Head and Neck Squamous Cell Carcinoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2024-07-23Clinical Trial Update: Neoadjuvant Camrelizumab With Dalpiciclib for Resectable Head and Neck Squamous Cell Carcinomas [Phase 1]
Phase 1 neoadjuvant trial combining camrelizumab with dalpiciclib for resectable head and neck squamous cell carcinoma is currently recruiti…
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CLINICAL_TRIALS research · 2024-07-19Clinical Trial Update: AK117 (Anti-CD47) + Anti-EGFR for R/M HNSCC [Phase 2]
Phase 2 clinical trial evaluating AK117, an anti-CD47 therapy, in combination with an anti-EGFR agent for recurrent/metastatic head and neck…
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CLINICAL_TRIALS research · 2024-07-19Clinical Trial Update: A Phase II Study of Anti-EGFR Antibody-drug Conjugate (ADC) Combine With CDK4/6 Inhibitors Posterior Line in the Treatment of Recurrent/Metastatic CDKN2A Gene Variant Head and Neck Squamous Cell Carcinoma [Phase 2]
Phase II study evaluating an anti-EGFR antibody-drug conjugate in combination with a CDK4/6 inhibitor for recurrent/metastatic head and neck…
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CLINICAL_TRIALS research · 2024-07-17Clinical Trial Update: QUILT-2.025 NANT Neoepitope Yeast Vaccine (YE-NEO-001): Adjuvant Immunotherapy Using a Personalized Neoepitope Yeast-Based Vaccine To Induce T-Cell Responses In Subjects W/ Previously Treated Cancers. [Phase 1]
Phase 1 trial update for YE-NEO-001, NantBioScience's personalized neoepitope yeast vaccine, evaluating adjuvant immunotherapy to elicit T-c…
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CLINICAL_TRIALS research · 2024-07-17Clinical Trial Update: Phase 1/2 Study of Autologous SCG142 TCR T Cells in Patients With HPV16/52-positive Carcinoma [Phase 1, Phase 2]
Phase 1/2 trial evaluating autologous SCG142 TCR T cells for HPV16/52-positive squamous cell carcinomas across multiple HPV-related sites; c…
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CLINICAL_TRIALS trial_result · 2024-07-16Clinical Trial Update: A Study of Pembrolizumab (MK-3475) With or Without Lenvatinib (E7080/MK-7902) as First Line (1L) Intervention in a Programmed Cell Death-ligand 1 (PD-L1) Selected Population With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC) (MK-7902-010) (KEYNOTE-010) [Phase 3]
This is a Phase 3 trial evaluating pembrolizumab with or without lenvatinib as first-line treatment in PD-L1–selected recurrent or metastati…
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CLINICAL_TRIALS trial_result · 2024-07-05Clinical Trial Update: A Study of XmAb®23104 in Subjects With Selected Advanced Solid Tumors (DUET-3) [Phase 1]
This update reports the completion of a Phase 1 study (DUET-3) evaluating XmAb23104 in patients with selected advanced solid tumors.
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CLINICAL_TRIALS trial_result · 2024-07-01Clinical Trial Update: Safety, Tolerability and Pharmacokinetics Investigation of Stimotimagene Copolymerplasmid [Phase 1]
Phase 1 trial evaluating safety, tolerability, and pharmacokinetics of Stimotimagene Copolymerplasmid in multiple cancer types; the study ha…
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CLINICAL_TRIALS trial_result · 2024-07-01Clinical Trial Update: A Study of PRT3645 in Participants With Select Advanced or Metastatic Solid Tumors [Phase 1]
A Phase 1 study of PRT3645 conducted by Prelude Therapeutics in patients with several advanced solid tumors has completed, including breast …
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CLINICAL_TRIALS research · 2024-07-01Clinical Trial Update: Dose De-escalation and Sentinel LN Mapping Driven Radiotherapy of Contralateral Neck in Ipsilateral Node Positive HNSCC [NA]
This entry describes an ongoing clinical trial investigating dose de-escalation and sentinel lymph node mapping-guided radiotherapy for ipsi…
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CLINICAL_TRIALS trial_result · 2024-06-28Clinical Trial Update: Sodium Thiosulfate in Preventing Ototoxicity for Squamous Cell Cancer Patients Undergoing Chemoradiation With Cisplatin [Phase 2]
Phase 2 trial evaluating sodium thiosulfate to prevent cisplatin-induced ototoxicity in patients with head and neck squamous cell carcinoma …
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CLINICAL_TRIALS research · 2024-06-28Clinical Trial Update: Immunotherapy and SBRT for Metastatic Head and Neck Carcinomas [Phase 1, Phase 2]
This entry describes a Phase 1/2 clinical trial investigating immunotherapy in combination with stereotactic body radiotherapy for metastati…
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CLINICAL_TRIALS research · 2024-06-27Clinical Trial Update: A Study of LVGN6051 Combination Therapy in Patient With Head and Neck Squamous Cell Carcinoma (HNSCC) [Phase 2]
A Phase 2 study evaluating LVGN6051 in combination therapy for head and neck squamous cell carcinoma is currently recruiting.
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CLINICAL_TRIALS trial_result · 2024-06-25Clinical Trial Update: Smoking Tobacco Cessation Integrated Program of Patients Treated for the Head and the Neck Cancer [NA]
Completed clinical trial evaluating a Smoking Tobacco Cessation Integrated Program for patients treated for head and neck squamous cell carc…
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CLINICAL_TRIALS research · 2024-06-25Clinical Trial Update: Identification of Pattern and Factors Affecting Recurrence in Head and Neck Carcinoma
An ongoing clinical trial at Sohag University is studying patterns and factors related to recurrence in head and neck squamous cell carcinom…
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CLINICAL_TRIALS trial_result · 2024-06-21Clinical Trial Update: Safety and Efficacy of Tipifarnib in Head and Neck Cancer With HRAS Mutations and Impact of HRAS on Response to Therapy [Phase 2]
Phase 2 trial evaluating tipifarnib in HRAS-mutant head and neck squamous cell carcinoma has completed, with results posted assessing safety…
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CLINICAL_TRIALS trial_result · 2024-06-14Clinical Trial Update: Nivolumab Plus Pemetrexed for Head and Neck Squamous Cell Carcinoma [Phase 2]
This update notes the completion of a Phase 2 trial evaluating the combination of nivolumab and pemetrexed in head and neck squamous cell ca…
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CLINICAL_TRIALS trial_result · 2024-06-13Clinical Trial Update: Study of ADCT-301 in Patients With Selected Advanced Solid Tumors [Phase 1]
Phase 1 trial update for ADCT-301 (camidanlumab tesirine) in selected advanced solid tumors; the study has been terminated and results have …
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CLINICAL_TRIALS trial_result · 2024-05-28Clinical Trial Update: Phase 1 Study of BAY1905254 - An Early Clinical Research Study to Evaluate a New Drug Called Bapotulimab (BAY1905254) in the Expansion Cohort in Combination With Pembrolizumab in Head and Neck Cancer That Has Returned or is Discovered to be Metastatic and is Expressing PDL1. [Phase 1]
Phase 1 expansion cohort study of Bapotulimab (BAY1905254) in combination with pembrolizumab in PD-L1–expressing head and neck squamous cell…
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CLINICAL_TRIALS trial_result · 2024-05-24Clinical Trial Update: Hearing Loss and the Effects of Statin Drugs in People With Head and Neck Squamous Cell Carcinoma Treated With Cisplatin Chemoradiation
A completed clinical trial from NIDCD examined whether statin therapy influences hearing loss in patients with head and neck squamous cell c…
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CLINICAL_TRIALS research · 2024-05-17Clinical Trial Update: Tislelizumab Combined With Chemotherapy Followed by Surgery Versus Up-front Surgery in Resectable Head and Neck Squamous Cell Carcinoma (REDUCTION-I) [Phase 3]
A Phase 3 trial (REDUCTION-I) is evaluating tislelizumab with chemotherapy followed by surgery versus upfront surgery in resectable head and…
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CLINICAL_TRIALS research · 2024-05-17Clinical Trial Update: Tislelizumab Combined With Chemotherapy Followed by Surgery Versus Up-front Surgery in Resectable Clinically Node-negative Head and Neck Squamous Cell Carcinoma [Phase 2]
A Phase 2 trial evaluating tislelizumab plus chemotherapy followed by surgery versus upfront surgery in resectable, clinically node-negative…
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CLINICAL_TRIALS research · 2024-05-17Clinical Trial Update: Neoadjuvant DaRT for Locally Advanced Oral Cavity SCC [NA]
A clinical trial update for neoadjuvant Diffusing Alpha-emitters Radiation Therapy (DaRT) in locally advanced oral cavity squamous cell carc…
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CLINICAL_TRIALS trial_result · 2024-05-14Clinical Trial Update: PBI-MST-01 (NCT04541108) Substudy MSD-03: Intratumoral Microdosing of Pembrolizumab Alone and With MK-0482 or MK-4830 in HNSCC or STS [EARLY_Phase 1]
An early-phase trial evaluating intratumoral microdosing of pembrolizumab alone or with MK-0482 or MK-4830 in head and neck squamous cell ca…
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CLINICAL_TRIALS trial_result · 2024-05-14Clinical Trial Update: Standard and Delayed FDG PET/CT After Chemoradiation Therapy in Assessing Patients With Metastatic Head and Neck Squamous Cell Cancer [NA]
Clinical trial update noting an evaluation of standard and delayed FDG PET/CT after chemoradiation in patients with metastatic head and neck…