Major Depressive Disorder
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS withdrawal · 2026-04-07Clinical Trial Update: Non-Inferiority RCT Comparing Online and On-Site CBT in MDDi [NA]
A non-inferiority randomized trial comparing online versus on-site cognitive-behavioral therapy for Major Depressive Disorder has been withd…
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CLINICAL_TRIALS withdrawal · 2026-03-12Clinical Trial Update: Lifestyle MIND- Feasibility of Wait-list Control [NA]
A feasibility trial of a Lifestyle MIND intervention for individuals with Type 2 diabetes mellitus and serious mental illness (including sch…
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CLINICAL_TRIALS withdrawal · 2026-03-04Clinical Trial Update: N2O for Acute Suicidality and Depression in the ED [Phase 2]
A Phase 2 clinical trial evaluating nitrous oxide for acute suicidality and major depressive disorder in the emergency department has been w…
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CLINICAL_TRIALS withdrawal · 2026-02-25Clinical Trial Update: Repeated Neurocognitive Measurements in Depressed Patients [Phase 1, Phase 2]
A Phase 1/Phase 2 clinical trial evaluating repeated neurocognitive measurements in patients with major depressive disorder has been withdra…
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CLINICAL_TRIALS withdrawal · 2026-02-25Clinical Trial Update: Assessment of Hedonic and Motivational States in Major Depression ( MOODDIS) [NA]
Clinical trial MOODDIS assessing hedonic and motivational states in major depression has been withdrawn.
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CLINICAL_TRIALS withdrawal · 2026-02-13Clinical Trial Update: Transcranial Low Intensity Focused Ultrasound Neuromodulation as a Probe to Study Human Emotion and Cognitive Function [NA]
Clinical trial NCT05194332 on transcranial low-intensity focused ultrasound neuromodulation to study emotion and cognition in adults with ma…
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CLINICAL_TRIALS withdrawal · 2026-01-21Clinical Trial Update: NESBID: Neuro-Stimulation of the Brain in Depression [NA]
NESBID, a trial of neuro-stimulation for depression, has been withdrawn. The study involved transcranial direct current stimulation for majo…
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CLINICAL_TRIALS withdrawal · 2026-01-21Clinical Trial Update: Long-term Potentiation Disruption Underlying Cognitive Impairment in ECT [EARLY_Phase 1]
An EARLY Phase 1 clinical trial investigating long-term potentiation disruption underlying cognitive impairment in electroconvulsive therapy…
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CLINICAL_TRIALS withdrawal · 2026-01-12Clinical Trial Update: Low-Intensity Focused Ultrasound for Treatment-Resistant Depression [NA]
Trial evaluating low-intensity focused ultrasound for treatment-resistant depression has been suspended.
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CLINICAL_TRIALS withdrawal · 2026-01-05Clinical Trial Update: Common Factors Group Psychotherapy for General Mental Health Concerns [NA]
A clinical trial evaluating common factors group psychotherapy for general mental health concerns has been withdrawn, with target conditions…
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CLINICAL_TRIALS withdrawal · 2025-09-29Clinical Trial Update: Rapid Acting TMS for Suicide Ideation in Depression [NA]
The clinical trial NCT05100004 evaluating rapid-acting transcranial magnetic stimulation for suicide ideation in major depressive disorder h…
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CLINICAL_TRIALS withdrawal · 2025-09-25Clinical Trial Update: Investigating the Protective Impact of LY-2940094 on Stress-induced Depression- and Anxiety-related Phenotypes in Humans [Phase 2]
Phase 2 trial evaluating LY-2940094 for protection against stress-induced depression and anxiety phenotypes has been withdrawn before comple…
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CLINICAL_TRIALS withdrawal · 2025-09-24Clinical Trial Update: Noninvasive Transcutaneous Vagal Nerve Stimulation (tcVNS) for Neuromodulating the Conscious State [NA]
The Northwestern University trial on noninvasive transcutaneous vagal nerve stimulation for neuromodulating the conscious state has been wit…
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CLINICAL_TRIALS withdrawal · 2025-07-14Clinical Trial Update: The Phosphodiesterase 4 Inhibitor Roflumilast as an Adjunct to Antidepressants in Major Depressive Disorder Patients [Phase 1, Phase 2]
A Phase 1/Phase 2 clinical trial evaluating roflumilast as an adjunct to antidepressants in adults with major depressive disorder has been w…
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CLINICAL_TRIALS withdrawal · 2025-07-14Clinical Trial Update: The Phosphodiesterase 5 Inhibitor Sildenafil as an Adjunct to Antidepressants in Major Depressive Disorder Patients [NA]
The study evaluating sildenafil as an adjunct to antidepressants for major depressive disorder has been withdrawn.
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CLINICAL_TRIALS withdrawal · 2025-07-14Clinical Trial Update: The DPP-4 Inhibitor Vildagliptin as Adjunct in Major Depressive Disorder Patients [Phase 1, Phase 2]
A phase 1/2 clinical trial evaluating vildagliptin as an adjunctive treatment for major depressive disorder was withdrawn.
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CLINICAL_TRIALS withdrawal · 2025-07-14Clinical Trial Update: The Phosphodiesterase Inhibitor Tadalafil as an Adjunct to Antidepressants in Major Depressive Disorder Patients [Phase 1, Phase 2]
A Phase 1/2 trial evaluating tadalafil as an adjunct to antidepressants for major depressive disorder has been withdrawn.
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CLINICAL_TRIALS withdrawal · 2025-06-25Clinical Trial Update: A Study of Participants With Moderate or Severe Major Depressive Disorder (MDD) Requiring Urgent Symptom Control in a Psychiatric Emergency
A clinical trial studying participants with moderate to severe major depressive disorder in a psychiatric emergency setting has been withdra…
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CLINICAL_TRIALS withdrawal · 2025-06-11Clinical Trial Update: Evaluating an Online Wellness Intervention for Greek Adolescents [NA]
The clinical trial evaluating an online wellness intervention for Greek adolescents has been withdrawn. The study targeted depressive sympto…
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CLINICAL_TRIALS withdrawal · 2025-06-05Clinical Trial Update: A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Depression
A non-interventional pilot study investigating the role of gut microbiota in depression has been withdrawn from the clinical trial registry.
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CLINICAL_TRIALS withdrawal · 2025-06-05Clinical Trial Update: ANGIOTENSIN AGENTS AND REDUCTION OF THE PRESCRIPTION OF ANTIDEPRESSANT DRUGS: A RETROSPECTIVE COHORT STUDY USING REAL-WORLD DATA
A retrospective real-world study examined whether angiotensin agents (ACE inhibitors and ARBs) influence antidepressant prescribing. The tri…
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CLINICAL_TRIALS withdrawal · 2025-06-04Clinical Trial Update: Waitlist-Control Trial of Smartphone CBT for Major Depressive Disorder (MDD), Withdrawn [NA]
A waitlist-controlled trial evaluating smartphone-based cognitive behavioral therapy for Major Depressive Disorder was withdrawn.
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CLINICAL_TRIALS withdrawal · 2025-05-26Clinical Trial Update: Waitlist-Control Trial of Smartphone CBT for Major Depressive Disorder (MDD) [NA]
A waitlist-controlled trial of smartphone-delivered cognitive behavioral therapy for Major Depressive Disorder has been withdrawn.
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CLINICAL_TRIALS withdrawal · 2025-05-04Clinical Trial Update: Sleep Quality, Cognitive Performance, and Computerized Cognitive Training
A clinical trial examining sleep quality, cognitive performance, and computerized cognitive training for bipolar disorder and major depressi…
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CLINICAL_TRIALS withdrawal · 2025-04-27Clinical Trial Update: A Study to Assess Feasibility of Using Clinician-directed and Digital Application Supported Cognitive Behavior Therapy (CBT) in Conjunction With Esketamine in Participants With Treatment-resistant Depression [Phase 1]
A Phase 1 study evaluating the feasibility of combining clinician-directed and digital CBT with esketamine for treatment-resistant depressio…