Myeloproliferative Neoplasm
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-21Clinical Trial Update: Active Myeloid Target Compound Combinations in MDS/MPN Overlap Syndromes Overlap Syndromes (ABNL-MARRO) [Phase 1, Phase 2]
A clinical trial update on active myeloid-target compound combinations for myelodysplastic syndromes with myeloproliferative neoplasm overla…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Azacitidine and Quizartinib for the Treatment of Myelodysplastic Syndrome or Myelodysplastic/Myeloproliferative Neoplasm With FLT3 or CBL Mutations [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating the combination of azacitidine and quizartinib for patients with chronic myelomonocytic leukemia, myel…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Olutasidenib Combined With Co-targeted Therapy in Relapsed or Refractory IDH1-mutated Myeloid Malignancies Harboring Activated Signaling Pathway Mutations [Phase 2]
This entry outlines a Phase 2 clinical trial testing olutasidenib in combination with a co-targeted therapy for relapsed or refractory IDH1-…
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CLINICAL_TRIALS trial_result · 2026-04-14Clinical Trial Update: Chemotherapy, Total Body Irradiation, and Post-Transplant Cyclophosphamide in Reducing Rates of Graft Versus Host Disease in Patients With Hematologic Malignancies Undergoing Donor Stem Cell Transplant [Phase 1, Phase 2]
This is a Phase 1/2 clinical trial update. It evaluates a conditioning strategy using chemotherapy, total body irradiation, and post-transpl…
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: Mechanism of Action of Interferon in the Treatment of Myeloproliferative Neoplasms
This clinical trial investigates the mechanism of action of interferon in the treatment of myeloproliferative neoplasms and is currently rec…
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CLINICAL_TRIALS trial_result · 2026-04-14Clinical Trial Update: Combination Chemotherapy (FLAG-Ida) With Pivekimab Sunirine (PVEK [IMGN632]) for the Treatment of Newly Diagnosed Adverse Risk Acute Myeloid Leukemia and Other High-Grade Myeloid Neoplasms [Phase 1]
Phase 1 study evaluating FLAG-Ida chemotherapy plus pivekimab sunirine (IMGN632) for newly diagnosed adverse-risk acute myeloid leukemia and…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Venetoclax in Combination With ASTX727 for the Treatment of Chronic Myelomonocytic Leukemia and Other Myelodysplastic Syndrome/Myeloproliferative Neoplasm [Phase 2]
Clinical trial update of a Phase 2 study evaluating venetoclax in combination with ASTX727 (oral decitabine/cedazuridine) for chronic myelom…
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CLINICAL_TRIALS other · 2026-04-13Clinical Trial Update: Brain MRF in Children, Adolescents and Young Adults With Acute Leukemia [NA]
Clinical trial evaluating brain MRI feasibility (Brain MRF) in children, adolescents, and young adults with acute leukemia is currently susp…
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CLINICAL_TRIALS research · 2026-03-16Clinical Trial Update: Decitabine With Ruxolitinib, Fedratinib or Pacritinib for the Treatment of Accelerated/Blast Phase Myeloproliferative Neoplasms [Phase 2]
A Phase 2 clinical trial evaluating decitabine in combination with JAK inhibitors (ruxolitinib, fedratinib, or pacritinib) for accelerated o…
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CLINICAL_TRIALS research · 2026-03-12Clinical Trial Update: Graft Versus Host Disease-Reduction Strategies for Donor Blood Stem Cell Transplant Patients With Acute Leukemia or Myelodysplastic Syndrome (MDS) [Phase 2]
This is a Phase 2 clinical trial update evaluating strategies to reduce graft-versus-host disease in donor blood stem cell transplant patien…
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CLINICAL_TRIALS research · 2026-03-11Clinical Trial Update: Ivosidenib and Venetoclax With or Without Azacitidine in Treating Patients With IDH1 Mutated Hematologic Malignancies [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating combinations of ivosidenib and venetoclax with or without azacitidine in IDH1-mutated hematologic mali…
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CLINICAL_TRIALS trial_result · 2026-03-02Clinical Trial Update: Edetate Calcium Disodium or Succimer in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome Undergoing Chemotherapy [Phase 1]
This clinical trial update describes a Phase 1 study of edetate calcium disodium or succimer in patients with acute myeloid leukemia or myel…
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CLINICAL_TRIALS research · 2026-02-25Clinical Trial Update: Evaluation of the Pathobiology of CALR-mutated MPN Cells
Clinical trial investigating the pathobiology of CALR-mutated myeloproliferative neoplasm cells; the study is currently recruiting.
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CLINICAL_TRIALS research · 2026-02-20Clinical Trial Update: Leukemia and Lymphoma Society (LLS) Services Impact on Outcomes and Care [NA]
This clinical trial update describes a University of Miami-sponsored study evaluating how Leukemia & Lymphoma Society services affect patien…
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CLINICAL_TRIALS research · 2026-01-28Clinical Trial Update: Combination Navitoclax, Venetoclax and Decitabine for Advanced Myeloid Neoplasms [Phase 1]
Phase 1 clinical trial evaluating a triple combination of navitoclax, venetoclax, and decitabine for advanced myeloid neoplasms. The study i…
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CLINICAL_TRIALS research · 2026-01-02Clinical Trial Update: Preemptive CIML NK Cell Therapy After Hematopoietic Stem Cell Transplantation [Phase 1]
Phase 1 clinical trial evaluating preemptive CIML NK cell therapy after hematopoietic stem cell transplantation in patients with acute myelo…
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CLINICAL_TRIALS trial_result · 2025-12-19Clinical Trial Update: Comparing the Addition of an Anti-Cancer Drug, Pomalidomide, to the Usual Chemotherapy Treatment (Daunorubicin and Cytarabine Liposome) in Newly Diagnosed Acute Myeloid Leukemia With Myelodysplastic Syndrome-Related Changes [Phase 2]
Phase 2 trial evaluating adding pomalidomide to the standard liposomal daunorubicin/cytarabine chemotherapy in newly diagnosed acute myeloid…
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CLINICAL_TRIALS trial_result · 2025-12-18Clinical Trial Update: Study of Venetoclax and Azacitidine in Advanced BCR-ABL Negative Myeloproliferative Neoplasms [Phase 2]
Phase 2 study evaluating venetoclax in combination with azacitidine in advanced BCR-ABL negative myeloproliferative neoplasms is currently r…
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CLINICAL_TRIALS trial_result · 2025-12-04Clinical Trial Update: Maintenance Fedratinib to Prevent Post-Transplant Relapse in Myeloproliferative Neoplasms [Phase 1]
A Phase 1 trial evaluating maintenance fedratinib to prevent post-transplant relapse in myeloproliferative neoplasms has been terminated.
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CLINICAL_TRIALS trial_result · 2025-11-20Clinical Trial Update: Dexrazoxane Hydrochloride in Preventing Heart-Related Side Effects of Chemotherapy in Participants With Blood Cancers [Phase 2]
Phase 2 trial evaluating Dexrazoxane hydrochloride to prevent heart-related side effects of chemotherapy in people with blood cancers; the s…
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CLINICAL_TRIALS trial_result · 2025-10-01Clinical Trial Update: Safety of Flonoltinib Maleate Tablets for the Treatment of Patients With Myeloproliferative [Phase 1, Phase 2]
This clinical trial update reports safety findings from Phase 1/2 studies of Flonoltinib Maleate Tablets in patients with myeloproliferative…
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CLINICAL_TRIALS research · 2025-07-31Clinical Trial Update: Efficacy and Safety of Ropeginterferon Alfa 2b (P1101) for Patients With Polycythemia Vera [Phase 4]
This clinical trial update reports on a Phase 4 study of Ropeginterferon alfa-2b (P1101) for polycythemia vera, focusing on efficacy and saf…
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CLINICAL_TRIALS trial_result · 2025-07-20Clinical Trial Update: Haplo Peripheral Blood Sct In GVHD Prevention [Phase 1]
Phase 1 trial update reporting the completion of a haploidentical peripheral blood stem cell transplantation approach for the prevention of …
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CLINICAL_TRIALS trial_result · 2025-07-02Clinical Trial Update: Intra-patient Dose Escalation Study to Investigate Safety and Feasibility of Vactosertib in Treating Anemic MPN Patients [Phase 2]
Phase 2 intra-patient dose-escalation trial assessing the safety and feasibility of Vactosertib in anemic myeloproliferative neoplasm patien…
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CLINICAL_TRIALS research · 2025-06-27Clinical Trial Update: Vedolizumab Plus Post-transplant Cyclophosphamide and Short Course Tacrolimus for the Prevention of Graft Versus Host Disease in Patients Undergoing Allogeneic Hematopoietic Cell Transplantation After Reduced Intensity Conditioning [Phase 2]
Phase 2 trial evaluating vedolizumab with post-transplant cyclophosphamide and tacrolimus to prevent graft-versus-host disease in patients u…