Medulloblastoma
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CLINICAL_TRIALS research · 2025-12-04Clinical Trial Update: Multicenter Register for Children and Young Adults With Intracranial Localized Medulloblastoma, CNS-PNET or Ependymoma
A multicenter registry for children and young adults with intracranial localized medulloblastoma, CNS primitive neuroectodermal tumor, or ep…
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CLINICAL_TRIALS research · 2025-12-04Clinical Trial Update: International Society of Paediatric Oncology (SIOP) PNET 5 Medulloblastoma [Phase 2, Phase 3]
This entry reports the status of the SIOP PNET5 medulloblastoma trial (Phase 2/3) for pediatric brain tumors, currently ACTIVE_NOT_RECRUITIN…
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CLINICAL_TRIALS research · 2025-11-21Clinical Trial Update: 68-Ga DOTATATE PET/MRI in the Diagnosis and Management of Somatostatin Receptor Positive CNS Tumors. [Phase 4]
A Phase 4 clinical trial evaluating the use of the radiotracer 68-Gallium DOTATATE PET/MRI for diagnosing and managing somatostatin receptor…
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CLINICAL_TRIALS research · 2025-11-13Clinical Trial Update: A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma [Phase 2]
Phase 2 clinical trial investigating a clinical and molecular risk-directed therapy for newly diagnosed medulloblastoma; status is ACTIVE_NO…
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CLINICAL_TRIALS trial_result · 2025-11-06Clinical Trial Update: Selpercatinib for the Treatment of Advanced Solid Tumors, Lymphomas, or Histiocytic Disorders With Activating RET Gene Alterations, a Pediatric MATCH Treatment Trial [Phase 2]
This update reports on a Phase 2 pediatric MATCH trial evaluating selpercatinib for patients with activating RET gene alterations across adv…
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CLINICAL_TRIALS trial_result · 2025-10-30Clinical Trial Update: Testing the Safety and Tolerability of CX-4945 in Patients With Recurrent Medulloblastoma Who May or May Not Have Surgery [Phase 1, Phase 2]
This terminated Phase 1/2 trial assessed the safety and tolerability of CX-4945 (silmitasertib) in pediatric patients with recurrent medullo…
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CLINICAL_TRIALS trial_result · 2025-10-23Clinical Trial Update: Personalized Risk-Adapted Therapy in Post-Pubertal Patients With Newly-Diagnosed Medulloblastoma [Phase 2]
A Phase 2 trial evaluating personalized risk-adapted therapy in post-pubertal patients with newly diagnosed medulloblastoma was terminated.
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CLINICAL_TRIALS trial_result · 2025-10-16Clinical Trial Update: Larotrectinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With NTRK Fusions (A Pediatric MATCH Treatment Trial) [Phase 2]
Phase 2 pediatric MATCH trial evaluating larotrectinib in patients with NTRK gene fusions has posted results; the study remains active but n…
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CLINICAL_TRIALS trial_result · 2025-10-02Clinical Trial Update: Pharmacoscopy for Patients With Refractory Primary Brain Tumors [Phase 2]
Phase 2 clinical trial update for pharmacoscopy in patients with refractory primary brain tumors, currently not yet recruiting.
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CLINICAL_TRIALS research · 2025-09-23Clinical Trial Update: Flavored, Oral Irinotecan VAL-413 (Orotecan®) Given With Temozolomide for Treatment of Recurrent Pediatric Solid Tumors [Phase 1]
Phase 1 study evaluating flavored oral irinotecan VAL-413 (Orotecan) with temozolomide for recurrent pediatric solid tumors is currently rec…
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CLINICAL_TRIALS trial_result · 2025-09-15Clinical Trial Update: Hyperfractionated Versus Conventionally Fractionated Radiotherapy in Standard Risk Medulloblastoma (PNET4) [Phase 3]
This Phase 3 clinical trial comparing hyperfractionated radiotherapy to conventionally fractionated radiotherapy in standard-risk medullobla…
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CLINICAL_TRIALS trial_result · 2025-08-13Clinical Trial Update: Proton Beam Radiotherapy for Medulloblastoma and Pineoblastoma [NA]
A clinical trial evaluating proton beam radiotherapy for medulloblastoma and pineoblastoma has completed and posted results.
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CLINICAL_TRIALS research · 2025-07-22Clinical Trial Update: Atovaquone Combined With Radiation in Children With Malignant Brain Tumors [Phase 1]
A Phase 1 clinical trial evaluating atovaquone in combination with radiation for pediatric malignant brain tumors is currently recruiting.
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CLINICAL_TRIALS trial_result · 2025-07-16Clinical Trial Update: Metformin for Brain Repair in Children With Cranial-Spinal Radiation for Medulloblastoma [Phase 3]
Phase 3 clinical trial evaluating metformin for brain repair in children who previously received cranial-spinal radiation for medulloblastom…
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CLINICAL_TRIALS research · 2025-07-11Clinical Trial Update: Fimepinostat in Treating Brain Tumors in Children and Young Adults [EARLY_Phase 1]
This is an early-phase 1 trial update on fimepinostat for pediatric and young adult brain tumors, including DIPG, recurrent anaplastic astro…
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CLINICAL_TRIALS research · 2025-07-09Clinical Trial Update: PEP-CMV in Recurrent MEdulloblastoma/Malignant Glioma [Phase 1]
Phase 1 clinical trial update for PEP-CMV in recurrent medulloblastoma and malignant glioma.
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CLINICAL_TRIALS trial_result · 2025-06-29Clinical Trial Update: Immune Checkpoint Inhibitor Nivolumab in People With Recurrent Select Rare CNS Cancers [Phase 2]
A Phase 2 trial of nivolumab in patients with recurrent select rare CNS cancers (medulloblastoma, ependymoma, pineal region tumors, choroid …
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CLINICAL_TRIALS research · 2025-06-17Clinical Trial Update: A Phase 0/1 Study of cDNA for TP53, Checkpoint Inhibition and Radiation in Children With Recurrent, Progressive or Refractory CNS Malignancies. [EARLY_Phase 1]
An early-phase trial evaluating TP53 cDNA gene therapy combined with checkpoint inhibition and radiation in children with recurrent or refra…
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CLINICAL_TRIALS trial_result · 2025-06-03Clinical Trial Update: Tipifarnib for the Treatment of Advanced Solid Tumors, Lymphoma, or Histiocytic Disorders With HRAS Gene Alterations, a Pediatric MATCH Treatment Trial [Phase 2]
Phase 2 pediatric MATCH trial results for Tipifarnib in HRAS-altered solid tumors and histiocytic disorders; the study has posted results an…
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CLINICAL_TRIALS research · 2025-05-07Clinical Trial Update: Novel Molecular Targets and Innovative Therapeutic Perspective in Medulloblastoma [EARLY_Phase 1]
This clinical trial update describes an early-phase 1 study in pediatric medulloblastoma investigating novel molecular targets and innovativ…
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CLINICAL_TRIALS trial_result · 2025-04-20Clinical Trial Update: Volitinib in Treating Patients With Recurrent or Refractory Primary CNS Tumors [Phase 1]
Volitinib is being studied in a Phase 1 trial for patients with recurrent or refractory primary CNS tumors, with the study currently listed …
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CLINICAL_TRIALS research · 2025-04-11Clinical Trial Update: Systemic Biomarkers to Predict Radiation-Induced Neurocognitive Decline
A Tata Memorial Centre study is investigating systemic biomarkers to predict radiation-induced neurocognitive decline in patients with brain…
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CLINICAL_TRIALS research · 2025-04-09Clinical Trial Update: Focal Radiotherapy Plus Low Dose Craniospinal Irradiation Followed by Adjuvant Chemotherapy in WNT Medulloblastoma. [NA]
A clinical trial evaluating focal radiotherapy with low-dose craniospinal irradiation followed by adjuvant chemotherapy for WNT-activated me…
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CLINICAL_TRIALS research · 2025-03-25Clinical Trial Update: Integrated Analysis of Therapy Response and Resistence in Embryonal Tumors and Gliomas
This clinical trial update outlines an integrated analysis of how embryonal tumors and gliomas respond to therapy and develop resistance, in…
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CLINICAL_TRIALS trial_result · 2025-03-20Clinical Trial Update: Busulfan, Melphalan, Topotecan Hydrochloride, and a Stem Cell Transplant in Treating Patients With Newly Diagnosed or Relapsed Solid Tumor [Phase 1]
Phase 1 trial evaluating a conditioning regimen of busulfan, melphalan, and topotecan hydrochloride followed by stem cell transplantation in…