Glioblastoma
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CLINICAL_TRIALS research · 2025-12-16Clinical Trial Update: Vortioxetine for Newly Diagnosed Glioblastoma [Phase 2]
A Phase 2 clinical trial update from the University of Zurich investigates vortioxetine for newly diagnosed glioblastoma and is not yet recr…
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CLINICAL_TRIALS trial_result · 2025-12-15Clinical Trial Update: Identification of Treatment Concentrations of Defactinib or VS-6766 for the Treatment of Patients With Glioblastoma [EARLY_Phase 1]
An early-phase 1 clinical trial at Emory University is identifying treatment concentrations for Defactinib and VS-6766 in patients with glio…
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CLINICAL_TRIALS research · 2025-12-15Clinical Trial Update: Tofacitinib in Recurrent GBM Patients [Phase 3]
Phase 3 clinical trial update for tofacitinib in recurrent glioblastoma; the study is active but not recruiting.
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CLINICAL_TRIALS research · 2025-12-12Clinical Trial Update: Different Approaches for CART-EGFR-IL13Ra2 Dosing in Recurrent GBM [Phase 1]
Provides an update on dosing strategies being explored in a Phase 1 trial of CART-EGFR-IL13Ra2 for recurrent glioblastoma, which is currentl…
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CLINICAL_TRIALS trial_result · 2025-12-10Clinical Trial Update: Study of Tinostamustine for Adjuvant Treatment of Glioblastoma [EARLY_Phase 1]
Completed EARLY Phase 1 clinical trial investigating tinostamustine as adjuvant treatment for glioblastoma.
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CLINICAL_TRIALS trial_result · 2025-12-10Clinical Trial Update: Safety And Effectiveness Of NaviFUS System With Bevacizumab In Recurrent Glioblastoma [NA]
This clinical trial update describes a study of the NaviFUS System combined with bevacizumab for recurrent glioblastoma, focusing on safety …
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CLINICAL_TRIALS trial_result · 2025-12-10Clinical Trial Update: OKN-007 in Combination With Adjuvant Temozolomide Chemoradiotherapy for Newly Diagnosed Glioblastoma [Phase 1]
An update on a Phase 1 trial evaluating OKN-007 in combination with adjuvant temozolomide chemoradiotherapy for newly diagnosed glioblastoma…
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CLINICAL_TRIALS research · 2025-12-10Clinical Trial Update: Assessment of Early Post-operative Nuclear Imaging in Neurosurgery: a Safety and Feasibility Study in Patients Operated for Glioblastoma [NA]
Clinical trial update describing a safety and feasibility study of early post-operative nuclear imaging in glioblastoma patients; recruitmen…
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CLINICAL_TRIALS research · 2025-12-09Clinical Trial Update: Phase 1/2 Study of Silevertinib (BDTX-1535) in Patients With Glioblastoma or Non-Small Cell Lung Cancer With EGFR Mutations [Phase 1, Phase 2]
Phase 1/2 study of Silevertinib (BDTX-1535) in glioblastoma and EGFR-mutant non-small cell lung cancer is currently active but not recruitin…
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CLINICAL_TRIALS research · 2025-12-08Clinical Trial Update: Treatment of Relapsed/Refractory Intracranial Glioma in Patients Under 22 Years of Age [Phase 1, Phase 2]
A Phase 1/2 clinical trial update for relapsed/refractory intracranial glioma in patients under 22 years, currently recruiting.
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CLINICAL_TRIALS trial_result · 2025-12-05Clinical Trial Update: Dose Finding for Intraoperative Photodynamic Therapy of Glioblastoma [Phase 2]
Phase 2 dose-finding study evaluating intraoperative photodynamic therapy for glioblastoma has completed.
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CLINICAL_TRIALS research · 2025-12-04Clinical Trial Update: Phase I/IIa Study of Concomitant Radiotherapy With Olaparib and Temozolomide in Unresectable High Grade Gliomas Patients [Phase 1, Phase 2]
A Phase I/IIa clinical trial is evaluating the safety and feasibility of combining radiotherapy with olaparib and temozolomide in unresectab…
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CLINICAL_TRIALS research · 2025-12-03Clinical Trial Update: A Safety Study of Pharmacologic Ascorbate and Ferumoxytol in Addition to Standard of Care Chemoradiation in Glioblastoma [Phase 1]
Phase 1 safety study evaluating pharmacologic ascorbate and ferumoxytol in addition to standard-of-care chemoradiation for glioblastoma.
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CLINICAL_TRIALS research · 2025-12-02Clinical Trial Update: Silibinin in Association With Concomitant Chemoradiotherapy and Maintenance Temozolomide in STAT3 Positive IDH Wild-type, Newly Diagnosed Glioblastoma Patients [NA]
This clinical trial is evaluating silibinin in combination with concomitant chemoradiotherapy and maintenance temozolomide for newly diagnos…
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CLINICAL_TRIALS trial_result · 2025-11-28Clinical Trial Update: First-in-Human, Phase 1b/2a Trial of a Multipeptide Therapeutic Vaccine in Patients With Progressive Glioblastoma [Phase 1, Phase 2]
The document reports completion of a first-in-human Phase 1b/2a trial of a multipeptide therapeutic vaccine for progressive glioblastoma, wi…
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CLINICAL_TRIALS research · 2025-11-28Clinical Trial Update: Multitracer [18F]Fluciclovine and 18F-FDG PET, and Advanced MRI for Metabolic Profiling of Glioblastoma [EARLY_Phase 1]
Early-phase, multi-tracer PET imaging study combining [18F]Fluciclovine and 18F-FDG PET with advanced MRI for metabolic profiling in gliobla…
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CLINICAL_TRIALS trial_result · 2025-11-26Clinical Trial Update: Multi-kinase Inhibitor TG02 (TG02) in Elderly Newly Diagnosed or Adult Relapsed Patients With Anaplastic Astrocytoma or Glioblastoma. [Phase 1]
Phase 1 trial of the multi-kinase inhibitor TG02 in elderly newly diagnosed or adult relapsed patients with anaplastic astrocytoma or gliobl…
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CLINICAL_TRIALS trial_result · 2025-11-24Clinical Trial Update: Nivolumab in Patients With IDH-Mutant Gliomas With and Without Hypermutator Phenotype [Phase 2]
A Phase 2 trial of nivolumab in IDH-mutant gliomas, with and without hypermutator phenotype, has results posted on ClinicalTrials.gov.
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CLINICAL_TRIALS trial_result · 2025-11-24Clinical Trial Update: A Study in Recurrent Glioblastoma (GB) [Phase 2]
Phase 2 results from a Lilly-sponsored study in recurrent glioblastoma have been posted.
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CLINICAL_TRIALS trial_result · 2025-11-24Clinical Trial Update: Safety and Preliminary Efficacy of a Metabolically Armed Chimeric Antigen Receptor T Cell Therapy Targeting EGFRvIII for Recurrent Glioblastoma [EARLY_Phase 1]
An early-phase trial update reports safety and preliminary efficacy of a metabolically armed CAR-T cell therapy targeting EGFRvIII in recurr…
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CLINICAL_TRIALS research · 2025-11-21Clinical Trial Update: A Phase I/II Clinical Trial on the Per-operative Intratumoral Administration of Myeloid Dendritic Cells Plus Ipilimumab and Nivolumab, Followed by Repeated Intracavitary Plus Intravenous Administration of Nivolumab in Patients With Recurrent Glioblastoma. [Phase 1, Phase 2]
Phase I/II trial evaluating per-operative intratumoral autologous myeloid dendritic cells with ipilimumab and nivolumab, followed by repeate…
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CLINICAL_TRIALS research · 2025-11-21Clinical Trial Update: hSTAR GBM (Hematopoetic Stem Cell (HPC) Rescue for GBM) [Phase 2]
A Phase 2 clinical trial evaluating hematopoietic stem cell rescue for glioblastoma (hSTAR GBM) is currently recruiting.
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CLINICAL_TRIALS research · 2025-11-21Clinical Trial Update: Oxidative Phosphorylation Targeting In Malignant Glioma Using Metformin Plus Radiotherapy Temozolomide [Phase 2]
Phase 2 clinical trial evaluating metformin plus radiotherapy and temozolomide to target oxidative phosphorylation in glioblastoma, IDH-wild…
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CLINICAL_TRIALS research · 2025-11-20Clinical Trial Update: A Phase 0/1 Study of BDTX-1535 in Recurrent High-Grade Glioma (rHGG) and Newly Diagnosed Glioblastoma (nGBM) Participants With EGFR Alterations or Fusions [EARLY_Phase 1]
A Phase 0/1 study of BDTX-1535 in patients with recurrent high-grade glioma and newly diagnosed glioblastoma with EGFR alterations or fusion…
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CLINICAL_TRIALS research · 2025-11-20Clinical Trial Update: LAM561 With RT and TMZ for Adults With Glioblastoma [Phase 2, Phase 3]
Clinical trial update for LAM561 in combination with radiotherapy and temozolomide for adults with glioblastoma (Phase 2/Phase 3) shows the …