Head and Neck Squamous Cell Carcinoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2025-09-15Clinical Trial Update: A Study of GI-108, an Anti-CD73-IgG4 Fc-IL-2v Bispecific Fusion Protein, as Monotherapy in Patients With Advanced or Metastatic Solid Tumors [Phase 1, Phase 2]
Phase 1/2 clinical trial update for GI-108, a bispecific anti-CD73-IL-2v fusion protein, being studied as monotherapy in advanced or metasta…
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CLINICAL_TRIALS research · 2025-09-15Clinical Trial Update: Improved Oral Health in Head and Neck Cancer Survivors [NA]
A clinical trial from Uppsala University focusing on improving oral health in survivors of head and neck cancer; the study is not yet recrui…
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CLINICAL_TRIALS research · 2025-09-12Clinical Trial Update: Docetaxel/Pembrolizumab in Head and Neck Squamous Cell Carcinoma [Phase 2]
A Phase 2 trial evaluating the combination of docetaxel and pembrolizumab for head and neck squamous cell carcinoma is currently active but …
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CLINICAL_TRIALS research · 2025-09-11Clinical Trial Update: [18F]-AraG PET Imaging in LA HNSCC [EARLY_Phase 1]
This is an early-phase study evaluating [18F]-AraG PET imaging in locally advanced head and neck squamous cell carcinoma, currently not yet …
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CLINICAL_TRIALS research · 2025-09-11Clinical Trial Update: HPV-16 Vaccination and Pembrolizumab Plus Cisplatin for "Intermediate Risk" HPV-16-associated Head and Neck Squamous Cell Carcinoma [Phase 2]
A Phase 2 clinical trial update evaluating HPV-16 vaccination in combination with pembrolizumab and cisplatin for intermediate-risk HPV-16-a…
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CLINICAL_TRIALS research · 2025-09-10Clinical Trial Update: A Phase I/II Trial of HCB101 in Combination With Pembrolizumab for Patients With Platinum-Refractory, Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (SirH&N Trial) [Phase 1, Phase 2]
This clinical trial update concerns a Phase I/II study evaluating HCB101 in combination with pembrolizumab for platinum-refractory, recurren…
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CLINICAL_TRIALS trial_result · 2025-09-09Clinical Trial Update: Effectiveness of an Enhanced Tobacco Intervention Protocol Compared to Standard Treatment in Helping Head and Neck and Lung Cancer Patients Starting Treatment to Reduce Cigarette Use [NA]
Completed clinical trial evaluating an enhanced tobacco intervention protocol versus standard treatment to reduce cigarette use in patients …
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CLINICAL_TRIALS research · 2025-09-09Clinical Trial Update: A Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated CAR T, in Participants With Solid Tumors That Express EGFR and Have Lost HLA-A*02 Expression [Phase 1, Phase 2]
A2 Biotherapeutics is evaluating A2B395, an allogeneic logic-gated CAR T therapy, in Phase 1/2 trials for solid tumors expressing EGFR and l…
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CLINICAL_TRIALS research · 2025-09-09Clinical Trial Update: A Study of NX-1607 in Adults With Advanced Malignancies [Phase 1]
A Phase 1 study evaluating NX-1607 in adults with advanced malignancies is actively recruiting across multiple tumor types, including ovaria…
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CLINICAL_TRIALS research · 2025-09-05Clinical Trial Update: A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients With Solid Tumors [Phase 1]
Phase 1 first-in-human trial evaluating OKN4395 in combination with pembrolizumab in patients with solid tumors is currently recruiting. The…
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CLINICAL_TRIALS research · 2025-09-03Clinical Trial Update: PDO Based Drug Sensitive Test in R/M HNSCC
A recruiting clinical trial evaluating a patient-derived organoid–based drug sensitivity test for recurrent/metastatic head and neck squamou…
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CLINICAL_TRIALS trial_result · 2025-09-02Clinical Trial Update: Trial Evaluating Adapted Chemotherapy in Patients With Squamous Carcinoma [Phase 2]
A Phase 2 clinical trial evaluating adapted chemotherapy for head and neck squamous cell carcinoma has completed.
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CLINICAL_TRIALS research · 2025-09-02Clinical Trial Update: Stereotactic Radiotherapy Combined With Chemotherapy or Not for Treatment of Oligometastases in HNSCC [Phase 2]
Phase 2 clinical trial evaluating stereotactic radiotherapy with or without chemotherapy for oligometastatic head and neck squamous cell car…
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CLINICAL_TRIALS other · 2025-09-02Clinical Trial Update: Trial of Laryngeal Preservation Comparing Induced CT Followed by RT vs CT Concomitant to RT [Phase 3]
This is an update on a Phase 3 clinical trial comparing induction chemotherapy followed by radiotherapy versus radiotherapy with concurrent …
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CLINICAL_TRIALS research · 2025-08-29Clinical Trial Update: Predictive Biomarkers for PD-1 Inhibitor Response in Squamous Cell Carcinoma
This clinical trial update discusses predictive biomarkers for response to PD-1 inhibitors in squamous cell carcinomas, spanning esophageal,…
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CLINICAL_TRIALS research · 2025-08-29Clinical Trial Update: Influencing Factors for Physical Activity in People With Head and Neck Cancer
A completed clinical trial evaluating factors that influence physical activity in people with head and neck squamous cell carcinoma, focusin…
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CLINICAL_TRIALS research · 2025-08-29Clinical Trial Update: Tislelizumab Combined With Chemotherapy for Different Cycles of Neoadjuvant Therapy for Locally Advanced Resectable Squamous Cell Carcinoma of the Head and Neck (NeoTempo) [Phase 2]
Phase 2 trial evaluating tislelizumab combined with chemotherapy as neoadjuvant therapy for locally advanced, resectable head and neck squam…
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CLINICAL_TRIALS research · 2025-08-28Clinical Trial Update: Neoadjuvant Immunochemotherapy and Postoperative Adjuvant Immunotherapy for Head and Neck Squamous Cell Carcinoma Invading the Skull Base [Phase 2]
A Phase 2 clinical trial assessing neoadjuvant chemoimmunotherapy followed by postoperative adjuvant immunotherapy for head and neck squamou…
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CLINICAL_TRIALS research · 2025-08-27Clinical Trial Update: SYS6002 Plus JMT101 and Enlonstobart Injection in Participants With HNSCC [Phase 2]
A Phase 2 clinical trial evaluating the combination of SYS6002 with JMT101 and Enlonstobart Injection in participants with head and neck squ…
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CLINICAL_TRIALS trial_result · 2025-08-21Clinical Trial Update: Study of Cetuximab Plus/Minus Weekly Paclitaxel After Progression To First-Line Pembrolizumab Plus Platinum-5FU in Subjects With Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck. [Phase 2]
This Phase 2 trial investigates cetuximab with or without weekly paclitaxel in patients with recurrent/metastatic head and neck squamous cel…
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CLINICAL_TRIALS trial_result · 2025-08-20Clinical Trial Update: Study of Pembrolizumab Given Prior to Surgery and in Combination With Radiotherapy Given Post-surgery for Advanced Head and Neck Squamous Cell Carcinoma (MK-3475-689) [Phase 3]
This Phase 3 trial update covers pembrolizumab given before surgery and with post-surgical radiotherapy for advanced head and neck squamous …
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CLINICAL_TRIALS research · 2025-08-20Clinical Trial Update: Pembrolizumab in Combination With Low-dose PFas Neoadjuvant Treatment for Locally Advanced HNSCC [Phase 2]
A Phase 2 clinical trial evaluating pembrolizumab in combination with low-dose PFas neoadjuvant treatment for locally advanced head and neck…
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CLINICAL_TRIALS research · 2025-08-20Clinical Trial Update: Immune Response in Cervical Lymph Nodes of Patients With Head and Neck Cancer
This clinical trial update describes a study evaluating immune responses in cervical lymph nodes of patients with head and neck squamous cel…
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CLINICAL_TRIALS trial_result · 2025-08-17Clinical Trial Update: Pyrimethamine as an Inhibitor of NRF2 in HPV-unrelated Locally Advanced Head and Neck Squamous Cell Carcinoma [EARLY_Phase 1]
Completed early-phase 1 trial evaluating pyrimethamine as an NRF2 inhibitor in HPV-unrelated locally advanced head and neck squamous cell ca…
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CLINICAL_TRIALS research · 2025-08-17Clinical Trial Update: Study of Zanzalintinib (XL092) + Pembrolizumab vs Pembrolizumab in Subjects With PD-L1 Positive Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma [Phase 2, Phase 3]
Clinical trial update on a phase 2/3 study comparing Zanzalintinib (XL092) plus pembrolizumab to pembrolizumab alone in PD-L1-positive recur…