Graft-versus-host Disease
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2025-01-16Clinical Trial Update: Acalabrutinib in CLL and MCL Patients Subjected to Allogeneic Hematopoietic Stem Cell Transplantation (alloSCT) [Phase 2]
Phase 2 trial evaluating acalabrutinib in patients with chronic lymphocytic leukemia and mantle cell lymphoma after allogeneic stem cell tra…
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CLINICAL_TRIALS trial_result · 2025-01-07Clinical Trial Update: Adoptive Immunotherapy With Activated Marrow Infiltrating Lymphocytes and Cyclophosphamide Graft-Versus-Host Disease Prophylaxis in Patients With Relapse of Hematologic Malignancies After Allogeneic Hematopoietic Cell Transplantation [Phase 1]
Phase 1 trial update on adoptive immunotherapy using activated marrow-infiltrating lymphocytes with cyclophosphamide for GVHD prophylaxis in…
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CLINICAL_TRIALS withdrawal · 2025-01-07Clinical Trial Update: Extracorporeal Photopheresis and Mesenchymal Stem Cell Infusion for GVHD [Phase 2]
A Phase 2 trial evaluating extracorporeal photopheresis in combination with mesenchymal stem cell infusion for graft-versus-host disease has…
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FDA approval · 2024-12-30FDA Approved: REZUROCK — Supplemental Application (Kadmon Pharmaceuticals, LLC)
The FDA approved a supplemental NDA for REZUROCK (belumosudil) from Kadmon Pharmaceuticals, LLC.
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CLINICAL_TRIALS research · 2024-12-27Clinical Trial Update: Universal CNK-UT Therapy for Refractory aGVHD [Phase 1]
A Phase 1 clinical trial update for Universal CNK-UT Therapy targeting refractory acute graft-versus-host disease. The study is currently re…
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CLINICAL_TRIALS research · 2024-12-27Clinical Trial Update: Post-Transplant Cyclophosphamide, Bortezomib and Abatacept for the Prevention of Graft-versus-Host-Disease (GvHD) [Phase 1, Phase 2]
Phase 1/2 clinical trial evaluating post-transplant cyclophosphamide, bortezomib, and abatacept to prevent graft-versus-host disease is curr…
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CLINICAL_TRIALS research · 2024-12-27Clinical Trial Update: Oral Pooled Fecal Microbiotherapy to Prevent Allogeneic Hematopoietic Cell Transplantation Complications (PHOEBUS Trial) [Phase 2]
Phase 2 clinical trial update on oral pooled fecal microbiotherapy to prevent complications after allogeneic hematopoietic cell transplantat…
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CLINICAL_TRIALS research · 2024-12-20Clinical Trial Update: GvHD Prophylaxis in Unrelated Donor HCT: Randomized Trial Comparing PTCY Versus ATG [Phase 3]
Phase 3 randomized trial comparing post-transplant cyclophosphamide versus anti-thymocyte globulin for graft-versus-host disease prophylaxis…
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CLINICAL_TRIALS research · 2024-12-18Clinical Trial Update: Analysis of Intestinal Defensin Expression in Acute GVHD
A completed University of Freiburg trial analyzes intestinal defensin expression in acute graft-versus-host disease. The study also relates …
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CLINICAL_TRIALS research · 2024-12-16Clinical Trial Update: A Phase I-II Study of High-Dose Post-Transplant Cyclophosphamide, Bortezomib, and Abatacept for the Prevention of Graft-Versus-Host Disease (GVHD) Following Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) [Phase 1, Phase 2]
Phase 1/2 clinical trial evaluating high-dose post-transplant cyclophosphamide combined with bortezomib and abatacept to prevent graft-versu…
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CLINICAL_TRIALS trial_result · 2024-12-13Clinical Trial Update: Ibrutinib and Rituxan for Chronic GVHD [Phase 2]
Phase 2 trial of combination therapy with ibrutinib and rituximab for chronic graft-versus-host disease has been terminated with results pos…
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CLINICAL_TRIALS trial_result · 2024-12-12Clinical Trial Update: Efficacy and Safety of KD025 in Subjects With cGVHD After At Least 2 Prior Lines of Systemic Therapy [Phase 2]
Phase 2 trial evaluating KD025 for chronic graft-versus-host disease after at least two prior systemic therapies was terminated, with effica…
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CLINICAL_TRIALS research · 2024-12-12Clinical Trial Update: Decidua Stroma Cells for Steroid Resistent Acute Graft-versus-host Disease After Allo-HSCT [Phase 2]
A Phase 2 clinical trial evaluating decidua stromal cells for steroid-resistant acute graft-versus-host disease after allogeneic HSCT is cur…
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CLINICAL_TRIALS trial_result · 2024-12-10Clinical Trial Update: 18-FLT PET/MR Imaging to Predict Graft Failure and GVHD in Bone Marrow Transplant Patients [EARLY_Phase 1]
An early Phase 1 trial evaluates 18-FLT PET/MR imaging to predict graft failure and graft-versus-host disease in bone marrow transplant pati…
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CLINICAL_TRIALS trial_result · 2024-12-06Clinical Trial Update: Prevention of Severe Acute Graft-versus-host Disease in Adult Patients Using a daGOAT Model [Phase 2]
Phase 2 trial completed evaluating a daGOAT model for preventing severe acute graft-versus-host disease in adult transplant patients.
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CLINICAL_TRIALS research · 2024-12-04Clinical Trial Update: Cell Free DNA Profiling As a Tool to Monitor Clinically-Relevant Events in Allogeneic Hematopoietic Stem Cell Transplantation
A recruiting clinical trial from the University of Turin investigates cell-free DNA profiling as a tool to monitor clinically relevant event…
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CLINICAL_TRIALS trial_result · 2024-12-03Clinical Trial Update: Fecal Microbiota Transplantation With Ruxolitinib and Steroids as an Upfront Treatment of Severe Acute Intestinal GVHD [Phase 1, Phase 2]
A Phase 1/2 trial evaluating fecal microbiota transplantation with ruxolitinib and steroids as upfront treatment for severe acute intestinal…
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CLINICAL_TRIALS trial_result · 2024-11-27Clinical Trial Update: A Phase 1/2 Study to Evaluate Axatilimab in Participants With Active cGVHD [Phase 1, Phase 2]
Results from a Phase 1/2 study of Axatilimab in participants with active chronic graft-versus-host disease have been posted; the trial has c…
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CLINICAL_TRIALS research · 2024-11-27Clinical Trial Update: Tissue-resident Immune Cell Subsets in aGVHD
A clinical trial from Nanfang Hospital/Southern Medical University is investigating tissue-resident immune cell subsets in acute graft-versu…
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CLINICAL_TRIALS research · 2024-11-21Clinical Trial Update: MORPHEE : Mechanisms of Cell Death Induced by Extracorporeal Photochemotherapy [NA]
ClinicalTrials.gov entry MORPHEE investigates mechanisms of cell death induced by extracorporeal photochemotherapy, with conditions includin…
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CLINICAL_TRIALS research · 2024-11-20Clinical Trial Update: Posaconazole Tablet As Primary Prophylaxis of HSCT Patients with Gastrointestinal GVHD
A clinical trial is evaluating posaconazole tablets as primary prophylaxis against invasive fungal disease in hematopoietic stem cell transp…
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CLINICAL_TRIALS trial_result · 2024-11-13Clinical Trial Update: SHR0302 and Steroid As First Line Therapy for Chronic GVHD [EARLY_Phase 1]
An early-phase clinical trial evaluating SHR0302 with steroids as first-line therapy for chronic graft-versus-host disease has completed.
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CLINICAL_TRIALS trial_result · 2024-11-08Clinical Trial Update: Study of Pharmacokinetics, Activity and Safety of Ruxolitinib in Pediatric Patients With Grade II-IV Acute Graft vs. Host Disease [Phase 1, Phase 2]
Phase 1/2 study evaluating pharmacokinetics, activity, and safety of ruxolitinib in pediatric patients with Grade II-IV acute graft-versus-h…
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CLINICAL_TRIALS trial_result · 2024-11-06Clinical Trial Update: A Study of Itacitinib for the Treatment of Chronic Graft Versus Host Disease (cGVHD) [Phase 2]
A Phase 2 trial evaluating itacitinib for chronic graft-versus-host disease was terminated, with results posted in 2024.
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CLINICAL_TRIALS trial_result · 2024-11-06Clinical Trial Update: Prevention of Severe Acute Graft-versus-host Disease in Pediatric Patients Using a daGOAT Model [Phase 2]
Phase 2 clinical trial investigating prevention of severe acute graft-versus-host disease in pediatric transplant patients using a daGOAT mo…