Head and Neck Squamous Cell Carcinoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS other · 2025-06-25Clinical Trial Update: FAPi Radioligand OpeN-Label, Phase 1 Study to Evaluate Safety, Tolerability and DosImetry of [Lu-177]-PNT6555; A Dose Escalation Study for TReatment of Patients With Select Solid Tumors (FRONTIER) [Phase 1]
A Phase 1 dose-escalation trial of Lu-177-labeled PNT6555 (FRONTIER) for selected solid tumors assessing safety, tolerability and dosimetry;…
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CLINICAL_TRIALS research · 2025-06-24Clinical Trial Update: Identification of Individual Histological and Blood Markers in Patients With Recurrent or Metastatic Upper Aerodigestive Tract Squamous Cell Carcinoma in Response to Immunotherapies [NA]
A sponsor-initiated clinical trial is recruiting to identify histological and blood biomarkers in patients with recurrent or metastatic uppe…
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CLINICAL_TRIALS research · 2025-06-22Clinical Trial Update: Preoperative Pembrolizumab and Chemotherapy in Resectable, Recurrent HNSCC [Phase 2]
This document outlines a Phase 2 trial evaluating preoperative pembrolizumab in combination with chemotherapy for resectable and recurrent h…
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CLINICAL_TRIALS research · 2025-06-19Clinical Trial Update: An Open-label Study Using ASP-1929 Photoimmunotherapy in Combination With Anti-PD1 Therapy in EGFR Expressing Advanced Solid Tumors [Phase 1, Phase 2]
Open-label Phase 1/2 trial evaluating ASP-1929 photoimmunotherapy in combination with anti-PD1 therapy for EGFR-expressing advanced solid tu…
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CLINICAL_TRIALS research · 2025-06-18Clinical Trial Update: Noninvasive Intratumor Heterogeneity Evaluation in HNSCC
This clinical trial update describes an ongoing study evaluating noninvasive intratumor heterogeneity in head and neck squamous cell carcino…
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CLINICAL_TRIALS research · 2025-06-13Clinical Trial Update: A Clinical Trial of Neoadjuvant Targeted Therapy, Immunotherapy, and Lysogenic HSV-Based Virotherapy in Resectable Head and Neck Squamous Cell Carcinoma [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating neoadjuvant targeted therapy, immunotherapy, and lysogenic HSV-based virotherapy in patients with rese…
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CLINICAL_TRIALS trial_result · 2025-06-13Clinical Trial Update: A Study of LGK974 in Patients With Malignancies Dependent on Wnt Ligands [Phase 1]
Phase 1 clinical trial update of LGK974, a Wnt pathway inhibitor, in malignancies dependent on Wnt ligands; the study included several cance…
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CLINICAL_TRIALS trial_result · 2025-06-11Clinical Trial Update: Phase-2 Dacomitinib Study on Patients With EGFR-Driven Advanced Solid Tumours With Low EGFR-AS1 IncRNA Expr or Other Novel Emerging Biomarkers [Phase 2]
Phase-2 study of dacomitinib in EGFR-driven advanced solid tumours, including non-small cell lung cancer and head and neck squamous cell car…
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CLINICAL_TRIALS trial_result · 2025-06-11Clinical Trial Update: AVID100 in Advanced Epithelial Carcinomas [Phase 1, Phase 2]
A phase 1/2 trial of AVID100 for advanced epithelial carcinomas was terminated; results were posted in June 2025.
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CLINICAL_TRIALS trial_result · 2025-06-08Clinical Trial Update: Study of NKTR 255 in Combination With Cetuximab in Solid Tumors [Phase 1, Phase 2]
Phase 1/2 study evaluating NKTR-255 in combination with cetuximab in solid tumors, including head and neck squamous cell carcinoma and color…
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CLINICAL_TRIALS research · 2025-06-08Clinical Trial Update: Personalized, Adaptive Treatment for Locally Advanced Head and Neck Cancer [Phase 1]
A Phase 1 trial at the University of Chicago is evaluating a personalized, adaptive treatment approach for locally advanced head and neck sq…
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CLINICAL_TRIALS trial_result · 2025-06-08Clinical Trial Update: Trial Combining Pembrolizumab and Cesium 131 Brachytherapy With Salvage Surgery in HNSCC [Phase 1, Phase 2]
An ongoing Phase 1/Phase 2 trial evaluating pembrolizumab with Cesium-131 brachytherapy followed by salvage surgery for head and neck squamo…
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CLINICAL_TRIALS research · 2025-06-04Clinical Trial Update: AK104 and Low-dose Radiation in Recurrent/Metastatic HNSCC After Failure of First-line Systemic Therapy [Phase 2]
A Phase 2 clinical trial evaluating AK104 in combination with low-dose radiation for recurrent or metastatic head and neck squamous cell car…
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CLINICAL_TRIALS trial_result · 2025-06-03Clinical Trial Update: REirradiation and Programmed Cell Death Protein 1 (PD-1) Blockade On Recurrent Squamous Cell Head and Neck Tumors [Phase 1, Phase 2]
This document reports the completion of a Phase 1/2 clinical trial assessing reirradiation with a PD-1 inhibitor in patients with recurrent …
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CLINICAL_TRIALS research · 2025-06-03Clinical Trial Update: AK129 Combination Therapy for Advanced Solid Tumors [Phase 1, Phase 2]
AK129 is being studied in Phase 1/2 trials for multiple advanced solid tumors, including non-small cell lung cancer and head and neck squamo…
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CLINICAL_TRIALS trial_result · 2025-05-31Clinical Trial Update: Real-time Margin Assessment in Head and Neck Cancer [Phase 2]
Phase 2 clinical trial update on a real-time margin assessment technique for head and neck cancer during surgery.
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CLINICAL_TRIALS trial_result · 2025-05-30Clinical Trial Update: A Lithium-containing Mouthwash Prevention and Treatment of Oral Mucositis and Dysgeusia in Patients Undergoing Radiotherapy [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating a lithium-containing mouthwash to prevent and treat oral mucositis and dysgeusia in patients undergoin…
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CLINICAL_TRIALS research · 2025-05-29Clinical Trial Update: Discontinuation of Tobacco Dependence in Smoking Patients With Squamous Cell Carcinoma of the Head-neck District: Multicenter Prospective Observational Study
A multicenter prospective observational study assessing tobacco cessation in patients with head and neck squamous cell carcinoma. The study …
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CLINICAL_TRIALS trial_result · 2025-05-28Clinical Trial Update: Radiomics Model for Assessing Lymph Node Status in cN0 Patients withHNSCC
A completed clinical trial update describing a radiomics model designed to assess lymph node status in clinically node-negative head and nec…
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CLINICAL_TRIALS trial_result · 2025-05-25Clinical Trial Update: Lenvatinib (E7080/MK-7902) in Combination With Pembrolizumab (MK-3475) vs. Standard Chemotherapy and Lenvatinib Monotherapy in Participants With Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma That Progressed After Platinum Therapy and Immunotherapy (MK-7902-009/E7080-G000-228/LEAP-009) [Phase 2]
Phase 2 study LEAP-009 evaluated lenvatinib plus pembrolizumab versus standard chemotherapy and lenvatinib alone in recurrent/metastatic hea…
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CLINICAL_TRIALS trial_result · 2025-05-23Clinical Trial Update: A Study of NM21-1480 in Adult Patients With Advanced Solid Tumors [Phase 1, Phase 2]
A clinical trial update reports termination of the NM21-1480 study in adults with advanced solid tumors, including non-small cell lung cance…
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CLINICAL_TRIALS research · 2025-05-22Clinical Trial Update: COM902 (A TIGIT Inhibitor) in Subjects With Advanced Malignancies [Phase 1]
Phase 1 study of COM902, a TIGIT inhibitor, in patients with advanced malignancies is ongoing and currently not recruiting.
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CLINICAL_TRIALS trial_result · 2025-05-22Clinical Trial Update: Neoadjuvant Chemotherapy, Tislelizumab With Afatinib for HNSCC [Phase 2]
Phase 2 neoadjuvant trial evaluating tislelizumab with afatinib for head and neck squamous cell carcinoma has completed status.
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CLINICAL_TRIALS trial_result · 2025-05-22Clinical Trial Update: Expression & Epigenetic Silencing of MicroRNA for Predicting Therapeutic Response and Prognosis of HPV-negative HNSCC
The clinical trial studied expression and epigenetic silencing of a microRNA as predictors of therapeutic response and prognosis in HPV-nega…
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CLINICAL_TRIALS trial_result · 2025-05-20Clinical Trial Update: A Study of JAB-3312 in Adult Patients With Advanced Solid Tumors in China [Phase 1]
The Phase 1 study of JAB-3312 in adults with advanced solid tumors in China has completed.