Malignant Glioma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-04-23Clinical Trial Update: Adoptive Cellular Therapy in Pediatric Patients With High-grade Gliomas [Phase 1]
Phase 1 trial evaluating adoptive cellular therapy in pediatric patients with high-grade gliomas; the study has been terminated and results …
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CLINICAL_TRIALS trial_result · 2026-04-17Clinical Trial Update: Association of Peripheral Blood Immunologic Response to Therapeutic Response to Adjuvant Treatment With Immune Checkpoint Inhibition (ICI) in Patients With Newly Diagnosed Glioblastoma or Gliosarcoma [Phase 2]
A Phase 2 clinical trial update exploring whether peripheral blood immunologic biomarkers predict response to adjuvant immune checkpoint inh…
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CLINICAL_TRIALS trial_result · 2026-04-16Clinical Trial Update: Assessment of Safety and Feasibility of ExAblate Blood-Brain Barrier (BBB) Disruption in GBM Patients
This clinical trial update summarizes the safety and feasibility findings of using ExAblate focused ultrasound to disrupt the blood-brain ba…
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CLINICAL_TRIALS trial_result · 2026-04-16Clinical Trial Update: A Phase I/II Study of Zotiraciclib for Recurrent Malignant Gliomas With Isocitrate Dehydrogenase 1 or 2 (IDH1 or IDH2) Mutations [Phase 1, Phase 2]
A Phase I/II clinical trial evaluating zotiraciclib for recurrent malignant gliomas with IDH1 or IDH2 mutations; the study is currently recr…
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CLINICAL_TRIALS trial_result · 2026-04-13Clinical Trial Update: Retifanlimab With or Without Difluoromethylornithine for the Treatment of Progressive High Grade Gliomas [Phase 1, Phase 2]
Clinical trial update on a phase 1/2 study evaluating retifanlimab with or without difluoromethylornithine for progressive high-grade glioma…
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CLINICAL_TRIALS trial_result · 2026-04-06Clinical Trial Update: Optune for Children With High-Grade Glioma or Ependymoma, and Optune With Radiation Therapy for Children With DIPG [NA]
This ClinicalTrials.gov entry reports ongoing pediatric trials of Optune (Tumor Treating Fields) for malignant glioma and ependymoma, and in…
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CLINICAL_TRIALS trial_result · 2026-04-03Clinical Trial Update: 9-ING-41 in Patients With Advanced Cancers [Phase 2]
Actuate Therapeutics' Phase 2 trial of 9-ING-41 in patients with advanced cancers is currently active but not recruiting, with pancreatic ca…
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CLINICAL_TRIALS trial_result · 2026-03-06Clinical Trial Update: Photodynamic Diagnosis for Malignant Brain Glioma With 5-Aminolevulinic Acid（5-ALA） [Phase 3]
A Phase 3 trial evaluating photodynamic diagnosis with 5-aminolevulinic acid (5-ALA) for malignant glioma of the brain has completed.
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CLINICAL_TRIALS trial_result · 2026-03-06Clinical Trial Update: D2C7 for Adult Patients With Recurrent Malignant Glioma [Phase 1]
Phase 1 trial update of D2C7 in adults with recurrent malignant glioma has completed.
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CLINICAL_TRIALS trial_result · 2026-03-04Clinical Trial Update: Comprehensive Analysis of Chemotherapy and Targeted Therapy Outcomes in Recurrent Malignant Gliomas
This clinical trial update reports a comprehensive analysis of chemotherapy and targeted therapy outcomes in recurrent malignant gliomas, in…
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CLINICAL_TRIALS trial_result · 2026-01-22Clinical Trial Update: Re-Administration of C134 in Patients With Recurrent GBM (C134-HSV-1) [Phase 1]
Phase 1 study evaluating re-administration of C134 in patients with recurrent glioblastoma and related brain gliomas has been terminated.
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CLINICAL_TRIALS trial_result · 2025-09-19Clinical Trial Update: Study of IK-595 in RAS- or RAF-altered Advanced Tumors [Phase 1]
Phase 1 study of IK-595 in Ras- or Raf-altered advanced tumors has been terminated.
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CLINICAL_TRIALS trial_result · 2025-09-09Clinical Trial Update: Safety and Tolerability of Carboxyamidotriazole Orotate (CTO) in Solid Tumors or With Temodar® in Glioblastoma or Other Recurrent Malignant Gliomas or in Combination With Temodar® and Radiation Therapy for Patients With Newly Diagnosed Glioblastoma and Malignant Gliomas [Phase 1]
A Phase 1 study reports on the safety and tolerability of Carboxyamidotriazole Orotate (CTO) in solid tumors and in combination with temozol…
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CLINICAL_TRIALS trial_result · 2025-08-12Clinical Trial Update: Open-label Study Investigating of OKN-007 Combined With Temozolomide in Patients With Recurrent Glioblastoma [Phase 2]
Open-label Phase 2 trial evaluating OKN-007 in combination with temozolomide for recurrent glioblastoma has completed.
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CLINICAL_TRIALS trial_result · 2025-07-11Clinical Trial Update: Lerapolturev in Recurrent Malignant Glioma [Phase 2]
Phase 2 clinical trial results update for Lerapolturev in recurrent malignant glioma; the study has completed and results have been posted.
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CLINICAL_TRIALS trial_result · 2025-06-03Clinical Trial Update: Tipifarnib for the Treatment of Advanced Solid Tumors, Lymphoma, or Histiocytic Disorders With HRAS Gene Alterations, a Pediatric MATCH Treatment Trial [Phase 2]
Phase 2 pediatric MATCH trial results for Tipifarnib in HRAS-altered solid tumors and histiocytic disorders; the study has posted results an…
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CLINICAL_TRIALS trial_result · 2025-05-29Clinical Trial Update: MK-3475 in Combination With MRI-guided Laser Ablation in Recurrent Malignant Gliomas [Phase 1, Phase 2]
The study evaluates pembrolizumab in combination with MRI-guided laser ablation for recurrent malignant gliomas, with Phase 1/2 results post…
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CLINICAL_TRIALS trial_result · 2025-05-07Clinical Trial Update: Antisense102: Pilot Immunotherapy for Newly Diagnosed Malignant Glioma [Phase 1]
An update reports the completion of a Phase 1 pilot immunotherapy trial (Antisense102) for newly diagnosed malignant glioma. The study evalu…
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CLINICAL_TRIALS trial_result · 2025-05-02Clinical Trial Update: Pilot Immunotherapy Trial for Recurrent Malignant Gliomas [Phase 1]
A Phase 1 pilot immunotherapy trial for recurrent malignant gliomas has completed (status COMPLETED).
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CLINICAL_TRIALS trial_result · 2025-04-20Clinical Trial Update: Volitinib in Treating Patients With Recurrent or Refractory Primary CNS Tumors [Phase 1]
Volitinib is being studied in a Phase 1 trial for patients with recurrent or refractory primary CNS tumors, with the study currently listed …
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CLINICAL_TRIALS trial_result · 2025-03-14Clinical Trial Update: AMPLIFYing NEOepitope-specific VACcine Responses in Progressive Diffuse Glioma [Phase 1]
Phase 1 trial evaluating a neoepitope-specific cancer vaccine for progressive malignant glioma has completed. The update indicates the study…
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CLINICAL_TRIALS trial_result · 2025-03-13Clinical Trial Update: Modulation of Ciliogenesis in Glioma Stem Cells [NA]
This clinical trial update reports on a study investigating modulation of ciliogenesis in glioma stem cells for glioblastoma and malignant g…
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CLINICAL_TRIALS trial_result · 2025-02-14Clinical Trial Update: ONC201 in Pediatric H3 K27M Gliomas [Phase 1]
Phase 1 trial update of ONC201 in pediatric H3 K27M gliomas including Diffuse Intrinsic Pontine Glioma and malignant glioma has been termina…
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CLINICAL_TRIALS trial_result · 2025-01-23Clinical Trial Update: 18F-DOPA-PET in Planning Surgery in Patients With Gliomas [EARLY_Phase 1]
A Phase 1 clinical trial evaluating 18F-DOPA-PET imaging to aid surgical planning for malignant glioma and recurrent brain neoplasms has com…
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CLINICAL_TRIALS trial_result · 2024-11-22Clinical Trial Update: Neo-adjuvant Evaluation of Glioma Lysate Vaccines in WHO Grade II Glioma [Phase 1]
Phase 1 trial evaluating neo-adjuvant glioma lysate vaccines in WHO Grade II glioma has completed.