Head and Neck Squamous Cell Carcinoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2025-08-15Clinical Trial Update: Dose Escalation Study of mRNA-2752 for Intratumoral Injection to Participants in Advanced Malignancies [Phase 1]
Phase 1 dose-escalation and expansion study of intratumoral mRNA-2752 in advanced malignancies has completed, with expansion cohorts in seve…
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CLINICAL_TRIALS research · 2025-08-15Clinical Trial Update: Study of Safety and Tolerability of BCA101 Monotherapy and in Combination Therapy in Patients With EGFR-driven Advanced Solid Tumors [Phase 1]
Phase 1 study evaluating safety and tolerability of BCA101 as monotherapy and in combination in EGFR-driven advanced solid tumors. The trial…
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CLINICAL_TRIALS trial_result · 2025-08-15Clinical Trial Update: A Study of SNS-101 (Anti VISTA) Monotherapy and in Combination With Cemiplimab in Patients With Advanced Solid Tumors [Phase 1, Phase 2]
A clinical trial update for SNS-101 (anti-VISTA) as monotherapy and in combination with cemiplimab in adults with advanced solid tumors, cur…
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CLINICAL_TRIALS research · 2025-08-14Clinical Trial Update: 2 Courses of Concurrent Cisplatin Chemoradiotherapy After Surgery for High-risk Head and Neck Squamous Cell Carcinoma [Phase 3]
A Phase 3 trial evaluating two courses of concurrent cisplatin chemoradiotherapy after surgery for high-risk head and neck squamous cell car…
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CLINICAL_TRIALS research · 2025-08-12Clinical Trial Update: Establishment of Squamous Cell Organoids of the Head and Neck to Assess Their Response to Innovative Therapies
The study aims to establish organoids from head and neck squamous cell carcinoma to assess their response to innovative therapies.
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CLINICAL_TRIALS trial_result · 2025-08-11Clinical Trial Update: A Study of the Intratumoral Microdose Administration of PBA-0405 in Patients With Solid Tumors [EARLY_Phase 1]
Early-phase study update on intratumoral microdose administration of PBA-0405 in solid tumors; the trial status is completed.
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CLINICAL_TRIALS research · 2025-08-11Clinical Trial Update: A Phase 0 Multicenter Study of the Pharmacodynamic Effects of Intratumoral Microdose Administration of PBA-0111 in Patients With Solid Tumors [EARLY_Phase 1]
Phase 0 multicenter study evaluating pharmacodynamic effects of intratumoral microdosing with PBA-0111 in solid tumors; the trial is current…
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CLINICAL_TRIALS trial_result · 2025-08-07Clinical Trial Update: Phase 1, First-in-human, Dose-finding and Expansion Study to Evaluate XmAb®808 in Combination With Pembrolizumab in Advanced Solid Tumors [Phase 1]
Phase 1, first-in-human dose-finding and expansion study of XmAb808 in combination with pembrolizumab in advanced solid tumors; the trial ha…
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CLINICAL_TRIALS trial_result · 2025-08-07Clinical Trial Update: Oncolytic Adenovirus TILT-123 and Avelumab for Treatment of Solid Tumors Refractory to or Progressing After Anti-PD(L)1 [Phase 1]
Phase 1 trial evaluating the combination of oncolytic adenovirus TILT-123 with Avelumab in solid tumors that progressed after anti-PD-(L)1 t…
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CLINICAL_TRIALS research · 2025-08-06Clinical Trial Update: A Study of Nimotuzumab Plus Adebrelimab With Chemotherapy in Cisplatin-Ineligible Patients With Head And Neck Squamous Cell Carcinoma [Phase 1, Phase 2]
A clinical trial update describes an ongoing Phase 1/2 study of nimotuzumab plus adebrelimab with chemotherapy in cisplatin-ineligible patie…
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CLINICAL_TRIALS trial_result · 2025-08-03Clinical Trial Update: Evorpacept (ALX148) in Combination With Pembrolizumab and Chemotherapy in Patients With Advanced Head and Neck Squamous Cell Carcinoma (ASPEN-04) [Phase 2]
A Phase 2 trial update (ASPEN-04) evaluating evorpacept in combination with pembrolizumab and chemotherapy for advanced head and neck squamo…
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CLINICAL_TRIALS research · 2025-08-01Clinical Trial Update: Evorpacept (ALX148) in Combination With Pembrolizumab in Patients With Advanced Head and Neck Squamous Cell Carcinoma (ASPEN-03) [Phase 2]
A Phase 2 clinical trial ASPEN-03 evaluating Evorpacept (ALX148) in combination with pembrolizumab for advanced head and neck squamous cell …
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CLINICAL_TRIALS trial_result · 2025-08-01Clinical Trial Update: TransCon (TC) TLR7/8 Agonist, TC IL-2 β/γ, Pembrolizumab Prior to Surgery for Advanced Head and Neck Squamous Cell Carcinoma [Phase 2]
Phase 2 trial evaluating TransCon TLR7/8 agonist, TransCon IL-2 beta/gamma, and pembrolizumab before surgery in advanced head and neck squam…
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CLINICAL_TRIALS trial_result · 2025-07-31Clinical Trial Update: Camrelizumab in Combination With Chemotherapy or Apatinib Mesylate as First-Line Treatment for R/M HNSCC [Phase 2]
A Phase 2 study evaluating camrelizumab in combination with chemotherapy or apatinib mesylate as first-line therapy for recurrent or metasta…
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CLINICAL_TRIALS trial_result · 2025-07-31Clinical Trial Update: MGC018 With or Without MGA012 in Advanced Solid Tumors [Phase 1, Phase 2]
This clinical trial update reports results from the combination of MGC018 with or without MGA012 (pembrolizumab) in advanced solid tumors. T…
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CLINICAL_TRIALS research · 2025-07-31Clinical Trial Update: Neoadjuvant and Adjuvant Toripalimab and Cetuximab in Patients With Recurrent, Resectable Squamous Cell Carcinoma of Head and Neck: a Prospective, Single-arm,Phase II Study [Phase 2]
This ClinicalTrials.gov update describes a Phase 2, single-arm study evaluating neoadjuvant and adjuvant toripalimab plus cetuximab in local…
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CLINICAL_TRIALS trial_result · 2025-07-31Clinical Trial Update: Neoadjuvant Tislelizumab With Afatinib for Resectable Head and Neck Squamous Cell Carcinoma [Phase 2]
This document reports a Phase 2 neoadjuvant trial evaluating the combination of tislelizumab and afatinib for resectable head and neck squam…
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CLINICAL_TRIALS research · 2025-07-31Clinical Trial Update: Sacituzumab Tirumotecan and Toripalimab in the First-line Treatment of HNSCC [Phase 2]
Phase 2 trial examining the combination of sacituzumab tirumotecan and toripalimab as first-line therapy for recurrent or metastatic head an…
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CLINICAL_TRIALS research · 2025-07-31Clinical Trial Update: Low-Dose Weekly vs High-Dose Cisplatin [NA]
A clinical trial comparing low-dose weekly versus high-dose cisplatin in locally advanced head and neck squamous cell carcinoma is currently…
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CLINICAL_TRIALS research · 2025-07-31Clinical Trial Update: Iparomlimab and Tuvonralimab in HNSCC [Phase 2]
Phase 2 trial investigating iparomlimab and tuvonralimab for recurrent/metastatic head and neck squamous cell carcinoma is currently recruit…
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CLINICAL_TRIALS research · 2025-07-29Clinical Trial Update: PD-1 Inhibitor Therapy Versus Radiotherapy in MPR Patients With Locally Advanced HNSCC After Neoadjuvant Immunochemotherapy (HNC-SYSU-006) [Phase 2]
This phase 2 clinical trial compares PD-1 inhibitor therapy to radiotherapy in locally advanced head and neck squamous cell carcinoma patien…
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CLINICAL_TRIALS research · 2025-07-29Clinical Trial Update: Identification of the Pathogenetic Mechanisms Underlying Squamous Cell Carcinomas
A clinical trial focused on identifying the pathogenetic mechanisms underlying squamous cell carcinomas of the head and neck and anus; curre…
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CLINICAL_TRIALS trial_result · 2025-07-25Clinical Trial Update: IPI-549 in Patients With Locally Advanced HPV+ and HPV- Head and Neck Squamous Cell Carcinoma [Phase 2]
Phase 2 clinical trial of IPI-549 in locally advanced HPV+ and HPV- head and neck squamous cell carcinoma has completed enrollment with resu…
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CLINICAL_TRIALS research · 2025-07-25Clinical Trial Update: Thermoradiotherapy for Locally Advanced Head and Neck Cancer Patients [Phase 1]
Phase 1 clinical trial evaluating thermoradiotherapy for locally advanced head and neck cancers; recruitment is ongoing.
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CLINICAL_TRIALS research · 2025-07-24Clinical Trial Update: Testing the Safety of Giving a Standard Dose of Radiation Over a Shorter Period of Time for Patients Who Had Surgery for Intermediate-Risk Head and Neck Cancer [Phase 1]
Phase 1 clinical trial assessing the safety of delivering a standard dose of radiation over a shorter period after surgery for intermediate-…