Head and Neck Squamous Cell Carcinoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS withdrawal · 2025-11-19Clinical Trial Update: Neoadjuvant Radiotherapy Plus Targeted Therapy and Immunotherapy vs. Targeted Therapy Plus Immunotherapy in Resectable HNSCC [Phase 2]
Phase 2 trial investigating neoadjuvant radiotherapy combined with targeted therapy and immunotherapy versus targeted therapy and immunother…
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CLINICAL_TRIALS trial_result · 2025-11-18Clinical Trial Update: Uniform FDG-PET Guided Gradient Dose Prescription to Reduce Late Radiation Toxicity [Phase 3]
Phase 3 clinical trial evaluating uniform FDG-PET guided gradient dose prescription to reduce late radiation toxicity in head and neck squam…
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CLINICAL_TRIALS research · 2025-11-17Clinical Trial Update: Study BT5528-100 in Patients With Advanced Solid Tumors Associated With EphA2 Expression [Phase 1, Phase 2]
Clinical trial update for BT5528-100 (Phase 1/2) in EphA2-expressing advanced solid tumors. The study includes urothelial carcinoma, ovarian…
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CLINICAL_TRIALS trial_result · 2025-11-17Clinical Trial Update: The BURAN Study of Buparlisib in Patients With Recurrent or Metastatic HNSCC [Phase 3]
Phase 3 BURAN study evaluating buparlisib in recurrent or metastatic head and neck squamous cell carcinoma has completed.
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CLINICAL_TRIALS research · 2025-11-10Clinical Trial Update: Selective Adjuvant Therapy for HPV-mediated Oropharynx SCCs Based on Residual Circulating Tumor DNA Levels (SAVAL) [Phase 2]
Phase 2 clinical trial evaluating adjuvant therapy tailored by residual circulating tumor DNA in patients with HPV-positive oropharyngeal sq…
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CLINICAL_TRIALS research · 2025-11-10Clinical Trial Update: Recombinant EphB4-HSA Fusion Protein With Standard Chemotherapy Regimens in Treating Patients With Advanced or Metastatic Solid Tumors [Phase 1]
Phase 1 trial evaluating a recombinant EphB4-HSA fusion protein in combination with standard chemotherapy for advanced or metastatic solid t…
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CLINICAL_TRIALS research · 2025-11-10Clinical Trial Update: CIMAvax Vaccine, Nivolumab, and Pembrolizumab in Treating Patients With Advanced Non-small Cell Lung Cancer or Squamous Head and Neck Cancer [Phase 1, Phase 2]
Phase 1/Phase 2 clinical trial update evaluating CIMAvax-EGF vaccine in combination with nivolumab and pembrolizumab for advanced or metasta…
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CLINICAL_TRIALS research · 2025-11-06Clinical Trial Update: Study of ARRY-614 Plus Either Nivolumab or Nivolumab+Ipilimumab [Phase 1, Phase 2]
Clinical trial update for ARRY-614 in combination with nivolumab or nivolumab plus ipilimumab (Phase 1/2) currently active and not recruitin…
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CLINICAL_TRIALS trial_result · 2025-11-04Clinical Trial Update: A Phase I/II Study of VLS-1488 in Subjects With Advanced Cancer [Phase 1, Phase 2]
Phase I/II study evaluating VLS-1488 in adults with advanced cancer; the trial is currently recruiting across multiple solid-tumor indicatio…
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CLINICAL_TRIALS research · 2025-10-24Clinical Trial Update: NBTXR3 Activated by Radiotherapy for Patients With Advanced Cancers Treated With An Anti-PD-1 Therapy [Phase 1]
A Phase 1 trial evaluating NBTXR3 activated by radiotherapy in combination with anti-PD-1 therapy for patients with advanced cancers; the st…
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CLINICAL_TRIALS trial_result · 2025-10-22Clinical Trial Update: Recombinant EphB4-HSA Fusion Protein and Pembrolizumab, MK-3475 [Phase 2]
Phase 2 trial evaluating the combination of recombinant EphB4-HSA fusion protein with pembrolizumab has completed and results are posted.
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CLINICAL_TRIALS trial_result · 2025-10-22Clinical Trial Update: Phase II Trial of Magrolimab and Cetuximab With Pembrolizumab or Docetaxel for Recurrent/Metastatic Head Neck Squamous Cell Carcinoma [Phase 2]
A Phase II trial evaluating magrolimab and cetuximab with either pembrolizumab or docetaxel for recurrent/metastatic head and neck squamous …
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CLINICAL_TRIALS research · 2025-10-22Clinical Trial Update: Olaparib in Combination With Pembrolizumab and Carboplatin as First-Line Treatment of Recurrent or Metastatic Head and Neck Squamous-Cell Carcinoma [Phase 2]
A Phase 2 clinical trial update evaluating a combination of Olaparib, Pembrolizumab, and Carboplatin as first-line therapy for recurrent or …
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CLINICAL_TRIALS research · 2025-10-22Clinical Trial Update: Comparing an Investigational Scan (F-18 NaF PET/CT) to Standard of Care Imaging (F-18 FDG PET/CT) for Evaluating Vascular Complications in Patients Receiving Radiation Therapy for Head and Neck Cancer [EARLY_Phase 1]
This early-phase 1 clinical trial compares an investigational F-18 NaF PET/CT imaging approach to standard F-18 FDG PET/CT for evaluating va…
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CLINICAL_TRIALS trial_result · 2025-10-22Clinical Trial Update: A Study of HFB301001 in Adult Patients With Advanced Solid Tumors [Phase 1]
The Phase 1 trial of HFB301001 in adults with advanced solid tumors has been terminated.
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CLINICAL_TRIALS trial_result · 2025-10-20Clinical Trial Update: A Phase II Study of ACR-368 and Low Dose Gemcitabine in R/M HNSCC [Phase 2]
A Phase II clinical trial evaluating ACR-368 in combination with low-dose gemcitabine for recurrent/metastatic head and neck squamous cell c…
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CLINICAL_TRIALS research · 2025-10-20Clinical Trial Update: A Study to Assess Safety, Tolerability and Imaging Characteristics of [68Ga]Ga-DPI-4452 and to Assess Safety, Tolerability, and Efficacy of [177Lu]Lu-DPI-4452 in Participants With Unresectable Locally Advanced or Metastatic Solid Tumors [Phase 1, Phase 2]
A Phase 1/2 clinical trial update describing safety, tolerability, and imaging with [68Ga]Ga-DPI-4452 and safety, tolerability, and efficacy…
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CLINICAL_TRIALS research · 2025-10-16Clinical Trial Update: Study of the Monoclonal Antibody IMT-009 in Patients With Advanced Solid Tumors or Lymphomas [Phase 1, Phase 2]
Clinical trial update describing a Phase 1/2 study of the monoclonal antibody IMT-009 in various advanced solid tumors and lymphomas, with t…
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CLINICAL_TRIALS research · 2025-10-16Clinical Trial Update: A Study of the Use of Fat Flap Reconstruction to Reduce Neck Injury After Cancer Treatment [NA]
This is a status update on a Memorial Sloan Kettering trial evaluating fat flap reconstruction to reduce neck injury after treatment for hea…
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CLINICAL_TRIALS research · 2025-10-15Clinical Trial Update: Decitabine and Nivolumab in Participants With Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck [Phase 1]
A Phase 1 clinical trial evaluating decitabine in combination with nivolumab for recurrent/metastatic head and neck squamous cell carcinoma;…
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CLINICAL_TRIALS research · 2025-10-15Clinical Trial Update: A Study of ASP-1929 Photoimmunotherapy in Combination With Pembrolizumab in First-line Treatment of Locoregional Recurrent Squamous Cell Carcinoma of the Head and Neck With No Distant Metastases [Phase 3]
Phase 3 study evaluating ASP-1929 photoimmunotherapy in combination with pembrolizumab as first-line treatment for locoregionally recurrent …
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CLINICAL_TRIALS trial_result · 2025-10-14Clinical Trial Update: Cisplatin + Radiation in SCCHN and Correlation With Oxidative Stress Markers [Phase 2]
Phase 2 study evaluating cisplatin with radiation in head and neck squamous cell carcinoma and examining its relationship with oxidative str…
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CLINICAL_TRIALS research · 2025-10-08Clinical Trial Update: A Clinical Study of Intratumoral MVR-T3011 (T3011) Given as a Single Agent and in Combination With Intravenous Pembrolizumab in Participants With Advanced or Metastatic Solid Tumors [Phase 1, Phase 2]
This clinical trial update describes a Phase 1/2 study of intratumoral MVR-T3011 given alone or with pembrolizumab in adults with advanced o…
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CLINICAL_TRIALS research · 2025-10-07Clinical Trial Update: Chemoradiation vs Immunotherapy and Radiation for Head and Neck Cancer [Phase 2]
Phase 2 clinical trial update comparing chemoradiation versus immunotherapy with radiation for head and neck squamous cell carcinoma; the st…
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CLINICAL_TRIALS trial_result · 2025-10-07Clinical Trial Update: A Study of Tislelizumab in Combination With Investigational Agents in Participants With Head and Neck Squamous Cell Carcinoma [Phase 2]
Phase 2 study of tislelizumab in combination with investigational agents for head and neck squamous cell carcinoma; the trial is currently a…