Gastroesophageal Junction Cancer
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2025-11-04Clinical Trial Update: Spevatamig (PT886) as Monotherapy or in Combination With Chemo and/or ICI, for the Treatment of Patients With Advanced Gastric, Gastroesophageal Junction, Pancreatic Ductal or Biliary Tract Carcinomas (the TWINPEAK Study) [Phase 1, Phase 2]
Spevatamig (PT886) is being studied as a monotherapy or in combination with chemotherapy and/or immune checkpoint inhibitors in Phase 1/2 tr…
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CLINICAL_TRIALS research · 2025-10-09Clinical Trial Update: A Study to Assess the Safety and Efficacy of AZD7789 in Participants With Advanced or Metastatic Solid Cancer [Phase 1, Phase 2]
Clinical trial update on AZD7789 evaluating safety and efficacy in participants with advanced or metastatic solid cancers in Phase 1/2.
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CLINICAL_TRIALS research · 2025-09-16Clinical Trial Update: A Clinical Study To Evaluate Camrelizumab (SHR-1210) Plus Capecitabine and Oxaliplatin Followed by Sequential Treatment With Camrelizumab Plus Apatinib Mesylate in Advanced or Metastatic Gastric Cancer (GC) or Gastroesophageal Junction Cancer (GEJ) Without Prior Systemic Therapy [Phase 3]
Phase 3 trial evaluating camrelizumab with capecitabine and oxaliplatin, followed by camrelizumab with apatinib, in advanced/metastatic gast…
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CLINICAL_TRIALS research · 2025-09-10Clinical Trial Update: ASKB589 in Combination With CAPOX and PD-1 Inhibitors in Patients With Advanced, and Unresectable G/GEJ Cancer. [Phase 1, Phase 2]
The document summarizes a Phase 1/Phase 2 clinical trial evaluating ASKB589 in combination with CAPOX chemotherapy and PD-1 inhibitors for p…
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CLINICAL_TRIALS research · 2025-09-10Clinical Trial Update: Neoadjuvant Radiotherapy Plus Tegafur, Oxaliplatin and Iparomlimab and Tuvonralimab in Resectable Gastric and GE-junction Cancer : A Randomized, Two-arm, Prospective Trial (TRIUNITE-05) [Phase 2]
Phase 2 randomized trial evaluating neoadjuvant radiotherapy plus tegafur, oxaliplatin, iparomlimab, and tuvonralimab in resectable gastric …
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CLINICAL_TRIALS research · 2025-09-09Clinical Trial Update: A Study of NX-1607 in Adults With Advanced Malignancies [Phase 1]
A Phase 1 study evaluating NX-1607 in adults with advanced malignancies is actively recruiting across multiple tumor types, including ovaria…
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CLINICAL_TRIALS research · 2025-09-04Clinical Trial Update: Chemoradiation and Pembrolizumab Followed by Pembrolizumab and Lenvatinib Before Surgery for the Treatment of Non-metastatic Esophageal or Esophageal/Gastroesophageal Junction Cancer [Phase 2]
A Phase 2 clinical trial update evaluating chemoradiation with pembrolizumab, followed by pembrolizumab and lenvatinib before surgery for no…
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CLINICAL_TRIALS research · 2025-09-03Clinical Trial Update: Immunotherapy Combined With Anti-angiogenic Therapy and Chemotherapy for Potentially Resectable MSI-H, dMMR Locally Advanced Gastric or Gastroesophageal Junction Adenocarcinoma [Phase 2]
A Phase 2 clinical trial is evaluating a combination of immunotherapy, anti-angiogenic therapy, and chemotherapy in MSI-H/dMMR locally advan…
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CLINICAL_TRIALS research · 2025-08-21Clinical Trial Update: Zimberelimab Anti-PD1 +/- Domvanalimab in Resectable Mmrd Gastric Cancer [Phase 2]
Phase 2 trial update examining zimberelimab with or without domvanalimab in resectable MSI-H/dMMR gastric and gastroesophageal junction canc…
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CLINICAL_TRIALS research · 2025-08-20Clinical Trial Update: Comparing the Efficacy and Safety of Chemotherapy Combined With or Without Immunotherapy as an Adjuvant Treatment After Radical Surgery for Patients With Resectable Adenocarcinoma of the Esophagogastric Junction of Gastric Cancer [Phase 4]
A Phase 4 clinical trial update evaluating adjuvant chemotherapy with or without immunotherapy after radical surgery for resectable gastric …
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CLINICAL_TRIALS research · 2025-08-06Clinical Trial Update: A Study of BL-M07D1 Combination Therapy in Patients With Unresectable Locally Advanced or Metastatic HER2-positive Gastric or Gastroesophageal Junction Adenocarcinoma [Phase 2]
Phase 2 clinical trial evaluating BL-M07D1 in combination therapy for unresectable locally advanced or metastatic HER2-positive gastric or g…
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CLINICAL_TRIALS research · 2025-07-29Clinical Trial Update: Efficacy and Safety of AK112 Combined Chemotherapy as Neoadjuvant Treatment for Signet Ring Cell-containing G/GEJ Adenocarcinoma [Phase 2]
A Phase 2 trial is evaluating AK112 in combination with chemotherapy as neoadjuvant therapy for signet ring cell-containing gastric or gastr…
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CLINICAL_TRIALS research · 2025-07-29Clinical Trial Update: Pucotenlimab Combined With Chemotherapy as Perioperative Treatment for Locally Advanced Gastroesophageal Junction Carcinoma [NA]
Clinical trial update shows pucotenlimab with chemotherapy is being studied as perioperative therapy for locally advanced gastroesophageal j…
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CLINICAL_TRIALS research · 2025-07-16Clinical Trial Update: Perioperative Tislelizumab Plus Chemotherapy Versus Chemotherapy Alone in MHC-II-Positive Gastric/GEJ Cancer [Phase 3]
A Phase 3 trial is investigating perioperative tislelizumab plus chemotherapy versus chemotherapy alone for MHC-II-positive gastric/GEJ canc…
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CLINICAL_TRIALS research · 2025-07-11Clinical Trial Update: T-Dxd in Combination With Ramucirumab as HER2 Low Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating trastuzumab deruxtecan in combination with ramucirumab for HER2-low gastric or gastroesophageal juncti…
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CLINICAL_TRIALS research · 2025-07-11Clinical Trial Update: Pembrolizumab, Olaparib, Recurrent/Advanced Gastric and Gastro-esophageal Junction(GEJ) Cancer [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating the combination of pembrolizumab and olaparib for recurrent/advanced gastric cancer and gastroesophage…
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CLINICAL_TRIALS research · 2025-06-25Clinical Trial Update: A Clinical Trail of KJ015 in Patients With HER2-Expressing Solid Tumors [Phase 1]
A Phase 1 trial update for KJ015 in HER2-expressing solid tumors shows the study is not yet recruiting.
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CLINICAL_TRIALS research · 2025-06-10Clinical Trial Update: TremelImumab aNd Durvalumab For the Non-operatIve Management (NOM) of MSI-high Resectable GC/GEJC. [Phase 2]
A Phase 2 study testing tremelimumab plus durvalumab for non-operative management of MSI-high resectable gastric cancer and gastroesophageal…
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CLINICAL_TRIALS research · 2025-06-08Clinical Trial Update: Neoadjuvant Capecitabine, Oxaliplatin, Docetaxel and Atezolizumab in Resectable Gastric and GE-junction Cancer (PANDA) [Phase 2]
Phase 2 neoadjuvant trial PANDA investigates a four-drug regimen (capecitabine, oxaliplatin, docetaxel, and atezolizumab) for resectable gas…
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CLINICAL_TRIALS research · 2025-06-08Clinical Trial Update: Robotic Versus Laparoscopic Radical Surgery for Locally Advanced Gastric Cancer [NA]
A clinical trial comparing robotic versus laparoscopic radical surgery for locally advanced gastric cancer is currently recruiting in China.
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CLINICAL_TRIALS research · 2025-06-05Clinical Trial Update: Ivonescimab (AK112) Plus Paclitaxel as Second-line Therapy in Patients With Advanced G/GEJ Cancer [Phase 2]
Phase 2 trial update for Ivonescimab (AK112) plus paclitaxel as second-line therapy in advanced gastric/gastroesophageal junction cancer; th…
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CLINICAL_TRIALS research · 2025-05-28Clinical Trial Update: Neoadjuvant Chemo-hypoRT Plus PD-1 Antibody (Tislelizumab) in Resectable LA-G/GEJ [Phase 2]
This clinical trial update describes a Phase 2 study evaluating neoadjuvant chemotherapy and hypofractionated radiotherapy combined with the…
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CLINICAL_TRIALS research · 2025-05-25Clinical Trial Update: Optimal Nutritional Palliation of Obstructed GEJ Cancer [NA]
ClinicalTrials.gov update describing a study on optimal nutritional palliation for obstructed gastroesophageal junction cancer, currently no…
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CLINICAL_TRIALS research · 2025-05-22Clinical Trial Update: Registry for Esophageal and Gastroesophageal Junction Cancer
This clinical trial registry entry indicates a Memorial Sloan Kettering Cancer Center study on esophageal cancer and gastroesophageal juncti…
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CLINICAL_TRIALS research · 2025-05-07Clinical Trial Update: XELOX Combined With Sintilimab and HBO for Advanced or Metastatic GC/GEJC [Phase 1, Phase 2]
A Phase 1/2 trial evaluating XELOX (capecitabine plus oxaliplatin) in combination with sintilimab and hyperbaric oxygen therapy for advanced…