Medulloblastoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2025-03-20Clinical Trial Update: Busulfan, Melphalan, Topotecan Hydrochloride, and a Stem Cell Transplant in Treating Patients With Newly Diagnosed or Relapsed Solid Tumor [Phase 1]
Phase 1 trial evaluating a conditioning regimen of busulfan, melphalan, and topotecan hydrochloride followed by stem cell transplantation in…
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CLINICAL_TRIALS trial_result · 2025-03-10Clinical Trial Update: Infusion of Panobinostat (MTX110) Into the Fourth Ventricle in Children and Adults with Recurrent Medulloblastoma [EARLY_Phase 1]
An early-phase study examining intraventricular infusion of panobinostat (MTX110) into the fourth ventricle for recurrent medulloblastoma in…
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CLINICAL_TRIALS trial_result · 2025-02-07Clinical Trial Update: Evaluation of LY2606368 Therapy in Combination With Cyclophosphamide or Gemcitabine for Children and Adolescents With Refractory or Recurrent Group 3/Group 4 or SHH Medulloblastoma Brain Tumors [Phase 1]
Phase 1 trial evaluating the safety and preliminary activity of the CHK1 inhibitor prexasertib (LY2606368) in combination with cyclophospham…
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CLINICAL_TRIALS trial_result · 2024-10-10Clinical Trial Update: Phase I Study of APX005M in Pediatric Central Nervous System Tumors [Phase 1]
Phase I study of APX005M in pediatric central nervous system tumors; the trial is active but not recruiting and results have been posted. Sp…
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: Erdafitinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With FGFR Mutations (A Pediatric MATCH Treatment Trial) [Phase 2]
Phase 2 update on erdafitinib for FGFR-mutant relapsed or refractory pediatric cancers enrolled in the Pediatric MATCH trial; results were p…
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CLINICAL_TRIALS trial_result · 2024-05-31Clinical Trial Update: SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors [Phase 1]
The SJDAWN Phase 1 trial at St. Jude evaluated molecularly-driven doublet therapies for children and young adults with recurrent brain tumor…
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CLINICAL_TRIALS trial_result · 2024-05-06Clinical Trial Update: Study of Genistein in Pediatric Oncology Patients (UVA-Gen001) [Phase 2]
Phase 2 pediatric trial of Genistein for various cancers was terminated, with results posted.
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CLINICAL_TRIALS trial_result · 2024-04-26Clinical Trial Update: Molecular-Guided Therapy for Relapsed and Refractory Childhood Cancer [NA]
A completed pediatric trial evaluated molecular-guided therapy for relapsed and refractory cancers, including neuroblastoma and medulloblast…
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CLINICAL_TRIALS trial_result · 2024-04-25Clinical Trial Update: Olaparib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Defects in DNA Damage Repair Genes (A Pediatric MATCH Treatment Trial) [Phase 2]
A pediatric MATCH phase 2 trial assessed olaparib in children with relapsed or refractory advanced solid tumors or non-Hodgkin lymphoma carr…
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CLINICAL_TRIALS trial_result · 2024-04-24Clinical Trial Update: Palbociclib in Treating Patients With Relapsed or Refractory Rb Positive Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Activating Alterations in Cell Cycle Genes (A Pediatric MATCH Treatment Trial) [Phase 2]
Phase 2 pediatric MATCH trial evaluating palbociclib in relapsed or refractory pediatric tumors with activating alterations in cell cycle ge…
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CLINICAL_TRIALS trial_result · 2024-04-08Clinical Trial Update: Phase 1b Study PVSRIPO for Recurrent Malignant Glioma in Children [Phase 1]
Phase 1b trial update for PVSRIPO in recurrent malignant glioma in children has completed enrollment and results posted.
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CLINICAL_TRIALS trial_result · 2024-04-05Clinical Trial Update: Molecular-Guided Therapy for Childhood Cancer [NA]
A completed clinical trial evaluating molecular-guided therapy for several childhood cancers, with results posted in April 2024.
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CLINICAL_TRIALS trial_result · 2023-10-06Clinical Trial Update: 177Lu-DTPA-Omburtamab Radioimmunotherapy for Recurrent or Refractory Medulloblastoma [Phase 1, Phase 2]
Phase 1/2 trial of 177Lu-DTPA-omburtamab for recurrent or refractory medulloblastoma in children; study terminated with posted results.
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CLINICAL_TRIALS trial_result · 2023-03-24Clinical Trial Update: A Study of Bempegaldesleukin (BEMPEG: NKTR-214) in Combination With Nivolumab in Children, Adolescents and Young Adults With Recurrent or Treatment-resistant Cancer [Phase 1, Phase 2]
A phase 1/2 trial evaluating bempegaldesleukin (BEMPEG) in combination with nivolumab in pediatric and young adult patients with recurrent o…
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CLINICAL_TRIALS trial_result · 2022-12-29Clinical Trial Update: Study of Nifurtimox to Treat Refractory or Relapsed Neuroblastoma or Medulloblastoma [Phase 2]
Phase 2 clinical trial evaluating nifurtimox for refractory or relapsed neuroblastoma or medulloblastoma has completed and results were post…
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CLINICAL_TRIALS trial_result · 2022-10-05Clinical Trial Update: Adavosertib and Irinotecan Hydrochloride in Treating Younger Patients With Relapsed or Refractory Solid Tumors [Phase 1, Phase 2]
Phase 1/2 trial evaluating adavosertib in combination with irinotecan hydrochloride for relapsed or refractory solid tumors in younger patie…
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CLINICAL_TRIALS trial_result · 2022-02-07Clinical Trial Update: Vaccine Immunotherapy for Recurrent Medulloblastoma and Primitive Neuroectodermal Tumor [Phase 2]
Phase 2 clinical trial of a vaccine immunotherapy for recurrent medulloblastoma and primitive neuroectodermal tumor has completed and result…
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CLINICAL_TRIALS trial_result · 2022-01-11Clinical Trial Update: Concurrent Carboplatin and Reduced Dose Craniospinal Radiation for Medulloblastoma and Primitive Neuroectodermal Tumor (PNET) [Phase 2]
Phase 2 trial evaluating concurrent carboplatin with reduced-dose craniospinal irradiation for metatstic medulloblastoma and high-risk supra…
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CLINICAL_TRIALS trial_result · 2021-11-18Clinical Trial Update: Efficacy of Dual Task Training on Children With Ataxia After Medulloblastoma Resection [Phase 2]
Phase 2 trial evaluating dual task training for improving ataxia in children after medulloblastoma resection.
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CLINICAL_TRIALS trial_result · 2021-11-05Clinical Trial Update: Study Assessing the Feasibility of a Surgery and Chemotherapy-Only in Children With Wnt Positive Medulloblastoma [EARLY_Phase 1]
A phase 1/early feasibility trial evaluating surgery and chemotherapy only in children with Wnt-positive medulloblastoma was terminated; res…
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CLINICAL_TRIALS trial_result · 2021-10-26Clinical Trial Update: Melphalan, Carboplatin, Mannitol, and Sodium Thiosulfate in Treating Patients With Recurrent or Progressive CNS Embryonal or Germ Cell Tumors [Phase 1, Phase 2]
Phase 1/2 clinical trial evaluating melphalan, carboplatin, mannitol, and sodium thiosulfate for recurrent or progressive central nervous sy…
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CLINICAL_TRIALS trial_result · 2021-09-22Clinical Trial Update: Comparative Study of Sensitivity of Ga-DOTATOC PET vs Octreoscan SPECT + CT [Phase 2]
Phase 2 trial comparing Ga-DOTATOC PET sensitivity to Octreoscan SPECT+CT in medulloblastoma and related neuroendocrine tumors; results post…
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CLINICAL_TRIALS trial_result · 2021-08-27Clinical Trial Update: Ribociclib and Everolimus in Treating Children With Recurrent or Refractory Malignant Brain Tumors [Phase 1]
Phase 1 trial evaluating ribociclib with everolimus in pediatric patients with recurrent or refractory malignant brain tumors; completed wit…
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CLINICAL_TRIALS trial_result · 2021-02-02Clinical Trial Update: Safety of 68Ga-DOTA-tyr3-Octreotide PET in Diagnosis of Solid Tumors [Phase 1, Phase 2]
Phase 1/2 clinical trial evaluating the safety of 68Ga-DOTA-tyr3-Octreotide PET in diagnosing solid tumors has completed with posted results…
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CLINICAL_TRIALS trial_result · 2021-01-28Clinical Trial Update: Cytomegalovirus (CMV) RNA-Pulsed Dendritic Cells for Pediatric Patients and Young Adults With WHO Grade IV Glioma, Recurrent Malignant Glioma, or Recurrent Medulloblastoma [Phase 1]
Phase 1 trial evaluating CMV RNA-pulsed dendritic cells in pediatric and young adult patients with recurrent malignant glioma and related br…