Glioblastoma
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CLINICAL_TRIALS other · 2025-11-20Clinical Trial Update: Evaluation of Image Quality and Safety of the MyVeo Surgical Visualization Headset During Standard Neurosurgical and Reconstructive Procedures Using Compatible Microscopes.
Clinical trial update evaluating the image quality and safety of the MyVeo Surgical Visualization Headset in neurosurgical and reconstructiv…
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CLINICAL_TRIALS research · 2025-11-19Clinical Trial Update: Correlative Analysis Between Magnetic Resonance Spectroscopy (MRS) and Essential Clinicobiological Data in Glioblatoma Multiforme (GBM) [NA]
A clinical trial update describing a correlative study that analyzes magnetic resonance spectroscopy data alongside clinicobiological data i…
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CLINICAL_TRIALS trial_result · 2025-11-19Clinical Trial Update: Phase I Pilot Study to Evaluate the Anti-glioblastoma Effect of S-Gboxin in Standard Treatment of Glioblastoma/Diffuse Midline Glioma and Response to Treatment (Regardless of Mutation Status) [Phase 1]
A Phase I pilot study evaluating S-Gboxin in combination with standard glioblastoma therapy; the trial assessing anti-glioblastoma effects i…
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CLINICAL_TRIALS research · 2025-11-18Clinical Trial Update: B7H3/IL13Ra2 Bispecific Armored Chimeric Antigen Receptor T-Cell Therapy Study for Recurrent/Refractory Glioblastoma [Phase 1]
A Phase 1 study is investigating a B7H3/IL13Ra2 bispecific armored CAR T-cell therapy for recurrent or refractory glioblastoma. The trial is…
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CLINICAL_TRIALS trial_result · 2025-11-17Clinical Trial Update: Efficacy and Safety of Pembrolizumab (MK-3475) Plus Lenvatinib (E7080/MK-7902) in Previously Treated Participants With Select Solid Tumors (MK-7902-005/E7080-G000-224/LEAP-005) [Phase 2]
Phase 2 trial evaluating pembrolizumab plus lenvatinib in previously treated patients with select solid tumors; results on efficacy and safe…
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CLINICAL_TRIALS trial_result · 2025-11-13Clinical Trial Update: Testing the Ability of AMG 232 (KRT 232) to Get Into the Tumor in Patients With Brain Cancer [Phase 1]
A Phase 1 clinical trial of AMG 232 (KRT-232) in patients with brain cancers including glioblastoma and gliosarcoma was terminated; the stud…
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CLINICAL_TRIALS research · 2025-11-12Clinical Trial Update: Neoadjuvant Chemoradiotherapy With or Without Concurrent Azeliragon in Patients With Newly Diagnosed Glioblastoma [EARLY_Phase 1]
An early-phase trial evaluates neoadjuvant chemoradiotherapy with or without concurrent azeliragon in newly diagnosed glioblastoma. The stud…
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CLINICAL_TRIALS trial_result · 2025-11-12Clinical Trial Update: A Study of Cobolimab Plus Dostarlimab in Pediatric and Young Adult Participants With Cancer [Phase 1, Phase 2]
This document details an ongoing Phase 1/2 clinical trial evaluating cobolimab in combination with dostarlimab in pediatric and young adult …
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CLINICAL_TRIALS research · 2025-11-12Clinical Trial Update: Longitudinal Assessment of Marrow and Blood in Patients With Glioblastoma
The clinical trial examining marrow and blood changes in glioblastoma patients is currently suspended.
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CLINICAL_TRIALS trial_result · 2025-11-10Clinical Trial Update: Neoadjuvant Chemoradiation for Resectable Glioblastoma [Phase 2]
A Phase 2 trial evaluating neoadjuvant chemoradiation for resectable glioblastoma was terminated, with results posted.
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CLINICAL_TRIALS research · 2025-11-10Clinical Trial Update: Vigilant ObservatIon of GlIadeL WAfer ImplaNT Registry
Completed registry update for Vigilant Observation of Gliadel Wafer Implant Registry documenting the study status and findings to date.
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CLINICAL_TRIALS research · 2025-11-10Clinical Trial Update: Magnetic Resonance Imaging for Improving Knowledge of Brain Tumor Biology in Patients With Resectable Glioblastoma [NA]
This clinical trial update describes a study using magnetic resonance imaging to improve understanding of brain tumor biology in patients wi…
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CLINICAL_TRIALS research · 2025-11-10Clinical Trial Update: INdividualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT) [Phase 2]
INSIGhT is a Phase 2 clinical trial investigating individualized screening of innovative therapies for glioblastoma; recruitment is currentl…
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EMA approval · 2025-11-06EMA Authorised: Temodal (temozolomide) — Merck Sharp & Dohme B.V.
The EMA authorised Temodal (temozolomide) for glioma, with Merck Sharp & Dohme B.V. as the marketing authorisation holder; decision date 06/…
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CLINICAL_TRIALS research · 2025-11-03Clinical Trial Update: Oral Gallium Maltolate for the Treatment of Relapsed and Refractory Glioblastoma [Phase 1]
Phase 1 trial evaluating oral gallium maltolate for relapsed and refractory glioblastoma; the study is currently not recruiting.
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CLINICAL_TRIALS research · 2025-11-03Clinical Trial Update: BRiTE - Bispecific T Cell Engager for Patients With Glioblastoma [Phase 1]
Phase 1 clinical trial update for BRiTE, a bispecific T cell engager, being studied in glioblastoma.
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CLINICAL_TRIALS research · 2025-10-31Clinical Trial Update: ETAPA I: Peptide-based Tumor Associated Antigen Vaccine in GBM [Phase 1]
Phase 1 clinical trial evaluating a peptide-based tumor-associated antigen vaccine for glioblastoma, a malignant glioma. The study is curren…
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CLINICAL_TRIALS research · 2025-10-29Clinical Trial Update: Anti-GARP Chimeric Antigen Receptor T Cell Therapy for the Treatment of Recurrent Grade III or IV Gliomas [Phase 1]
Phase 1 trial update for an Anti-GARP CAR-T cell therapy targeting recurrent Grade 2-4 gliomas (including glioblastoma), currently recruitin…
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CLINICAL_TRIALS research · 2025-10-29Clinical Trial Update: Peposertib and Radiation Therapy, Followed by Temozolomide for the Treatment of Patients With Newly Diagnosed MGMT Unmethylated Glioblastoma or Gliosarcoma [Phase 1]
Phase 1 trial evaluating peposertib with radiation therapy followed by temozolomide for newly diagnosed MGMT unmethylated glioblastoma or gl…
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CLINICAL_TRIALS other · 2025-10-28Clinical Trial Update: Assessment of Novel Metabolic Imaging Modalities as A Predictor Of Therapeutic EfficacyiIn Glioblastoma (GBM) [Phase 2]
A Phase 2 clinical trial investigating novel metabolic imaging modalities as predictors of therapeutic efficacy in glioblastoma has been sus…
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CLINICAL_TRIALS trial_result · 2025-10-24Clinical Trial Update: Infigratinib in Recurrent High-Grade Glioma Patients [EARLY_Phase 1]
Early-phase trial of infigratinib in patients with recurrent high-grade glioma, including glioblastoma, was terminated; results have been po…
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CLINICAL_TRIALS trial_result · 2025-10-22Clinical Trial Update: ASP8374 + Cemiplimab in Recurrent Glioma [Phase 1]
Phase 1 trial evaluating ASP8374 in combination with cemiplimab for recurrent glioblastoma has completed.
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CLINICAL_TRIALS withdrawal · 2025-10-22Clinical Trial Update: Activated Autologous T Cells Against Glioma Cancer Stem Cell Antigens for Patients With Recurrent Glioblastoma [Phase 1]
This clinical trial update indicates the phase I study of activated autologous T cells targeting glioma cancer stem cell antigens in patient…
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CLINICAL_TRIALS trial_result · 2025-10-21Clinical Trial Update: Solriamfetol in Improving Sleep in Patients With Grade II-IV Glioma [Phase 2]
A Phase 2 trial of solriamfetol for sleep improvement in patients with glioma (grade II–IV) including glioblastoma was terminated, with resu…
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CLINICAL_TRIALS research · 2025-10-21Clinical Trial Update: NG101m Adjuvant Therapy in Glioblastoma Patients [Phase 1, Phase 2]
A Phase 1/2 clinical trial of NG101m as adjuvant therapy for glioblastoma is listed as not yet recruiting.