Head and Neck Squamous Cell Carcinoma
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CLINICAL_TRIALS trial_result · 2017-11-17Clinical Trial Update: Combined FDG PET/CT Imaging in Response Evaluation After Radiochemotherapy in Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma (HNSCC)
A completed clinical trial evaluating the use of combined FDG PET/CT imaging to assess response after radiochemotherapy in locally advanced …
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CLINICAL_TRIALS trial_result · 2017-11-13Clinical Trial Update: Ficlatuzumab, Cisplatin and IMRT in Locally Advanced Head and Neck Squamous Cell Carcinoma [Phase 1]
Phase 1 trial assessing ficlatuzumab with cisplatin and IMRT in locally advanced head and neck squamous cell carcinoma has been terminated.
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CLINICAL_TRIALS trial_result · 2017-10-27Clinical Trial Update: Evaluation of the Tolerance of Afatinib in Combination With Docetaxel and Cisplatin in LAHNSCC Induction Chemotherapy [Phase 1]
This Phase 1 trial evaluates tolerability/safety of adding afatinib to docetaxel and cisplatin as induction chemotherapy for locally advance…
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CLINICAL_TRIALS trial_result · 2017-10-26Clinical Trial Update: Reirradiation and Erbitux in the HNSCC [Phase 2]
Phase 2 clinical trial evaluating reirradiation with cetuximab in head and neck squamous cell carcinoma has completed.
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CLINICAL_TRIALS trial_result · 2017-10-25Clinical Trial Update: Induction Chemotherapy With Afatinib, Ribavirin, and Weekly Carboplatin/Paclitaxel for Stage IVA/IVB HPV Associated Oropharynx Squamous Cell Cancer (OPSCC) [Phase 1]
Phase 1 trial evaluating induction chemotherapy with afatinib, ribavirin, and weekly carboplatin/paclitaxel for HPV-associated stage IVA/IVB…
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CLINICAL_TRIALS trial_result · 2017-10-23Clinical Trial Update: LUX-Head&Neck 2: A Phase III Trial of Afatinib (BIBW 2992) Versus Placebo for the Treatment of Head and Neck Squamous Cell Cancer After Treatment With Chemo-radiotherapy [Phase 3]
Phase III trial evaluating Afatinib versus placebo for head and neck squamous cell carcinoma after chemoradiotherapy; the study was terminat…
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CLINICAL_TRIALS trial_result · 2017-10-23Clinical Trial Update: A Phase I Study to Evaluate the Safety, Tolerability and Efficacy of MEDI4736 (Durvalumab) With Tremelimumab in Head and Neck Cancer [Phase 1]
This is a completed Phase I trial evaluating the safety, tolerability and preliminary efficacy of durvalumab (MEDI4736) in combination with …
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CLINICAL_TRIALS trial_result · 2017-10-18Clinical Trial Update: TumorGraft- Guided Therapy for Improved Outcomes in Head and Neck Squamous Cell Cancer- A Feasibility Study [NA]
This completed feasibility trial assessed tumor graft-guided therapy as a treatment approach for head and neck squamous cell carcinoma.
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CLINICAL_TRIALS trial_result · 2017-10-16Clinical Trial Update: Phase 2 Study of GSK1363089 (Formerly XL880) in Adults With Squamous Cell Cancer of the Head and Neck [Phase 2]
Phase 2 trial of GSK1363089 (formerly XL880) in adults with head and neck squamous cell carcinoma has completed enrollment and posted result…
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CLINICAL_TRIALS trial_result · 2017-08-31Clinical Trial Update: Cetuximab and Recombinant Interleukin-12 in Treating Patients With Squamous Cell Carcinoma of the Head and Neck That is Recurrent, Metastatic, or Cannot Be Removed by Surgery [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating the combination of cetuximab and recombinant interleukin-12 in patients with head and neck squamous ce…
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CLINICAL_TRIALS trial_result · 2017-08-28Clinical Trial Update: Interstitial Photodynamic Therapy in Treating Patients With Recurrent Head and Neck Cancer [Phase 2]
Phase 2 trial evaluating interstitial photodynamic therapy for recurrent head and neck cancer was terminated; results have been posted.
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CLINICAL_TRIALS trial_result · 2017-08-16Clinical Trial Update: The Clinical Relevance of Immune Cells and CTC in HNSCC Patients
The update discusses the clinical relevance of immune cells and circulating tumor cells in head and neck squamous cell carcinoma. It highlig…
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CLINICAL_TRIALS research · 2017-08-10Clinical Trial Update: The Clinical Relevance of P16 Expressing CTCs Detection Comparing With HPV Infection in Cancer Tissue in HNSCC Patients.
This clinical trial study in head and neck squamous cell carcinoma evaluates the clinical relevance of detecting P16-expressing circulating …
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FDA approval · 2017-08-09FDA Approved: DOCETAXEL — Original Application (Jiangsu Hengrui Pharmaceuticals Co., Ltd.)
FDA approved a generic version of docetaxel under an original ANDA from Jiangsu Hengrui Pharmaceuticals Co., Ltd., enabling market authoriza…
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CLINICAL_TRIALS trial_result · 2017-07-31Clinical Trial Update: Phase III Trial of PET/CT vs. CTSurveilance for Head and Neck Cancer [Phase 3]
The Phase III trial comparing PET/CT surveillance with CTSurveillance for head and neck squamous cell carcinoma was terminated.
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CLINICAL_TRIALS trial_result · 2017-07-28Clinical Trial Update: DAHANCA 28A: Phase I/II Study on Accelerated, Hyperfractionated Radiotherapy With Concomitant Cisplatin and Nimorazole [Phase 1, Phase 2]
Phase I/II trial (DAHANCA 28A) investigates accelerated, hyperfractionated radiotherapy with concomitant cisplatin and nimorazole in head an…
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CLINICAL_TRIALS trial_result · 2017-07-27Clinical Trial Update: Study of RADPLAT and Tarceva in Locally Advanced Head and Neck Squamous Cell Carcinoma (SCCA) [Phase 2]
Phase 2 clinical trial update evaluating the combination of RADPLAT (radiation with intra-arterial cisplatin) and Tarceva (erlotinib) for lo…
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CLINICAL_TRIALS trial_result · 2017-07-06Clinical Trial Update: Study of MK-3475 (Pembrolizumab) in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma After Treatment With Platinum-based and Cetuximab Therapy (MK-3475-055/KEYNOTE-055) [Phase 2]
Phase 2 trial of pembrolizumab (MK-3475) in recurrent or metastatic head and neck squamous cell carcinoma after platinum and cetuximab thera…
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CLINICAL_TRIALS trial_result · 2017-07-06Clinical Trial Update: A Study of MEHD7945A in Combination With Cisplatin and 5-Fluorouracil (5-FU) or Paclitaxel and Carboplatin in Participants With Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck (R/M SCCHN) [Phase 1]
This completed Phase 1 trial evaluated MEHD7945A in combination with cisplatin/5-FU or paclitaxel/carboplatin in patients with recurrent/met…
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CLINICAL_TRIALS trial_result · 2017-06-26Clinical Trial Update: Oral Rigosertib for Squamous Cell Carcinoma [Phase 2]
A Phase 2 clinical trial evaluating oral rigosertib for various squamous cell carcinomas has completed.
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CLINICAL_TRIALS research · 2017-06-23Clinical Trial Update: the Study of Effect of Chronomodulated Chemotherapy on the Dendritic Cells Subsets in the Treatment of Advanced Nasopharyngeal Cancer [Phase 2]
Phase 2 study evaluating chronomodulated chemotherapy's effect on dendritic cell subsets in advanced nasopharyngeal carcinoma. The trial is …
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CLINICAL_TRIALS trial_result · 2017-06-23Clinical Trial Update: Platinum-based Chemoradiotherapy and Rigosertib in Head and Neck Cancer [Phase 1]
Phase 1 trial evaluating platinum-based chemoradiotherapy with rigosertib for head and neck cancer has completed.
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CLINICAL_TRIALS trial_result · 2017-06-14Clinical Trial Update: Study of DCA (Dichloroacetate) in Combination With Cisplatin and Definitive Radiation in Head and Neck Carcinoma [Phase 2]
Phase 2 trial investigating DCA in combination with cisplatin and definitive radiation for head and neck squamous cell carcinoma; study comp…
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CLINICAL_TRIALS trial_result · 2017-06-09Clinical Trial Update: A Post Marketing Surveillance Study to Assess the Safety and Efficacy of Cetuximab Plus Radiotherapy in Locally Advanced Squamous Cell Carcinoma of the Head and Neck
This post-marketing surveillance trial evaluating cetuximab plus radiotherapy in unresectable locally advanced head and neck squamous cell c…
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CLINICAL_TRIALS withdrawal · 2017-06-08Clinical Trial Update: Pharmacodynamic Effects and Predictive Biomarkers With Ruxolitinib in Operable Head and Neck Cancer [EARLY_Phase 1]
The document reports the withdrawal of a Phase 1 trial evaluating pharmacodynamic effects and predictive biomarkers of ruxolitinib in operab…