Head and Neck Squamous Cell Carcinoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Anti-PD-1 mAb Plus Metabolic Modulator in Solid Tumor Malignancies [Phase 2]
Phase 2 clinical trial evaluating a PD-1–blocking monoclonal antibody in combination with a metabolic modulator for several solid tumors is …
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Clinical Study of GT201 in Combination With PD-1 Inhibitor for Advanced Head and Neck Tumors [NA]
Grit Biotechnology is conducting a clinical trial to assess GT201 in combination with a PD-1 inhibitor for advanced head and neck squamous c…
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Neoadjuvant Treatment of Locally Advanced HNSCC With Pertuzumab Combined With Lenvatinib. [Phase 2]
Phase 2 neoadjuvant trial combining pertuzumab with lenvatinib for locally advanced head and neck squamous cell carcinoma; enrollment is cur…
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: Neoadjuvant Chemotherapy and Programmed Cell Death Protein 1(PD-1) Inhibition for Head and Neck Cancer Treatment De-escalation (NeoScorch HN) [Phase 2]
A Phase 2 trial assesses neoadjuvant chemotherapy combined with a PD-1 inhibitor for head and neck squamous cell carcinoma with the goal of …
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: Testing the Addition of the Drug BMX-001, a Radioprotector, or a Placebo to the Usual Chemoradiation Therapy for Patients With Head and Neck Cancer [Phase 2]
This Phase 2 clinical trial is evaluating BMX-001 as a radioprotector added to standard chemoradiation therapy for head and neck cancers and…
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: Remote Audiometry to Monitor for Treatment-Related Hearing Loss in Patients With H&N SCC Receiving Cisplatin and/or Radiation [NA]
A clinical trial update describes remote audiometry being studied to monitor treatment-related hearing loss in patients with head and neck s…
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: Study to Assess GTAEXS617 in Participants With Advanced Solid Tumors [Phase 1, Phase 2]
A Phase 1/2 clinical trial of GTAEXS617 in adults with advanced solid tumors is currently recruiting. The study encompasses head and neck sq…
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: A Study to Investigate Safety of AZD6750 in Adult Participants With Select Advanced or Metastatic Solid Tumors [Phase 1, Phase 2]
AstraZeneca is conducting a Phase 1/2 trial to evaluate the safety of AZD6750 in adults with select advanced or metastatic solid tumors; the…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: Pembrolizumab, INCB081776, and Radiation Therapy for Head and Neck Squamous Cell Carcinoma [EARLY_Phase 1]
An early-phase 1 clinical trial update evaluating pembrolizumab in combination with INCB081776 and radiation therapy for head and neck squam…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: Study of Safety and Tolerability of Nivolumab Treatment Alone or in Combination With Relatlimab or Ipilimumab in Head and Neck Cancer [Phase 2]
This clinical trial update describes a Phase 2 study evaluating the safety and tolerability of Nivolumab alone or in combination with Relatl…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: Diagnostic Performance Of 4D Dynamic LAFOV FDG-PET Acquisition for Differentiation of Residual Disease and Post-radiation Inflammation in Head Neck SCC Treated by Radiotherapy.
A clinical trial evaluating a 4D dynamic LAFOV FDG-PET protocol to distinguish residual disease from post-radiation inflammation in head and…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: A Phase 3 Study to Evaluate Petosemtamab Plus Pembrolizumab vs Pembrolizumab in First-line Treatment of Head and Neck Cancer (LiGeR - HN1) [Phase 3]
Phase 3 clinical trial update: Merus B.V. is evaluating Petosemtamab in combination with pembrolizumab versus pembrolizumab alone as first-l…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: Oropharynx (OPX) Biomarker Trial
Mayo Clinic is conducting a biomarker-focused clinical trial in patients with HPV-positive and HPV-negative oropharyngeal cancer across stag…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: Re-radiotherapy Combined With Chidamide for the Treatment of Recurrent Head and Neck Squamous Cell Carcinoma After Radiotherapy [Phase 1]
A Phase 1 clinical trial is evaluating re-radiotherapy combined with chidamide for recurrent head and neck squamous cell carcinoma after pri…
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: A Study Investigating the Efficacy and Safety of the Combination of Iparomlimab and Tuvonralimab With or Without Chemotherapy in Second-line and Subsequent Treatments for Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma [NA]
An ongoing clinical trial is evaluating the combination of iparomlimab and tuvonralimab, with or without chemotherapy, for second-line and s…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors [Phase 1]
Phase 1 clinical trial update showing LY4052031 being studied in advanced or metastatic urothelial cancer and other solid tumors; the study …
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma [Phase 2]
Phase 2 clinical trial evaluating pembrolizumab given alone versus the standard chemotherapy with radiation after surgery for recurrent head…
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: Postoperative Radiotherapy Combined With Nimotuzumab Followed by Benmelstobart in High-Risk Patients With Head and Neck Squamous Cell Carcinoma [Phase 3]
A Phase 3 study is evaluating postoperative radiotherapy plus Nimotuzumab followed by Benmelstobart in high-risk head and neck squamous cell…
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: Postoperative Radiotherapy With Nimotuzumab ± Benmelstobart in Intermediate-Risk Head and Neck Squamous Cell Carcinoma: A Randomized Controlled Trial [Phase 2, Phase 3]
A randomized study is evaluating postoperative radiotherapy with Nimotuzumab, with or without Benmelstobart, for intermediate-risk head and …
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: Testing the Addition of Ipatasertib to Usual Chemotherapy and Radiation for Head and Neck Cancer [Phase 1]
A Phase 1 clinical trial is evaluating the addition of the AKT inhibitor ipatasertib to standard chemotherapy and radiation for locally adva…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Radiotherapy With Cisplatin vs. Docetaxel-cetuximab in HNSCC: ERCC1 Biomarker Enrichment and Interaction Design [Phase 2]
This Phase 2 trial compares radiotherapy with cisplatin versus a docetaxel-cetuximab regimen in head and neck squamous cell carcinoma, focus…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Testing Whether Cemiplimab (REGN2810) Plus CDX-1140 Given Prior to Surgery Are Better Than Cemiplimab (REGN2810) Alone in Patients With Stage III-IV Head and Neck Cancer [Phase 2]
Phase 2 trial evaluating cemiplimab plus CDX-1140 given before surgery to determine if the combination improves outcomes versus cemiplimab a…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: 3D Specimen Maps for RT Planning
A Vanderbilt University Medical Center trial update describes 3D specimen maps to aid radiation therapy planning for head and neck cancers. …
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: A Bidirectional Study of Individualized Postoperative Adjuvant Treatment Decision Model for Locally Advanced Head and Neck Squamous Cell Carcinoma Based on Multimodal Dynamic Data
This clinical trial update describes an ongoing bidirectional study to develop an individualized postoperative adjuvant treatment decision m…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Cyclophosphamide and Etoposide as a Metronomic Therapy in Advanced Head and Neck Squamous Cell Cancer [Phase 2]
Phase 2 clinical trial update evaluating metronomic cyclophosphamide and etoposide for advanced head and neck squamous cell carcinoma; statu…