Myeloproliferative Neoplasms

CLINICAL_TRIALS trial_result · 2026-04-24

Clinical Trial Update: Testing the Effect of Taking Ruxolitinib and CPX-351 in Combination for the Treatment of Advanced Phase Myeloproliferative Neoplasms [Phase 1, Phase 2]

The Phase 1/2 study evaluating the combination of ruxolitinib and CPX-351 in advanced phase myeloproliferative neoplasms was terminated, wit…

CLINICAL_TRIALS trial_result · 2026-04-21

Clinical Trial Update: Predictive Clinical and Biological Parameters in Acute Leukemia, Myelodysplastic Syndromes and Myeloproliferative Disorders-HEMATO-BIO-IPC-2013-015 [NA]

This clinical trial update reports on predictive clinical and biological parameters across acute leukemia, myelodysplastic syndromes, and my…

CLINICAL_TRIALS trial_result · 2026-04-17

Clinical Trial Update: Fedratinib in Myelodysplastic /Myeloproliferative Neoplasms (MDS/MPNs) and Chronic Neutrophilic Leukemia (CNL) [Phase 2]

Phase 2 study of fedratinib in myeloproliferative neoplasms, chronic neutrophilic leukemia, and myelodysplastic syndromes; the trial is not …

CLINICAL_TRIALS trial_result · 2026-04-01

Clinical Trial Update: Safety and Tolerability Study of INCB057643 in Participants With Myelofibrosis and Other Advanced Myeloid Neoplasms [Phase 1]

An update on a Phase 1 safety and tolerability study of INCB057643 in myelofibrosis and other advanced myeloid neoplasms, with the trial cur…

CLINICAL_TRIALS trial_result · 2026-01-05

Clinical Trial Update: A Phase 1 Trial of CD25/Treg-depleted DLI Plus Ipilimumab for Myeloid Disease Relapse After Matched-HCT [Phase 1]

Phase 1 trial evaluating a combination of CD25/Treg-depleted donor lymphocyte infusion with ipilimumab for relapse of myeloid diseases after…

CLINICAL_TRIALS trial_result · 2025-12-22

Clinical Trial Update: PTCy + Sirolimus/VIC-1911 as GVHD Prophylaxis in Myeloablative PBSC Transplantation [Phase 1, Phase 2]

Phase 1/2 trial evaluating GVHD prophylaxis with post-transplant cyclophosphamide plus sirolimus and VIC-1911 in myeloablative peripheral bl…

CLINICAL_TRIALS trial_result · 2025-12-03

Clinical Trial Update: Aprepitant Versus Hydroxyzine in Persistent Aquagenic Pruritus for Patients With Myeloproliferative Neoplasms [Phase 3]

A Phase 3 randomized trial comparing aprepitant to hydroxyzine in persistent aquagenic pruritus for patients with myeloproliferative neoplas…

CLINICAL_TRIALS trial_result · 2025-11-05

Clinical Trial Update: Ivosidenib and Ruxolitinib in Patients With Advanced Myeloproliferative Neoplasms (MPNs) That Have an IDH1 Gene Mutation [Phase 1]

A Phase 1 clinical trial is evaluating the combination of ivosidenib and ruxolitinib in adults with advanced myeloproliferative neoplasms ha…

CLINICAL_TRIALS trial_result · 2025-10-08

Clinical Trial Update: A Phase 1/2 Study of CPI-0610 With and Without Ruxolitinib in Patients With Hematologic and Myeloproliferative Malignancies [Phase 1, Phase 2]

Phase 1/2 clinical trial evaluating CPI-0610 with and without ruxolitinib in patients with hematologic and myeloproliferative malignancies. …

CLINICAL_TRIALS trial_result · 2025-09-15

Clinical Trial Update: Myeloproliferative Neoplasms (MPN) and COVID-19

Clinical trial update indicating completion of a study on myeloproliferative neoplasms and COVID-19. Sponsor: Fondazione per la Ricerca Ospe…

CLINICAL_TRIALS trial_result · 2025-08-13

Clinical Trial Update: P1101 in Treating Patients With Early PMF or Overt PMF at Low or Intermediate-1 Risk [Phase 3]

A Phase 3 clinical trial evaluating P1101 in patients with early or overt primary myelofibrosis at low or intermediate-1 risk is currently r…

CLINICAL_TRIALS trial_result · 2025-07-30

Clinical Trial Update: Role of Monocytes Sub-populations in Thrombosis Associated With Myeloproliferative Neoplasms (MonSThr)

Update on a completed clinical trial investigating how monocyte sub-populations contribute to thrombosis in myeloproliferative neoplasms (Mo…

CLINICAL_TRIALS trial_result · 2025-07-30

Clinical Trial Update: MASCOT Registry of Patients With Myeloproliferative Neoplasms Associated Splanchnic Vein Thrombosis

This clinical trial registry update reports that the MASCOT study of patients with myeloproliferative neoplasms and splanchnic vein thrombos…

CLINICAL_TRIALS trial_result · 2025-07-20

Clinical Trial Update: A Study of VAC85135, a Neoantigen Vaccine Regimen, Concurrently Administered With Ipilimumab for the Treatment of Myeloproliferative Neoplasms [Phase 1]

Phase 1 trial evaluating VAC85135, a neoantigen vaccine, given with ipilimumab for myeloproliferative neoplasms has completed.

CLINICAL_TRIALS trial_result · 2025-04-22

Clinical Trial Update: Tocilizumab for the Prevention of Graft Versus Host Disease After Cord Blood Transplantation [Phase 2]

Phase 2 trial evaluating tocilizumab to prevent graft-versus-host disease after cord blood transplantation has been completed.

CLINICAL_TRIALS trial_result · 2025-03-07

Clinical Trial Update: Myeloablative Hematopoietic Progenitor Cell Transplantation (HPCT) for Pediatric Malignancies

This completed clinical trial evaluated myeloablative hematopoietic progenitor cell transplantation in pediatric patients with chronic myelo…

CLINICAL_TRIALS trial_result · 2025-02-21

Clinical Trial Update: SYTHROM Cohort, Myeloproliferative Neoplasia With Normal CBC and Thrombotic Complications

The SYTHROM cohort trial in myeloproliferative neoplasms with thrombotic complications has completed, evaluating the impact of cytoreductive…

CLINICAL_TRIALS trial_result · 2025-02-14

Clinical Trial Update: A Study Evaluating Safety and Tolerability, and Pharmacokinetics of Navitoclax Monotherapy and in Combination With Ruxolitinib in Participants With Myeloproliferative Neoplasm [Phase 1]

This clinical trial update describes a Phase 1 study evaluating the safety, tolerability, and pharmacokinetics of navitoclax as monotherapy …

CLINICAL_TRIALS trial_result · 2025-01-13

Clinical Trial Update: Ivosidenib and Combination Chemotherapy for the Treatment of IDH1 Mutant Relapsed or Refractory Acute Myeloid Leukemia [Phase 1]

Phase 1 trial evaluating the addition of ivosidenib to chemotherapy for IDH1-mutant relapsed or refractory acute myeloid leukemia, including…

CLINICAL_TRIALS trial_result · 2024-12-18

Clinical Trial Update: Combined Ruxolitinib and Enasidenib in Patients With Accelerated/Blast-phase Myeloproliferative Neoplasm or Chronic-phase Myelofibrosis With an IDH2 Mutation [Phase 2]

A Phase 2 study evaluating the combination of ruxolitinib and enasidenib in patients with accelerated- or blast-phase myeloproliferative neo…

CLINICAL_TRIALS trial_result · 2024-12-11

Clinical Trial Update: Pegasys® in Patients With Myeloproliferative Diseases [Phase 2]

A Phase 2 clinical trial evaluating Pegasys in patients with myeloproliferative neoplasms has completed, with results posted.

CLINICAL_TRIALS trial_result · 2024-12-10

Clinical Trial Update: CAR-NK Cells Production and Expansion From Patients With Lympho or Myeloproliferative Disorders and From Healthy Donors [NA]

Clinical trial update on producing and expanding CAR-NK cells from patients with lymphoproliferative or myeloproliferative disorders and fro…

CLINICAL_TRIALS trial_result · 2024-10-15

Clinical Trial Update: Post-transplantation Benadamustine and Cyclophosphamide in Patients With Refractory Myeloid Malignancies [Phase 2]

Phase 2 trial evaluating post-transplantation bendamustine and cyclophosphamide in refractory myeloid malignancies has completed.

CLINICAL_TRIALS trial_result · 2024-07-23

Clinical Trial Update: Haploidentical Allogeneic Peripheral Blood Transplantation: Examining Checkpoint Immune Regulators' Expression [Phase 3]

Phase 3 trial evaluating haploidentical allogeneic peripheral blood transplantation with analysis of checkpoint immune regulator expression;…

CLINICAL_TRIALS trial_result · 2024-06-27

Clinical Trial Update: BeFluBu vs FluBuRux Conditioning in Haploidentical HCT [Phase 2]

Phase 2 clinical trial comparing BeFluBu vs FluBuRux conditioning regimens in haploidentical stem cell transplantation is currently recruiti…

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