Leptomeningeal Metastasis
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Zorifertinib Plus Intra-Ommaya CSF Chemotherapy for Leptomeningeal Progression in NSCLC After Third-Generation EGFR-TKI [Phase 2]
Phase 2 trial investigating Zorifertinib with intra-Ommaya CSF chemotherapy for leptomeningeal progression in non-small cell lung cancer aft…
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: Double-Dose Third-Generation EGFR-TKI Plus Bevacizumab and Intrathecal Chemotherapy for Refractory Leptomeningeal Metastatic NSCLC: A Phase II Study [NA]
A Phase II trial is evaluating a double-dose third-generation EGFR-TKI combined with bevacizumab and intrathecal chemotherapy for leptomenin…
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CLINICAL_TRIALS research · 2026-04-03Clinical Trial Update: Testing Proton Craniospinal Radiation Therapy Versus the Usual Radiation Therapy for Leptomeningeal Metastasis, RADIATE-LM Trial [Phase 3]
A Phase 3 trial comparing proton craniospinal radiation therapy to usual radiation therapy for leptomeningeal metastasis is currently recrui…
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CLINICAL_TRIALS research · 2026-04-02Clinical Trial Update: Tumor Treating Fields for the Treatment of Leptomeningeal Metastases of the Spine in Patients With Breast or Lung Cancer [NA]
A Mayo Clinic-sponsored trial is evaluating Tumor Treating Fields (TTFields) delivered via the Optune device for leptomeningeal metastases i…
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CLINICAL_TRIALS research · 2026-04-02Clinical Trial Update: Intravenous and Intrathecal Nivolumab in Treating Patients With Leptomeningeal Disease [Phase 1]
Phase 1 study evaluating intravenous and intrathecal nivolumab for leptomeningeal disease in melanoma and non-small cell lung cancer patient…
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CLINICAL_TRIALS research · 2026-04-02Clinical Trial Update: Pulsatile High-dose Furmonertinib in EGFR-mutant NSCLC With Leptomeningeal Metastasis [NA]
A clinical trial is evaluating pulsatile high-dose furmonertinib for EGFR-mutant non-small cell lung cancer with leptomeningeal metastasis; …
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CLINICAL_TRIALS research · 2026-03-31Clinical Trial Update: Study of Craniospinal Irradiation With Linac Based Volumetric Modulated Arc Therapy (VMAT) for Patients With Leptomeningeal Metastasis [NA]
A clinical trial update describes a study of craniospinal irradiation using linac-based VMAT for leptomeningeal metastasis, with the trial c…
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CLINICAL_TRIALS research · 2026-03-24Clinical Trial Update: Intrathecal Pemetrexed for Leptomeningeal Metastasis in EGFR-Mutant NSCLC [Phase 2]
A Phase 2 clinical trial evaluating intrathecal pemetrexed for leptomeningeal metastasis in EGFR-mutant non-small cell lung cancer is curren…
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CLINICAL_TRIALS research · 2026-03-23Clinical Trial Update: Prospective Evaluation Of High-Dose Systemic Methotrexate In Patients With Breast Cancer And Leptomeningeal Metastasis [Phase 2]
Phase 2 clinical trial evaluating high-dose systemic methotrexate in patients with metastatic breast cancer and leptomeningeal metastasis; c…
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CLINICAL_TRIALS research · 2026-03-05Clinical Trial Update: Brain Tumor-Specific Immune Cells (IL13Ralpha2-CAR T Cells) for the Treatment of Leptomeningeal Glioblastoma, Ependymoma, or Medulloblastoma [Phase 1]
Phase 1 clinical trial evaluating IL13Ralpha2-CAR T cells for treating leptomeningeal metastasis, glioblastoma, ependymoma, and medulloblast…
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CLINICAL_TRIALS research · 2026-03-02Clinical Trial Update: Intrathecal Injection Pemetrexed And Bevacizumab in Patients With Leptomeningeal Metastases in NSCLC [Phase 1]
A Phase 1 clinical trial is evaluating intrathecal pemetrexed in combination with bevacizumab for leptomeningeal metastases in non-small cel…
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CLINICAL_TRIALS research · 2026-02-23Clinical Trial Update: Trastuzumab Deruxtecan (T-DXd) for People With Brain Cancer [Phase 2]
Phase 2 clinical trial evaluating trastuzumab deruxtecan for brain cancer, including glioblastoma, currently recruiting.
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CLINICAL_TRIALS research · 2026-02-23Clinical Trial Update: Tucatinib, Trastuzumab and Capecitabine With Brain and/or Spinal Radiotherapy (XRT) in Patients With HER2+, HER2 Mutated and/or HER2-amplified Metastatic Breast Cancer and Leptomeningeal Disease: A Multi-centre Phase II, Single Arm Feasibility Study [Phase 2]
A multi-centre Phase II feasibility trial evaluating tucatinib, trastuzumab, and capecitabine with brain/spinal radiotherapy in patients wit…
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CLINICAL_TRIALS research · 2026-02-09Clinical Trial Update: Radiation Therapy Followed by Intrathecal Trastuzumab/Pertuzumab in HER2+ Breast Leptomeningeal Disease [Phase 1, Phase 2]
This is an early-phase trial evaluating radiation therapy followed by intrathecal trastuzumab and pertuzumab for HER2-positive breast cancer…
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CLINICAL_TRIALS research · 2026-02-04Clinical Trial Update: Development of a Novel Graded Prognostic Assessment (BC-LGPA) Model for Breast Cancer Leptomeningeal Metastasis
The completed study reports the development of the BC-LGPA prognostic model for patients with leptomeningeal metastasis arising from breast …
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CLINICAL_TRIALS research · 2026-01-30Clinical Trial Update: Intrathecal Pemetrexed for Leptomeningeal Metastasis From Lung Adenocarcinoma That Progressed After Osimertinib. [Phase 2]
A Phase 2 clinical trial is evaluating intrathecal pemetrexed for leptomeningeal metastasis from lung adenocarcinoma that progressed after O…
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CLINICAL_TRIALS research · 2026-01-02Clinical Trial Update: Concurrent Azeliragon With Craniospinal Irradiation [Phase 1]
A Phase 1 clinical trial evaluating azeliragon in combination with craniospinal irradiation for patients with high-grade glioma and leptomen…
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CLINICAL_TRIALS research · 2025-12-30Clinical Trial Update: A Prospective Single Arm Phase II Exploratory Study on the Combination of Whole Brain Radiotherapy, Thiotepa Intrathecal Injection and Systemic Treatment of Primary Diseases in the Treatment of Solid Tumor Leptomeningeal Metastasis [Phase 2]
Phase II exploratory, single-arm trial evaluating the combination of whole brain radiotherapy, thiotepa intrathecal injection, and systemic …
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CLINICAL_TRIALS research · 2025-12-04Clinical Trial Update: Evaluate the Safety, Tolerability, Biodistribution Characteristics and Preliminary Efficacy of BioTTT001 [Phase 1, Phase 2]
Phase 1/2 clinical trial evaluating BioTTT001 for safety, tolerability, biodistribution, and preliminary efficacy in leptomeningeal metastas…
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CLINICAL_TRIALS research · 2025-12-04Clinical Trial Update: Efficacy and Safety of Intrathecal Administration of Thiotepa in Combination With Trastuzumab in Breast Cancer With Leptomeningeal Metastasis [Phase 2]
A Phase 2 clinical trial evaluating intrathecal thiotepa in combination with trastuzumab for leptomeningeal metastasis from HER2-positive br…
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CLINICAL_TRIALS research · 2025-11-28Clinical Trial Update: Study in Patients With Breast Cancer Leptomeningeal Metastasis
A Johns Hopkins study enrolling patients with leptomeningeal metastasis from breast cancer; currently recruiting.
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CLINICAL_TRIALS research · 2025-11-25Clinical Trial Update: Testing of the Anti Cancer Drugs CB-839 HCl (Telaglenastat) and MLN0128 (Sapanisertib) in Advanced Stage Non-small Cell Lung Cancer [Phase 1]
Phase 1 clinical trial update testing Telaglenastat and Sapanisertib in advanced non-small cell lung cancer with brain and leptomeningeal me…
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CLINICAL_TRIALS research · 2025-11-18Clinical Trial Update: Capecitabine, Tucatinib, and Intrathecal Trastuzumab for Breast Cancer Patients With Leptomeningeal Disease [Phase 2]
Phase 2 clinical trial evaluating capecitabine, tucatinib, and intrathecal trastuzumab for leptomeningeal metastasis/disease in HER2-positiv…
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CLINICAL_TRIALS research · 2025-10-02Clinical Trial Update: Intrathecal Double Checkpoint Inhibition [Phase 1]
This Phase 1 clinical trial from the University of Zurich investigates intrathecal double checkpoint inhibition for leptomeningeal metastasi…
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CLINICAL_TRIALS research · 2025-09-29Clinical Trial Update: Intra-pemetrexed Plus Third-generation Small Molecule TKI Drugs (e.g. 'Osimertinib') Versus Third-generation Small Molecule TKI Drugs Alone for Leptomeningeal Metastasis From Epidermal Growth Factor Receptor Mutation-Positive Non-Small-cell Lung Cancer [NA]
A recruiting clinical trial evaluating adding pemetrexed to a third-generation EGFR tyrosine kinase inhibitor (e.g., osimertinib) versus the…