Leptomeningeal Metastasis
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2025-09-17Clinical Trial Update: A Two-cohort Study of SHR-A1811 in the Treatment of HER2-positive Breast Cancer With Brain Metastases [Phase 1, Phase 2]
This is a two-cohort Phase 1/Phase 2 study evaluating SHR-A1811 for HER2-positive breast cancer with brain metastases.
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CLINICAL_TRIALS research · 2025-08-21Clinical Trial Update: Phase I/II Study of Intrathecal/Ommaya T-DXd in HER2-Expressing Breast Cancer With Leptomeningeal/Brain Metastases [Phase 1, Phase 2]
Phase I/II study investigating intrathecal administration of trastuzumab deruxtecan (T-DXd) via Ommaya for HER2-expressing breast cancer wit…
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CLINICAL_TRIALS research · 2025-08-01Clinical Trial Update: Multiple Dose Intraventricular Administration of Rhenium-186 NanoLiposome for Leptomeningeal Metastases [Phase 1]
Phase 1 clinical trial evaluating multiple-dose intraventricular administration of Rhenium-186 NanoLiposome for leptomeningeal metastasis. T…
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CLINICAL_TRIALS research · 2025-07-29Clinical Trial Update: Firmonertinib Combined With Intrathecal Injection for the Treatment of EGFR Mutant NSCLC With Leptomeningeal Metastases [Phase 4]
A Phase 4 trial evaluating firmonertinib in combination with intrathecal injection for EGFR-mutant non-small cell lung cancer with leptomeni…
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CLINICAL_TRIALS research · 2025-06-05Clinical Trial Update: AI-Based Ultrasound Prediction Model for Intracranial Pressure and Prognosis in Lung Cancer Patients With Leptomeningeal Metastasis: A Dual-Center Study
This clinical trial update describes a dual-center study evaluating an AI-based ultrasound model to predict intracranial pressure and progno…
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CLINICAL_TRIALS research · 2025-05-20Clinical Trial Update: Intrathecal PD-1/VEGF Bispecific Antibody Plus Pemetrexed for Leptomeningeal Metastasis [Phase 1, Phase 2]
An early-phase clinical trial at Guangzhou Medical University is evaluating intrathecal delivery of a PD-1/VEGF bispecific antibody in combi…
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CLINICAL_TRIALS research · 2025-05-20Clinical Trial Update: Intrathecal Combination of Programmed Death-1 (PD-1)/Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA-4) Bispecific Antibody and Pemetrexed for Leptomeningeal Metastasis [Phase 1, Phase 2]
A Phase 1/2 clinical trial is investigating intrathecal administration of a PD-1/CTLA-4 bispecific antibody with pemetrexed for leptomeninge…
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CLINICAL_TRIALS research · 2025-05-18Clinical Trial Update: Intrathecal Dual Checkpoint Inhibitor (PD-1 and CTLA-4) in Combination With Pemetrexed for Leptomeningeal Metastasis [Phase 1, Phase 2]
A Phase 1/2 clinical trial is evaluating intrathecal dual PD-1 and CTLA-4 checkpoint inhibition with pemetrexed for leptomeningeal metastasi…
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CLINICAL_TRIALS research · 2025-04-27Clinical Trial Update: A Real-world Study on the Treatment of Non-small Cell Lung Cancer With Leptomeningeal Metastasis in China
Clinical trial update for a real-world study in China assessing treatment of leptomeningeal metastasis from non-small cell lung cancer; the …
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CLINICAL_TRIALS research · 2025-04-15Clinical Trial Update: A Clinical Study of Furmonertinib in the Treatment of EGFR-Mutated NSCLC With Leptomeningeal Metastases
Clinical trial update for furmonertinib in EGFR-mutated non-small cell lung cancer with leptomeningeal metastasis; the study is currently ac…
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CLINICAL_TRIALS research · 2025-04-03Clinical Trial Update: Intrathecal Application of PD1 Antibody in Metastatic Solid Tumors With Leptomeningeal Disease (IT-PD1/ NOA 26) [Phase 1]
Phase 1 clinical trial evaluating intrathecal administration of a PD-1 antibody for leptomeningeal metastasis from metastatic solid tumors. …
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CLINICAL_TRIALS research · 2025-03-30Clinical Trial Update: A Study of the Safety and Efficacy of Pemetrexed Combined with Nivolumab Via Intraventricular Injection for the Treatment of Refractory Non-squamous Non-small Cell Lung Cancer with Leptomeningeal Metastases [Phase 2]
A Phase 2 trial is evaluating intraventricular pemetrexed plus nivolumab for refractory non-squamous non-small cell lung cancer with leptome…
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CLINICAL_TRIALS research · 2025-03-06Clinical Trial Update: Evaluating High-dose Furmonertinib with Bevacizumab and Pemetrexed for EGFRm NSCLC with Leptomeningeal Metastasis [NA]
A ClinicalTrials.gov entry describes a study evaluating high-dose furmonertinib in combination with bevacizumab and pemetrexed for EGFR-muta…
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CLINICAL_TRIALS research · 2025-01-09Clinical Trial Update: Ivonescimab Combined With Chemotherapy for the Treatment of Leptomeningeal Metastases Failed to EGFR-TKIs [NA]
Clinical trial update indicates Ivonescimab (AK112) combined with chemotherapy for leptomeningeal metastasis in non-small cell lung cancer a…
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CLINICAL_TRIALS research · 2024-11-26Clinical Trial Update: Retrospective Study on Leptomeningeal Metastasis of Solid Tumors
This document describes a retrospective study on leptomeningeal metastasis from solid tumors. The study is currently enrolling by invitation…
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CLINICAL_TRIALS research · 2024-08-09Clinical Trial Update: Efficacy and Safety of Intrathecal Administration of Thiotepa in Combination With Methotrexate in Breast Cancer With Leptomeningeal Metastasis [Phase 2]
A Phase 2 clinical trial is evaluating the efficacy and safety of intrathecal thiotepa in combination with methotrexate for leptomeningeal m…
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CLINICAL_TRIALS research · 2024-05-28Clinical Trial Update: Safety and Efficacy of Whole Brain LDRT+ICI+Intrathecal Chemotherapy in Refractory Meningeal Metastasis of Lung Cancer [Phase 1]
A Phase 1 clinical trial update evaluating safety and efficacy of combining whole-brain low-dose radiotherapy with a PD-1 inhibitor and intr…
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CLINICAL_TRIALS research · 2024-05-16Clinical Trial Update: Standardized Clinical Assessment of Patients With Leptomeningeal Metastasis
This ClinicalTrials.gov entry reports that the University of Zurich is recruiting participants for a study evaluating standardized clinical …
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CLINICAL_TRIALS research · 2017-10-26Clinical Trial Update: A Prospective, Observational Trial on the Diagnostic and Prognostic of LM
This entry describes a prospective observational trial evaluating diagnostic and prognostic aspects of leptomeningeal metastasis, in the con…
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CLINICAL_TRIALS research · 2017-01-24Clinical Trial Update: Detection of CSF Next Generation Sequencing in the Application of Brain Metastases From Lung Adenocarcinoma or Meningeal Metastasis
A clinical trial sponsored by Shandong Cancer Hospital and Institute is evaluating cerebrospinal fluid next-generation sequencing for detect…
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CLINICAL_TRIALS research · 2016-06-17Clinical Trial Update: A Multi-center Prospective Observational Biomarker Study on EGFRm+ Non-small Cell Lung Cancer Patients With Leptomeningeal Metastasis
A multi-center prospective observational biomarker study in EGFR-mutant non-small cell lung cancer patients with leptomeningeal metastasis.
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CLINICAL_TRIALS research · 2013-10-29Clinical Trial Update: Clinical and Pharmacological Study With 2B3-101 in Patients With Breast Cancer and Leptomeningeal Metastases [Phase 2]
Phase 2 clinical and pharmacological study of 2B3-101 in patients with breast cancer and leptomeningeal metastases; current status is unknow…