Head and Neck Squamous Cell Carcinoma
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: JAB-3068 Activity in Adult Patients With Advanced Solid Tumors [Phase 1, Phase 2]
A completed Phase 1/Phase 2 trial update for JAB-3068 in adults with advanced solid tumors, including Esophageal Squamous Cell Carcinoma, No…
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CLINICAL_TRIALS research · 2024-09-19Clinical Trial Update: a Multicentre Phase III Study of Risk-based Treatment Intensification With Hyperfractionated Radiotherapy in Head and Neck Cancer Patients [Phase 3]
A multicentre Phase III trial is evaluating risk-based treatment intensification with hyperfractionated radiotherapy in head and neck squamo…
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: Optimized Diffusion-Weighted Imaging for the Evaluation of Post-Treatment Squamous Cell Carcinoma in the Neck: Comparative Study With FDG PET/CT [NA]
A terminated diagnostic trial comparing diffusion-weighted imaging with FDG PET/CT for evaluating post-treatment head and neck squamous cell…
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CLINICAL_TRIALS research · 2024-09-19Clinical Trial Update: Neoadjuvant Tislelizumab in Combination With Dasatinib and Quercetin in Resectable HNSCC (COIS-01) [Phase 2]
A Phase 2 neoadjuvant trial (COIS-01) examines tislelizumab with dasatinib and quercetin for resectable head and neck squamous cell carcinom…
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: A Study to Evaluate NT219 Alone and in Combination with ERBITUX® (Cetuximab) in Adults with Advanced Solid Tumors and Head and Neck Cancer [Phase 1, Phase 2]
Clinical trial update reporting completion of a Phase 1/2 study evaluating NT219 alone and in combination with cetuximab (ERBITUX) in adults…
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CLINICAL_TRIALS research · 2024-09-03Clinical Trial Update: Surgery and Reducing Ionizing Radiation of the Unknown Primary [Phase 2]
A Phase 2 clinical trial update describes evaluating surgical management with reduced ionizing radiation for unknown primary head and neck c…
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CLINICAL_TRIALS research · 2024-08-28Clinical Trial Update: Effects of Neoadjuvant Therapy With Carboplatin, Paclitaxel Combined With Anti-PD-1 Drugs on Pain, Anxiety and Depression in Patients With Resectable Head and Neck Squamous Cell Carcinoma
A clinical trial is evaluating neoadjuvant therapy with carboplatin, paclitaxel, and anti-PD-1 drugs to assess effects on pain, anxiety, and…
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CLINICAL_TRIALS research · 2024-08-28Clinical Trial Update: Effects of Neoadjuvant Therapy With Carboplatin, Paclitaxel Combined With Anti-PD-1 Drugs on Cognitive Function in Patients With Resectable Head and Neck Squamous Cell Carcinoma
This clinical trial update notes recruitment for a neoadjuvant therapy study combining carboplatin and paclitaxel with an anti-PD-1 drug in …
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CLINICAL_TRIALS trial_result · 2024-08-27Clinical Trial Update: Radiotherapy Plus Xevinapant in Older Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma [Phase 2]
Phase 2 trial of radiotherapy plus Xevinapant for older patients with locally advanced head and neck squamous cell carcinoma has been suspen…
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CLINICAL_TRIALS research · 2024-08-27Clinical Trial Update: De-escalation Radiation Strategy After NAC in Combination With ICI in LAHNSCC [Phase 1, Phase 2]
A Phase 1/Phase 2 clinical trial is evaluating a de-escalation radiation strategy after neoadjuvant chemotherapy in combination with an immu…
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CLINICAL_TRIALS trial_result · 2024-08-22Clinical Trial Update: Erlotinib, Docetaxel, and Radiation Therapy in Stage III or Stage IV Squamous Cell Carcinoma of the Head and Neck [Phase 2]
Phase 2 trial evaluating erlotinib and docetaxel in combination with radiation therapy for stage III/IV squamous cell carcinoma of the head …
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CLINICAL_TRIALS research · 2024-08-21Clinical Trial Update: Immunotherapy and Carbon Ion Radiotherapy In Solid Cancers With Stable Disease [Phase 2]
Phase 2 clinical trial exploring immunotherapy combined with carbon ion radiotherapy in solid cancers with stable disease, currently recruit…
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CLINICAL_TRIALS research · 2024-08-20Clinical Trial Update: ARTEMIS-006: HS-20093 in Patients With Head and Neck Squamous Cell Carcinoma and Other Solid Tumors [Phase 2]
The document describes an ongoing Phase 2 study ARTEMIS-006 (HS-20093) for head and neck squamous cell carcinoma and other solid tumors. The…
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CLINICAL_TRIALS research · 2024-08-16Clinical Trial Update: A RC198 Study in Subjects With Locally Advanced Unresectable or Metastatic Solid Tumors [Phase 1]
RemeGen's RC198 is being evaluated in a Phase 1 study across locally advanced unresectable or metastatic solid tumors, including melanoma, u…
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CLINICAL_TRIALS research · 2024-08-09Clinical Trial Update: Efficacy and Safety of PD-1 Plus Chemotherapy in Poorly Differentiated Locally Advanced (LA) HNSCC [Phase 2]
An ongoing Phase 2 clinical trial assessing the efficacy and safety of a PD-1 inhibitor in combination with chemotherapy for poorly differen…
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CLINICAL_TRIALS research · 2024-08-09Clinical Trial Update: Liquid Biopsy for Early DiagNosis of Squamous Cell Carcinoma of the HeAd and NeCk rEgion
This clinical trial update notes ongoing recruitment for a study evaluating a liquid biopsy approach for early diagnosis of head and neck sq…
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CLINICAL_TRIALS research · 2024-08-06Clinical Trial Update: AK112 Plus AP Regimen for Operable Locally Advanced Head and Neck Squamous Cell Carcinoma [Phase 2]
Phase 2 study evaluating AK112 in combination with an AP regimen as neoadjuvant therapy for operable locally advanced head and neck squamous…
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CLINICAL_TRIALS trial_result · 2024-08-01Clinical Trial Update: Pembrolizumab in Combination With Cisplatin and Intensity Modulated Radiotherapy (IMRT) in Head and Neck Cancer [Phase 2]
Phase 2 trial of pembrolizumab with cisplatin and intensity-modulated radiotherapy for head and neck squamous cell carcinoma has completed w…
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CLINICAL_TRIALS trial_result · 2024-08-01Clinical Trial Update: Study Evaluating the Efficacy of Niraparib and Dostarlimab (TSR-042) in Recurrent/Metastatic HNSCC [Phase 2]
Phase 2 clinical trial evaluating the combination of niraparib and dostarlimab (TSR-042) in recurrent/metastatic head and neck cancer is cur…
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CLINICAL_TRIALS trial_result · 2024-07-31Clinical Trial Update: Paclitaxel Albumin-Stabilized Nanoparticle Formulation and Carboplatin Followed By Chemoradiation in Treating Patients With Recurrent Head and Neck Cancer [Phase 1]
Phase 1 trial of nab-paclitaxel (albumin-bound paclitaxel) with carboplatin followed by chemoradiation in patients with recurrent head and n…
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CLINICAL_TRIALS research · 2024-07-31Clinical Trial Update: A Phase II Study of MRG003 Injection Combined With Pucotenlimab Injection ± Cisplatin Injection in the Neoadjuvant Treatment Locally Advanced EGFR-positive Head and Neck Squamous Cell Carcinoma [Phase 2]
Phase II neoadjuvant trial evaluating MRG003 with Pucotenlimab, with or without cisplatin, for EGFR-positive locally advanced head and neck …
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CLINICAL_TRIALS withdrawal · 2024-07-25Clinical Trial Update: Testing the Addition of an Investigational Drug, Xevinapant, to Usual Radiation Therapy Plus Cisplatin/Carboplatin for Patients With Head and Neck Cancer [Phase 2]
Phase 2 trial evaluating Xevinapant added to standard radiation therapy plus cisplatin/carboplatin for head and neck cancers has been withdr…
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CLINICAL_TRIALS trial_result · 2024-07-23Clinical Trial Update: Cabozantinib in Combination With Cetuximab in Patients With Recurrent or Metastatic Head and Neck Squamous Cell Cancer [Phase 1]
Phase 1 trial evaluating cabozantinib in combination with cetuximab for recurrent or metastatic head and neck squamous cell carcinoma has co…
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CLINICAL_TRIALS trial_result · 2024-07-23Clinical Trial Update: Birinapant and Intensity Modulated Re-Irradiation Therapy in Treating Patients With Locally Recurrent Head and Neck Squamous Cell Carcinoma [Phase 1]
A Phase 1 trial evaluating birinapant in combination with intensity-modulated re-irradiation therapy for locally recurrent head and neck squ…
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CLINICAL_TRIALS trial_result · 2024-07-23Clinical Trial Update: Bintrafusp Alfa and Stereotactic Body Radiation Therapy for the Treatment of Recurrent or Second Primary Head and Neck Squamous Cell Cancer [Phase 1, Phase 2]
Phase 1/2 trial evaluating Bintrafusp alfa in combination with stereotactic body radiation therapy for recurrent or second primary head and …