Head and Neck Squamous Cell Carcinoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2025-05-20Clinical Trial Update: [68Ga]Ga-FAPI-46 in Staging of Head and Neck Carcinomas [Phase 2]
Phase 2 clinical trial investigating the imaging agent [68Ga]Ga-FAPI-46 for staging head and neck squamous cell carcinoma is currently recru…
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CLINICAL_TRIALS research · 2025-05-18Clinical Trial Update: Measurable Residual Disease Detection Using Tumor-Informed ctDNA Surveillance After Curative-Intent Treatment in HPV-Independent Squamous Cell Carcinoma of the Head and Neck
This clinical trial is evaluating tumor-informed circulating tumor DNA (ctDNA) surveillance for detecting measurable residual disease after …
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CLINICAL_TRIALS research · 2025-05-18Clinical Trial Update: Cetuximab + Tislelizumab + Chemotherapy in the Treatment of Unresectable LA HNSCC [Phase 2]
Phase 2 clinical trial evaluating cetuximab plus tislelizumab and chemotherapy for unresectable locally advanced head and neck squamous cell…
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CLINICAL_TRIALS trial_result · 2025-05-15Clinical Trial Update: Durvalumab With or Without Metformin in Treating Participants With Head and Neck Squamous Cell Carcinoma [EARLY_Phase 1]
Early-phase 1 clinical trial evaluating durvalumab with or without metformin in head and neck squamous cell carcinoma, including oral cavity…
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CLINICAL_TRIALS trial_result · 2025-05-15Clinical Trial Update: Pilot Study of Metformin in Head and Neck Squamous Cell Cancer and Its Effects on Stromal-epithelial Metabolic Uncoupling [EARLY_Phase 1]
A Phase 1 pilot trial studying metformin in head and neck squamous cell carcinoma and its effects on stromal-epithelial metabolic uncoupling…
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CLINICAL_TRIALS trial_result · 2025-05-15Clinical Trial Update: Radiation Therapy and MK-3475 for Patients With Recurrent/Metastatic Head and Neck Cancer, Renal Cell Cancer, Melanoma, and Lung Cancer [Phase 1]
Phase 1 study evaluating the safety of combining radiation therapy with pembrolizumab (MK-3475) in patients with recurrent/metastatic head a…
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CLINICAL_TRIALS trial_result · 2025-05-15Clinical Trial Update: Circulating Tumor DNA in Predicting Outcomes in Patients With Stage IV Head and Neck Cancer or Stage III-IV Non-small Cell Lung Cancer
A completed clinical trial evaluating whether circulating tumor DNA can predict outcomes in patients with stage IV head and neck cancer or s…
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CLINICAL_TRIALS trial_result · 2025-05-13Clinical Trial Update: Testing Lenvatinib and Cetuximab in Patients With Advanced Head and Neck Squamous Cell Carcinoma and Cutaneous Squamous Cell Carcinoma [Phase 1]
This clinical trial update reports completion of a Phase 1 study evaluating lenvatinib in combination with cetuximab in patients with advanc…
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CLINICAL_TRIALS trial_result · 2025-05-11Clinical Trial Update: De-Escalation Therapy for Human Papillomavirus Negative Disease [Phase 2]
This clinical trial update reports Phase 2 results for de-escalation therapy in HPV-negative head and neck squamous cell carcinoma; results …
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CLINICAL_TRIALS trial_result · 2025-05-09Clinical Trial Update: A Study of Setanaxib Co-Administered With Pembrolizumab in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of Head and Neck (SCCHN) [Phase 2]
This document reports the completion of a Phase 2 trial evaluating Setanaxib co-administered with Pembrolizumab in recurrent or metastatic h…
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CLINICAL_TRIALS trial_result · 2025-05-09Clinical Trial Update: Study Comparing RT With Cetuximab + Xevinapant to RT With Cetuximab-placebo in Patients With Head and Neck Cancer [Phase 3]
A Phase 3 trial comparing radiotherapy with cetuximab plus Xevinapant versus radiotherapy with cetuximab plus placebo in head and neck squam…
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CLINICAL_TRIALS trial_result · 2025-05-08Clinical Trial Update: Paclitaxel Plus Cetuximab After First-line Checkpoint Inhibitor Failure [Phase 2]
Phase 2 trial evaluating paclitaxel plus cetuximab in head and neck squamous cell carcinoma after failure of first-line checkpoint inhibitor…
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CLINICAL_TRIALS research · 2025-05-08Clinical Trial Update: Adjuvant Immunotherapy After Salvage Surgery in Head and Neck Squamous Cell Carcinoma [Phase 2]
This ClinicalTrials.gov entry reports a Phase 2 trial evaluating adjuvant immunotherapy after salvage surgery for head and neck squamous cel…
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CLINICAL_TRIALS trial_result · 2025-05-08Clinical Trial Update: A Trial of Durvalumab and Tremelimumab in Combination With SBRT in Patients With Metastatic Cancer [Phase 1, Phase 2]
This clinical trial update reports a completed Phase 1/2 study evaluating durvalumab in combination with tremelimumab and SBRT for metastati…
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CLINICAL_TRIALS other · 2025-05-08Clinical Trial Update: Pilot Study of MPB-2043 Enhanced MRI for Nodal Staging in Head and Neck Squamous Cell Carcinomas [Phase 1]
Phase 1 pilot study evaluating MPB-2043-enhanced MRI for nodal staging in head and neck squamous cell carcinoma; the trial is currently recr…
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CLINICAL_TRIALS research · 2025-05-07Clinical Trial Update: Chemo-radiotherapy Versus Radiotherapy in the Treatment of Salivary Glands and Nasal Tumors (IMRT or Protontherapy) [Phase 3]
Phase 3 trial comparing chemo-radiotherapy to radiotherapy alone for head and neck squamous cell carcinoma of the salivary glands and nasal …
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CLINICAL_TRIALS trial_result · 2025-05-07Clinical Trial Update: Randomized Trial of Avelumab-cetuximab-radiotherapy Versus SOCs in LA SCCHN (REACH) [Phase 3]
Phase 3 randomized trial evaluating avelumab-cetuximab-radiotherapy versus standard of care in locally advanced head and neck squamous cell …
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CLINICAL_TRIALS research · 2025-05-07Clinical Trial Update: A Study of BL-B01D1+PD-1 Monoclonal Antibody in Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma and Other Solid Tumors [Phase 2]
This Phase 2 study of BL-B01D1 in combination with a PD-1 monoclonal antibody for recurrent or metastatic head and neck squamous cell carcin…
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CLINICAL_TRIALS research · 2025-05-07Clinical Trial Update: Trial Evaluating the Tolerance and Safety of Durvalumab - RT Combination for Treatment in SCCHN [Phase 2]
Clinical trial update on the safety and tolerability of durvalumab combined with radiotherapy for head and neck squamous cell carcinoma (Pha…
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CLINICAL_TRIALS trial_result · 2025-05-06Clinical Trial Update: Chemotherapy and Locoregional Therapy Trial (Surgery or Radiation) for Patients With Head and Neck Cancer [Phase 2]
A Phase 2 trial evaluating chemotherapy with locoregional therapy (surgery or radiation) for head and neck squamous cell carcinoma, includin…
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CLINICAL_TRIALS research · 2025-04-30Clinical Trial Update: A Prospective, Multicenter, Multicohort Phase II Study: Evaluating the Efficacy and Safety of Preoperative Neoadjuvant Treatment With a PD-1 Inhibitor in Combination With Chemotherapy in Locally Advanced Laryngeal and Hypopharyngeal Squamous Cell Carcinoma [Phase 2]
Phase II multicenter study evaluating neoadjuvant therapy with a PD-1 inhibitor in combination with chemotherapy for locally advanced laryng…
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CLINICAL_TRIALS trial_result · 2025-04-29Clinical Trial Update: Window of Opportunity Trial of Nivolumab and Tadalafil in Patients With Squamous Cell Carcinoma of the Head and Neck [EARLY_Phase 1]
This early-phase window-of-opportunity trial tests the combination of nivolumab and tadalafil in patients with head and neck squamous cell c…
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CLINICAL_TRIALS research · 2025-04-27Clinical Trial Update: Prospective Observational Study to Validate Circulating HPVDNA and Prognostic Genomic Biomarkers in HPV-associated OPSCC
A prospective observational study sponsored by UNC Lineberger to validate circulating HPV DNA and prognostic genomic biomarkers in HPV-assoc…
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CLINICAL_TRIALS withdrawal · 2025-04-27Clinical Trial Update: Chemo-embolization for Head and Neck Cancer [Phase 2]
The Phase 2 trial of chemo-embolization for head and neck squamous cell carcinoma has been withdrawn.
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CLINICAL_TRIALS research · 2025-04-24Clinical Trial Update: Study of NEO-201 in Solid Tumors Expansion Cohorts [Phase 1, Phase 2]
Precision Biologics is expanding cohorts in a Phase 1/2 study of NEO-201 in solid tumors, including non-small cell lung cancer, head and nec…