Glioblastoma
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CLINICAL_TRIALS research · 2026-04-03Clinical Trial Update: Testing the Addition of the Chemotherapy Drug Lomustine (Gleostine) to the Usual Treatment (Temozolomide and Radiation Therapy) for Newly Diagnosed MGMT Methylated Glioblastoma [Phase 3]
A Phase 3 trial is evaluating adding lomustine to standard temozolomide and radiation therapy for newly diagnosed MGMT-methylated glioblasto…
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CLINICAL_TRIALS research · 2026-04-03Clinical Trial Update: DSC-MRI in Measuring rCBV for Early Response to Bevacizumab in Patients With Recurrent Glioblastoma [NA]
This clinical trial update discusses the use of DSC-MRI derived rCBV to measure early response to bevacizumab in patients with recurrent gli…
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CLINICAL_TRIALS research · 2026-04-03Clinical Trial Update: Identifying Findings on Brain Scans That Could Help Make Better Predictions About Brain Cancer Progression, The GABLE Trial [Phase 2]
A Phase 2 clinical trial named GABLE is investigating imaging findings that could help predict progression in glioblastoma, IDH-wildtype, an…
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CLINICAL_TRIALS trial_result · 2026-04-02Clinical Trial Update: Pediatric Long-Term Follow-up and Rollover Study [Phase 4]
Pediatric long-term follow-up and rollover study (Phase 4) sponsored by Novartis is active but not recruiting, tracking outcomes in children…
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CLINICAL_TRIALS research · 2026-04-02Clinical Trial Update: The Feasibility and Efficacy of Dose Timing (Morning vs Evening) of Temozolomide in the Treatment of Glioblastoma [NA]
This clinical trial will assess whether administering temozolomide in the morning versus the evening is feasible and potentially more effect…
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CLINICAL_TRIALS research · 2026-04-01Clinical Trial Update: A Study Comparing Niraparib With Temozolomide in Adult Participants With Newly-diagnosed, MGMT Unmethylated Glioblastoma [Phase 3]
This entry describes an ongoing Phase 3 clinical trial comparing niraparib to temozolomide in adults with newly diagnosed MGMT unmethylated …
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CLINICAL_TRIALS trial_result · 2026-03-31Clinical Trial Update: Phase 1 Open-label Study of 123I-ATT001 in Subjects With Relapsed Glioblastoma [Phase 1]
A Phase 1 open-label study evaluating the radiopharmaceutical 123I-ATT001 in relapsed glioblastoma has completed.
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CLINICAL_TRIALS research · 2026-03-31Clinical Trial Update: Targeted Pediatric High-Grade Glioma Therapy
A pediatric clinical trial is currently recruiting to evaluate a targeted therapy for high-grade gliomas, including diffuse intrinsic pontin…
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CLINICAL_TRIALS research · 2026-03-31Clinical Trial Update: Azeliragon in MGMT Unmethylated Glioblastoma [Phase 2]
Phase 2 clinical trial update for Azeliragon in MGMT unmethylated glioblastoma. The study is currently listed as active but not recruiting.
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CLINICAL_TRIALS trial_result · 2026-03-30Clinical Trial Update: Pivotal, Randomized, Open-label Study of Optune® (Tumor Treating Fields) Concomitant With RT & TMZ for the Treatment of Newly Diagnosed GBM [NA]
This update reports the completion of a pivotal randomized study evaluating Optune Tumor Treating Fields in combination with radiotherapy an…
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CLINICAL_TRIALS trial_result · 2026-03-30Clinical Trial Update: NovoTTF Treatment Signatures in Glioblastoma Patients at Autopsy
A completed clinical study evaluating signatures of Tumor Treating Fields therapy (NovoTTF-100A System) in glioblastoma patients, with autop…
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CLINICAL_TRIALS trial_result · 2026-03-30Clinical Trial Update: Study of ABBV-637 or ABBV-155 With ERAS-801 for People With Glioblastoma [Phase 1]
Phase 1 trial evaluating ABBV-637 or ABBV-155 in combination with ERAS-801 for glioblastoma and gliosarcoma is currently recruiting.
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CLINICAL_TRIALS research · 2026-03-30Clinical Trial Update: A Phase Ib/II Clinical Trial to Evaluate the Safety and Efficacy of JL15003 Injection in Patients With Recurrent Glioblastoma (rGBM) [Phase 1, Phase 2]
This clinical trial update describes a Phase Ib/II study of JL15003 injection for recurrent glioblastoma and notes that the study is current…
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CLINICAL_TRIALS research · 2026-03-30Clinical Trial Update: A Phase 1b/2a Study to Evaluate the Safety, Pharmacokinetics, and Objective Response of STAR-001 (LP-184) in Combination With Spironolactone in Supratentorial Glioblastoma at First Progression [Phase 1, Phase 2]
This clinical trial update describes a Phase 1b/2a study evaluating STAR-001 (LP-184) in combination with spironolactone for supratentorial …
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CLINICAL_TRIALS research · 2026-03-30Clinical Trial Update: Sacituzumab Govitecan in Recurrent Glioblastoma [Phase 2]
A Phase 2 clinical trial evaluating sacituzumab govitecan for recurrent glioblastoma is currently recruiting.
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CLINICAL_TRIALS research · 2026-03-30Clinical Trial Update: HSV-tk + Valacyclovir + SBRT + Chemotherapy for Recurrent GBM [Phase 1, Phase 2]
A Phase 1/2 clinical trial update evaluating HSV-tk gene therapy with valacyclovir and SBRT plus chemotherapy for recurrent glioblastoma and…
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CLINICAL_TRIALS trial_result · 2026-03-30Clinical Trial Update: Use of Fluorescence in Gliomas
A clinical trial evaluating fluorescence-guided techniques in glioma surgery has completed, including participants with glioblastoma and oth…
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CLINICAL_TRIALS research · 2026-03-30Clinical Trial Update: HSV-tk and XRT and Chemotherapy for Newly Diagnosed GBM [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating HSV-tk gene therapy in combination with radiotherapy and chemotherapy for newly diagnosed glioblastoma…
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CLINICAL_TRIALS other · 2026-03-30Clinical Trial Update: Treatment Intensification With Temozolomide in Adults With a Glioblastoma [Phase 3]
A Phase 3 clinical trial assesses intensified temozolomide therapy in adults with glioblastoma; sponsored by Centre Oscar Lambret, currently…
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CLINICAL_TRIALS other · 2026-03-30Clinical Trial Update: WSD0922-FU for the Treatment of Glioblastoma, Anaplastic Astrocytoma, or Non-small Cell Lung Cancer With Central Nervous System Metastases [Phase 1]
Phase 1 clinical trial update for WSD0922-FU evaluating safety and preliminary activity in glioblastoma, anaplastic astrocytoma, and non-sma…
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CLINICAL_TRIALS trial_result · 2026-03-27Clinical Trial Update: Hyperpolarized Carbon-13 (13C) Pyruvate Imaging in Patients With Glioblastoma [Phase 1]
Phase 1 trial of hyperpolarized carbon-13 pyruvate imaging in glioblastoma patients has completed, evaluating this metabolic imaging approac…
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CLINICAL_TRIALS trial_result · 2026-03-27Clinical Trial Update: Immunotherapy With Autologous Tumor Lysate-Loaded Dendritic Cells In Patients With Newly Diagnosed Glioblastoma Multiforme [Phase 1, Phase 2]
A Phase 1/2 trial evaluating an autologous tumor lysate-loaded dendritic cell vaccine in patients with newly diagnosed glioblastoma has comp…
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: A Feasibility Study to Evaluate the Safety of the TheraSphere Glioblastoma (GBM) Device in Patients With Recurrent GBM [Phase 1]
A Phase 1 feasibility trial is evaluating the safety of the TheraSphere Glioblastoma Device in patients with recurrent glioblastoma; the stu…
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: Multiple Intracerebral Doses of Neural Stem Cell-Based Virotherapy (NSC-CRAd-S-pk7) for the Treatment of Recurrent High-Grade Gliomas [Phase 1]
A Phase 1 study of multiple intracerebral doses of NSC-CRAd-S-pk7 for recurrent high-grade gliomas (glioblastoma) is currently suspended.
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CLINICAL_TRIALS research · 2026-03-27Clinical Trial Update: Comparison of Skin Closure Techniques in Oncological Neurosurgical Procedures: Intradermal Running Suture Versus Transdermal Interrupted Sutures [NA]
This clinical trial compares intradermal running sutures with transdermal interrupted sutures for skin closure in oncologic neurosurgical pr…