Major Depressive Disorder
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2025-05-08Clinical Trial Update: Effects of Low-intensity Transcranial Magnetic Stimulation on Major Depressive Disorder, and on 5-hydroxyindoleacetic Acid and Brain-derived Neurotrophic Factor Levels [Phase 1, Phase 2]
An ongoing Phase 1/2 clinical trial from Universidad de Guanajuato is evaluating the effects of low-intensity transcranial magnetic stimulat…
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CLINICAL_TRIALS research · 2025-05-07Clinical Trial Update: Neural Correlates of Stress and Perceived Control in Adolescent Depression [NA]
A McLean Hospital clinical trial investigating neural correlates of stress and perceived control in adolescents with major depressive disord…
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CLINICAL_TRIALS research · 2025-05-07Clinical Trial Update: Cognitive Dysfunction and Inflammation in Depression: Experimental Inhibition Via Infliximab [Phase 2]
Phase 2 clinical trial from Massachusetts General Hospital evaluating infliximab to address cognitive dysfunction and inflammation in major …
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CLINICAL_TRIALS research · 2025-05-06Clinical Trial Update: The Effects of Psilocybin on Self-Focus and Self-Related Processing in Major Depressive Disorder [Phase 3]
Phase 3 clinical trial evaluating the effects of psilocybin on self-focus and self-related processing in Major Depressive Disorder; currentl…
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CLINICAL_TRIALS trial_result · 2025-05-06Clinical Trial Update: Is Betwixt App Effective and Acceptable? [NA]
The document reports the completion of a clinical trial conducted by the University of Nottingham evaluating the Betwixt app for major depre…
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CLINICAL_TRIALS trial_result · 2025-05-06Clinical Trial Update: Emotion Focused Therapy for Competitive Athletes [NA]
This entry reports the completion of a clinical trial evaluating emotion-focused therapy for depression and anxiety in competitive athletes,…
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CLINICAL_TRIALS research · 2025-05-06Clinical Trial Update: Resilience in Adolescent Development
A University of Texas Southwestern Medical Center–sponsored clinical trial is recruiting adolescents to study resilience development and its…
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CLINICAL_TRIALS research · 2025-05-06Clinical Trial Update: The OBSERVE Protocol
Clinical trial update announcing the OBSERVE protocol for major depressive disorder, with recruitment ongoing at Yale University.
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CLINICAL_TRIALS research · 2025-05-06Clinical Trial Update: Modified Interactive Screening Program Plus MINDBODYSTRONG: A Mental Health Resiliency Intervention for Nurses [NA]
This clinical trial update describes a mental health resiliency intervention for nurses that combines a Modified Interactive Screening Progr…
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CLINICAL_TRIALS research · 2025-05-06Clinical Trial Update: A Trial of Dextromethorphan and Bupropion Sustained-Release Tablets in Patients With Major Depressive Disorder [Phase 3]
Phase 3 study evaluating a dextromethorphan and bupropion sustained-release tablet for major depressive disorder; currently recruiting.
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CLINICAL_TRIALS research · 2025-05-04Clinical Trial Update: Imaging to Improve Brain Stimulation
A VA-sponsored clinical trial titled Imaging to Improve Brain Stimulation is studying Major depressive disorder and is currently active but …
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CLINICAL_TRIALS withdrawal · 2025-05-04Clinical Trial Update: Sleep Quality, Cognitive Performance, and Computerized Cognitive Training
A clinical trial examining sleep quality, cognitive performance, and computerized cognitive training for bipolar disorder and major depressi…
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CLINICAL_TRIALS research · 2025-05-04Clinical Trial Update: Evaluation of the Efficacy and Safety of Subcutaneous Ketamine in the Treatment of Depressive Episode With Suicidal Ideation and/or Behavior in Adolescents [Phase 3]
Phase 3 trial evaluating the efficacy and safety of subcutaneous ketamine for depressive episodes with suicidal ideation/behavior in adolesc…
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CLINICAL_TRIALS research · 2025-05-04Clinical Trial Update: Dallas 2K: A Natural History Study of Depression
Dallas 2K is a natural history study of depression sponsored by the University of Texas Southwestern Medical Center, currently recruiting.
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CLINICAL_TRIALS research · 2025-05-04Clinical Trial Update: Teen Brain Online II: Understanding How Social Media Affects the Teen Brain [NA]
A ClinicalTrials.gov update shows the Teen Brain Online II study, examining how social media affects the teen brain, is currently recruiting…
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CLINICAL_TRIALS trial_result · 2025-05-02Clinical Trial Update: Clinical Trial of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder [Phase 3]
A Phase 3 trial evaluating lumateperone as adjunctive therapy for major depressive disorder has completed and results have been posted.
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CLINICAL_TRIALS trial_result · 2025-05-02Clinical Trial Update: Study of the Safety, Tolerability, Electrophysiological Effects and Efficacy of DMT in Humans [Phase 1]
Phase 1 study assessing safety, tolerability, electrophysiological effects, and preliminary efficacy of N,N-Dimethyltryptamine in adults wit…
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CLINICAL_TRIALS research · 2025-05-02Clinical Trial Update: RCT Protocol for 'OverThinking': A Mobile EMI for Reducing Experiential Avoidance [NA]
A protocol for a mobile ecological momentary intervention to reduce experiential avoidance in people with depression and anxiety, with study…
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CLINICAL_TRIALS trial_result · 2025-05-02Clinical Trial Update: Behavior, Biology and Well-Being Study [NA]
The University of Wisconsin–Madison sponsored the Behavior, Biology and Well-Being Study completed with results posted in May 2025. It focus…
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CLINICAL_TRIALS research · 2025-05-02Clinical Trial Update: Relief From Stress Via Social Protection in Senegal [NA]
Georgetown University-sponsored clinical trial in Senegal is studying relief from stress via social protection for distress, major depressiv…
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CLINICAL_TRIALS research · 2025-05-01Clinical Trial Update: Substance Consumption, Personality, and Cognitive Functioning of Chess Players
A completed clinical trial evaluating substance use, personality traits, and cognitive functioning in chess players.
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CLINICAL_TRIALS research · 2025-05-01Clinical Trial Update: Deciphering Principles of Network Dynamics Underlying Depression Symptom Severity From Multi-day Intracranial Recordings in Patients With Major Depression
This completed clinical trial studies how brain network dynamics, measured via multi-day intracranial recordings, relate to depression sympt…
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CLINICAL_TRIALS research · 2025-05-01Clinical Trial Update: Ambulatory Electrodermal Activity Measurements as Part of Identification and Prevention of Job Burnout
A Tampere University Hospital-led clinical trial is evaluating ambulatory electrodermal activity measurements to help identify and prevent j…
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CLINICAL_TRIALS research · 2025-05-01Clinical Trial Update: Effects of Intranasal Ketamine on Depression and Anxiety in Palliative Care Cancer Patients [EARLY_Phase 1]
This is an early Phase 1 clinical trial evaluating intranasal ketamine for depressive symptoms and anxiety in cancer patients receiving pall…
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CLINICAL_TRIALS research · 2025-05-01Clinical Trial Update: Home-based Non-invasive Brain Stimulation for Treatment-resistant Depression Feasibility, Efficacy and Biomarker of Treatment Response [NA]
This clinical trial update describes a feasibility and efficacy study of home-based non-invasive brain stimulation for treatment-resistant m…