Leptomeningeal Metastasis
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-04-22Clinical Trial Update: GDC-0084 With Radiation Therapy for People With PIK3CA-Mutated Solid Tumor Brain Metastases or Leptomeningeal Metastases [Phase 1]
Phase 1 study of GDC-0084 with radiation therapy in patients with PIK3CA-mutated solid tumor brain metastases or leptomeningeal metastases; …
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CLINICAL_TRIALS trial_result · 2026-04-02Clinical Trial Update: High-dose Furmonertinib Combined With Bevacizumab and Intrathecal Pemetrexed Chemotherapy in Patients With EGFR-mutated Non-small Cell Lung Cancer and Meningeal Metastasis [Phase 2]
A Phase 2 trial evaluated high-dose furmonertinib in combination with bevacizumab and intrathecal pemetrexed for EGFR-mutated metastatic non…
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CLINICAL_TRIALS trial_result · 2025-09-30Clinical Trial Update: Allogeneic, Antigen-Presenting, GM-CSF-secreting, SV-BR-1-GM Whole Cell-Therapeutic Vaccine and Immunotherapy: A Phase I Pilot Safety and Feasibility Study for Solid Tumor Patients With CNS Metastases [Phase 1]
A Phase I pilot safety and feasibility study of the SV-BR-1-GM whole-cell vaccine for solid tumors with CNS metastases (brain metastases and…
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CLINICAL_TRIALS trial_result · 2025-09-29Clinical Trial Update: Immune Checkpoint Inhibitor Combined With Pemetrexed Intrathecal Injection for Leptomeningeal Metastasis From Solid Tumors [Phase 1, Phase 2]
ClinicalTrials.gov update describes a Phase 1/2 study evaluating an immune checkpoint inhibitor in combination with intrathecal pemetrexed f…
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CLINICAL_TRIALS trial_result · 2025-07-25Clinical Trial Update: Pembrolizumab And Lenvatinib In Leptomeningeal Metastases [Phase 2]
This clinical trial update reports that the Phase 2 study of pembrolizumab and lenvatinib in leptomeningeal metastasis has been terminated.
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CLINICAL_TRIALS trial_result · 2025-06-24Clinical Trial Update: DS-8201a for trEatment of aBc, BRain Mets, And Her2[+] Disease [Phase 2]
Phase 2 results update for DS-8201a (trastuzumab deruxtecan) in advanced HER2-positive breast cancer, including patients with brain metastas…
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CLINICAL_TRIALS trial_result · 2025-05-04Clinical Trial Update: Intrathecal Pemetrexed for Leptomeningeal Metastasis [Phase 1, Phase 2]
A phase 1/2 clinical trial evaluating intrathecal pemetrexed for leptomeningeal metastasis has completed. The study was sponsored by The Fir…
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CLINICAL_TRIALS trial_result · 2025-04-06Clinical Trial Update: Proton Cranio-spinal Irradiation for Leptomeningeal Metastasis [NA]
A clinical trial is investigating proton craniospinal irradiation for leptomeningeal metastasis and is currently recruiting.
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CLINICAL_TRIALS trial_result · 2025-03-26Clinical Trial Update: Intraventricular Administration of Rhenium-186 NanoLiposome for Leptomeningeal Metastases [Phase 1]
Update on a Phase 1 clinical trial evaluating intraventricular administration of Rhenium-186 NanoLiposome for leptomeningeal metastasis, spo…
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CLINICAL_TRIALS trial_result · 2025-02-11Clinical Trial Update: CSF Analysis in EGFR Mutant Non-Small Cell Lung Cancer With Leptomeningeal Disease [NA]
This entry describes a recruiting clinical trial evaluating CSF analysis in patients with EGFR-mutant non-small cell lung cancer and leptome…
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CLINICAL_TRIALS trial_result · 2024-12-30Clinical Trial Update: Study of TY-9591 in Patients With a Lung Cancer With Brain or Leptomeningeal Metastases With EGFR Mutation [Phase 2]
A Phase 2 trial of TY-9591 in non-small cell lung cancer with EGFR activating mutation and brain or leptomeningeal metastases has completed.
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CLINICAL_TRIALS trial_result · 2024-06-06Clinical Trial Update: Microfluidic Device to Diagnose Leptomeningeal Metastasis in Breast Cancer
The ClinicalTrials.gov record indicates the study evaluating a microfluidic diagnostic device for leptomeningeal metastasis in breast cancer…
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CLINICAL_TRIALS trial_result · 2024-06-04Clinical Trial Update: Double Dose of Third-generation EGFR-TKI Plus Intrathecal Pemetrexed Versus Double Dose of Third-generation EGFR-TKI in Patients With LM Progression Following the Treatment of Routine Dose of Third-generation EGFR-TKI [Phase 2]
Phase 2 trial assessing double-dose third-generation EGFR-TKI with intrathecal pemetrexed versus double-dose third-generation EGFR-TKI in le…
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CLINICAL_TRIALS trial_result · 2024-05-06Clinical Trial Update: Efficacy and Safety of Intraventricule Pemetrexed Disodium Administered Via Ommaya Reservoir
This clinical trial tests intraventricular pemetrexed disodium delivered via an Ommaya reservoir for leptomeningeal metastasis and lung canc…
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CLINICAL_TRIALS trial_result · 2022-05-23Clinical Trial Update: Clinical Observation of ICI Combined With Recombinant Human Endostatin on Leptomeningeal Metastasis of Lung Cancer [Phase 2]
Phase 2 clinical trial evaluating an immune checkpoint inhibitor combined with recombinant human endostatin for leptomeningeal metastasis fr…
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CLINICAL_TRIALS trial_result · 2021-04-20Clinical Trial Update: Clinical Efficacy and Safety of EGFR-TKI Combined With Nimotuzumab in the Treatment of Leptomeningeal Metastases From Lung Cancer [Phase 2]
Phase 2 clinical trial evaluating the efficacy and safety of an EGFR-TKI combined with nimotuzumab for leptomeningeal metastases in lung can…
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CLINICAL_TRIALS trial_result · 2020-06-11Clinical Trial Update: Osimertinib With Bevacizumab for Leptomeningeal Metastasis From EGFR-mutation Non-Small Cell Lung Cancer [Phase 2]
Phase 2 trial evaluating osimertinib with bevacizumab for leptomeningeal metastasis in EGFR-mutant non-small cell lung cancer is in progress…
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CLINICAL_TRIALS trial_result · 2020-05-27Clinical Trial Update: Efficacy and Safety of Recombinant Human Endostatin in Non-Small Cell Lung Cancer With Leptomeningeal Metastasis [Phase 4]
Clinical trial update evaluating recombinant human endostatin for leptomeningeal metastasis in non-small cell lung cancer (Phase 4) with eff…
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CLINICAL_TRIALS trial_result · 2020-05-27Clinical Trial Update: Efficacy and Safety of Durvalumab in Non-Small Cell Lung Cancer With Leptomeningeal Metastasis [Phase 4]
Phase 4 trial update evaluating the efficacy and safety of durvalumab in leptomeningeal metastasis.
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CLINICAL_TRIALS trial_result · 2019-12-26Clinical Trial Update: Concurrent Intrathecal-pemetrexed and Involved-field Radiotherapy for Leptomeningeal Metastasis From Solid Tumors [Phase 1, Phase 2]
Phase 1/2 trial evaluating concurrent intrathecal pemetrexed with involved-field radiotherapy for leptomeningeal metastasis from solid tumor…
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CLINICAL_TRIALS trial_result · 2019-11-04Clinical Trial Update: Osimertinib With or Without Bevacizumab for EGFR- Mutant Non-small Cell Lung Cancer With Leptomeningeal Metastasis [Phase 2]
Phase 2 trial evaluating osimertinib with or without bevacizumab for EGFR-mutant non-small cell lung cancer with leptomeningeal metastasis.
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CLINICAL_TRIALS trial_result · 2019-08-01Clinical Trial Update: Concurrent Involved-field Radiotherapy and Intrathecal Chemotherapy for Leptomeningeal Metastases From Solid Tumors [Phase 2]
Phase 2 trial evaluating concurrent involved-field radiotherapy with intrathecal chemotherapy for leptomeningeal metastases from solid tumor…
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CLINICAL_TRIALS trial_result · 2018-03-27Clinical Trial Update: Intrathecal Rituximab in Lymphoid Malignancies Involving Central Nervous System [Phase 1, Phase 2]
A phase 1/2 trial of intrathecal rituximab for lymphoid malignancies involving the central nervous system was terminated with results posted…
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CLINICAL_TRIALS trial_result · 2016-05-16Clinical Trial Update: RTA 744 Injection in Patients With Leptomeningeal Disease [Phase 1]
Phase 1 trial of RTA 744 injection for leptomeningeal disease in patients with neoplastic meningitis and other CNS/solid tumors has been ter…
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CLINICAL_TRIALS trial_result · 2014-02-24Clinical Trial Update: Study to Demonstrate the Safety of WBR Administered at the Same Time as Intrathecal Liposomal Cytarabine (DepoCyte®) Versus Intrathecal Liposomal Cytarabine (DepoCyte®) Administered After WBR for the Treatment of Solid Tumour Neoplastic Meningitis in Patients With or Without Brain Metastasis. [Phase 1]
This Phase 1 trial assesses the safety of giving whole-brain radiation therapy (WBR) at the same time as intrathecal liposomal cytarabine (D…