Glioblastoma
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CLINICAL_TRIALS trial_result · 2016-02-24Clinical Trial Update: Evaluation Of The Treatment Effectiveness Of Glioblastoma / Gliosarcoma Through The Suppression Of The PI3K/Akt Pathway In Compared With MK-3475 [Phase 1, Phase 2]
Phase 1/2 clinical trial evaluating suppression of the PI3K/Akt pathway in glioblastoma and gliosarcoma, compared with pembrolizumab (MK-347…
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CLINICAL_TRIALS withdrawal · 2016-02-22Clinical Trial Update: Combining Radiotherapy and Temozolomide With Dichloroacetate in Patients With Newly Diagnosed Glioblastoma [Phase 1]
Phase 1 trial of radiotherapy and temozolomide with dichloroacetate for newly diagnosed glioblastoma has been withdrawn.
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CLINICAL_TRIALS withdrawal · 2016-02-15Clinical Trial Update: EGFRBi-Armed Autologous T Cells in Treating Patients With Recurrent or Refractory Glioblastoma [Phase 1, Phase 2]
A Phase 1/Phase 2 trial evaluating EGFRBi-armed autologous T cells for adult brain glioblastoma and gliosarcoma has been withdrawn.
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CLINICAL_TRIALS trial_result · 2016-01-29Clinical Trial Update: Comparison of Different Methods to Test MGMT Status in Glioblastoma Patients
This update reports results from a completed clinical trial comparing different methods to test MGMT status in glioblastoma patients.
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CLINICAL_TRIALS research · 2016-01-26Clinical Trial Update: Trial of Hypofractionated Intensity Modulated Radiation Therapy With Temozolomide and Granulocyte-macrophage Colony-stimulating Factor for Patients With Newly Diagnosed Glioblastoma Multiforme [Phase 2]
A Phase 2 clinical trial at Zhejiang Cancer Hospital is evaluating hypofractionated IMRT with temozolomide and GM-CSF for newly diagnosed gl…
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CLINICAL_TRIALS research · 2016-01-21Clinical Trial Update: A Explore Study of Bevacizumab Combined With Conventional Therapy in Glioblastoma [NA]
This is an update on a glioblastoma clinical trial evaluating bevacizumab combined with conventional therapy; the study's phase and status a…
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CLINICAL_TRIALS trial_result · 2016-01-20Clinical Trial Update: Everolimus and Gefitinib in Treating Patients With Progressive Glioblastoma Multiforme or Progressive Metastatic Prostate Cancer [Phase 1, Phase 2]
A phase 1/2 trial assessed the combination of everolimus with gefitinib in patients with progressive glioblastoma and progressive metastatic…
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CLINICAL_TRIALS trial_result · 2015-12-10Clinical Trial Update: AMG 102 and Avastin for Recurrent Malignant Glioma [Phase 2]
Phase 2 trial results for AMG 102 in combination with Avastin (bevacizumab) for recurrent malignant glioma have been posted. The study inclu…
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CLINICAL_TRIALS trial_result · 2015-12-10Clinical Trial Update: Memantine for Recurrent Glioblastoma [Phase 2]
A Phase 2 trial of memantine for recurrent glioblastoma was terminated; results were posted in 2015.
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CLINICAL_TRIALS research · 2015-12-07Clinical Trial Update: The Effect of Escitalopram on Mood, Quality of Life and Cognitive Functioning in Glioblastoma Patients [Phase 2, Phase 3]
This document discusses a clinical trial evaluating escitalopram for mood, quality of life, and cognitive function in glioblastoma patients.…
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CLINICAL_TRIALS trial_result · 2015-12-03Clinical Trial Update: The Effect of Duloxetine on Mood, Quality of Life and Cognitive Functioning in Glioblastoma Patients [Phase 3]
A Phase 3 trial assessed duloxetine for mood, quality of life, and cognitive functioning in glioblastoma patients; the study has been termin…
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CLINICAL_TRIALS trial_result · 2015-11-20Clinical Trial Update: A Study of Avastin (Bevacizumab) and Irinotecan Versus Temozolomide Radiochemistry in Patients With Glioblastoma [Phase 2]
Phase 2 clinical trial comparing Avastin (bevacizumab) with irinotecan versus temozolomide-based radiochemotherapy in patients with glioblas…
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CLINICAL_TRIALS trial_result · 2015-11-17Clinical Trial Update: Computer Planned Radiation Therapy Plus Chemotherapy in Treating Patients With Glioblastoma Multiforme [Phase 1, Phase 2]
This clinical trial update reports on a Phase 1/2 study evaluating computer-planned radiation therapy combined with chemotherapy for gliobla…
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CLINICAL_TRIALS trial_result · 2015-11-10Clinical Trial Update: Preoperative Chemoradiation for Glioblastoma [Phase 1]
Phase 1 results from a preoperative chemoradiation trial for glioblastoma have completed. The update summarizes the study's safety and feasi…
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CLINICAL_TRIALS withdrawal · 2015-11-06Clinical Trial Update: Phase II Sorafenib With Radiation and Temozolomide in Newly Diagnosed Glioblastoma or Gliosarcoma [Phase 2]
A Phase II trial evaluating sorafenib with radiation and temozolomide for newly diagnosed glioblastoma or gliosarcoma was withdrawn.
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CLINICAL_TRIALS trial_result · 2015-10-29Clinical Trial Update: Ph II SAHA and Bevacizumab for Recurrent Malignant Glioma Patients [Phase 2]
Phase II trial evaluating vorinostat (SAHA) in combination with bevacizumab for recurrent malignant glioma, including glioblastoma. The stud…
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CLINICAL_TRIALS research · 2015-10-23Clinical Trial Update: Pilot Viability of 11C-MET-PET as a Post-surgery Baseline Scan in High-grade Gliomas
An update on a pilot study evaluating 11C-MET-PET as a post-surgery baseline imaging tool for high-grade gliomas, including glioblastoma.
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CLINICAL_TRIALS trial_result · 2015-10-20Clinical Trial Update: Safe Study of Dendritic Cell (DC) Based Therapy Targeting Tumor Stem Cells in Glioblastoma [Phase 1, Phase 2]
The completed Phase 1/2 clinical trial evaluated a dendritic cell–based therapy targeting tumor stem cells in glioblastoma, focusing on safe…
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CLINICAL_TRIALS trial_result · 2015-10-14Clinical Trial Update: Vaccine Therapy, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme [Phase 1]
A Phase 1 trial evaluating a vaccine therapy in combination with temozolomide and radiation for newly diagnosed glioblastoma multiforme has …
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CLINICAL_TRIALS trial_result · 2015-10-02Clinical Trial Update: VEGF Trap in Treating Patients With Recurrent Malignant Gliomas That Did Not Respond to Temozolomide [Phase 2]
Phase 2 trial evaluating aflibercept (VEGF Trap) for recurrent malignant gliomas unresponsive to temozolomide has completed; results were po…
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CLINICAL_TRIALS trial_result · 2015-09-29Clinical Trial Update: RO4929097, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Malignant Glioma [Phase 1]
This Phase 1 trial assessed RO4929097 in combination with temozolomide and radiation therapy for newly diagnosed malignant glioma and has co…
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CLINICAL_TRIALS research · 2015-09-22Clinical Trial Update: Study of the Safety and Efficacy of Dichloroacetate (DCA) in Glioblastoma and Other Recurrent Brain Tumors [Phase 1]
This entry notes completion of a Phase 1 study evaluating dichloroacetate (DCA) for glioblastoma and other recurrent brain tumors.
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FDA approval · 2015-09-18FDA Approved: TEMODAR — Supplemental Application (Merck Sharp & Dohme LLC)
The FDA approved a supplemental application for TEMODAR (temozolomide) submitted by Merck Sharp & Dohme LLC.
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CLINICAL_TRIALS trial_result · 2015-09-09Clinical Trial Update: Imaging Trial With I-124-CLR1404 in Patients With Newly Diagnosed or Recurrent Glioblastoma [Phase 2]
A Phase 2 imaging trial of the radiopharmaceutical I-124-CLR1404 for glioblastoma was terminated.
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CLINICAL_TRIALS trial_result · 2015-08-26Clinical Trial Update: Neo-adjuvant Treatment With Temozolomide and Bevacizumab Previous to Temozolomide Plus Radiation Plus Bevacizumab Therapy in Unresectable Glioblastoma [Phase 2]
Phase 2 trial assessing neoadjuvant temozolomide and bevacizumab before temozolomide plus radiation and bevacizumab in patients with unresec…