Head and Neck Squamous Cell Carcinoma
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Sign up freeTop drugs studied for this disease
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FDA approval · 2024-05-10FDA Approved: CISPLATIN — Original Application (Apotex Corp.)
FDA approved the original application for cisplatin from Apotex Corp., enabling the generic version to be marketed in the United States.
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CLINICAL_TRIALS trial_result · 2024-05-09Clinical Trial Update: A Study of Pembrolizumab (MK-3475) Plus Carboplatin and Paclitaxel as First-line Treatment of Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (MK-3475-B10/KEYNOTE B10) [Phase 4]
Phase 4 trial MK-3475-B10 (KEYNOTE B10) evaluating pembrolizumab with carboplatin and paclitaxel as first-line therapy for recurrent/metasta…
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CLINICAL_TRIALS research · 2024-05-08Clinical Trial Update: Real-time Detection of ctDNA and/or HPV DNA in High-risk Locally-advanced Head and Neck Squamous Cell Carcinoma
This clinical trial update describes a study evaluating real-time detection of circulating tumor DNA (ctDNA) and HPV DNA in patients with hi…
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CLINICAL_TRIALS trial_result · 2024-05-08Clinical Trial Update: EACH: Evaluating Avelumab in Combination With Cetuximab in Head and Neck Cancer [Phase 2]
This is a Phase 2 trial update evaluating the combination of avelumab and cetuximab for head and neck squamous cell carcinoma, sponsored by …
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CLINICAL_TRIALS trial_result · 2024-05-06Clinical Trial Update: Comparison of Concomitant Cisplatin Versus Carboplatin and 5-fluorouracil With Radiotherapy for Locally Advanced Head and Neck Squamous Cell Carcinoma
A completed clinical trial comparing concomitant cisplatin versus carboplatin plus 5-fluorouracil with radiotherapy in locally advanced head…
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CLINICAL_TRIALS trial_result · 2024-05-02Clinical Trial Update: P53 Mutational Status and cf HPV DNA for the Management of HPV-associated OPSCC [Phase 2]
A Phase 2 clinical trial evaluating P53 mutational status and circulating cell-free HPV DNA as biomarkers to guide management of HPV-associa…
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CLINICAL_TRIALS research · 2024-04-25Clinical Trial Update: A Clinical Study of Anti-CD70 UCAR-T in Relapsed or Refractory Solid Tumors [Phase 1]
This is a Phase 1 clinical trial studying Anti-CD70 UCAR-T for relapsed or refractory solid tumors, with not yet recruiting status.
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CLINICAL_TRIALS trial_result · 2024-04-15Clinical Trial Update: Study to Evaluate Safety and Efficacy of TJ107 Combine With PD-1 in Patients With Solid Tumors [Phase 2]
Phase 2 trial evaluating safety and efficacy of TJ107 combined with PD-1 in patients with solid tumors, including triple-negative breast can…
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CLINICAL_TRIALS trial_result · 2024-04-11Clinical Trial Update: Radiotherapy With Double Checkpoint Blockade of Locally Advanced HNSCC [Phase 2]
Phase 2 trial update on radiotherapy with double checkpoint blockade for locally advanced head and neck squamous cell carcinoma has complete…
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CLINICAL_TRIALS trial_result · 2024-04-04Clinical Trial Update: Bempegaldesleukin (NKTR-214) With Radiation and Anti-PD-1 Immunotherapy for Head and Neck Squamous Cell Carcinoma [Phase 2]
Phase 2 trial evaluating bempegaldesleukin (NKTR-214) with radiation and anti-PD-1 for head and neck squamous cell carcinoma was terminated;…
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CLINICAL_TRIALS trial_result · 2024-04-01Clinical Trial Update: Nivolumab, Carboplatin, and Paclitaxel in Treating Patients With Stage III-IV Head and Neck Squamous Cell Carcinoma That Can Be Removed by Surgery [Phase 2]
A phase 2 trial evaluated the combination of nivolumab with carboplatin and paclitaxel in patients with stage III-IV head and neck squamous …
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CLINICAL_TRIALS trial_result · 2024-03-15Clinical Trial Update: Palbociclib With Cetuximab and IMRT for Locally Advanced Squamous Cell Carcinoma [Phase 1, Phase 2]
Clinical trial update on palbociclib combined with cetuximab and IMRT for locally advanced head and neck squamous cell carcinoma (phases 1 a…
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CLINICAL_TRIALS trial_result · 2024-03-08Clinical Trial Update: A Safety and Tolerability Study of NC318 in Subjects With Advanced or Metastatic Solid Tumors [Phase 1, Phase 2]
A safety and tolerability study of NC318 in advanced or metastatic solid tumors completed Phase 1/2 with results posted in 2024.
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CLINICAL_TRIALS trial_result · 2024-02-14Clinical Trial Update: Bevacizumab/Ph 2 for Locally Advanced Head and Neck Cancer [Phase 2]
Phase 2 trial update evaluating bevacizumab in locally advanced head and neck squamous cell carcinoma; completed with results posted.
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CLINICAL_TRIALS trial_result · 2024-02-09Clinical Trial Update: Phase III Trial Comparing Methotrexate and Cetuximab in First-line Treatment of Recurrent and/or Metastatic Squamous Cell Head and Neck Cancer [Phase 3]
Phase 3 trial comparing methotrexate versus cetuximab in first-line treatment of recurrent/metastatic squamous cell carcinoma of the head an…
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CLINICAL_TRIALS trial_result · 2024-02-05Clinical Trial Update: Streptococcus Salivarius K12 for Prevention and Treatment of Oral Mucositis in Patients Undergoing Radiotherapy [Phase 2]
Phase 2 trial update evaluating Streptococcus Salivarius K12 for prevention and treatment of oral mucositis in patients undergoing radiother…
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CLINICAL_TRIALS trial_result · 2024-02-01Clinical Trial Update: Neoadjuvant Tislelizumab Plus Chemotherapy for Resectable Locally-advanced Head and Neck Squamous Cell Carcinoma [Phase 2]
A Phase 2 clinical trial evaluating neoadjuvant tislelizumab in combination with chemotherapy for resectable locally-advanced head and neck …
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CLINICAL_TRIALS trial_result · 2024-01-30Clinical Trial Update: Vaccination With Flt3L, Radiation, and Poly-ICLC [Phase 1, Phase 2]
Phase 1/2 clinical trial evaluating vaccination with Flt3L, radiation, and Poly-ICLC in cancer patients.
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CLINICAL_TRIALS trial_result · 2024-01-23Clinical Trial Update: Envafolimab Combined With Chemotherapy in Neoadjuvant and Conversion Therapy for Head and Neck Squamous Cell Carcinoma [Phase 2]
Phase 2 trial exploring Envafolimab plus chemotherapy as neoadjuvant and conversion therapy for head and neck squamous cell carcinoma.
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CLINICAL_TRIALS trial_result · 2024-01-10Clinical Trial Update: Targeting PD-1 Therapy Resistance With Focused High or High and Low Dose Radiation in SCCHN [Phase 2]
Phase 2 trial results evaluate whether adding focused high-dose radiation to PD-1–directed therapy can overcome resistance in head and neck …
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CLINICAL_TRIALS trial_result · 2024-01-09Clinical Trial Update: Study of Post-Op Adjuvant Concurrent Chemo-RT With or Without Nimotuzumab for Head & Neck Cancer [Phase 3]
Phase 3 study evaluating post-operative adjuvant concurrent chemoradiotherapy with or without nimotuzumab for head and neck squamous cell ca…
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CLINICAL_TRIALS trial_result · 2023-12-20Clinical Trial Update: Enoblituzumab Plus Retifanlimab or Tebotelimab in Head and Neck Cancer [Phase 2]
Phase 2 trial evaluating enoblituzumab in combination with retifanlimab or tebotolimab in head and neck cancer was terminated, with results …
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CLINICAL_TRIALS trial_result · 2023-12-20Clinical Trial Update: Advanced First-line Treatment of Short-term Postoperative Progression of Head and Neck Squamous Cell Carcinoma [Phase 2]
Phase 2 clinical trial update for advanced first-line treatment of short-term postoperative progression in head and neck squamous cell carci…
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CLINICAL_TRIALS trial_result · 2023-12-08Clinical Trial Update: Durvalumab (MEDI4736) With Cetuximab in Previously Treated Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma [Phase 2]
Phase 2 clinical trial evaluating durvalumab with cetuximab in previously treated recurrent or metastatic head and neck squamous cell carcin…
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CLINICAL_TRIALS trial_result · 2023-12-06Clinical Trial Update: Trigriluzole With Nivolumab and Pembrolizumab in Treating Patients With Metastatic or Unresectable Solid Malignancies or Lymphoma [Phase 1]
Phase 1 trial assessing trigriluzole in combination with nivolumab and pembrolizumab for various metastatic or unresectable solid tumors and…