Major Depressive Disorder
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2025-04-30Clinical Trial Update: Kintsugi Voice Device Pivotal Study
Recruitment is underway for a pivotal study evaluating the Kintsugi Voice Device for depression across multiple severities. The trial is cur…
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CLINICAL_TRIALS trial_result · 2025-04-30Clinical Trial Update: Multiphase Optimization Trial of Incentives for Veterans to Encourage Walking [NA]
A VA-sponsored multiphase optimization trial evaluated incentives to encourage walking among veterans to reduce sedentary behavior; the stud…
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CLINICAL_TRIALS research · 2025-04-30Clinical Trial Update: Physical Activity Program for TRD [NA]
Clinical trial investigating a physical activity program for treatment-resistant depression and major depressive disorder; currently recruit…
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CLINICAL_TRIALS trial_result · 2025-04-29Clinical Trial Update: A Study of the Efficacy of Intravenous Esketamine in Adult Patients With Treatment-Resistant Depression [Phase 2]
This Phase 2 trial update reports on the efficacy of intravenous esketamine in adults with treatment-resistant major depressive disorder. Th…
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CLINICAL_TRIALS research · 2025-04-29Clinical Trial Update: Combining Light Therapy and CPAP in Depression [NA]
This trial investigates combining light therapy with CPAP for major depressive disorder and obstructive sleep apnea-related sleep disturbanc…
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CLINICAL_TRIALS trial_result · 2025-04-29Clinical Trial Update: A Safety and Efficacy Study of JNJ26489112 in Patients With Treatment-Resistant Major Depressive Disorder [Phase 2]
A Phase 2 safety and efficacy study of JNJ26489112 in treatment-resistant major depressive disorder was terminated. No results are provided …
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FDA approval · 2025-04-28FDA Approved: SPRAVATO — Supplemental Application (Janssen Pharmaceuticals Inc.)
FDA approves a supplemental application for SPRAVATO (esketamine hydrochloride) submitted by Janssen Pharmaceuticals Inc.
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CLINICAL_TRIALS trial_result · 2025-04-27Clinical Trial Update: A Study of Seltorexant as Adjunctive Therapy to Antidepressants in Adult and Elderly Participants With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant and Long-term Safety Extension Treatment With Seltorexant [Phase 3]
Phase 3 study of Seltorexant as adjunctive therapy to antidepressants for adults and elderly with major depressive disorder with insomnia sy…
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CLINICAL_TRIALS trial_result · 2025-04-27Clinical Trial Update: A Study to Evaluate the Effects of a Single-Dose and Repeat-Administration of Intranasal Esketamine on On-Road Driving in Participants With Major Depressive Disorder [Phase 1]
A Phase 1 study evaluating the effects of single-dose and repeat-administration intranasal esketamine on on-road driving performance in adul…
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CLINICAL_TRIALS trial_result · 2025-04-27Clinical Trial Update: A Study to Investigate the Safety, Tolerability, and Pharmacodynamics of JNJ-54175446 in Participants With Major Depressive Disorder [Phase 1]
A Phase 1 study assessing safety, tolerability, and pharmacodynamics of JNJ-54175446 in adults with Major Depressive Disorder has completed.
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CLINICAL_TRIALS trial_result · 2025-04-27Clinical Trial Update: A Study of Oral Seltorexant as an add-on Medication to an Antidepressant on On-road Driving Performance in Participants With Major Depressive Disorder [Phase 1]
This Phase 1 study has completed. It evaluated oral Seltorexant as an add-on to antidepressant therapy to assess on-road driving performance…
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CLINICAL_TRIALS research · 2025-04-27Clinical Trial Update: A Study to Investigate the Antidepressant Mechanism-of-action of JNJ-42847922 in Participants With Major Depressive Disorder [Phase 1]
This entry reports the completion of a Phase 1 study investigating the antidepressant mechanism-of-action of Janssen's JNJ-42847922 in adult…
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CLINICAL_TRIALS trial_result · 2025-04-27Clinical Trial Update: A Study of Seltorexant as Adjunctive Therapy to Antidepressants in Adolescents With Major Depressive Disorder Who Have an Inadequate Response to Selective Serotonin Reuptake Inhibitor (SSRI) and Psychotherapy [Phase 1]
Phase 1 study evaluating Seltorexant as an add-on to antidepressants in adolescents with major depressive disorder who had an inadequate res…
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CLINICAL_TRIALS withdrawal · 2025-04-27Clinical Trial Update: A Study to Assess Feasibility of Using Clinician-directed and Digital Application Supported Cognitive Behavior Therapy (CBT) in Conjunction With Esketamine in Participants With Treatment-resistant Depression [Phase 1]
A Phase 1 study evaluating the feasibility of combining clinician-directed and digital CBT with esketamine for treatment-resistant depressio…
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CLINICAL_TRIALS trial_result · 2025-04-27Clinical Trial Update: Study to Evaluate the Performance Validity and Test-Retest Reliability of a Computer-Administered Cognitive Test Battery in Participants With Major Depressive Disorder (MDD)
This completed clinical trial evaluated the performance validity and test-retest reliability of a computer-administered cognitive test batte…
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CLINICAL_TRIALS research · 2025-04-27Clinical Trial Update: Pharmacogenetic-Guided Antidepressant Prescribing in Adolescents With Anxiety and Depression [NA]
This clinical trial investigates pharmacogenetic-guided prescribing of antidepressants for adolescents with anxiety and depression and is cu…
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CLINICAL_TRIALS trial_result · 2025-04-27Clinical Trial Update: A Safety, Efficacy and Biomarker Study of JNJ-42847922 in Participants With Major Depressive Disorder [Phase 1]
This update covers a Phase 1 safety, efficacy and biomarker study of JNJ-42847922 in people with major depressive disorder, which has comple…
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CLINICAL_TRIALS withdrawal · 2025-04-27Clinical Trial Update: A Study of Esketamine Nasal Spray Plus a New Standard-of-care Oral Antidepressant or Placebo Nasal Spray Plus a New Standard-of-care Oral Antidepressant in Adult and Elderly Participants With Treatment-resistant Depression [Phase 3]
A Phase 3 study of esketamine nasal spray plus a standard antidepressant for treatment-resistant depression has been withdrawn.
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CLINICAL_TRIALS trial_result · 2025-04-27Clinical Trial Update: MRI-Guided High-Definition Transcranial Direct Current Stimulation (tDCS) for Depression [NA]
This clinical trial update reports the completion of a study evaluating MRI-guided high-definition transcranial direct current stimulation f…
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CLINICAL_TRIALS research · 2025-04-27Clinical Trial Update: A Study to Describe Routine Treatment Pathways in Participants With Major Depression and Active Suicidal Ideation With Intent in Italy
A completed clinical trial update describing a study conducted in Italy to describe routine treatment pathways for adults with major depress…
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CLINICAL_TRIALS withdrawal · 2025-04-27Clinical Trial Update: New Mothers Alpha-Stim [NA]
A clinical trial (NCT04770181) evaluating New Mothers Alpha-Stim for anxiety, depression, insomnia, and sleep quality has been withdrawn.
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CLINICAL_TRIALS trial_result · 2025-04-27Clinical Trial Update: A Standard of Care Study of Patients With Major Depressive Disorder Who Have Had an Inadequate Response to a Selective Serotonin Reuptake/Serotonin-Norepinephrine Reuptake Inhibitor Antidepressant
A standard-of-care study in adults with major depressive disorder has been terminated after inadequate response to an SSRI/SNRI antidepressa…
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CLINICAL_TRIALS trial_result · 2025-04-25Clinical Trial Update: Generated AI-informed Intervention (Emohaa) vs Group ACT vs WL on Emotional Distress [NA]
Completed clinical trial evaluating an AI-informed intervention (Emohaa) vs Group ACT vs waitlist on emotional distress, with conditions inc…
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CLINICAL_TRIALS research · 2025-04-25Clinical Trial Update: Mental Health and PreP [NA]
A clinical trial is planned to study Major Depressive Disorder in individuals taking PrEP, sponsored by Assistance Publique - Hôpitaux de Pa…
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CLINICAL_TRIALS trial_result · 2025-04-25Clinical Trial Update: Affect Treatment for Depression and Anxiety [NA]
A UCLA-sponsored clinical trial investigating a treatment for depression and anxiety has completed.