Hereditary Spastic Paraplegia
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: STOP-HSP.Net: a Registry for Hereditary Spastic Paraplegia as an Integration Tool for Future Therapeutic Strategies
This document discusses STOP-HSP.Net, a registry for hereditary spastic paraplegia designed to integrate data to support future therapeutic …
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CLINICAL_TRIALS research · 2026-03-23Clinical Trial Update: Phenotype, Genotype and Biomarkers 2
A University of Miami–sponsored clinical trial investigating phenotype, genotype, and biomarkers across motor neuron diseases, including ALS…
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CLINICAL_TRIALS research · 2026-03-18Clinical Trial Update: Hereditary Spastic Paraplegia Genomic Sequencing Initiative (HSPseq)
This clinical trial update describes the HSPseq Genomic Sequencing Initiative at Boston Children's Hospital to study genomic sequencing in h…
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CLINICAL_TRIALS research · 2026-03-18Clinical Trial Update: Registry and Natural History Study for Early Onset Hereditary Spastic Paraplegia
A registry and natural history study for early onset hereditary spastic paraplegia is currently recruiting.
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CLINICAL_TRIALS research · 2026-03-18Clinical Trial Update: Spastic Paraplegia - Centers of Excellence Research Network
A Boston Children's Hospital-led centers of excellence research network is actively recruiting participants for a study on hereditary spasti…
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CLINICAL_TRIALS research · 2026-03-12Clinical Trial Update: The Effect of Targeting the Plantaris Muscle-tendon in Surgical Correction of Ankle Equinus in Children [NA]
This University of Alberta clinical trial is evaluating whether targeting the plantaris muscle-tendon can help surgically correct ankle equi…
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CLINICAL_TRIALS research · 2026-03-06Clinical Trial Update: Genetic and Physical Study of Childhood Nerve and Muscle Disorders
The National Institute of Neurological Disorders and Stroke is sponsoring a study that is currently recruiting children to investigate the g…
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CLINICAL_TRIALS research · 2025-09-24Clinical Trial Update: Retrospective Study on the WalkOn AFO in Children or Teenagers With Neurological Pathologies
A completed retrospective study evaluates the WalkOn ankle-foot orthosis in children and teenagers with various neurological conditions.
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CLINICAL_TRIALS research · 2025-08-22Clinical Trial Update: Gait Analysis Parameter and Upper Limb Evaluation in Adult Patients With Neurological or Metabolic Pathology [NA]
This clinical trial update describes the assessment of gait analysis parameters and upper-limb evaluation in adults with various neurologica…
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CLINICAL_TRIALS research · 2025-07-03Clinical Trial Update: Phenotype, Genotype & Biomarkers in ALS and Related Disorders
An ongoing University of Miami-led clinical trial investigating phenotype, genotype, and biomarkers in amyotrophic lateral sclerosis and rel…
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CLINICAL_TRIALS research · 2025-05-29Clinical Trial Update: Enhancement of Quality of Work And Life [NA]
ClinicalTrials.gov update for the study 'Enhancement of Quality of Work And Life' sponsored by Radboud University Medical Center, currently …
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CLINICAL_TRIALS research · 2025-05-14Clinical Trial Update: Administration of MELPIDA to Determine the Safety and Efficacy for Patients With Spastic Paraplegia Type 50 [Phase 1]
A Phase 1 clinical trial evaluating the safety and potential efficacy of MELPIDA in patients with hereditary spastic paraplegia (Spastic Par…
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CLINICAL_TRIALS research · 2025-05-04Clinical Trial Update: Robot-assisted Walking Treatment in Hereditary Spastic Paraplegia (HSP)
A clinical trial update announcing a robot-assisted walking treatment being studied for hereditary spastic paraplegia, currently recruiting.
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CLINICAL_TRIALS research · 2025-04-20Clinical Trial Update: A Prospective Cohort Study of Surgical Treatment for Foot Deformities in HSP
This ClinicalTrials.gov entry describes a prospective cohort study evaluating surgical treatment for foot deformities in Hereditary Spastic …
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CLINICAL_TRIALS research · 2025-03-30Clinical Trial Update: Natural History Study of Patients with HPDL Mutations
This is an ongoing natural history study of individuals with HPDL mutations to document clinical features and disease progression.
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CLINICAL_TRIALS research · 2025-02-26Clinical Trial Update: A Prospective Cohort Study of ITB Treatment for HSP
A prospective cohort study evaluating intrathecal baclofen treatment for hereditary spastic paraplegia, currently recruiting.
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CLINICAL_TRIALS research · 2025-01-30Clinical Trial Update: Flexibility, Resistance, Aerobic, Movement Execution Training in Adults With Hereditary Spastic Paraplegia [NA]
This clinical trial entry outlines a recruiting study evaluating a flexibility, resistance, aerobic, and movement execution training program…
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CLINICAL_TRIALS research · 2024-06-27Clinical Trial Update: Calcium Folinate Treatment of Spastic Paraplegia 56 [EARLY_Phase 1]
This early-phase 1 clinical trial is evaluating calcium folinate for Hereditary Spastic Paraplegia and is currently recruiting.