assess tumor proli…
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CLINICAL_TRIALS research · 2025-06-27Clinical Trial Update: Study of Oral LY3410738 in Patients With Advanced Hematologic Malignancies With IDH1 or IDH2 Mutations [Phase 1]
Phase 1 study of oral LY3410738 in patients with IDH1/IDH2-mutant hematologic malignancies is currently active but not recruiting.
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CLINICAL_TRIALS research · 2025-06-12Clinical Trial Update: Protocol For Genomically Profiling, Collecting, Archiving And Distributing Blood And Bone Marrow Specimens From Children And Young Adults With Hematologic Malignancy
This document outlines a clinical trial protocol to genomically profile, collect, archive, and distribute blood and bone marrow specimens fr…
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CLINICAL_TRIALS other · 2025-04-30Clinical Trial Update: Long-term Study Evaluating the Effect of Givinostat in Patients With Chronic Myeloproliferative Neoplasms [Phase 2]
This clinical trial update describes a long-term Phase 2 study of Givinostat in patients with chronic myeloproliferative neoplasms and notes…
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CLINICAL_TRIALS trial_result · 2025-04-22Clinical Trial Update: Tocilizumab for the Prevention of Graft Versus Host Disease After Cord Blood Transplantation [Phase 2]
Phase 2 trial evaluating tocilizumab to prevent graft-versus-host disease after cord blood transplantation has been completed.
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CLINICAL_TRIALS research · 2025-04-06Clinical Trial Update: Mutant CALR-peptide Based Vaccine in Patients With Mutated CALR Myeloproliferative Neoplasm [Phase 1]
Phase 1 clinical trial update for a CALR-mutant peptide vaccine in myeloproliferative neoplasms; the study is currently recruiting.
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CLINICAL_TRIALS research · 2025-03-24Clinical Trial Update: Anti-NKG2A Monoclonal Antibody for AML or MDS Patients Undergoing Haploidentical Transplantation [Phase 2]
Phase 2 clinical trial evaluating an anti-NKG2A monoclonal antibody in Acute Myeloid Leukemia or Myelodysplastic Syndromes patients undergoi…
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CLINICAL_TRIALS trial_result · 2025-03-07Clinical Trial Update: Myeloablative Hematopoietic Progenitor Cell Transplantation (HPCT) for Pediatric Malignancies
This completed clinical trial evaluated myeloablative hematopoietic progenitor cell transplantation in pediatric patients with chronic myelo…
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CLINICAL_TRIALS research · 2025-03-04Clinical Trial Update: Italian Network MDS Registry
An Italian network registry study for myelodysplastic syndromes and related myeloproliferative neoplasms is currently recruiting participant…
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CLINICAL_TRIALS trial_result · 2025-02-21Clinical Trial Update: SYTHROM Cohort, Myeloproliferative Neoplasia With Normal CBC and Thrombotic Complications
The SYTHROM cohort trial in myeloproliferative neoplasms with thrombotic complications has completed, evaluating the impact of cytoreductive…
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CLINICAL_TRIALS trial_result · 2025-02-14Clinical Trial Update: A Study Evaluating Safety and Tolerability, and Pharmacokinetics of Navitoclax Monotherapy and in Combination With Ruxolitinib in Participants With Myeloproliferative Neoplasm [Phase 1]
This clinical trial update describes a Phase 1 study evaluating the safety, tolerability, and pharmacokinetics of navitoclax as monotherapy …
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CLINICAL_TRIALS research · 2025-02-14Clinical Trial Update: Registry of Patients With MPNs in Taiwan
An ongoing clinical trial in Taiwan for patients with myeloproliferative neoplasms shows the study is currently active but not recruiting.
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CLINICAL_TRIALS trial_result · 2025-01-13Clinical Trial Update: Ivosidenib and Combination Chemotherapy for the Treatment of IDH1 Mutant Relapsed or Refractory Acute Myeloid Leukemia [Phase 1]
Phase 1 trial evaluating the addition of ivosidenib to chemotherapy for IDH1-mutant relapsed or refractory acute myeloid leukemia, including…
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CLINICAL_TRIALS research · 2024-12-31Clinical Trial Update: Clinical Significance of Leukocyte Cell Population Data in Patients With Myeloproliferative Neoplasms (MPNs)
This clinical trial update describes a study on the clinical significance of leukocyte cell population data in patients with myeloproliferat…
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CLINICAL_TRIALS research · 2024-12-27Clinical Trial Update: Long-term Efficacy of Once Daily Versus Twice Daily Aspirin in High-risk MPN Patients With Aspirin Resistance [Phase 3]
Phase 3 clinical trial update evaluating long-term efficacy of once-daily versus twice-daily aspirin in high-risk myeloproliferative neoplas…
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CLINICAL_TRIALS trial_result · 2024-12-18Clinical Trial Update: Combined Ruxolitinib and Enasidenib in Patients With Accelerated/Blast-phase Myeloproliferative Neoplasm or Chronic-phase Myelofibrosis With an IDH2 Mutation [Phase 2]
A Phase 2 study evaluating the combination of ruxolitinib and enasidenib in patients with accelerated- or blast-phase myeloproliferative neo…
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CLINICAL_TRIALS trial_result · 2024-12-11Clinical Trial Update: Pegasys® in Patients With Myeloproliferative Diseases [Phase 2]
A Phase 2 clinical trial evaluating Pegasys in patients with myeloproliferative neoplasms has completed, with results posted.
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CLINICAL_TRIALS trial_result · 2024-12-10Clinical Trial Update: CAR-NK Cells Production and Expansion From Patients With Lympho or Myeloproliferative Disorders and From Healthy Donors [NA]
Clinical trial update on producing and expanding CAR-NK cells from patients with lymphoproliferative or myeloproliferative disorders and fro…
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CLINICAL_TRIALS research · 2024-12-04Clinical Trial Update: Children, Adolescents and Young Adults with Myeloproliferative Neoplasia: Study of Clinico-biological Characteristics and Complications (VYP)
Clinical trial update for a study of clinico-biological characteristics and complications in children, adolescents and young adults with mye…