Medulloblastoma
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CLINICAL_TRIALS trial_result · 2025-03-10Clinical Trial Update: Infusion of Panobinostat (MTX110) Into the Fourth Ventricle in Children and Adults with Recurrent Medulloblastoma [EARLY_Phase 1]
An early-phase study examining intraventricular infusion of panobinostat (MTX110) into the fourth ventricle for recurrent medulloblastoma in…
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CLINICAL_TRIALS research · 2025-02-12Clinical Trial Update: Accurate Diagnosis and Grading of Pediatric Solid Tumors Based on Pathological Large Models
A clinical trial from Xinhua Hospital and Shanghai Jiao Tong University aims to improve diagnosis and grading of pediatric solid tumors usin…
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CLINICAL_TRIALS trial_result · 2025-02-07Clinical Trial Update: Evaluation of LY2606368 Therapy in Combination With Cyclophosphamide or Gemcitabine for Children and Adolescents With Refractory or Recurrent Group 3/Group 4 or SHH Medulloblastoma Brain Tumors [Phase 1]
Phase 1 trial evaluating the safety and preliminary activity of the CHK1 inhibitor prexasertib (LY2606368) in combination with cyclophospham…
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CLINICAL_TRIALS research · 2025-02-07Clinical Trial Update: Intraoperatively Observed Site of Origin and Growth Pattern of Medulloblastoma
This document updates an ongoing clinical study examining the intraoperative origin site and growth pattern of medulloblastoma. Recruitment …
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CLINICAL_TRIALS research · 2025-02-05Clinical Trial Update: GD2-CAR T Cells for Pediatric Brain Tumours [Phase 1]
Phase 1 trial evaluating GD2-CAR T cells for pediatric brain tumors is currently recruiting. The study targets medulloblastoma, embryonal tu…
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CLINICAL_TRIALS research · 2025-01-14Clinical Trial Update: Study Of Palbociclib Combined With Chemotherapy In Pediatric Patients With Recurrent/Refractory Solid Tumors [Phase 2]
Phase 2 pediatric trial evaluating palbociclib in combination with chemotherapy for recurrent or refractory solid tumors, including Ewing sa…
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CLINICAL_TRIALS research · 2024-12-27Clinical Trial Update: Clinical Trial to Assess the Safety and Efficacy of AloCELYVIR With Newly Diagnosed Diffuse Intrinsic Pontine Glioma (DIPG) in Combination With Radiotherapy or Medulloblastoma in Monotherapy [Phase 1, Phase 2]
Clinical trial evaluating AloCELYVIR for newly diagnosed diffuse intrinsic pontine glioma in combination with radiotherapy and pediatric med…
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CLINICAL_TRIALS withdrawal · 2024-10-26Clinical Trial Update: Chemotherapy and Donor Stem Transplant for the Treatment of Patients With High Grade Brain Cancer [Phase 1]
A Phase 1 trial investigating chemotherapy and donor stem cell transplantation for high-grade brain cancers has been withdrawn. The study in…
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CLINICAL_TRIALS research · 2024-10-15Clinical Trial Update: Apatinib Combined with Temozolomide and Etoposide Capsules in the Treatment of Recurrent Medulloblastoma in Children [Phase 2]
Phase 2 clinical trial evaluating apatinib in combination with temozolomide and etoposide capsules for recurrent medulloblastoma in children…
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CLINICAL_TRIALS trial_result · 2024-10-10Clinical Trial Update: Phase I Study of APX005M in Pediatric Central Nervous System Tumors [Phase 1]
Phase I study of APX005M in pediatric central nervous system tumors; the trial is active but not recruiting and results have been posted. Sp…
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CLINICAL_TRIALS withdrawal · 2024-10-09Clinical Trial Update: StrataXRT in Preventing Radiation Dermatitis in Pediatric Patients Undergoing Radiation Therapy to the Brain or Spinal Cord [Phase 1]
Phase 1 trial evaluating StrataXRT to prevent radiation dermatitis in pediatric patients undergoing brain or spinal irradiation has been wit…
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: Erdafitinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With FGFR Mutations (A Pediatric MATCH Treatment Trial) [Phase 2]
Phase 2 update on erdafitinib for FGFR-mutant relapsed or refractory pediatric cancers enrolled in the Pediatric MATCH trial; results were p…
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CLINICAL_TRIALS research · 2024-07-12Clinical Trial Update: In Vitro Models From Pediatric Brain Tumors
The update describes a study focused on developing in vitro models of pediatric brain tumors, including malignant glioma, ependymoma, and me…
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CLINICAL_TRIALS research · 2024-07-03Clinical Trial Update: Axitinib and Oral Metronomic Etoposide for Pediatric Children and AYA Refractory/Relapsing Medulloblastoma and Ependymoma [Phase 1, Phase 2]
A Phase 1/2 trial of axitinib combined with oral metronomic etoposide for pediatric and adolescent/young adult patients with relapsed/refrac…
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CLINICAL_TRIALS trial_result · 2024-05-31Clinical Trial Update: SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors [Phase 1]
The SJDAWN Phase 1 trial at St. Jude evaluated molecularly-driven doublet therapies for children and young adults with recurrent brain tumor…
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CLINICAL_TRIALS research · 2024-05-24Clinical Trial Update: Study of Sequential High-dose Chemotherapy in Children With High Risk Medulloblastoma [Phase 1, Phase 2]
A phase 1/phase 2 clinical trial evaluating sequential high-dose chemotherapy for children with high-risk medulloblastoma has been terminate…
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CLINICAL_TRIALS trial_result · 2024-05-06Clinical Trial Update: Study of Genistein in Pediatric Oncology Patients (UVA-Gen001) [Phase 2]
Phase 2 pediatric trial of Genistein for various cancers was terminated, with results posted.
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CLINICAL_TRIALS research · 2024-05-02Clinical Trial Update: Clinical Study of Allogeneic Vγ9Vδ2 T Cells in the Treatment of Brain Malignant Glioma [EARLY_Phase 1]
This entry describes an early-stage Phase 1 clinical study evaluating allogeneic Vγ9Vδ2 T cells for malignant gliomas, including glioblastom…
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CLINICAL_TRIALS trial_result · 2024-04-26Clinical Trial Update: Molecular-Guided Therapy for Relapsed and Refractory Childhood Cancer [NA]
A completed pediatric trial evaluated molecular-guided therapy for relapsed and refractory cancers, including neuroblastoma and medulloblast…
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CLINICAL_TRIALS trial_result · 2024-04-25Clinical Trial Update: Olaparib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Defects in DNA Damage Repair Genes (A Pediatric MATCH Treatment Trial) [Phase 2]
A pediatric MATCH phase 2 trial assessed olaparib in children with relapsed or refractory advanced solid tumors or non-Hodgkin lymphoma carr…
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CLINICAL_TRIALS trial_result · 2024-04-24Clinical Trial Update: Palbociclib in Treating Patients With Relapsed or Refractory Rb Positive Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Activating Alterations in Cell Cycle Genes (A Pediatric MATCH Treatment Trial) [Phase 2]
Phase 2 pediatric MATCH trial evaluating palbociclib in relapsed or refractory pediatric tumors with activating alterations in cell cycle ge…
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CLINICAL_TRIALS trial_result · 2024-04-08Clinical Trial Update: Phase 1b Study PVSRIPO for Recurrent Malignant Glioma in Children [Phase 1]
Phase 1b trial update for PVSRIPO in recurrent malignant glioma in children has completed enrollment and results posted.
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CLINICAL_TRIALS trial_result · 2024-04-05Clinical Trial Update: Molecular-Guided Therapy for Childhood Cancer [NA]
A completed clinical trial evaluating molecular-guided therapy for several childhood cancers, with results posted in April 2024.
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CLINICAL_TRIALS trial_result · 2023-10-06Clinical Trial Update: 177Lu-DTPA-Omburtamab Radioimmunotherapy for Recurrent or Refractory Medulloblastoma [Phase 1, Phase 2]
Phase 1/2 trial of 177Lu-DTPA-omburtamab for recurrent or refractory medulloblastoma in children; study terminated with posted results.
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CLINICAL_TRIALS trial_result · 2023-03-24Clinical Trial Update: A Study of Bempegaldesleukin (BEMPEG: NKTR-214) in Combination With Nivolumab in Children, Adolescents and Young Adults With Recurrent or Treatment-resistant Cancer [Phase 1, Phase 2]
A phase 1/2 trial evaluating bempegaldesleukin (BEMPEG) in combination with nivolumab in pediatric and young adult patients with recurrent o…