Merkel Cell Carcinoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2025-09-04Clinical Trial Update: A Study of FF-10850 Topotecan Liposome Injection in Advanced Solid Tumors Including Merkel Cell Carcinoma [Phase 1]
This is a Phase 1 trial update for FF-10850 liposome-encapsulated topotecan in advanced solid tumors, including Merkel cell carcinoma; the s…
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CLINICAL_TRIALS research · 2025-08-29Clinical Trial Update: MEM-288 Oncolytic Virus Alone and in Combination With Standard of Care Therapy in Advanced Solid Tumors [Phase 1]
Phase 1 study of MEM-288 oncolytic virus in advanced solid tumors, evaluating MEM-288 alone and in combination with standard-of-care therapy…
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CLINICAL_TRIALS trial_result · 2025-07-14Clinical Trial Update: Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of INCB099280 in Participants With Advanced Solid Tumors [Phase 1]
This Phase 1 trial reports on the safety, tolerability, pharmacokinetics, and pharmacodynamics of INCB099280 in participants with advanced s…
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CLINICAL_TRIALS trial_result · 2025-07-14Clinical Trial Update: Focused Ultrasound Ablation and PD-1 Antibody Blockade in Advanced Solid Tumors [Phase 1]
Phase 1 study evaluating the combination of focused ultrasound ablation with PD-1 antibody blockade in advanced solid tumors has been termin…
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CLINICAL_TRIALS trial_result · 2025-07-10Clinical Trial Update: Adoptive Transfer of Tumor Infiltrating Lymphocytes for Advanced Solid Cancers [Phase 2]
Phase 2 study evaluating adoptive transfer of tumor-infiltrating lymphocytes (TIL) for advanced solid cancers, with multiple site-specific i…
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CLINICAL_TRIALS research · 2025-07-09Clinical Trial Update: A Beta-only IL-2 ImmunoTherapY Study [Phase 1, Phase 2]
Medicennа Therapeutics is evaluating a beta-only IL-2 immunotherapy (MDNA11) in Phase 1/2 across multiple advanced solid tumors; recruitment…
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CLINICAL_TRIALS research · 2025-06-13Clinical Trial Update: DOTATOC PET/CT for Imaging NET Patients
ClinicalTrials.gov entry describes a DOTATOC PET/CT imaging study for neuroendocrine tumors, sponsored by the British Columbia Cancer Agency…
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CLINICAL_TRIALS research · 2025-06-05Clinical Trial Update: Study Comparing the Standard Administration of IO Versus the Same IO Administered Each 3 Months in Patients in Response After 6 Months of Standard IO [Phase 3]
A Phase 3 trial is evaluating whether an immune-oncology therapy given every three months after six months of standard administration is as …
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CLINICAL_TRIALS trial_result · 2025-04-09Clinical Trial Update: Adjuvant Therapy of Completely Resected Merkel Cell Carcinoma With Immune Checkpoint Blocking Antibodies vs Observation [Phase 2]
This update reports the completion of a Phase 2 trial evaluating adjuvant therapy with immune checkpoint blocking antibodies versus observat…
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CLINICAL_TRIALS trial_result · 2025-03-06Clinical Trial Update: Gene-Modified Immune Cells (FH-MCVA2TCR) in Treating Patients With Metastatic or Unresectable Merkel Cell Cancer [Phase 1, Phase 2]
Phase 1/2 trial evaluating FH-MCVA2TCR-engineered immune cells for metastatic or unresectable Merkel cell carcinoma; the study was terminate…
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CLINICAL_TRIALS withdrawal · 2025-02-21Clinical Trial Update: QUILT-3.045: NANT Merkel Cell Carcinoma (MCC) Vaccine: Combination Immunotherapy in Subjects With MCC Who Have Progressed on or After PD-L1 Therapy [Phase 1, Phase 2]
Update on QUILT-3.045, a Phase 1/2 trial of the NANT Merkel Cell Carcinoma vaccine in combination immunotherapy for patients with Merkel cel…
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CLINICAL_TRIALS trial_result · 2025-02-03Clinical Trial Update: Phase 1 Study of CK-301 (Cosibelimab) as a Single Agent in Subjects With Advanced Cancers [Phase 1]
Phase 1 study of cosibelimab (CK-301) as a single-agent therapy in adults with advanced cancers; the trial status is active but not recruiti…
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CLINICAL_TRIALS trial_result · 2025-01-29Clinical Trial Update: A Study of T-VEC (Talimogene Laherparepvec) With or Without Radiotherapy for Melanoma, Merkel Cell Carcinoma, or Other Solid Tumors [Phase 2]
Phase 2 study evaluating talimogene laherparepvec (T-VEC) with or without radiotherapy in melanoma and Merkel cell carcinoma (and other soli…
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CLINICAL_TRIALS research · 2024-10-01Clinical Trial Update: Sentinel Lymph Node Biopsy in Ocular Surface and Adnexal Cancers
Clinical trial update indicating recruitment for a study on sentinel lymph node biopsy in ocular surface and adnexal cancers.
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CLINICAL_TRIALS trial_result · 2024-09-23Clinical Trial Update: Immunotherapy With IFx-Hu2.0 Vaccine for Advanced Non-melanoma Skin Cancers [Phase 1]
Phase 1 clinical trial update on the IFx-Hu2.0 vaccine for advanced non-melanoma skin cancers, including Merkel cell carcinoma and cutaneous…
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CLINICAL_TRIALS trial_result · 2024-09-05Clinical Trial Update: How Microbes and Metabolism May Predict Skin Cancer Immunotherapy Outcomes
This clinical trial update discusses how gut microbes and metabolism may predict responses to skin cancer immunotherapy, though the study ha…
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CLINICAL_TRIALS research · 2024-08-12Clinical Trial Update: IFx-Hu2.0 Expanded Access Program
TuHURA Biosciences reports that the IFx-Hu2.0 Expanded Access Program is available for patients with cutaneous melanoma (Stage III/IV), Merk…
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CLINICAL_TRIALS trial_result · 2024-08-09Clinical Trial Update: QUILT-3.063: A Study of N-803, haNK and Avelumab in Patients With Merkel Cell Carcinoma That Has Progressed After Checkpoint Therapy [Phase 2]
A Phase 2 trial evaluating N-803 with haNK and Avelumab in Merkel cell carcinoma after checkpoint therapy was terminated, with results poste…
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CLINICAL_TRIALS research · 2024-07-22Clinical Trial Update: Study of Zirconium Zr 89 Crefmirlimab Berdoxam PET/CT in Subjects With Advanced or Metastatic Malignancies [Phase 2]
Phase 2 trial update for Zirconium-89 labeled Crefmirlimab Berdoxam PET/CT in advanced or metastatic cancers; the study is currently active …
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CLINICAL_TRIALS research · 2024-06-13Clinical Trial Update: Identification and Characterization of Circulating Tumor Cells Before and After Treatment (Surgery and Radiotherapy) in a Cohort of Patients Treated for Resectable Stage I-III Merkel Cell Carcinoma
A clinical trial evaluating circulating tumor cells before and after surgery and radiotherapy in patients with resectable stage I-III Merkel…
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CLINICAL_TRIALS trial_result · 2024-05-08Clinical Trial Update: Domatinostat in Combination With Avelumab in Patients With Advanced Merkel Cell Carcinoma Progressing on Anti-PD-(L)1 [Phase 2]
A Phase 2 study evaluating domatinostat in combination with avelumab in patients with advanced Merkel cell carcinoma who progressed on anti-…
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CLINICAL_TRIALS trial_result · 2024-05-08Clinical Trial Update: Comparing Radical Surgery and Radical Radiotherapy as First Definitive Treatment for Primary MCC [NA]
A completed clinical trial comparing radical surgery and radical radiotherapy as the first definitive treatment for primary Merkel Cell Carc…
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CLINICAL_TRIALS trial_result · 2024-05-02Clinical Trial Update: QUILT-3.009: Patients With Stage III (IIIB) or Stage (IV) Merkel Cell Carcinoma (MCC) [Phase 2]
Phase 2 QUILT-3.009 trial in Stage IIIB and Stage IV Merkel cell carcinoma sponsored by ImmunityBio has been terminated; results are posted.
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CLINICAL_TRIALS trial_result · 2024-02-08Clinical Trial Update: Testing the Addition of Radiation Therapy to Immunotherapy for Merkel Cell Carcinoma [Phase 2]
Phase 2 study evaluating whether adding radiation therapy to immunotherapy improves outcomes in Merkel cell carcinoma; results were posted i…
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CLINICAL_TRIALS trial_result · 2023-10-06Clinical Trial Update: L19IL2/L19TNF in Skin Cancer Patients [Phase 2]
Phase 2 clinical trial update for L19IL2/L19TNF in skin cancer patients with various skin cancers; status is unknown.