Merkel Cell Carcinoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: A Study to Investigate Safety of AZD6750 in Adult Participants With Select Advanced or Metastatic Solid Tumors [Phase 1, Phase 2]
AstraZeneca is conducting a Phase 1/2 trial to evaluate the safety of AZD6750 in adults with select advanced or metastatic solid tumors; the…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: Phase II Study of Peptide Receptor Radionuclide Therapy in Combination With Immunotherapy for Patients With Merkel Cell Cancer [Phase 2]
Phase II clinical trial of peptide receptor radionuclide therapy in combination with immunotherapy for Merkel cell carcinoma is currently re…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: Study to Investigate the Efficacy and Safety of RP1 in Adult Patients With Organ Transplants and Advanced Skin Malignancies [Phase 1, Phase 2]
A Phase 1/2 clinical trial update evaluating RP1 in adults with organ transplants and advanced skin cancers, including Merkel cell carcinoma…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: ASTX727 & Retifanlimab-dlwr for Advanced Merkel Cell After Progression on Anti-PD-(L)1 [Phase 1, Phase 2]
Phase 1/2 clinical trial evaluating the combination of ASTX727 (cedazuridine + decitabine) and retifanlimab-dlwr for advanced Merkel cell ca…
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: Placebo-Controlled Trial of IFx-Hu2.0 Followed By Pembrolizumab In Checkpoint Inhibitor Naïve Participants With Advanced Or Metastatic Merkel Cell Carcinoma [Phase 2, Phase 3]
A Phase 2/Phase 3 trial evaluating IFx-Hu2.0 followed by pembrolizumab in checkpoint inhibitor–naïve patients with advanced or metastatic Me…
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: A Study of Pembrolizumab in Japanese Pediatric Participants With Solid Tumors or Lymphomas and Japanese Adult Participants With Merkel Cell Carcinoma (MK-3475-G21/KEYNOTE-G21) [Phase 1, Phase 2]
A multi-phase clinical trial evaluating pembrolizumab in Japanese pediatric participants with solid tumors or lymphomas and Japanese adult p…
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CLINICAL_TRIALS trial_result · 2026-04-17Clinical Trial Update: Neoadjuvant Merkel Cell Carcinoma Therapy (Tx) With the PD-1 Inhibitor Cemiplimab [Phase 2]
Phase 2 trial evaluating neoadjuvant cemiplimab (PD-1 inhibitor) for stage I–II Merkel cell carcinoma; the study is not yet recruiting.
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Immunotherapy in Combination With Prednisone and Sirolimus for Kidney Transplant Recipients With Unresectable or Metastatic Skin Cancer [Phase 1, Phase 2]
Phase 1/2 trial evaluating immunotherapy in combination with prednisone and sirolimus for kidney transplant recipients with unresectable or …
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Testing Pembrolizumab Versus Observation in Patients With Merkel Cell Carcinoma After Surgery, STAMP Trial [Phase 3]
Phase 3 STAMP trial evaluating pembrolizumab versus observation after surgery for pathologic stage I–III cutaneous Merkel cell carcinoma; th…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers [Phase 2]
This Phase 2 clinical trial update evaluates the combination of talimogene laherparepvec (T-VEC) and nivolumab for patients with refractory …
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Adjuvant Avelumab in Merkel Cell Cancer [Phase 3]
Phase 3 trial evaluating adjuvant avelumab for Merkel cell carcinoma is currently active but not recruiting.
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Testing the Combination of Two Anticancer Drugs M1774 (Tuvusertib) and Avelumab to Evaluate Their Safety and Effectiveness in Treating Merkel Cell Skin Cancer, MATRiX Trial [Phase 2]
Phase 2 study of M1774 (tuvusertib) in combination with avelumab for Merkel cell carcinoma; currently active but not recruiting.
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CLINICAL_TRIALS research · 2026-04-09Clinical Trial Update: Immunotherapy Adjuvant Trial in Patients With Stage I-III Merkel Cell Carcinoma [Phase 2]
Phase 2 immunotherapy adjuvant trial for stage I-III Merkel cell carcinoma is active but not recruiting.
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CLINICAL_TRIALS trial_result · 2026-04-08Clinical Trial Update: Neoadjuvant Lenvatinib Plus Pembrolizumab in Merkel Cell Carcinoma [Phase 2]
A Phase 2 neoadjuvant trial combining lenvatinib with pembrolizumab in Merkel cell carcinoma is active-not-recruiting, with trial results po…
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CLINICAL_TRIALS research · 2026-04-07Clinical Trial Update: Study of Avelumab and/or Radiation Therapy in People With Advanced Merkel Cell Carcinoma [Phase 2]
A Phase 2 clinical trial update evaluating avelumab with or without radiation therapy for advanced Merkel cell carcinoma.
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CLINICAL_TRIALS research · 2026-04-07Clinical Trial Update: A Study of VET3-TGI in Patients With Solid Tumors [Phase 1]
Phase 1 clinical trial update for VET3-TGI in patients with solid tumors, currently recruiting across multiple cancer types.
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CLINICAL_TRIALS research · 2026-04-01Clinical Trial Update: Studying Off Label Insurance Coverage for Patients With Cutaneous Cancers a "Filter" Observational Study
An observational study examining off-label insurance coverage for patients with select cutaneous cancers, sponsored by Ohio State University…
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CLINICAL_TRIALS trial_result · 2026-03-27Clinical Trial Update: Study of Nanrilkefusp Alfa Alone and With Pembrolizumab in Adult Patients With Advanced/Metastatic Solid Tumors [Phase 1]
Phase 1 trial evaluating Nanrilkefusp alfa alone and with pembrolizumab in adults with advanced or metastatic solid tumors; the study (NCT04…
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CLINICAL_TRIALS trial_result · 2026-03-27Clinical Trial Update: Targeted Therapy and Avelumab in Merkel Cell Carcinoma [Phase 1, Phase 2]
This clinical trial update describes ongoing Phase 1 and Phase 2 studies evaluating a targeted therapy in combination with avelumab for meta…
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CLINICAL_TRIALS research · 2026-03-25Clinical Trial Update: Exercise to Boost Response to Checkpoint Blockade Immunotherapy [NA]
Clinical trial update describes an active-not-recruiting study investigating whether exercise can boost response to checkpoint blockade immu…
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EMA approval · 2026-03-24EMA Authorised: Zynyz (retifanlimab) — Incyte Biosciences Distribution B.V.
The European Medicines Agency authorised Zynyz (retifanlimab) for Merkel cell carcinoma; it has orphan medicine designation and is marketed …
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CLINICAL_TRIALS trial_result · 2026-03-18Clinical Trial Update: Plinabulin in Combination With Radiation/Immunotherapy in Patients With Select Advanced Cancers After Progression on PD-1 or PD-L1 Targeted Antibodies [Phase 1, Phase 2]
Phase 1/2 trial of plinabulin with radiation and immunotherapy in select advanced cancers after progression on PD-1/PD-L1 therapy was termin…
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CLINICAL_TRIALS research · 2026-03-11Clinical Trial Update: Atezolizumab and Bevacizumab in Treating Patients With Rare Solid Tumors [Phase 2]
A Phase 2 trial investigates the combination of atezolizumab and bevacizumab in several rare solid tumors, with the study currently not recr…
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CLINICAL_TRIALS research · 2026-03-11Clinical Trial Update: Studies of Dermatologic Diseases Biospecimen Acquisition Protocol
NIAMS is conducting a biospecimen acquisition protocol study for dermatologic diseases, currently recruiting dermatologic patients, healthy …
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CLINICAL_TRIALS research · 2026-03-10Clinical Trial Update: EMLA Topical Cream for Treatment of Pain in Patients Receiving Intra-Dermal Technetium 99 Injections for Lymphoscintigraphy for Skin Cancers [Phase 2]
Phase 2 clinical trial evaluating EMLA Topical Cream to reduce pain from intradermal Tc-99 injections used for lymphoscintigraphy in patient…