Hepatoblastoma
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CLINICAL_TRIALS trial_result · 2026-03-25Clinical Trial Update: Ivosidenib in Treating Patients With Advanced Solid Tumors, Lymphoma, or Histiocytic Disorders With IDH1 Mutations (A Pediatric MATCH Treatment Trial) [Phase 2]
Phase 2 pediatric MATCH trial evaluating IDH1-mutant tumors for response to ivosidenib; results for recurrent and refractory solid tumors, l…
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CLINICAL_TRIALS trial_result · 2026-01-21Clinical Trial Update: Interleukin-15 Armored Glypican 3-specific Chimeric Antigen Receptor Expressed in T Cells for Pediatric Solid Tumors [Phase 1]
This is an update on a Phase 1 trial of interleukin-15 armored GPC3-specific CAR-T cells for pediatric solid tumors, with results posted and…
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CLINICAL_TRIALS trial_result · 2025-01-01Clinical Trial Update: Neoadjuvant Dual Checkpoint Inhibition and Cryoablation in Relapsed/Refractory Pediatric Solid Tumors [Phase 2]
Phase 2 trial evaluating neoadjuvant dual checkpoint inhibition with cryoablation in relapsed/refractory pediatric solid tumors has complete…
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CLINICAL_TRIALS trial_result · 2024-06-12Clinical Trial Update: Yttrium-90 (TARE-Y90) in Children, Adolescents, and Young Adults With Liver Tumors
A pediatric trial evaluating Yttrium-90 radioembolization for liver tumors has been terminated.
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CLINICAL_TRIALS trial_result · 2024-06-11Clinical Trial Update: Psychosocial Situation of Children With Rare Solid Abdominal Tumors and Their Families
This update reports the completion of a clinical trial examining the psychosocial experiences of children with rare solid abdominal tumors a…
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CLINICAL_TRIALS trial_result · 2024-04-24Clinical Trial Update: Palbociclib in Treating Patients With Relapsed or Refractory Rb Positive Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Activating Alterations in Cell Cycle Genes (A Pediatric MATCH Treatment Trial) [Phase 2]
Phase 2 pediatric MATCH trial evaluating palbociclib in relapsed or refractory pediatric tumors with activating alterations in cell cycle ge…
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CLINICAL_TRIALS trial_result · 2023-09-13Clinical Trial Update: Vemurafenib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With BRAF V600 Mutations (A Pediatric MATCH Treatment Trial) [Phase 2]
This Phase 2 Pediatric MATCH trial evaluated vemurafenib in children with BRAF V600-mutant relapsed or refractory advanced solid tumors, non…
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CLINICAL_TRIALS trial_result · 2022-11-28Clinical Trial Update: Cabozantinib-S-Malate in Treating Younger Patients With Recurrent, Refractory, or Newly Diagnosed Sarcomas, Wilms Tumor, or Other Rare Tumors [Phase 2]
A Phase 2 clinical trial evaluating cabozantinib-s-maleate in pediatric patients with recurrent, refractory, or newly diagnosed sarcomas, Wi…
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CLINICAL_TRIALS trial_result · 2022-04-11Clinical Trial Update: Sequential PD-1/PD-L1 Inhibitor and LENvatinib in TLCT and Refractory Hepatoblastoma After Chemotherapy [Phase 2, Phase 3]
A phase 2/3 clinical trial evaluating sequential PD-1/PD-L1 inhibition followed by LENvatinib in transitional cell tumor and hepatoblastoma …
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CLINICAL_TRIALS trial_result · 2021-12-28Clinical Trial Update: Risk-Based Therapy in Treating Younger Patients With Newly Diagnosed Liver Cancer [Phase 3]
This entry reports results from a Phase 3 trial evaluating risk-based therapy for newly diagnosed hepatoblastoma in younger patients. The st…
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CLINICAL_TRIALS trial_result · 2021-12-28Clinical Trial Update: Risk-Based Therapy in Treating Younger Patients With Newly Diagnosed Liver Cancer [Phase 3]
A Phase 3 trial updates on risk-based therapy for newly diagnosed hepatoblastoma in younger patients, with active status and posted results.
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CLINICAL_TRIALS trial_result · 2018-11-02Clinical Trial Update: the Efficacy and Safety of Sugammadex in Children 0-2 Years Old [Phase 2, Phase 3]
A Phase 2/Phase 3 clinical trial evaluating the efficacy and safety of sugammadex in children aged 0-2 years for anesthesia-related use, wit…
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CLINICAL_TRIALS trial_result · 2018-10-17Clinical Trial Update: G-CSF Alone or Combination With GM-CSF on Prevention and Treatment of Infection in Children With Malignant Tumor [Phase 4]
A Phase 4 clinical trial evaluating G-CSF alone or in combination with GM-CSF for prevention and treatment of infection in children with mal…
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CLINICAL_TRIALS trial_result · 2018-05-29Clinical Trial Update: Cisplatin With or Without Sodium Thiosulfate in Treating Young Patients With Stage I, II, or III Childhood Liver Cancer [Phase 3]
This Phase 3 trial compares cisplatin with or without sodium thiosulfate in young patients with childhood liver cancer to assess whether thi…
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CLINICAL_TRIALS trial_result · 2017-06-05Clinical Trial Update: Alisertib in Treating Young Patients With Recurrent or Refractory Solid Tumors or Leukemia [Phase 2]
Phase 2 clinical trial update evaluating alisertib in pediatric patients with various recurrent or refractory solid tumors and leukemia; stu…
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CLINICAL_TRIALS trial_result · 2016-05-18Clinical Trial Update: Biomarkers in Tissue Samples From Young Patients With Liver Cancer
A completed clinical trial update from the Children's Oncology Group examining biomarkers in tissue samples from pediatric hepatoblastoma (l…
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CLINICAL_TRIALS trial_result · 2016-03-02Clinical Trial Update: A Phase I Dose Finding and Safety Study of Oral LDE225 in Children and a Phase II Portion to Assess Preliminary Efficacy in Recurrent or Refractory MB [Phase 1, Phase 2]
Phase I dose-finding and safety study of LDE225 (sonidegib) in children with recurrent or refractory medulloblastoma, with a Phase II portio…
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CLINICAL_TRIALS trial_result · 2015-03-30Clinical Trial Update: Cixutumumab in Treating Patients With Relapsed or Refractory Solid Tumors [Phase 2]
Phase 2 trial results for cixutumumab in relapsed or refractory solid tumors across multiple sarcomas and pediatric cancers.
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CLINICAL_TRIALS trial_result · 2013-09-17Clinical Trial Update: Irinotecan in Treating Young Patients With Refractory or Recurrent Hepatoblastoma [Phase 2]
Phase 2 trial evaluating irinotecan for hepatoblastoma in young patients; the document provides an update but the current status is unknown.
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CLINICAL_TRIALS trial_result · 2013-09-17Clinical Trial Update: Combination Chemotherapy and Thalidomide in Treating Younger Patients Undergoing Surgery For Newly Diagnosed Liver Cancer [Phase 2]
This clinical trial update describes a Phase 2 study of combining chemotherapy with thalidomide in pediatric patients undergoing surgery for…
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CLINICAL_TRIALS trial_result · 2013-06-14Clinical Trial Update: Combination Chemotherapy With or Without Amifostine in Treating Young Patients With Liver Cancer [Phase 3]
Phase 3 trial update evaluating chemotherapy with or without amifostine in young patients with hepatoblastoma.
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CLINICAL_TRIALS trial_result · 2013-06-05Clinical Trial Update: Oxaliplatin in Treating Young Patients With Recurrent Solid Tumors That Have Not Responded to Previous Treatment [Phase 2]
Phase 2 trial evaluating oxaliplatin in young patients with recurrent solid tumors that have not responded to prior treatment has completed.…
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CLINICAL_TRIALS trial_result · 2010-10-11Clinical Trial Update: Tandem Peripheral Blood Stem Cell (PBSC) Rescue for High Risk Solid Tumors [Phase 1, Phase 2]
This clinical trial update summarizes a Phase 1/2 study of tandem peripheral blood stem cell rescue for high-risk solid tumors. Eligible con…