Glioma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2025-11-24Clinical Trial Update: Nivolumab in Patients With IDH-Mutant Gliomas With and Without Hypermutator Phenotype [Phase 2]
A Phase 2 trial of nivolumab in IDH-mutant gliomas, with and without hypermutator phenotype, has results posted on ClinicalTrials.gov.
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CLINICAL_TRIALS research · 2025-11-24Clinical Trial Update: DETERMINE Trial Treatment Arm 03: Entrectinib in Adult, Paediatric and Teenage/Young Adult Patients With ROS1 Gene Fusion-Positive Cancers. [Phase 2, Phase 3]
This clinical trial update describes Arm 03 of the DETERMINE trial evaluating entrectinib in adults, pediatric, and teenage/young adult pati…
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CLINICAL_TRIALS research · 2025-11-24Clinical Trial Update: DETERMINE Trial Treatment Arm 06: Capmatinib in Adult Patients With Cancers Harbouring MET Dysregulations [Phase 2, Phase 3]
An ongoing DETERMINE trial (arm 06) investigates capmatinib for MET-dysregulated cancers, with Phase 2/3 testing and current recruitment.
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CLINICAL_TRIALS trial_result · 2025-11-24Clinical Trial Update: DETERMINE Trial Treatment Arm 05: Vemurafenib in Combination With Cobimetinib in Adult Patients With BRAF Positive Cancers. [Phase 2, Phase 3]
Phase 2/3 DETERMINE trial treatment arm 05 is evaluating the combination of vemurafenib and cobimetinib in adults with BRAF-positive cancers…
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CLINICAL_TRIALS research · 2025-11-20Clinical Trial Update: Safety and Feasibility of Preoperative and Intraoperative Image-Guided Resection of Gliomas [NA]
This clinical trial update reports on the safety and feasibility of preoperative and intraoperative image-guided resection of gliomas, spons…
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CLINICAL_TRIALS research · 2025-11-14Clinical Trial Update: Simultaneous Multinuclear Metabolic MRI in Newly Diagnosed or Recurrent Glioma [EARLY_Phase 1]
An early Phase 1 clinical trial evaluating simultaneous multinuclear metabolic MRI in patients with glioma, including newly diagnosed and re…
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CLINICAL_TRIALS research · 2025-11-10Clinical Trial Update: Developing a New Metabolic Imaging Approach (aMRI) for Evaluating Neurological Disease in Patients With Gliomas
This clinical trial update describes the development of a new metabolic imaging approach (aMRI) to evaluate neurological disease in patients…
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EMA approval · 2025-11-06EMA Authorised: Temodal (temozolomide) — Merck Sharp & Dohme B.V.
The EMA authorised Temodal (temozolomide) for glioma, with Merck Sharp & Dohme B.V. as the marketing authorisation holder; decision date 06/…
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CLINICAL_TRIALS research · 2025-11-04Clinical Trial Update: A Study of 177Lu-PSMA-617 in People With Gliomas [Phase 1]
A Phase 1 clinical trial is evaluating 177Lu-PSMA-617 in patients with gliomas and related subtypes and is currently recruiting.
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EMA approval · 2025-11-03EMA Authorised: Spexotras (trametinib dimethyl sulfoxide) — Novartis Europharm Limited
The European Medicines Agency authorised Spexotras (trametinib dimethyl sulfoxide) for glioma. The product carries orphan medicine designati…
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CLINICAL_TRIALS trial_result · 2025-11-03Clinical Trial Update: Nivolumab for Recurrent or Progressive IDH Mutant Gliomas [Phase 2]
Phase 2 trial of nivolumab for recurrent or progressive IDH-mutant gliomas has completed enrollment with results posted.
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CLINICAL_TRIALS other · 2025-10-28Clinical Trial Update: Assessment of Novel Metabolic Imaging Modalities as A Predictor Of Therapeutic EfficacyiIn Glioblastoma (GBM) [Phase 2]
A Phase 2 clinical trial investigating novel metabolic imaging modalities as predictors of therapeutic efficacy in glioblastoma has been sus…
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CLINICAL_TRIALS trial_result · 2025-10-24Clinical Trial Update: Infigratinib in Recurrent High-Grade Glioma Patients [EARLY_Phase 1]
Early-phase trial of infigratinib in patients with recurrent high-grade glioma, including glioblastoma, was terminated; results have been po…
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CLINICAL_TRIALS trial_result · 2025-10-21Clinical Trial Update: Solriamfetol in Improving Sleep in Patients With Grade II-IV Glioma [Phase 2]
A Phase 2 trial of solriamfetol for sleep improvement in patients with glioma (grade II–IV) including glioblastoma was terminated, with resu…
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CLINICAL_TRIALS research · 2025-10-21Clinical Trial Update: Residual IDH1-Mutant Tumor Cell Quantification Study [NA]
Clinical trial update for a study on quantifying residual IDH1-mutant tumor cells in glioma, sponsored by NYU Langone Health, currently not …
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CLINICAL_TRIALS trial_result · 2025-10-16Clinical Trial Update: Larotrectinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With NTRK Fusions (A Pediatric MATCH Treatment Trial) [Phase 2]
Phase 2 pediatric MATCH trial evaluating larotrectinib in patients with NTRK gene fusions has posted results; the study remains active but n…
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CLINICAL_TRIALS research · 2025-10-10Clinical Trial Update: Magnetic Resonance (MR) Imaging to Determine High Risk Areas in Patients With Malignant Gliomas and to Design Potential Radiation Plans and to Examine Metabolite Changes in Gliomas and Other Solid Tumors [NA]
ClinicalTrials.gov entry describing a Memorial Sloan Kettering Cancer Center study that uses MRI to identify high-risk areas in gliomas to g…
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CLINICAL_TRIALS research · 2025-10-06Clinical Trial Update: Chimeric Antigen Receptor (CAR) T Cells With a Chlorotoxin Tumor-Targeting Domain for the Treatment of MMP2+ Recurrent or Progressive Glioblastoma [Phase 1]
Phase 1 study of chlorotoxin-targeted CAR T cells targeting MMP2 in patients with recurrent glioblastoma and other recurrent gliomas. The tr…
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CLINICAL_TRIALS research · 2025-10-02Clinical Trial Update: Treatment of Patients With Recurrent High-Grade Glioma With APG-157 and Bevacizumab [Phase 1, Phase 2]
Clinical trial update for recurrent high-grade glioma treated with APG-157 in combination with bevacizumab, currently recruiting in Phase 1/…
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CLINICAL_TRIALS trial_result · 2025-10-02Clinical Trial Update: Pharmacoscopy for Patients With Refractory Primary Brain Tumors [Phase 2]
Phase 2 clinical trial update for pharmacoscopy in patients with refractory primary brain tumors, currently not yet recruiting.
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CLINICAL_TRIALS research · 2025-09-29Clinical Trial Update: A Study of GNC-039, a Tetra-specific Antibody, in Participants With Relapsed/Refractory or Metastatic Solid Tumors [Phase 1]
Phase 1 trial update for GNC-039, a tetra-specific antibody, in relapsed/refractory or metastatic solid tumors; currently recruiting.
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CLINICAL_TRIALS research · 2025-09-26Clinical Trial Update: Tumor Treating Fields for the Treatment of Brainstem Gliomas [NA]
An Emory University-sponsored clinical trial is enrolling participants to evaluate Tumor Treating Fields therapy for brainstem gliomas, a su…
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CLINICAL_TRIALS research · 2025-09-24Clinical Trial Update: Pilot Study of Mirtazapine for the Dual Tx of Depression and CINV in High-Grade Glioma Pts on TMZ [Phase 2]
Phase 2 pilot study evaluating mirtazapine for dual treatment of depression and chemotherapy-induced nausea and vomiting in patients with hi…
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CLINICAL_TRIALS research · 2025-09-23Clinical Trial Update: Evaluation of ex Vivo Drug Combination Optimization Platform in Recurrent High Grade Astrocytic Glioma [NA]
Clinical trial update evaluating an ex vivo drug combination optimization platform for recurrent high-grade astrocytic glioma, currently rec…
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CLINICAL_TRIALS research · 2025-09-23Clinical Trial Update: Memory Perception Assessment in Central/Non-central Nervous System Cancers [NA]
Clinical trial update on memory perception assessment in central and non-central nervous system cancers; the study includes glioblastoma and…